The Ligo Scientific Collaboration, The Virgo Collaboration, T. Abbott
et al.
The third Gravitational-Wave Transient Catalog (GWTC-3) describes signals detected with Advanced LIGO and Advanced Virgo up to the end of their third observing run. Updating the previous GWTC-2.1, we present candidate gravitational waves from compact binary coalescences during the second half of the third observing run (O3b) between 1 November 2019, 15:00 UTC and 27 March 2020, 17:00 UTC. There are 35 compact binary coalescence candidates identified by at least one of our search algorithms with a probability of astrophysical origin $p_\mathrm{astro}>0.5$. Of these, 18 were previously reported as low-latency public alerts, and 17 are reported here for the first time. Based upon estimates for the component masses, our O3b candidates with $p_\mathrm{astro}>0.5$ are consistent with gravitational-wave signals from binary black holes or neutron star-black hole binaries, and we identify none from binary neutron stars. However, from the gravitational-wave data alone, we are not able to measure matter effects that distinguish whether the binary components are neutron stars or black holes. The range of inferred component masses is similar to that found with previous catalogs, but the O3b candidates include the first confident observations of neutron star-black hole binaries. Including the 35 candidates from O3b in addition to those from GWTC-2.1, GWTC-3 contains 90 candidates found by our analysis with $p_\mathrm{astro}>0.5$ across the first three observing runs. These observations of compact binary coalescences present an unprecedented view of the properties of black holes and neutron stars.
Purpose: The summary presented herein represents Part II of the three-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, discussing principles of active surveillance and surgery as well as follow-up for patients after primary treatment. Please refer to Parts I and III for discussion of risk assessment, staging, and risk-based management (Part I), and principles of radiation and future directions (Part III). Materials and Methods: The systematic review utilized to inform this guideline was conducted by an independent methodological consultant. A research librarian conducted searches in Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. The methodology team supplemented searches of electronic databases with the studies included in the prior AUA review and by reviewing reference lists of relevant articles. Results: The Clinically Localized Prostate Cancer Panel created evidence- and consensus-based guideline statements to aid clinicians in the management of patients with clinically localized prostate cancer. Statements regarding active surveillance, surgical management, and patient follow-up are detailed. Conclusion: This guideline aims to inform clinicians treating patients with clinically localized prostate cancer. Continued research and publication of high-quality evidence from future trials will be essential to further improve care for these men.
Todd M. Morgan, S. Boorjian, M. Buyyounouski
et al.
Purpose: The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part I of a three-part series focusing on treatment decision-making at the time of suspected biochemical recurrence (BCR) after radical prostatectomy (RP). Please refer to Part II for discussion of treatment delivery for non-metastatic BCR after RP and Part III for discussion of evaluation and management of recurrence after radiotherapy (RT) and focal therapy, regional recurrence, and oligometastasis. Materials and Methods: The systematic review that informs this Guideline was based on searches in Ovid MEDLINE (1946 to July 21, 2022), Cochrane Central Register of Controlled Trials (through August 2022), and Cochrane Database of Systematic Reviews (through August 2022). Update searches were conducted on July 26, 2023. Searches were supplemented by reviewing electronic database reference lists of relevant articles. Results: In a collaborative effort between AUA, ASTRO, and SUO, the Salvage Therapy for Prostate Cancer Panel developed evidence- and consensus-based statements to provide guidance for the care of patients who experience BCR after initial definitive local therapy for clinically localized disease. Conclusions: Advancing work in the area of diagnostic tools (particularly imaging), biomarkers, radiation delivery, and biological manipulation with the evolving armamentarium of therapeutic agents will undoubtedly present new opportunities for patients to experience long-term control of their cancer while minimizing toxicity.
