Pruettha Aruvornlop, Sekkarin Ploypetch, Walasinee Sakcamduang
et al.
Feline mammary carcinoma (FMC) is the most prevalent reproductive tumor in queens and is characterized by aggressive metastatic progression and short survival. Protein phosphorylation is a crucial process in cell regulation, with dysregulation linked to cancer progression, including human breast cancer. Although phosphoproteins have emerged as diagnostic and predictive markers in human breast cancer, knowledge remains limited on their role in FMC. In this study, the phosphoproteomic profiles of specimens for FMC grades 1 (n = 6), grade 2 (n = 11), grade 3 (n = 14), and normal controls (n = 6) were compared by phosphoprotein enrichment coupled with liquid chromatography–tandem mass spectrometry. Seventeen downregulated phosphoproteins were identified across all FMC grades, many of which have established roles in human breast cancer pathogenesis and prognosis. Serine/threonine–protein phosphatase was identified as a potential growth promoter and therapeutic target, while acid phosphatase, prostate, and ribonuclease L were identified as tumor suppressors. Furthermore, the ABC-type glutathione-S-conjugate transporter was associated with multidrug resistance. Protein kinase AMP-activated noncatalytic subunit gamma 3 was associated with increased breast cancer risk. In this study, it was also found to be associated with Ki-67 expression in FMC (p = 0.03). These phosphoproteins interacted with various proteins, immune checkpoint molecules, and chemotherapy drugs associated with mammary cancer in both human and feline species. Furthermore, proteins, such as butyrophilin subfamily 1 member A1, keratin, type I cytoskeletal 10, HECT domain E3 ubiquitin protein ligase 3, nuclear receptor binding SET domain protein 3, and stomatin-like 2, were identified and implicated in cancer progression and prognosis. This study is the first phosphoproteomic investigation of FMC, highlighting the interactions of relevant phosphoproteins with other proteins and chemotherapy drugs associated with both feline and human mammary cancers. The findings provide valuable insights for the identification of diagnostic and prognostic biomarkers and potential therapeutic targets in cats with mammary carcinoma.
As a continuation of a previous paper (arXiv:2303.05769 [nlin.CD]), we introduce examples of H\'enon-type mappings that exhibit new horseshoe topologies in three and four dimensional spaces that are otherwise impossible in two dimensions.
AbstractIderivedamethodforcalculatingtheapproximatefractaldimension(D)fromasetofN valuesy sampledfromawaveformbetweentimezeroandt max withsamplinginterval. Thewaveformwassubjectedtoadoublelineartransformationthatmapsitintoaunitsquare. Thenormalizedabscissaofthesquareisx *i andthenormalizedordinateisy *i ,bothofthemdefinedasx *i =x i x max y *i =y i y min y max y min wherex max isthemaximumx i andy min andy max aretheminimumandmaximumy i . Thefractaldimensionofthewaveform( )isthenapproximatedbyD as ˇ D= 1 +ln(L)ln(2 N')whereL isthelengthofthecurveintheunitsquareandN 0 = N 1. * ThisworkwasoriginallypublishedinComplexityInternational,anon-linejournal. Sinceitspublication,thejournalbecameinactive, andseveralsymbolsbecamecorruptedon-line. AccordingtoComplexityInternational, theauthorisalwaystheownerofthearticle’scopyrightaslongastheidentificationofComplexityInternationalappearsinthecopies.SeveraltyposarecorrectedinthisversionuploadedtoarXiv. ** Email: csevcik@ivic.gob.ve 1 arXiv:1003.5266v1 [nlin.CD] 27 Mar 2010
In this work I present a detailed description of the simplest nonlinear model for an optical wavelength paramagnetic phaser, which is an acoustic analog of the class-B lasers. Despite of its simplicity, this model gives a satisfactory explanation of experimental data for optical-wavelength paramagnetic phasers based on high-quality acoustic Fabry-Perot resonators. In particular, this model was successfully used both for qualitative and quantitative interpretation of deterministic chaotic motions observed in spin-phonon system of a nonautonomous ruby phasers at liquid helium temperatures (see arXiv:0704.0123v1 [nlin.CD]).
Charalampos Skokos, Charalampos Skokos, C. Antonopoulos
et al.
