The Hubble Missing Globular Cluster Survey (MGCS) has taken one of the last opportunities to complete the census of Galactic globular clusters (GCs) started by past Hubble Space Telescope (HST) programs, securing high-resolution data for 34 GCs never observed before by HST. The previous papers of the series have highlighted the astrometric and photometric potential of the project by analyzing a subsample of targets. We present, and release to the community, the official astro-photometric catalogs of the MGCS for all GCs imaged by this project. We describe the data reduction using state-of-the-art techniques designed for HST. We discuss the photometric calibration and show, for the first time, the synergy with the Gaia catalog to ensure homogeneous photometry across our data set. We compute artificial-star tests that can be used to assess systematics and the completeness level of our data. We combined HST and Gaia data to refine the absolute PMs of our GCs, reaching a precision $\sim$3 times better than that of Gaia alone. We used these new PMs to update (and to determine for the first time for six systems) the associations between GCs and their putative galaxy progenitors. This work continues decades-long efforts of large Treasury programs in sharing precise and accurate atlases to the community for studying GCs across a wide range of scientific endeavors.
PURPOSE This guideline provides evidence-based recommendations for palliative external beam radiation therapy (RT) in symptomatic bone metastases. METHODS The American Society for Radiation Oncology (ASTRO) convened a task force to address 5 key questions regarding palliative RT in symptomatic bone metastases. Based on a systemic review by the Agency for Health Research and Quality, recommendations using predefined consensus-building methodology were established; evidence quality and recommendation strength were also assessed. RESULTS For palliative RT for symptomatic bone metastases, RT is recommended for managing pain from bone metastases and spine metastases with or without spinal cord or cauda equina compression. Regarding other modalities with RT, for patients with spine metastases causing spinal cord or cauda equina compression, surgery and postoperative RT are conditionally recommended over RT alone. Furthermore, dexamethasone is recommended for spine metastases with spinal cord or cauda equina compression. Patients with non-spine bone metastases requiring surgery are recommended postoperative RT. Symptomatic bone metastases treated with conventional RT are recommended 800 cGy in 1 fraction (800 cGy/1fx), 2000 cGy/5fx, 2400 cGy/6fx, or 3000 cGy/10fx. Spinal cord or cauda equina compression in patients ineligible for surgery and receiving conventional RT are recommended 800 cGy/1fx, 1600 cGy/2fx, 2000 cGy/5fx, or 3000 cGy/10fx. Symptomatic bone metastases in selected patients with good performance status without surgery or neurological symptoms/signs are conditionally recommended SBRT over conventional palliative RT. Spine bone metastases re-irradiated with conventional RT are recommended 800 cGy/1fx, 2000 cGy/5fx, 2400 cGy/6fx, or 2000 cGy/8fx; non-spine bone metastases re-irradiated with conventional RT are recommended 800 cGy/1fx, 2000 cGy/5fx, or 2400 cGy/6fx. Determination of an optimal RT approach/regimen requires whole person assessment, including prognosis, previous RT dose if applicable, risks to normal tissues, quality of life, cost implications, and patient goals and values. Relatedly, for patient-centered optimization of treatment-related toxicities and quality of life, shared decision-making is recommended. CONCLUSIONS Based on published data, the ASTRO task force's recommendations inform best clinical practices on palliative RT for symptomatic bone metastases.
Todd M. Morgan, S. Boorjian, M. Buyyounouski
et al.
Purpose: The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part I of a three-part series focusing on treatment decision-making at the time of suspected biochemical recurrence (BCR) after radical prostatectomy (RP). Please refer to Part II for discussion of treatment delivery for non-metastatic BCR after RP and Part III for discussion of evaluation and management of recurrence after radiotherapy (RT) and focal therapy, regional recurrence, and oligometastasis. Materials and Methods: The systematic review that informs this Guideline was based on searches in Ovid MEDLINE (1946 to July 21, 2022), Cochrane Central Register of Controlled Trials (through August 2022), and Cochrane Database of Systematic Reviews (through August 2022). Update searches were conducted on July 26, 2023. Searches were supplemented by reviewing electronic database reference lists of relevant articles. Results: In a collaborative effort between AUA, ASTRO, and SUO, the Salvage Therapy for Prostate Cancer Panel developed evidence- and consensus-based statements to provide guidance for the care of patients who experience BCR after initial definitive local therapy for clinically localized disease. Conclusions: Advancing work in the area of diagnostic tools (particularly imaging), biomarkers, radiation delivery, and biological manipulation with the evolving armamentarium of therapeutic agents will undoubtedly present new opportunities for patients to experience long-term control of their cancer while minimizing toxicity.