PURPOSE Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct disease from other head and neck tumors. This guideline provides evidence-based recommendations on the critical decisions in its curative treatment, including both definitive and postoperative radiation therapy (RT) management. METHODS ASTRO convened a task force to address 5 key questions on the use of RT for management of HPV-associated OPSCC. These questions included indications for definitive and postoperative RT and chemoradiation; dose-fractionation regimens and treatment volumes; preferred RT techniques and normal tissue considerations; and posttreatment management decisions. The task force did not address indications for primary surgery versus RT. Recommendations were based on a systematic literature review and created using a predefined consensus-building methodology and system for grading evidence quality and recommendation strength. RESULTS Concurrent cisplatin is recommended for patients receiving definitive RT with T3-4 disease and/or 1 node >3 cm, or multiple nodes. For similar patients who are ineligible for cisplatin, concurrent cetuximab, carboplatin/5-fluorouracil, or taxane-based systemic therapy are conditionally recommended. In the postoperative setting, RT with concurrent cisplatin (either schedule) is recommended for positive surgical margins or extranodal extension. Postoperative RT alone is recommended for pT3-4 disease, >2 nodes, or a single node >3 cm. Observation is conditionally recommended for pT1-2 disease and a single node ≤3 cm without other risk factors. For patients treated with definitive RT with concurrent systemic therapy, 7000 cGy in 33 to 35 fractions is recommended, and for patients receiving postoperative RT without positive surgical margins and extranodal extension, 5600 to 6000 cGy is recommended. For all patients receiving RT, intensity modulated RT over 3-dimensional techniques with reduction in dose to critical organs at risk (including salivary and swallowing structures) is recommended. Reassessment with positron emission tomography-computed tomography is recommended approximately 3 months after definitive RT/chemoradiation, and neck dissection is recommended for convincing evidence of residual disease; for equivocal positron emission tomography-computed tomography findings, either neck dissection or repeat imaging is recommended. CONCLUSIONS The role and practice of RT continues to evolve for HPV-associated OPSCC, and these guidelines inform best clinical practice based on the available evidence.
Todd M. Morgan, S. Boorjian, M. Buyyounouski
et al.
Purpose: The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part II of a three-part series focusing on treatment delivery for non-metastatic biochemical recurrence (BCR) after primary radical prostatectomy (RP). Please refer to Part I for discussion of treatment decision-making and Part III for discussion of evaluation and management of recurrence after radiotherapy (RT) and focal therapy, regional recurrence, and oligometastasis. Materials and Methods: The systematic review that informs this Guideline was based on searches in Ovid MEDLINE (1946 to July 21, 2022), Cochrane Central Register of Controlled Trials (through August 2022), and Cochrane Database of Systematic Reviews (through August 2022). Update searches were conducted on July 26, 2023. Searches were supplemented by reviewing electronic database reference lists of relevant articles. Results: In a collaborative effort between AUA, ASTRO, and SUO, the Salvage Therapy for Prostate Cancer Panel developed evidence- and consensus-based guideline statements to provide guidance for the care of patients who experience BCR after initial definitive local therapy for clinically localized disease. Conclusions: Optimizing and personalizing the approach to salvage therapy remains an ongoing area of work in the field of genitourinary oncology and represents an area of research and clinical care that requires well-coordinated, multi-disciplinary efforts.
Purpose: The summary presented herein represents Part III of the three-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, discussing principles of radiation and offering several future directions of further relevant study in patients diagnosed with clinically localized prostate cancer. Please refer to Parts I and II for discussion of risk assessment, staging, and risk-based management (Part I), and principles of active surveillance and surgery and follow-up (Part II). Materials and Methods: The systematic review utilized to inform this guideline was conducted by an independent methodological consultant. A research librarian conducted searches in Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. The methodology team supplemented searches of electronic databases with the studies included in the prior AUA review and by reviewing reference lists of relevant articles. Results: The Clinically Localized Prostate Cancer Panel created evidence- and consensus-based guideline statements to aid clinicians in the management of patients with clinically localized prostate cancer. Statements regarding management of patients using radiation therapy as well as important future directions of research are detailed herein. Conclusions: This guideline aims to inform clinicians treating patients with clinically localized prostate cancer. Continued research and publication of high-quality evidence from future trials will be essential to further improve care for these men.
