Hasil untuk "Norway"

Paul J. Devereux, Sandra E. Black, Kjell G. Salvanes

There is an extensive theoretical literature that postulates a trade-off between child quantity and quality within a family. However, there is little causal evidence that speaks to this theory. Using a rich data set on the entire population of Norway over an extended period of time, we examine the effects of family size and birth order on the educational attainment of children. We find a negative correlation between family size and children's education, but when we include indicators for birth order or use twin births as an instrument, family size effects become negligible. In addition, higher birth order has a significant and large negative effect on children's education. We also study adult earnings, employment, and teenage childbearing and find strong evidence for birth order effects with these outcomes, particularly among women. These findings suggest the need to revisit economic models of fertility and child "production," focusing not only on differences across families but differences within families as well.

D. Olweus

B. Strand, O. Dalgard, K. Tambs et al.

Sandra E. Black, P. Devereux, Kjell G. Salvanes

Lower birth weight babies have worse outcomes, both short-run in terms of one year mortality rates and longer run in terms of educational attainment and earnings. However, recent research has called into question whether birth weight itself is important or whether it simply reflects other hard-to-measure haracteristics. By applying within twin techniques using a unique dataset from Norway, we xamine both short-run and long-run outcomes for the same cohorts. We find that birth weight does matter; very small short-run fixed effect estimates can be misleading because longer-run effects on outcomes such as height, IQ, earnings, and education are significant and similar in magnitude to OLS estimates. Our estimates suggest that eliminating birth weight differences between socio-economic groups would have sizeable effects on the later outcomes of children from poorer families

Louise Melvin

Torleif Ruud, Jūratė Šaltytė Benth, Ajmal Hussain et al.

Abstract Background The aim of the study was to determine the effects on health care of an adapted Norwegian version of a Canadian model of collaborative care, involving general practitioners (GPs) and mental health specialists working together co-located in GP practices. In previous papers, we have shown that the adapted model was successfully implemented and found to be beneficial by participating GPs, improving their detection of anxiety in young people, and with a reduction in long term sickness benefits. The current study examines whether collaborative care was associated with changes in (a) the number of referrals from GPs to mental health services, (b) the number of GP patients provided outpatient visits in mental health services, (c) GPs’ recognition of common mental disorders, and (d) GPs’ prescription of various types of psychotropic medication. Methods The study was a cluster-randomised controlled trial of the collaborative care model in three GP practices (intervention group) compared with usual health care in three other practices (control group) in Oslo, Norway. A clinical psychologist and a psychiatrist from a community mental health centre worked half time and two hours per week, respectively, in each intervention practice for 18 months. They were available for case discussions and provided assessments and brief therapies. Structured data were extracted retrospectively from the electronic patient records of both GPs and mental health services for 12 months before and during the implementation of collaborative care for patients 16–65 years old. Data were analysed with generalized linear mixed models. Results There were no significant differences in referrals to mental health services (the primary outcome) and in the use of outpatient specialised mental health services. The GPs in the intervention practices diagnosed significantly more patients with common mental disorders (anxiety, depression), and these changes were significantly associated with a reduction in unexplained physical symptoms. Significant changes in prescribing patterns of psychotropic medication were consistent with the increased recognition of mental disorders, and their use was possibly more appropriate. Conclusions Collaborative care with co-located mental health specialists in GP practices led to an increased recognition of common mental disorders by those GPs. Due to a lack of structured clinical measurements in the electronic patient records, the clinical outcomes of the intervention were unknown.

Nicholas Steel, Clarissa Maria Mercedes Bauer-Staeb, John A Ford et al.

Summary: Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy across all countries (overall mean –0·18 years [95% UI –0·22 to –0·13]), with all countries having an absolute fall in life expectancy except for Ireland, Iceland, Sweden, Norway, and Denmark, which showed marginal improvement in life expectancy, and Belgium, which showed no change in life expectancy. Across countries, the causes of death responsible for the largest improvements in life expectancy from 1990 to 2011 were cardiovascular diseases and neoplasms. Deaths from cardiovascular diseases were the primary driver of reductions in life expectancy improvements during 2011–19, and deaths from respiratory infections and other COVID-19 pandemic-related outcomes were responsible for the decreases in life expectancy during 2019–21. Deaths from cardiovascular diseases and neoplasms in 2019 were attributable to high systolic blood pressure, dietary risks, tobacco smoke, high LDL cholesterol, high BMI, occupational risks, high alcohol use, and other risks including low physical activity. Exposure to these major risk factors differed by country, with trends of increasing exposure to high BMI and decreasing exposure to tobacco smoke observed in all countries during 1990–2021. Interpretation: The countries that best maintained improvements in life expectancy after 2011 (Norway, Iceland, Belgium, Denmark, and Sweden) did so through better maintenance of reductions in mortality from cardiovascular diseases and neoplasms, underpinned by decreased exposures to major risks, possibly mitigated by government policies. The continued improvements in life expectancy in five countries during 2019–21 indicate that these countries were better prepared to withstand the COVID-19 pandemic. By contrast, countries with the greatest slowdown in life expectancy improvements after 2011 went on to have some of the largest decreases in life expectancy in 2019–21. These findings suggest that government policies that improve population health also build resilience to future shocks. Such policies include reducing population exposure to major upstream risks for cardiovascular diseases and neoplasms, such as harmful diets and low physical activity, tackling the commercial determinants of poor health, and ensuring access to affordable health services. Funding: Gates Foundation.

