Hasil untuk "Ancient history"

Vanessa M. D’Costa, Christine E. King, Lindsay Kalan et al.

M. Ventura, C. Canchaya, A. Tauch et al.

Dake Zhao, Yang Yu, Yong Shen et al.

Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's initial function was likely that as a free radical scavenger. Melatonin presumably evolved in bacteria; it has been measured in both α-proteobacteria and in photosynthetic cyanobacteria. In early evolution, bacteria were phagocytosed by primitive eukaryotes for their nutrient value. According to the endosymbiotic theory, the ingested bacteria eventually developed a symbiotic association with their host eukaryotes. The ingested α-proteobacteria evolved into mitochondria while cyanobacteria became chloroplasts and both organelles retained their ability to produce melatonin. Since these organelles have persisted to the present day, all species that ever existed or currently exist may have or may continue to synthesize melatonin in their mitochondria (animals and plants) and chloroplasts (plants) where it functions as an antioxidant. Melatonin's other functions, including its multiple receptors, developed later in evolution. In present day animals, via receptor-mediated means, melatonin functions in the regulation of sleep, modulation of circadian rhythms, enhancement of immunity, as a multifunctional oncostatic agent, etc., while retaining its ability to reduce oxidative stress by processes that are, in part, receptor-independent. In plants, melatonin continues to function in reducing oxidative stress as well as in promoting seed germination and growth, improving stress resistance, stimulating the immune system and modulating circadian rhythms; a single melatonin receptor has been identified in land plants where it controls stomatal closure on leaves. The melatonin synthetic pathway varies somewhat between plants and animals. The amino acid, tryptophan, is the necessary precursor of melatonin in all taxa. In animals, tryptophan is initially hydroxylated to 5-hydroxytryptophan which is then decarboxylated with the formation of serotonin. Serotonin is either acetylated to N-acetylserotonin or it is methylated to form 5-methoxytryptamine; these products are either methylated or acetylated, respectively, to produce melatonin. In plants, tryptophan is first decarboxylated to tryptamine which is then hydroxylated to form serotonin.

I. Mathieson, S. A. Roodenberg, C. Posth et al.

Farming was first introduced to Europe in the mid-seventh millennium bc, and was associated with migrants from Anatolia who settled in the southeast before spreading throughout Europe. Here, to understand the dynamics of this process, we analysed genome-wide ancient DNA data from 225 individuals who lived in southeastern Europe and surrounding regions between 12000 and 500 bc. We document a west–east cline of ancestry in indigenous hunter-gatherers and, in eastern Europe, the early stages in the formation of Bronze Age steppe ancestry. We show that the first farmers of northern and western Europe dispersed through southeastern Europe with limited hunter-gatherer admixture, but that some early groups in the southeast mixed extensively with hunter-gatherers without the sex-biased admixture that prevailed later in the north and west. We also show that southeastern Europe continued to be a nexus between east and west after the arrival of farmers, with intermittent genetic contact with steppe populations occurring up to 2,000 years earlier than the migrations from the steppe that ultimately replaced much of the population of northern Europe.

S. Bonini, M. Premoli, S. Tambaro et al.

ETHNOPHARMACOLOGICAL RELEVANCE Cannabis sativa L. (C. sativa) is an annual dioecious plant, which shares its origins with the inception of the first agricultural human societies in Asia. Over the course of time different parts of the plant have been utilized for therapeutic and recreational purposes, for instance, extraction of healing oils from seed, or the use of inflorescences for their psychoactive effects. The key psychoactive constituent in C. sativa is called Δ-9-tetrahydrocannabinol (D9-THC). The endocannabinoid system seems to be phylogenetically ancient, as it was present in the most primitive vertebrates with a neuronal network. N-arachidonoylethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG) are the main endocannabinoids ligands present in the animal kingdom, and the main endocannabinoid receptors are cannabinoid type-1 (CB1) receptor and cannabinoid type-2 (CB2) receptor. AIM OF THE STUDY The review aims to provide a critical and comprehensive evaluation, from the ancient times to our days, of the ethnological, botanical, chemical and pharmacological aspects of C. sativa, with a vision for promoting further pharmaceutical research to explore its complete potential as a therapeutic agent. MATERIALS AND METHODS This study was performed by reviewing in extensive details the studies on historical significance and ethnopharmacological applications of C. sativa by using international scientific databases, books, Master's and Ph.D. dissertations and government reports. In addition, we also try to gather relevant information from large regional as well as global unpublished resources. In addition, the plant taxonomy was validated using certified databases such as Medicinal Plant Names Services (MPNS) and The Plant List. RESULTS AND CONCLUSIONS A detailed comparative analysis of the available resources for C. sativa confirmed its origin and traditional spiritual, household and therapeutic uses and most importantly its popularity as a recreational drug. The result of several studies suggested a deeper involvement of phytocannabinoids (the key compounds in C. sativa) in several others central and peripheral pathophysiological mechanisms such as food intake, inflammation, pain, colitis, sleep disorders, neurological and psychiatric illness. However, despite their numerous medicinal benefits, they are still considered as a menace to the society and banned throughout the world, except for few countries. We believe that this review will help lay the foundation for promoting exhaustive pharmacological and pharmaceutical studies in order to better understand the clinical relevance and applications of non-psychoactive cannabinoids in the prevention and treatment of life-threatening diseases and help to improve the legal status of C. sativa.