We introduce ASTRO, the"Autoregressive Search-Taught Reasoner", a framework for training language models to reason like search algorithms, explicitly leveraging self-reflection, backtracking, and exploration in their outputs. Recently, training large language models (LLMs) via reinforcement learning (RL) has led to the advent of reasoning models with greatly enhanced reasoning capabilities. Open-source replications of reasoning models, while successful, build upon models that already exhibit strong reasoning capabilities along with search behavior observed even before RL. As a result, it is yet unclear how to boost the reasoning capabilities of other non-reasoner models including Llama 3. ASTRO teaches such models to internalize structured search behavior through a synthetic dataset derived from Monte Carlo Tree Search (MCTS) over mathematical problem-solving trajectories. By converting search traces into natural language chain-of-thoughts that capture both successes and recoveries from failure, ASTRO bootstraps models with a rich prior for exploration during RL. We finetune our models on these search-derived traces and further improve performance via RL with verifiable rewards. We apply ASTRO to the Llama 3 family of models and achieve absolute performance gains of 16.0% on MATH-500, 26.9% on AMC 2023, and 20.0% on AIME 2024, especially improving upon challenging problems that require iterative correction. Our results demonstrate that search-inspired training offers a principled way to instill robust reasoning capabilities into open LLMs.
PURPOSE Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct disease from other head and neck tumors. This guideline provides evidence-based recommendations on the critical decisions in its curative treatment, including both definitive and postoperative radiation therapy (RT) management. METHODS ASTRO convened a task force to address 5 key questions on the use of RT for management of HPV-associated OPSCC. These questions included indications for definitive and postoperative RT and chemoradiation; dose-fractionation regimens and treatment volumes; preferred RT techniques and normal tissue considerations; and posttreatment management decisions. The task force did not address indications for primary surgery versus RT. Recommendations were based on a systematic literature review and created using a predefined consensus-building methodology and system for grading evidence quality and recommendation strength. RESULTS Concurrent cisplatin is recommended for patients receiving definitive RT with T3-4 disease and/or 1 node >3 cm, or multiple nodes. For similar patients who are ineligible for cisplatin, concurrent cetuximab, carboplatin/5-fluorouracil, or taxane-based systemic therapy are conditionally recommended. In the postoperative setting, RT with concurrent cisplatin (either schedule) is recommended for positive surgical margins or extranodal extension. Postoperative RT alone is recommended for pT3-4 disease, >2 nodes, or a single node >3 cm. Observation is conditionally recommended for pT1-2 disease and a single node ≤3 cm without other risk factors. For patients treated with definitive RT with concurrent systemic therapy, 7000 cGy in 33 to 35 fractions is recommended, and for patients receiving postoperative RT without positive surgical margins and extranodal extension, 5600 to 6000 cGy is recommended. For all patients receiving RT, intensity modulated RT over 3-dimensional techniques with reduction in dose to critical organs at risk (including salivary and swallowing structures) is recommended. Reassessment with positron emission tomography-computed tomography is recommended approximately 3 months after definitive RT/chemoradiation, and neck dissection is recommended for convincing evidence of residual disease; for equivocal positron emission tomography-computed tomography findings, either neck dissection or repeat imaging is recommended. CONCLUSIONS The role and practice of RT continues to evolve for HPV-associated OPSCC, and these guidelines inform best clinical practice based on the available evidence.