Mikkel Andreas Kvande, Sigurd Løite Jacobsen, Morten Goodwin et al.

Agricultural development is one of the most essential needs worldwide. In Norway, the primary foundation of grain production is based on geological and biological features. Existing research is limited to regional-scale yield predictions using artificial intelligence (AI) models, which provide a holistic overview of crop growth. In this paper, the authors propose detecting several field-scale crop types and use this analysis to predict yield production early in the growing season. In this study, the authors utilise a multi-temporal satellite image, meteorological, geographical, and grain production data corpus. The authors extract relevant vegetation indices from satellite images. Furthermore, the authors use field-area-specific features to build a field-based crop type classification model. The proposed model, consisting of a time-distributed network and a gated recurrent unit, can efficiently classify crop types with an accuracy of 70%. In addition, the authors justified that the attention-based multiple-instance learning models could learn semi-labelled agricultural data, and thus, allow realistic early in-season predictions for farmers.

Klaus Thanke Aspli, Jan O. Aaseth, Trygve Holmøy et al.

Skogholt’s disease is a rare neurological disorder that is only observed in a small Norwegian kindred. It typically manifests in adulthood with uncharacteristic neurological symptoms from both the peripheral and central nervous systems. The etiology of the observed cerebral white matter lesions and peripheral myelin pathology is unclear. Increased cerebrospinal fluid (CSF) concentrations of protein have been confirmed, and recently, very high concentrations of CSF total and phosphorylated tau have been detected in Skogholt patients. The symptoms and observed biomarker changes in Skogholt’s disease are largely nonspecific, and further studies are necessary to elucidate the disease mechanisms. Here, we report the results of neurochemical analyses of plasma and CSF, as well as results from the morphometric segmentation of cerebral magnetic resonance imaging. We analyzed the biomarkers Aβ_1––42, Aβ_1–40, Aβ_x–38, Aβ_x–40, Aβ_x–42, total and phosphorylated tau, glial fibrillary acidic protein, neurofilament light chain, platelet-derived growth factor receptor beta, and beta-trace protein. All analyzed CSF biomarkers, except neurofilament light chain and Aβ_1/x–42, were increased several-fold. In blood, none of these biomarkers were significantly different between the Skogholt and control groups. MRI volumetric segmentation revealed decreases in the ventricular, white matter, and choroid plexus volumes in the Skogholt group, with an accompanying increase in white matter lesions. The cortical thickness and subcortical gray matter volumes were increased in the Skogholt group. Pathophysiological changes resulting from choroidal dysfunction and/or abnormal CSF turnover, which may cause the increases in CSF protein and brain biomarker levels, are discussed.

J.-B. P. Koehl, J.-B. P. Koehl, J.-B. P. Koehl et al.

<p>The Svalbard Archipelago consists of three basement terranes that record a complex Neoproterozoic–Phanerozoic tectonic history, including four contractional events (Grenvillian, Caledonian, Ellesmerian, and Eurekan) and two episodes of collapse- to rift-related extension (Devonian–Carboniferous and late Cenozoic). Previous studies suggest that these three terranes likely accreted during the early to mid-Paleozoic Caledonian and Ellesmerian orogenies. Yet recent geochronological analyses show that the northwestern and southwestern terranes of Svalbard both record an episode of amphibolite (–eclogite) facies metamorphism in the latest Neoproterozoic, which may relate to the 650–550 <span class="inline-formula">Ma</span> Timanian Orogeny identified in northwestern Russia, northern Norway, and the Russian Barents Sea. However, discrete Timanian structures have yet to be identified in Svalbard and the Norwegian Barents Sea. Through analysis of seismic reflection, as well as regional gravimetric and magnetic data, this study demonstrates the presence of continuous thrust systems that are several kilometers thick, NNE-dipping, deeply buried, and extend thousands of kilometers from northwestern Russia to northeastern Norway, the northern Norwegian Barents Sea, and the Svalbard Archipelago. The consistency in orientation and geometry, as well as apparent linkage between these thrust systems and those recognized as part of the Timanian Orogeny in northwestern Russia and Novaya Zemlya, suggests that the mapped structures are likely Timanian. If correct, these findings would imply that Svalbard's three basement terranes and the Barents Sea were accreted onto northern Norway during the Timanian Orogeny and should hence be attached to Baltica and northwestern Russia in future Neoproterozoic–early Paleozoic plate tectonics reconstructions. In the Phanerozoic, the study suggests that the interpreted Timanian thrust systems represent major preexisting zones of weakness that were reactivated, folded, and overprinted by (i.e., controlled the formation of new) brittle faults during later tectonic events. These faults are still active at present and can be linked to folding and offset of the seafloor.</p>