Íñigo Olalde, Swapan Mallick, Swapan Mallick et al.

Genomics of the Iberian Peninsula Ancient DNA studies have begun to help us understand the genetic history and movements of people across the globe. Focusing on the Iberian Peninsula, Olalde et al. report genome-wide data from 271 ancient individuals from Iberia (see the Perspective by Vander Linden). The findings provide a comprehensive genetic time transect of the region. Linguistics analysis and genetic analysis of archaeological human remains dating from about 7000 years ago to the present elucidate the genetic impact of prehistoric and historic migrations from Europe and North Africa. Science, this issue p. 1230; see also p. 1153 Analyses of ancient human genomes document 7000 years of genetic changes in the Iberian Peninsula. We assembled genome-wide data from 271 ancient Iberians, of whom 176 are from the largely unsampled period after 2000 BCE, thereby providing a high-resolution time transect of the Iberian Peninsula. We document high genetic substructure between northwestern and southeastern hunter-gatherers before the spread of farming. We reveal sporadic contacts between Iberia and North Africa by ~2500 BCE and, by ~2000 BCE, the replacement of 40% of Iberia’s ancestry and nearly 100% of its Y-chromosomes by people with Steppe ancestry. We show that, in the Iron Age, Steppe ancestry had spread not only into Indo-European–speaking regions but also into non-Indo-European–speaking ones, and we reveal that present-day Basques are best described as a typical Iron Age population without the admixture events that later affected the rest of Iberia. Additionally, we document how, beginning at least in the Roman period, the ancestry of the peninsula was transformed by gene flow from North Africa and the eastern Mediterranean.

Charleen Gaunitz, A. Fages, Kristian Hanghøj et al.

A. Arzani, M. Ashraf

Margaret L. Antonio, Ziyue Gao, Hannah M. Moots et al.

A 10,000-year transect of Roman populations Rome wasn't built (or settled) in a day. Antonio et al. performed an ancestral DNA analysis to investigate the genetic changes that occurred in Rome and central Italy from the Mesolithic into modern times. By examining 127 Roman genomes and their archaeological context, the authors demonstrate a major ancestry shift in the Neolithic between hunter gatherers and farmers. A second ancestry shift is observed in the Bronze Age, likely coinciding with trade and an increased movement of populations. Genetic changes track the historical changes occurring in Rome and reflect gene flow from across the Mediterranean, Europe, and North Africa over time. Science, this issue p. 708 Whole-genome sequencing of ancient Romans reveals a dynamic population history and reflects historical events. Ancient Rome was the capital of an empire of ~70 million inhabitants, but little is known about the genetics of ancient Romans. Here we present 127 genomes from 29 archaeological sites in and around Rome, spanning the past 12,000 years. We observe two major prehistoric ancestry transitions: one with the introduction of farming and another prior to the Iron Age. By the founding of Rome, the genetic composition of the region approximated that of modern Mediterranean populations. During the Imperial period, Rome’s population received net immigration from the Near East, followed by an increase in genetic contributions from Europe. These ancestry shifts mirrored the geopolitical affiliations of Rome and were accompanied by marked interindividual diversity, reflecting gene flow from across the Mediterranean, Europe, and North Africa.