The scope of this literature review is observations of the products of first-stage evolution for binaries having components with M < 2 $M_\odot$. A taxonomy for these products comprises dwarfs ("blue stragglers"), giants ("yellow stragglers"), subdwarf B stars, and giant-like stars ("sub-subgiants" and "red stragglers"). This literature review is organized according to this taxonomy within three distinct environments: open star clusters, globular star clusters, and the Galactic field. This literature review is the Supplemental Material for Blue Stragglers and Friends: Initial Evolutionary Pathways in Close Low-Mass Binaries (Mathieu & Pols, 2025, ARAA, 63:467-512, doi: www.annualreviews.org/content/journals/10.1146/annurev-astro-071221-054402). It is intended to support and expand on Section 3 of the main text of this Annual Review of Astronomy and Astrophysics, where an integrated perspective on the common and contrasting astrophysical properties of these binary evolution products is provided. Figures used in the main text to highlight key observational results are referenced in this literature review. The closing date of this review is January 17, 2025, with some citations subsequently updated.
Todd M. Morgan, S. Boorjian, M. Buyyounouski
et al.
Purpose: The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part II of a three-part series focusing on treatment delivery for non-metastatic biochemical recurrence (BCR) after primary radical prostatectomy (RP). Please refer to Part I for discussion of treatment decision-making and Part III for discussion of evaluation and management of recurrence after radiotherapy (RT) and focal therapy, regional recurrence, and oligometastasis. Materials and Methods: The systematic review that informs this Guideline was based on searches in Ovid MEDLINE (1946 to July 21, 2022), Cochrane Central Register of Controlled Trials (through August 2022), and Cochrane Database of Systematic Reviews (through August 2022). Update searches were conducted on July 26, 2023. Searches were supplemented by reviewing electronic database reference lists of relevant articles. Results: In a collaborative effort between AUA, ASTRO, and SUO, the Salvage Therapy for Prostate Cancer Panel developed evidence- and consensus-based guideline statements to provide guidance for the care of patients who experience BCR after initial definitive local therapy for clinically localized disease. Conclusions: Optimizing and personalizing the approach to salvage therapy remains an ongoing area of work in the field of genitourinary oncology and represents an area of research and clinical care that requires well-coordinated, multi-disciplinary efforts.
C. Deville, Sophia C. Kamran, Scott C. Morgan
et al.
PURPOSE Our purpose was to develop a summary of recommendations regarding the management of patients with clinically localized prostate cancer based on the American Urologic Association/ ASTRO Guideline on Clinically Localized Prostate Cancer. METHODS The American Urologic Association and ASTRO convened a multidisciplinary, expert panel to develop recommendations based on a systematic literature review using an a priori defined consensus-building methodology. The topics covered were risk assessment, staging, risk-based management, principles of management including active surveillance, surgery, radiation, and follow-up after treatment. Presented are recommendations from the guideline most pertinent to radiation oncologists with an additional statement on health equity, diversity, and inclusion related to guideline panel composition and the topic of clinically localized prostate cancer. SUMMARY Staging, risk assessment, and management options in prostate cancer have advanced over the last decade and significantly affect shared decision-making for treatment management. Current advancements and controversies discussed to guide staging, risk assessment, and treatment recommendations include the use of advanced imaging and tumor genomic profiling. An essential active surveillance strategy includes prostate-specific antigen monitoring and periodic digital rectal examination with changes triggering magnetic resonance imaging and possible biopsy thereafter and histologic progression or greater tumor volume prompting consideration of definitive local treatment. The panel recommends against routine use of adjuvant radiation therapy (RT) for patients with prostate cancer after prostatectomy with negative nodes and an undetectable prostate-specific antigen, while acknowledging that patients at highest risk of recurrence were relatively poorly represented in the 3 largest randomized trials comparing adjuvant RT to early salvage and that a role may exist for adjuvant RT in selected patients at highest risk. RT for clinically localized prostate cancer has evolved rapidly, with new trial results, therapeutic combinations, and technological advances. The recommendation of moderately hypofractionated RT has not changed, and the updated guideline incorporates a conditional recommendation for the use of ultrahypofractionated treatment. Health disparities and inequities exist in the management of clinically localized prostate cancer across the continuum of care that can influence guideline concordance.