Tobias Hoffmann, Marco Micheli, Juan Luis Cano
et al.
Photometric measurements allow the determination of an asteroid's absolute magnitude, which often represents the sole means to infer its size. Photometric observations can be obtained in a variety of filters that can be unique to a specific observatory. Those observations are then calibrated into specific bands with respect to reference star catalogs. In order to combine all the different measurements for evaluation, photometric observations need to be converted to a common band, typically V-band. Current band-correction schemes in use by IAU's Minor Planet Center, JPL's Center for Near Earth Object Studies and ESA's NEO Coordination Centre use average correction values for the apparent magnitude derived from photometry of asteroids as the corrections are dependent on the typically unknown spectrum of the object to be corrected. By statistically analyzing the photometric residuals of asteroids, we develop a new photometric correction scheme that does not only consider the band, but also accounts for reference catalog and observatory. We describe a new statistical photometry correction scheme for asteroid observations with debiased corrections. Testing this scheme on a reference group of asteroids, we see a 36% reduction in the photometric residuals. Moreover, the new scheme leads to a more accurate and debiased determination of the H-G magnitude system and, in turn, to more reliable inferred sizes. We discuss the significant shift in the corrections with this "DePhOCUS" debiasing system, its limitations, and the impact for photometric and physical properties of all asteroids, especially Near-Earth Objects.
Outcomes for patients with esophageal cancer have improved over the last decade with the implementation of multimodality therapy. There are currently no comprehensive guidelines addressing multidisciplinary management of esophageal cancer that have incorporated the input of surgeons, radiation oncologists, and medical oncologists. To address the need for multidisciplinary input in the management of esophageal cancer and to meet current best practices for clinical practice guidelines, the current guidelines were created as a collaboration between The Society of Thoracic Surgeons (STS), American Society for Radiation Oncology (ASTRO), and the American Society of Clinical Oncology (ASCO). Physician representatives chose 8 key clinical questions pertinent to the care of patients with locally advanced, resectable thoracic esophageal cancer (excluding cervical location). A comprehensive literature review was performed identifying 227 articles that met the inclusion criteria covering the use of induction chemotherapy, chemotherapy vs chemoradiotherapy before surgery, optimal radiation dose, the value of esophagectomy, timing of esophagectomy, the approach and extent of lymphadenectomy, the use of minimally invasive esophagectomy, and the value of adjuvant therapy after resection. The relevant data were reviewed and voted on by the panel with 80% of the authors, with 75% agreement on class and level of evidence. These data were then complied into the guidelines document.
We develop a tool, which we name Protoplanetary Disk Operator Network (PPDONet), that can predict the solution of disk-planet interactions in protoplanetary disks in real-time. We base our tool on Deep Operator Networks (DeepONets), a class of neural networks capable of learning non-linear operators to represent deterministic and stochastic differential equations. With PPDONet we map three scalar parameters in a disk-planet system -- the Shakura \& Sunyaev viscosity $α$, the disk aspect ratio $h_\mathrm{0}$, and the planet-star mass ratio $q$ -- to steady-state solutions of the disk surface density, radial velocity, and azimuthal velocity. We demonstrate the accuracy of the PPDONet solutions using a comprehensive set of tests. Our tool is able to predict the outcome of disk-planet interaction for one system in less than a second on a laptop. A public implementation of PPDONet is available at \url{https://github.com/smao-astro/PPDONet}.
Jens Biele, Matthias Grott, Michael E. Zolensky
et al.