Hisashi Hayakawa

On a centennial timescale, solar activity was quantified based on records of instrumental sunspot observations. This article briefly discusses several aspects of the recent archival investigations of historical sunspot records in the 17th to 18th centuries. This article also reviews the recent updates for the active day fraction and positions of the reported sunspot groups of the Maunder Minimum to show their significance within the observational history. These archival investigations serve as base datasets for reconstructing solar activity.

Pavel Vladimirovich Kuzenkov, Yury Mironovich Mogarichev

This article discusses the chronology of the appearance of the toponym Mangup and its variants in written sources. Mangup (Mankop, Mankup) is the name of the town of Theodoro in Turkish, Russian and Moldavian sources from the 1470s on. By all appearance, this late Tatar name came through the Crimean Khanate to the Moscow State and Moldavia. The given research analyses the accounts on the khan (prince) of “Mankop” who was defeated, with two other khans, on the Don by the Lithuanians ca 1396. The scholarship usually unites this event with the account of the battle of the Grand Duke Olgerd of Lithuania with three Tatar “princes” at Sinie Vody in 1362, sometimes associating the khan of “Mankop” with the prince bearing the Christian name Dmitrii. The analysis undertaken shows that the account on the Lithuanian army sent by Vytautas victory on the Don over three Tatar khans originates from the sixteenth-century Polish historian Maciej Stryjkowski. In earlier chronicles and historical works there is only a contamination of the victories over the Tatars of Olgerd and his nephew Vytautas. It is obvious that Maciej Stryjkowski twice described the same Lithuanian-Tatar battle, on the Sinie Vody of Olgerd with three princes called Kutlubach soltan, Kaczybejkierej, and Dimejter soltan, and on the Don of “Olgerd, a lord of Lithuania,” sent by Vytautas, with three “brother-princes, of Krym, Kirkiel, and Mankop.” The titles of the princes are possibly invented by Maciej Stryjkowski, who, trying to give a learned interpretation to his phantom duplicate of Olgerd’s victory, correlated the possessions of the three defeated Tatar leaders with three urban centers in Crimea known to him: Krym (Solkhat), Kyrk-Er (Chufut-Kale) and Mangup. In this way the complex of texts about the fourteenth-century Lithuanian-Tatar battles should be excluded from the number of sources directly related to the history of Mangup.

M. Spyrou, K. Bos, A. Herbig et al.

Over the past decade, a genomics revolution, made possible through the development of high-throughput sequencing, has triggered considerable progress in the study of ancient DNA, enabling complete genomes of past organisms to be reconstructed. A newly established branch of this field, ancient pathogen genomics, affords an in-depth view of microbial evolution by providing a molecular fossil record for a number of human-associated pathogens. Recent accomplishments include the confident identification of causative agents from past pandemics, the discovery of microbial lineages that are now extinct, the extrapolation of past emergence events on a chronological scale and the characterization of long-term evolutionary history of microorganisms that remain relevant to public health today. In this Review, we discuss methodological advancements, persistent challenges and novel revelations gained through the study of ancient pathogen genomes. This article reviews recent advances in ancient pathogen genomics, from methodological improvements in retrieving whole genomes to evolutionary analyses of ancient pathogens that remain relevant to public health. Focusing on the evolutionary history of the plague pathogen Yersinia pestis, the authors present unique insights afforded by the study of ancient pathogen genomes.

Siyu Duan, Jun Wang, Qi Su

Cultural heritage serves as the enduring record of human thought and history. Despite significant efforts dedicated to the preservation of cultural relics, many ancient artefacts have been ravaged irreversibly by natural deterioration and human actions. Deep learning technology has emerged as a valuable tool for restoring various kinds of cultural heritages, including ancient text restoration. Previous research has approached ancient text restoration from either visual or textual perspectives, often overlooking the potential of synergizing multimodal information. This paper proposes a novel Multimodal Multitask Restoring Model (MMRM) to restore ancient texts, particularly emphasising the ideograph. This model combines context understanding with residual visual information from damaged ancient artefacts, enabling it to predict damaged characters and generate restored images simultaneously. We tested the MMRM model through experiments conducted on both simulated datasets and authentic ancient inscriptions. The results show that the proposed method gives insightful restoration suggestions in both simulation experiments and real-world scenarios. To the best of our knowledge, this work represents the pioneering application of multimodal deep learning in ancient text restoration, which will contribute to the understanding of ancient society and culture in digital humanities fields.