CompOSE (CompStar Online Supernovae Equations of State) is an online repository of equations of state (EoS) for use in nuclear physics and astrophysics, e.g., in the description of compact stars or the simulation of core-collapse supernovae and neutron-star mergers, see https://compose.obspm.fr. The main services, offered via the website, are: a collection of data tables in a flexible and easily extendable data format for different EoS types and related physical quantities with extensive documentation and referencing; software for download to extract and to interpolate these data and to calculate additional quantities; webtools to generate EoS tables that are customized to the needs of the users and to illustrate dependencies of various EoS quantities in graphical form. This manual is an update of previous versions that are available on the CompOSE website, at arXiv:1307.5715 [astro-ph.SR], and that was originally published in the journal “Physics of Particles and Nuclei” with doi:10.1134/S1063779615040061. It contains a detailed description of the service, containing a general introduction as well as instructions for potential contributors and for users. Short versions of the manual for EoS users and providers will also be available as separate publications.
We present observations of the two closest globular clusters, NGC 6121 and NGC 6397, taken with the NIRISS detector of JWST. The combination of our new JWST data with archival Hubble Space Telescope (HST) images allows us to compute proper motions, disentangle cluster members from field objects, and probe the main sequence (MS) of the clusters down to <0.1 $M_\odot$ as well as the brighter part of the white-dwarf sequence. We show that theoretical isochrones fall short in modeling the low-mass MS and discuss possible explanations for the observed discrepancies. Our analysis suggests that the lowest-mass members of both clusters are significantly more metal-rich and oxygen-poor than their higher-mass counterparts. It is unclear whether the difference is caused by a genuine mass-dependent chemical heterogeneity, low-temperature atmospheric processes altering the observed abundances, or systematic shortcomings in the models. We computed the present-day local luminosity and mass functions of the two clusters; our data reveal a strong flattening of the mass function indicative of a significant preferential loss of low-mass stars in agreement with previous dynamical models for these two clusters. We have made our NIRISS astro-photometric catalogs and stacked images publicly available to the community.
Klaus Rubke, Amparo Marco, Ignacio Negueruela
et al.
Massive stars condition the evolution of the interstellar medium by the amount of energy released during their lives and especially by their deaths as supernova explosions. The vast amounts of spectroscopic data for massive stars provided by previous and existing instruments on ground-based and space-based telescopes have already saturated our capability to process them by the use of human routines. As a consequence, there is a pressing need for machine-assisted tools to help handle incoming data. To this end, we present the development of a massive star spectroscopic multiwavelength interactive database designed for scientific research and a fully automatic stellar parameter determination tool. Here we show the preliminary results of the application of these tools to optical spectra of O-type stars.
A number of studies based on data collected by the $\textit{Hubble Space Telescope}$ ($\textit{HST}$) GO-13297 program "HST Legacy Survey of Galactic Globular Clusters: Shedding UV Light on Their Populations and Formation" have investigated the photometric properties of a large sample of Galactic globular clusters and revolutionized our understanding of their stellar populations. In this paper, we expand previous studies by focusing our attention on the stellar clusters' internal kinematics. We computed proper motions for stars in 56 globular and one open clusters by combining the GO-13297 images with archival $\textit{HST}$ data. The astro-photometric catalogs released with this paper represent the most complete and homogeneous collection of proper motions of stars in the cores of stellar clusters to date, and expand the information provided by the current (and future) $\textit{Gaia}$ data releases to much fainter stars and into the crowded central regions. We also census the general kinematic properties of stellar clusters by computing the velocity-dispersion and anisotropy radial profiles of their bright members. We study the dependence on concentration and relaxation time, and derive dynamical distances. Finally, we present an in-depth kinematic analysis of the globular cluster NGC 5904.
CompOSE (CompStar Online Supernovae Equations of State) is an online repository of equations of state (EoS) for use in nuclear physics and astrophysics, e.g., in the description of compact stars or the simulation of core-collapse supernovae and neutron-star mergers, see http://compose.obspm.fr. The main services, offered via the website, are: a collection of data tables in a flexible and easily extendable data format for different EoS types and related physical quantities with extensive documentation and referencing; software for download to extract and to interpolate these data and to calculate additional quantities; webtools to generate EoS tables that are customized to the needs of the users and to illustrate dependencies of various EoS quantities in graphical form. This manual is an update of previous versions that are available on the CompOSE website, at arXiv:1307.5715 [astro-ph.SR], and that was originally published in the journal "Physics of Particles and Nuclei" with doi:10.1134/S1063779615040061. It contains a detailed description of the service, containing a general introduction as well as instructions for potential contributors and for users. Short versions of the manual for EoS users and providers will also be available as separate publications.