S. Rives, S. L. Maude, H. Hiramatsu et al.

Cornelia Geßner, Alena Krüger, Lars P. Folkow et al.

The mammalian brain is characterized by high energy expenditure and small energy reserves, making it dependent on continuous vascular oxygen and nutritional supply. The brain is therefore extremely vulnerable to hypoxia. While neurons of most terrestrial mammals suffer from irreversible damage after only short periods of hypoxia, neurons of the deep-diving hooded seal (Cystophora cristata) show a remarkable hypoxia-tolerance. To identify the molecular mechanisms underlying the intrinsic hypoxia-tolerance, we excised neurons from the visual cortices of hooded seals and mice (Mus musculus) by laser capture microdissection. A comparison of the neuronal transcriptomes suggests that, compared to mice, hooded seal neurons are endowed with an enhanced aerobic metabolic capacity, a reduced synaptic transmission and an elevated antioxidant defense. Publicly available whole-tissue brain transcriptomes of the bowhead whale (Balaena mysticetus), long-finned pilot whale (Globicephala melas), minke whale (Balaenoptera acutorostrata) and killer whale (Orcinus orca), supplemented with 2 newly sequenced long-finned pilot whales, suggest that, compared to cattle (Bos taurus), the cetacean brain also displays elevated aerobic capacity and reduced synaptic transmission. We conclude that the brain energy balance of diving mammals is preserved during diving, due to reduced synaptic transmission that limits energy expenditure, while the elevated aerobic capacity allows efficient use of oxygen to restore energy balance during surfacing between dives.

Jens Bjerring-Hansen, Ross Deans Kristensen-McLachlan, Philip Diderichsen et al.

In this paper we present an OCR correction pipeline for 19th century printed Danish fraktur (gothic/blackletter). The work has been carried out at the University of Copenhagen in relation to a research project involving digital explorations of a corpus of some 900 Danish and Norwegian novels from 1870 to 1899, totalling app. 65 million words. Roughly 25% of these novels are printed in the traditional fraktur font, which was almost totally dominating in the beginning of the 19th century. These texts are important culturally, since they represent mostly forgotten, popular novels, however they pose technical and methodological challenges in terms of processing the text from printed page to digital corpus. In order to provide the best possible material for digital literary analysis as well as more linguistic studies, we designed an OCR correction pipeline for the fraktur part of the corpus consisting of several different heuristic correction steps, with reference to a gold standard. The first step is a preprocessing step which takes care of obvious and unambiguous OCR errors. In the second step we align our primary OCR output candidate (the output from Tesseract using the Fraktur.traineddata pretrained OCR model) with several other OCR output candidates and perform selective correction with reference to these. Especially the Danish “æ” and “ø” characters can be successfully recovered with reference to the Danish, non-fraktur dan.traineddata Tesseract model. Finally, in the third step, we employ the SymSpell spell checker to perform spelling correction backed by a word form dictionary hand-crafted from various relevant sources. The pipeline reduces the word error rate by 7.6 percentage points from 10.5% (89.5% correctly recognized word forms) to 2.8% (97.2% correctly recognized word forms) - an improvement of almost 73%. The character error rate (CER) similarly decreased from 1.94% to 0.54%.

Mette Pernille Myklebust, Anna Thor, Benedikte Rosenlund et al.