Xiaoyu Yuan, Xiaohua Huang, Zibo Zhang et al.

The Houma Alliance Book, one of history's earliest calligraphic examples, was unearthed in the 1970s. These artifacts were meticulously organized, reproduced, and copied by the Shanxi Provincial Institute of Cultural Relics. However, because of their ancient origins and severe ink erosion, identifying characters in the Houma Alliance Book is challenging, necessitating the use of digital technology. In this paper, we propose a new ancient handwritten character recognition database for the Houma alliance book, along with a novel benchmark based on deep learning architectures. More specifically, a collection of 26,732 characters samples from the Houma Alliance Book were gathered, encompassing 327 different types of ancient characters through iterative annotation. Furthermore, benchmark algorithms were proposed by combining four deep neural network classifiers with two data augmentation methods. This research provides valuable resources and technical support for further studies on the Houma Alliance Book and other ancient characters. This contributes to our understanding of ancient culture and history, as well as the preservation and inheritance of humanity's cultural heritage.

Or Graur

The Milky Way's name and role in ancient Egyptian culture remain unclear. One suggestion is that the Milky Way may have been a celestial depiction of the sky goddess Nut. In this work, I test this association using an interdisciplinary approach. In the first part of this paper, I combine astronomical simulations of the ancient Egyptian night sky with primary Egyptian sources to map the goddess Nut onto the Milky Way. With her head and groin firmly associated by primary texts with the western and eastern horizons, respectively, I argue that the summer and winter orientations of the Milky Way could be construed as figurative markers of Nut's torso (or backbone) and her arms, respectively. In the second part of this paper, I situate Nut within the global, multicultural mythology of the Milky Way. Specifically, I show that Nut's roles in the afterlife and the autumn bird migration are consistent with similar roles attributed to the Milky Way by other cultures. Finally, I show that Nut's identification with the Milky Way may even have echoes in contemporary African conceptions of the Galaxy.

E. Willerslev, D. Meltzer

J. Kratzer, M. Lanaspa, M. N. Murphy et al.

Jiajie Zhu, Ji-Cheng Li, Liangjun Yang et al.

Acupuncture is characterized by the insertion of a fine metal needle through the skin of the human body at an acupuncture point (acupoint) in Traditional Chinese Medicine (TCM). It is an ancient form of therapy, and has a long history of prosperity and decline. Due to the persistent efforts of TCM practitioners, a number of well‐designed clinical trials regarding acupuncture have been published in the past decade. Besides, numerous basic researches aiming to reveal the mechanisms of acupuncture have also been conducted. Several scientific explanations have been obtained to interpret the arcane TCM theory. This review provides brief information of acupuncture, including its history, status, evidence, and mechanisms.

Hans-E. Porst

Not only motivated by the fact that the publication of the GAFT first appeared 60 years ago in print we reconstruct its history and so show that it is no exaggeration to claim that it has appeared already 75 years ago!

Margaret Byrne, Cristina E. Ramalho, Sarah Tapper et al.

Topographically heterogeneous areas are likely to act as refugia for species because they facilitate survival during regional climatic stress due to availability of a range of microenvironments. The Stirling Ranges are a topographically complex area in the generally subdued and ancient landscape of south-western Australia. We investigated the influence of these landscape features on the evolutionary history of the rare woody shrub, Banksia brownii through a combined approach using phylogeographic analysis of sequence data from three chloroplast sequences, the trnV–ndhC, trnQ–rps16, and rpl32–ndhF intergenic spacer regions, and species distribution modeling. The Stirling Ranges showed high genetic diversity and differentiation among populations consistent with localized persistence and maintenance of large populations in an area that species distribution modeling identified as providing habitat stability at the Last Glacial Maximum as well as under warmer conditions. In contrast, populations in the adjacent subdued lowlands showed signals of low diversity, suggesting contraction, and subsequent expansion from localized refugia in the west. Cool summers are an important climatic variable for the species and species distribution modeling showed suitable habitat identified at the LGM suggesting expansion at this time following likely contraction during earlier warmer climatic oscillations. The isolated, coastal population at Vancouver Peninsula showed low diversity but no differentiation and it may have been established in more recent historical times, possibly through Aboriginal movement of seed. Our analysis of B. brownii highlights the complex evolutionary history of the species and the influence of topographic complexity and habitat heterogeneity in this global biodiversity hotspot.