We present an astrometric and photometric wide-field study of the Galactic open star cluster M37 (NGC 2099). The studied field was observed with ground-based images covering a region of about four square degrees in the Sloan-like filters ugi. We exploited the Gaia catalogue to calibrate the geometric distortion of the large field mosaics, developing software routines that can be also applied to other wide-field instruments. The data are used to identify the hottest white dwarf (WD) member candidates of M37. Thanks to the Gaia EDR3 exquisite astrometry we identified seven such WD candidates, one of which, besides being a high-probability astrometric member, is the putative central star of a planetary nebula. To our knowledge, this is a unique object in an open cluster, and we have obtained follow-up low-resolution spectra that are used for a qualitative characterisation of this young WD. Finally, we publicly release a three-colour atlas and a catalogue of the sources in the field of view, which represents a complement of existing material.
According to the current understanding of cosmic structure formation, the precursors of the most massive structures in the Universe began to form shortly after the Big Bang, in regions corresponding to the largest fluctuations in the cosmic density field. Observing these structures during their period of active growth and assembly—the first few hundred million years of the Universe—is challenging because it requires surveys that are sensitive enough to detect the distant galaxies that act as signposts for these structures and wide enough to capture the rarest objects. As a result, very few such objects have been detected so far. Here we report observations of a far-infrared-luminous object at redshift 6.900 (less than 800 million years after the Big Bang) that was discovered in a wide-field survey. High-resolution imaging shows it to be a pair of extremely massive star-forming galaxies. The larger is forming stars at a rate of 2,900 solar masses per year, contains 270 billion solar masses of gas and 2.5 billion solar masses of dust, and is more massive than any other known object at a redshift of more than 6. Its rapid star formation is probably triggered by its companion galaxy at a projected separation of 8 kiloparsecs. This merging companion hosts 35 billion solar masses of stars and has a star-formation rate of 540 solar masses per year, but has an order of magnitude less gas and dust than its neighbour and physical conditions akin to those observed in lower-metallicity galaxies in the nearby Universe. These objects suggest the presence of a dark-matter halo with a mass of more than 100 billion solar masses, making it among the rarest dark-matter haloes that should exist in the Universe at this epoch.
Gaurav Singh, R. K. S. Yadav, Snehalata Sahu
et al.
We present the study of dynamical status of the globular cluster NGC 1851. A combination of multiwavelength space and ground-based data sets are used for the present analysis. In order to select the genuine cluster members, we used the astro-photometric data available from HST and GAIA-DR2 catalogs. The BSS radial distribution of the cluster is plotted from the center of the cluster to the outskirts. The radial distribution of BSS shows a central peak, followed by a dip at the intermediate radii (rmin ~ 90'') and a rising trend in the outskirts. We also estimated A+rh parameter as 0.391 +/- 0.006 to validate the findings of the radial distribution study. On the basis of the minima in the BSS radial distribution and the value of A+rh parameter, we conclude that NGC 1851 belongs to Family II classification and is an intermediate dynamical state cluster.
Abstract. The Hitomi (ASTRO-H) mission is the sixth Japanese x-ray astronomy satellite developed by a large international collaboration, including Japan, USA, Canada, and Europe. The mission aimed to provide the highest energy resolution ever achieved at E > 2 keV, using a microcalorimeter instrument, and to cover a wide energy range spanning four decades in energy from soft x-rays to gamma rays. After a successful launch on February 17, 2016, the spacecraft lost its function on March 26, 2016, but the commissioning phase for about a month provided valuable information on the onboard instruments and the spacecraft system, including astrophysical results obtained from first light observations. The paper describes the Hitomi (ASTRO-H) mission, its capabilities, the initial operation, and the instruments/spacecraft performances confirmed during the commissioning operations for about a month.
E. González-Álvarez, M. R. Zapatero Osorio, J. A. Caballero
et al.
