Hasil untuk "q-bio.NC"

Judith C. Brown

D. B. Wheeler, A. Randall, R. Tsien

P. Simon

The Cms, LHCb Collaborations V. Khachatryan, A. Sirunyan et al.

The standard model of particle physics describes the fundamental particles and their interactions via the strong, electromagnetic and weak forces. It provides precise predictions for measurable quantities that can be tested experimentally. The probabilities, or branching fractions, of the strange B meson () and the B0 meson decaying into two oppositely charged muons (μ+ and μ−) are especially interesting because of their sensitivity to theories that extend the standard model. The standard model predicts that the and decays are very rare, with about four of the former occurring for every billion mesons produced, and one of the latter occurring for every ten billion B0 mesons. A difference in the observed branching fractions with respect to the predictions of the standard model would provide a direction in which the standard model should be extended. Before the Large Hadron Collider (LHC) at CERN started operating, no evidence for either decay mode had been found. Upper limits on the branching fractions were an order of magnitude above the standard model predictions. The CMS (Compact Muon Solenoid) and LHCb (Large Hadron Collider beauty) collaborations have performed a joint analysis of the data from proton–proton collisions that they collected in 2011 at a centre-of-mass energy of seven teraelectronvolts and in 2012 at eight teraelectronvolts. Here we report the first observation of the µ+µ− decay, with a statistical significance exceeding six standard deviations, and the best measurement so far of its branching fraction. Furthermore, we obtained evidence for the µ+µ− decay with a statistical significance of three standard deviations. Both measurements are statistically compatible with standard model predictions and allow stringent constraints to be placed on theories beyond the standard model. The LHC experiments will resume taking data in 2015, recording proton–proton collisions at a centre-of-mass energy of 13 teraelectronvolts, which will approximately double the production rates of and B0 mesons and lead to further improvements in the precision of these crucial tests of the standard model.

S.

D. Raoult, T. Marrie, J. Mege

Jonathan Mond, P. Hay, B. Rodgers et al.

Bulat Batuev, Arsenii Onuchin, Sergey Sukhov

Precise control of signal propagation in modular neural networks represents a fundamental challenge in computational neuroscience. We establish a framework for identifying optimal control nodes that maximize stimulus transmission between weakly coupled neural populations. Using spiking stochastic block model networks, we systematically compare driver node selection strategies - including random sampling and topology-based centrality measures (degree, betweenness, closeness, eigenvector, harmonic, and percolation centrality) - to determine minimal control inputs for achieving inter-population synchronization. Targeted stimulation of just 10-20% of the most central neurons in the source population significantly enhances spiking propagation fidelity compared to random selection. This approach yields a 64-fold increase in signal transfer efficiency at critical inter-module connection densities. These findings establish a theoretical foundation for precision neuromodulation in biological neural systems and neurotechnology applications.

G. Aad, B. Abbott, J. Abdallah et al.

The distribution of particles inside hadronic jets produced in the decay of boosted W and Z bosons can be used to discriminate such jets from the continuum background. Given that a jet has been identified as likely resulting from the hadronic decay of a boosted W or Z boson, this paper presents a technique for further differentiating Z bosons from W bosons. The variables used are jet mass, jet charge, and a b-tagging discriminant. A likelihood tagger is constructed from these variables and tested in the simulation of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$W'\rightarrow WZ$$\end{document}W′→WZ for bosons in the transverse momentum range 200 GeV \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<p_\text {T}<$$\end{document}<pT< 400 GeV in \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\sqrt{s}=8$$\end{document}s=8 TeV pp collisions with the ATLAS detector at the LHC. For Z-boson tagging efficiencies of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\epsilon _Z=90$$\end{document}ϵZ=90, 50, and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$10\,\%$$\end{document}10%, one can achieve \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$W^+$$\end{document}W+-boson tagging rejection factors (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$1/\epsilon _{W^+}$$\end{document}1/ϵW+) of 1.7, 8.3 and 1000, respectively. It is not possible to measure these efficiencies in the data due to the lack of a pure sample of high \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p_\text {T}$$\end{document}pT, hadronically decaying Z bosons. However, the modelling of the tagger inputs for boosted W bosons is studied in data using a \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$t\bar{t}$$\end{document}tt¯-enriched sample of events in 20.3 fb\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${}^{-1}$$\end{document}-1 of data at \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\sqrt{s}=8$$\end{document}s=8 TeV. The inputs are well modelled within uncertainties, which builds confidence in the expected tagger performance.