Abstract MicroRNA-371a-3p (miR371) has been suggested as a sensitive biomarker in testicular germ cell cancer (TGCC). We aimed to compare miR371 with the classical biomarkers α-fetoprotein (AFP) and β-human chorionic gonadotropin (hCGβ). Overall, 180 patients were prospectively enrolled in the study, with serum samples collected before and after orchiectomy. We compared the use of digital droplet PCR (RT-ddPCR) with the quantitative PCR used by others for detection of miR371. The novel RT-ddPCR protocol showed high performance in detection of miR371 in serum samples. In the study cohort, miR371 was measured using RT-ddPCR. MiR371 detected CS1 of the seminoma and the non-seminoma sub-types with a sensitivity of 87% and 89%, respectively. The total sensitivity was 89%. After orchiectomy, miR371 levels declined in 154 of 159 TGCC cases. The ratio of miR371 pre- and post-orchiectomy was 20.5 in CS1 compared to 6.5 in systemic disease. AFP and hCGβ had sensitivities of 52% and 51% in the non-seminomas. MiR371 is a sensitive marker that performs better than the classical markers in all sub-types and clinical stages. Especially for the seminomas CS1, the high sensitivity of miR371 in detecting TGCC cells may have clinical implications.

Solvang Helene, Kristiansen Tobias, Bottheim Ruth Marie et al.

Working with daylight simulations on a regular basis, the authors discovered that it is increasingly challenging to achieve daylight criteria in new building projects. In addition to complex building designs, a new European Standard was published in 2018 named EN 17037:2018 Daylight in Buildings, which includes climate-based daylight simulations. These new criteria require a different type of simulation and presentation of results, compared to the simplified method of calculating average daylight factor, which is mostly used today. The authors have created, tested and validated scripts for performing climate-based daylighting simulations, using Rhinoceros and Grasshopper. The script designed for climate-based daylight simulations, showed too extensive differences between supposedly equivalent criteria for daylight factor and daylight autonomy, meaning it can’t be applied in construction projects as the only documentation of daylight availability. Further testing and investigation of the climate-based daylight script has to be done, in order to perform correct evaluations of realistic daylighting conditions.

A. V. Dyrrdal, K. Isaksen, J. K. S. Jacobsen et al.

<p>A number of seaside communities in Troms, northern Norway, are vulnerable to sudden weather-induced access disruptions due to high-impact weather and dependency on one or few roads. In this paper we study changes in winter weather known to potentially cause access disruptions in Troms, for the present climate (1958–2017) and two future periods (2041–2070; 2071–2100). We focus on climate indices associated with snow avalanches and weather that may lead to for example slippery road conditions. In two focus areas, the most important results show larger snow amounts now compared to 50 years ago, and heavy snowfall has become more intense and frequent. This trend is expected to turn in the future, particularly at low elevations where snow cover during winter might become a rarity by 2100. Strong snow drift, due to a combination of snowfall and wind speed, has slightly increased in the two focus areas, but a strong decrease is expected in the future due to less snow. Events of heavy rain during winter are rather infrequent in the present winter climate of Troms, but we show that these events are likely to occur much more often in all regions in the future.</p>

J. Lawesson, A. Moen

Patricia Schlagenhauf, Martin P. Grobusch, Davidson H. Hamer et al.

Abstract Background Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature review to elucidate key attributes of malaria in this group with a focus on possible areas of acquisition of malaria and treatment challenges. Results A total of 146 cases were identified from the GeoSentinel database from 1999 through September 2017, with a marked increase in 2014 and 2015. All patients originated from Eritrea and the main reporting GeoSentinel sites were in Norway, Switzerland, Sweden, Israel and Germany. The majority of patients (young adult males) were diagnosed with malaria following arrival in the host country. All patients had a possible exposure in Eritrea, but may have been exposed in documented transit countries including Ethiopia, Sudan and possibly Libya in detention centres. Most infections were due to Plasmodium vivax (84.2%), followed by Plasmodium falciparum (8.2%). Two patients were pregnant, and both had P. vivax malaria. Some 31% of the migrants reported having had malaria while in transit. The median time to onset of malaria symptoms post arrival in the host country was 39 days. Some 66% of patients were hospitalized and nine patients had severe malaria (according to WHO criteria), including five due to P. vivax. Conclusions The 146 cases of mainly late onset, sometimes severe, P. vivax malaria in Eritrean migrants described in this multi-site, global analysis reflect the findings of single-centre analyses identified in the literature search. Host countries receiving asylum-seekers from Eritrea need to be prepared for large surges in vivax and, to a lesser extent, falciparum malaria, and need to be aware and prepared for glucose-6-phosphate dehydrogenase deficiency testing and primaquine treatment, which is difficult to procure and mainly unlicensed in Europe. There is an urgent need to explore the molecular epidemiology of P. vivax in Eritrean asylum-seekers, to investigate the area of acquisition of P. vivax along common transit routes and to determine whether there has been re-introduction of malaria in areas, such as Libya, where malaria is considered eliminated, but where capable vectors and Plasmodium co-circulate.

M. B. Nielsen, A. Skogstad, S. B. Matthiesen et al.

Ronald R. Rindfuss, D. Guilkey, S. P. Morgan et al.