The ability of the Smaller Alignment Index (SALI) to distinguish chaotic from ordered motion, has been demonstrated recently in several publications. [Ch. Skokos, J. of Phys. A 34 (2001), 10029. Ch. Skokos, Ch. Antonopoulos, T. C. Bountis and M. N. Vrahatis, in Proceedings of the 4th GRACM Congress on Computational Mechanics, ed. D. T. Tsahalis (Univ. Patras, Patras, 2002). Vol. IV, p. 1496; in Libration Point Orbits and Applications, ed. G. GOmez, M. W. Lo and J. J. Masdemont (World Scientific, 2003), in press. nlin.CD/0210053.] Basically it is observed that in chaotic regions the SALI goes to zero very rapidly, while it fluctuates around a nonzero value in ordered regions. In this paper, we make a first step forward explaining these results by studying in detail the evolution of small deviations from regular orbits lying on the invariant tori of an integrable 2D Hamiltonian system. We show that, in general, any two initial deviation vectors will eventually fall on the "tangent space" of the torus, pointing in different directions due to the different dynamics of the 2 integrals of motion, which means that the SALI (or the smaller angle between these vectors) will oscillate away from zero for all time.
En: Proceedings of the 2001 ISSAOS School, Eds. G. Boffetta, G. Lacorata, G. Visconti, A. Vulpiani.-- 41 pages, 8 figures.-- ArXiv pre-print: http://arxiv.org/abs/nlin.CD/0205009
AbstractThe use of Nepomnjaščiǐ's Theorem in the proofs of independence results for bounded arithmetic theories is investigated. Using this result and similar ideas, it is shown that at least one ofS1orTLSdoes not prove the Matiyasevich-Robinson-Davis-Putnam Theorem. It is also established thatTLSdoes not prove a statement that roughly means nondeterministic linear time is equal to co-nondeterministic linear time. HereS1is a conservative extension of the well-studied theoryIΔ0andTLSis a theory for LOGSPACE reasoning.
The objective of this study is to study the effects of cereal supplementation, which contains many nutritional factors including amino acids on renal functions and morphological alteration in 5/6 nephrectomized rats. Spraque-Dawley rats, 250-300 g, were use in this study. Rats were divided into 4 groups. The first group has been undergone sham operation (SOR). Group 2, 3 and 4 undergone 5/6 nephrectomy by removed the right kidney and ligated 2/3 of renal artery. After surgery rats were kept in the individual cage for 5 weeks. Rats in group 1 and 2 (CNR) fed with normal protein diet only. Rats in group 3 were fed with normal protein diet and supplemented with 0.03 g/rat/day cereal (LNR). Rats in group 4 were fed with normal protein diet supplemented with 0.06 g/rat/day cereal (HNR). The cereal supplement was started 1 day after surgery. After 5 weeks rats were anesthetized and subjected to renal function study. At the end of the experiments, left kidney was isolated for the measurement of morphological alteration. There was no significant difference of body weight, blood pH, blood pressure and heart rate among all groups of rat post-treatment. However, rats with cereal supplementation had significant higher (P<0.05) plasma urea and plasma creatinine concentration than rat without cereal supplementation. Rats in CNR had slightly higher in GFR and RPF compared to the left kidney from SOR indicating functional compensatory. Rats in LNR groups had similar GFR and slightly lower RPF compared to CNR causing higher filtration fraction. Rats in HNR group had higher GFR and RPF than CNR group. The higher GFR caused urinary sodium excretion in HNR higher than in CNR while fractional excretion of sodium was similar. The higher urinary flow rate caused urinary potassium excretion slightly higher in HNR compare to CNR while fractional excretion of potassium was similar. The structural changes that observed were similar among all groups of nephrectomized rats. In conclusion, 0.03 mg/rat/day cereal supplement did not improve renal function while 0.06 mg/rat/day cereal supplement increase GFR and ERPF in 5/6 nephrectomized rats 5 weeks after treatment. Different levels of cereal supplement did not show any differnce on renal structural alteration compared with nephrectomized alone.
We present an analytical model which predicts the statistical properties of nonlinear interference noise in fiber links affected by PDL. We show that many features of NLIN, such as its phase and polarization rotation noise may be significantly modified by PDL components present in the link.