Q. Liu, Q. Ma, Gaoqiang Chen et al.

Abstract Friction stir processing (FSP) is applied to modify the surface microstructure of cast AZ91 magnesium alloy. The electrochemical and hydrogen evolution measurements reveal that the corrosion rate of processed alloy in 3.5 wt% NaCl solution is significantly decreased. This is mainly attributed to the alteration of corrosion process induced by modification on the morphology and distribution of β-Mg17Al12 phase via FSP. It is originally reported that the formation of a compact and continuous β phase layer on the FSPed surface owing to the segregation of fine β phase effectively enhances the stability and passivity of corrosion product film.

Marlene E Noack, Florian Tietjens, U. Latacz-Lohmann

After three decades of orienting agriculture towards ecological and social sustainability goals, the Ukraine war catapulted productivity and supply goals back onto the political agenda. Against this background, the present study aimed to establish how farmers and food consumers envision the future of agriculture. Application of Q-Methodology revealed three opinion groups for both farmers and consumers. In conclusion, the Ukraine war has not significantly shifted the balance between old and new societal demands on agriculture. Old discrepancies in the views of farmers and the non-farming population persist. While among the farmers surveyed the group of those who adhere to “business as usual” predominates, there is no group among the consumers surveyed who share this view. Rather, there is a majority desire among consumers for the sector to continue to be aligned with sustainability goals. Security of supply is only an issue for a small proportion of the consumers surveyed.

Robert Worden

Animals build Bayesian 3D models of their surroundings, to control their movements. There is strong selection pressure to make these models as precise as possible, given their sense data. A previous paper has described how a precise 3D model of space can be built by object tracking. This only works if 3D locations are stored with high spatial precision. Neural models of 3D spatial memory have large random errors; too large to support the tracking model. An alternative is described, in which neurons couple to a wave excitation in the brain, representing 3-D space. This can give high spatial precision, fast response, and other benefits. Three lines of evidence support the wave hypothesis: (1) it has better precision and speed than neural spatial memory, and is good enough to support object tracking; (2) the central body of the insect brain, whose form is highly conserved across all insect species, is well suited to hold a wave; and (3) the thalamus, whose round shape is conserved across all mammal species, is well suited to hold a wave. These lines of evidence strongly support the wave hypothesis.

R. Lazkoz, F. Lobo, Mar'ia Ortiz-Banos et al.

In this work, we consider an extension of symmetric teleparallel gravity, namely, f(Q) gravity, where the fundamental block to describe spacetime is the nonmetricity, Q. Within this formulation of gravitation, we perform an observational analysis of several modified f(Q) models using the redshift approach, where the f(Q) Lagrangian is reformulated as an explicit function of the redshift, f(z). Various different polynomial parametrizations of f(z) are proposed, including new terms which would allow for deviations from the Λ Cold Dark Matter model. Given a variety of observational probes, such as the expansion rate data from early type galaxies, type Ia supernovae, quasars, gamma ray bursts, baryon acoustic oscillations data, and cosmic microwave background distance priors, we have checked the validity of these models at the background level in order to verify if this new formalism provides us with plausible alternative models to explain the late time acceleration of the Universe. Indeed, this novel approach provides a different perspective on the formulation of observationally reliable alternative models of gravity.

K. Yang, D. Y. Oh, Seung Hoon Lee et al.

Optical microresonators are essential to a broad range of technologies and scientific disciplines. However, many of their applications rely on discrete devices to attain challenging combinations of ultra-low-loss performance (ultrahigh Q) and resonator design requirements. This prevents access to scalable fabrication methods for photonic integration and lithographic feature control. Indeed, finding a microfabrication bridge that connects ultrahigh-Q device functions with photonic circuits is a priority of the microcavity field. Here, an integrated resonator having a record Q factor over 200 million is presented. Its ultra-low-loss and flexible cavity design brings performance to integrated systems that has been the exclusive domain of discrete silica and crystalline microcavity devices. Two distinctly different devices are demonstrated: soliton sources with electronic repetition rates and high-coherence/low-threshold Brillouin lasers. This multi-device capability and performance from a single integrated cavity platform represents a critical advance for future photonic circuits and systems. Using silicon nitride waveguides processed by plasma-enhanced chemical vapour deposition, full integration of ultrahigh-Q resonators with other photonic devices is now possible, representing a critical advance for future photonic circuits and systems.