We report on radial velocity time series for two M0.0V stars, GJ338B and GJ338A, using the CARMENES spectrograph, complemented by ground-telescope photometry from Las Cumbres and Sierra Nevada observatories. We aim to explore the presence of small planets in tight orbits using the spectroscopic radial velocity technique. We obtained 159 and 70 radial velocity measurements of GJ338B and A, respectively, with the CARMENES visible channel. We also compiled additional relative radial velocity measurements from the literature and a collection of astrometric data that cover 200 a of observations to solve for the binary orbit. We found dynamical masses of 0.64$\pm$0.07M$_\odot$ for GJ338B and 0.69$\pm$0.07M$_\odot$ for GJ338A. The CARMENES radial velocity periodograms show significant peaks at 16.61$\pm$0.04 d (GJ338B) and 16.3$^{+3.5}_{-1.3}$ d (GJ338A), which have counterparts at the same frequencies in CARMENES activity indicators and photometric light curves. We attribute these to stellar rotation. GJ338B shows two additional, significant signals at 8.27$\pm$0.01 and 24.45$\pm$0.02 d, with no obvious counterparts in the stellar activity indices. The former is likely the first harmonic of the star's rotation, while we ascribe the latter to the existence of a super-Earth planet with a minimum mass of 10.27$^{+1.47}_{-1.38}$$M_{\oplus}$ orbiting GJ338B. GJ338B b lies inside the inner boundary of the habitable zone around its parent star. It is one of the least massive planets ever found around any member of stellar binaries. The masses, spectral types, brightnesses, and even the rotational periods are very similar for both stars, which are likely coeval and formed from the same molecular cloud, yet they differ in the architecture of their planetary systems.
Mariam Mir, Murtaza Najabat Ali, Umar Ansari
et al.
PurposeThe fabrication and characterization of a hydrogel-based conductometric sensor have been carried out. The purpose of this research is to fabricate a small robust hydrogel-based conductometric sensor for real-time monitoring of pH in the physiological range.Design/methodology/approachA pH-responsive Chitosan/Gelatin composite hydrogel has been used for this purpose. This study reports and analyzes the sensing response obtained from four hydrogel compositions with varying Chitosan/Gelatin ratios. The pH-responsive nature of the hydrogel has been mapped out through volumetric and conductometric tests. An attempt has been made to correlate these characteristics with the physico-chemical nature of the hydrogel through scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction techniques.FindingsThe four hydrogel compositions differed on the basis of gel composition ratios; the conductometric analysis results prove that the sensor with the hydrogel composition (Chitosan 2 per cent, Gelatin 7 per cent, ratio 1:2) produces the best pH resolution in the pH range of 4 to 9. The sensing mechanisms and the differences obtained between individual sensor outputs have been discussed in detail. On the basis of this extensivein vitroassessment, it has been concluded that while key pendant functional groups contribute to pH-responsive characteristics of the hydrogel, the overall sensitivity of the sensors gel component to surrounding pH is also determined by the crystalline to amorphous ratio of the hydrogel composite, its interpenetrating cross-linked structure and the relative ratio of the hydrophilic to the pH-sensitive components.Practical implicationsThe conductometric sensor results prove that the fabricated sensor with the shortlisted hydrogel composition shows good sensitivity in the physiological pH range (4 to 9) and it has the potential for use in point of care medical devices for diagnostic purposes.Originality/valueThis is the first reported version of the fabrication and testing and analysis/comparison of a hydrogel-based conductometric sensor based on this composition. The work is original and has not been replicated anywhere.
The Hitomi (ASTRO-H) mission is the sixth Japanese X-ray astronomy satellite developed by a large international collaboration, including Japan, USA, Canada, and Europe. The mission aimed to provide the highest energy resolution ever achieved at E > 2 keV, using a microcalorimeter instrument, and to cover a wide energy range spanning four decades in energy from soft X-rays to gamma-rays. After a successful launch on 2016 February 17, the spacecraft lost its function on 2016 March 26, but the commissioning phase for about a month provided valuable information on the on-board instruments and the spacecraft system, including astrophysical results obtained from first light observations. The paper describes the Hitomi (ASTRO-H) mission, its capabilities, the initial operation, and the instruments/spacecraft performances confirmed during the commissioning operations for about a month.