P. Kofinas, A. Dounis, G. Vouros

Abstract This study proposes a cooperative multi-agent system for managing the energy of a stand-alone microgrid. The multi-agent system learns to control the components of the microgrid so as this to achieve its purposes and operate effectively, by means of a distributed, collaborative reinforcement learning method in continuous actions-states space. Stand-alone microgrids present challenges regarding guaranteeing electricity supply and increasing the reliability of the system under the uncertainties introduced by the renewable power sources and the stochastic demand of the consumers. In this article we consider a microgrid that consists of power production, power consumption and power storage units: the power production group includes a Photovoltaic source, a fuel cell and a diesel generator; the power consumption group includes an electrolyzer unit, a desalination plant and a variable electrical load that represent the power consumption of a building; the power storage group includes only the Battery bank. We conjecture that a distributed multi-agent system presents specific advantages to control the microgrid components which operate in a continuous states and actions space: For this purpose we propose the use of fuzzy Q-Learning methods for agents representing microgrid components to act as independent learners, while sharing state variables to coordinate their behavior. Experimental results highlight both the effectiveness of individual agents to control system components, as well as the effectiveness of the multi-agent system to guarantee electricity supply and increase the reliability of the microgrid.

M. Ali

In this paper, two new approaches have been presented to view q‐rung orthopair fuzzy sets. In the first approach, these can viewed as L‐fuzzy sets, whereas the second approach is based on the notion of orbits. Uncertainty index is the quantity HA(x)=1−(A+(x))q−(A−(x))q , which remains constant for all points in an orbit. Certain operators can be defined in q‐ROF sets, which affect HA(x) when applied to some q‐ROF sets. Operators Iδ , Mδ,ν , and Kδ,ν have been defined. It is studied that how these operators affect HA(x) when applied to some q‐ROF set A.

K. Azizzadenesheli, E. Brunskill, Anima Anandkumar

We propose Bayesian Deep Q-Network (BDQN), a practical Thompson sampling based Reinforcement Learning (RL) Algorithm. Thompson sampling allows for targeted exploration in high dimensions through posterior sampling but is usually computationally expensive. We address this limitation by introducing uncertainty only at the output layer of the network through a Bayesian Linear Regression (BLR) model, which can be trained with fast closed-form updates and its samples can be drawn efficiently through the Gaussian distribution. We apply our method to a wide range of Atari games in Arcade Learning Environments. Since BDQN carries out more efficient exploration, it is able to reach higher rewards substantially faster than a key baseline, double deep Q network DDQN.

Wenzhi Yang, Yi-bei Zhang, Wan-ying Wu et al.

Traditional Chinese medicine (TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic “multicomponent and multitarget” feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as “herbal medicine” or “natural product”, and the pharmacopoeia quality monographs are actually chemical-markers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of “quality marker” (Q-marker), following the “property-effect-component” theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics, pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM. This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples.

Brian Long, Jeremy Miller, The SpaceTx Consortium

Mapping spatial distributions of transcriptomic cell types is essential to understanding the brain, with its exceptional cellular heterogeneity and the functional significance of its spatial organization. Spatial transcriptomics techniques are hoped to accomplish these measurements, but each method uses different experimental and computational protocols, with different trade-offs and optimizations. In 2017, the SpaceTx Consortium was formed to compare these methods and determine their suitability for large-scale spatial transcriptomic atlases. SpaceTx work included progress in tissue processing, taxonomy development, gene selection, image processing and data standardization, cell segmentation, cell type assignments, and visualization. Although the landscape of experimental methods has changed dramatically since the beginning of SpaceTx, the need for quantitative and detailed benchmarking of spatial transcriptomics methods in the brain is still unmet. Here, we summarize the work of SpaceTx and highlight outstanding challenges as spatial transcriptomics grows into a mature field. We also discuss how our progress provides a roadmap for benchmarking spatial transcriptomics methods in the future. Data and analyses from this consortium, along with code and methods are publicly available at https://spacetx.github.io/.

V. Khachatryan, A. Sirunyan, A. Tumasyan et al.

A bstractThe spectra of charged particles produced within the pseudorapidity window |η| 20 GeV, RpA exhibits weak momentum dependence and shows a moderate enhancement above unity.