We provide detailed background, theoretical and practical, on the specific heat cp of minerals and mixtures thereof, 'astro-materials', as well as background information on common minerals and other relevant solid substances found on the surfaces of solar system bodies. Furthermore, we demonstrate how to use specific heat and composition data for lunar samples and meteorites as well as a new database of endmember mineral heat capacities (the result of an extensive literature review) to construct reference models for the isobaric specific heat cP as a function of temperature for common solar system materials. Using a (generally linear) mixing model for the specific heat of minerals allows extrapolation of the available data to very low and very high temperatures, such that models cover the temperature range between 10 and 1000 K at least (and pressures from zero up to several kbars). We describe a procedure to estimate cp(T) for virtually any solid solar system material with a known mineral composition, e.g., model specific heat as a function of temperature for a number of typical meteorite classes with known mineralogical compositions. We present, as examples, the cp(T) curves of a number of well-described laboratory regolith analogues, as well as for planetary ices and 'tholins' in the outer solar system. Part II will review and present the heat capacity database for minerals and compounds and part III is going to cover applications, standard reference compositions, cp(T) curves and a comparison with new and literature experimental data.
Background: Coronary artery calcium (CAC) is a powerful novel risk indicator for atherosclerotic cardiovascular disease (ASCVD). Currently, there is no available ASCVD risk prediction tool that integrates traditional risk factors and CAC. Methods: To develop a CAC ASCVD risk tool for younger individuals in the general population, subjects aged 40 to 65 without prior cardiovascular disease from 3 population-based cohorts were included. Cox proportional hazards models were developed incorporating age, sex, systolic blood pressure, total and high-density lipoprotein cholesterol, smoking, diabetes mellitus, hypertension treatment, family history of myocardial infarction, high-sensitivity C-reactive protein, and CAC scores (Astro-CHARM model [Astronaut Cardiovascular Health and Risk Modification]) as dependent variables and ASCVD (nonfatal/fatal myocardial infarction or stroke) as the outcome. Model performance was assessed internally, and validated externally in a fourth cohort. Results: The derivation study comprised 7382 individuals with a mean age 51 years, 45% women, and 55% nonwhite. The median CAC was 0 (25th, 75th [0,9]), and 304 ASCVD events occurred in a median 10.9 years of follow-up. The c-statistic was 0.784 for the risk factor model, and 0.817 for Astro-CHARM (P<0.0001). In comparison with the risk factor model, the Astro-CHARM model resulted in integrated discrimination improvement (0.0252), and net reclassification improvement (0.121; P<0.0001), as well. The Astro-CHARM model demonstrated good discrimination (c=0.78) and calibration (Nam-D’Agostino &khgr;2, 13.2; P=0.16) in the validation cohort (n=2057; 55 events). A mobile application and web-based tool were developed to facilitate clinical application of this tool (www.AstroCHARM.org). Conclusion: The Astro-CHARM tool is the first integrated ASCVD risk calculator to incorporate risk factors, including high-sensitivity C-reactive protein and family history, and CAC data. It improves risk prediction in comparison with traditional risk factor equations and could be useful in risk-based decision making for cardiovascular disease prevention in the middle-aged general population.
To address the the problem of calibration of instrument systematics in transit light curves, we present the Python package ExoTiC-ISM. Transit spectroscopy can reveal many different chemical components in exoplanet atmospheres, but such results depend on well-calibrated transit light curve observations. Each transit data set will contain instrument systematics that depend on the instrument used and will need to be calibrated out with an instrument systematic model. The proposed solution in Wakeford et al. (2016) (arXiv:1601.02587 [astro-ph.EP]) is to use a marginalisation across a grid of systematic models in order to retrieve marginalised transit parameters. Doing this over observations in multiple wavelengths yields a robust transmission spectrum of an exoplanet. ExoTiC-ISM provides tools to perform this analysis, and its current capability contains a systematic grid that is applicable to the Wide Field Camera 3 (WFC3) detector on the Hubble Space Telescope (HST), particularly for the two infrared grisms G141 and G102. By modularisation of the code and implementation of more systematic grids, ExoTiC-ISM can be used for other instruments, and an implementation for select detectors on the James Webb Space Telescope (JWST) will provide robust transit spectra in the future.
E. González-Álvarez, M. R. Zapatero Osorio, J. A. Caballero
et al.
We report on radial velocity time series for two M0.0V stars, GJ338B and GJ338A, using the CARMENES spectrograph, complemented by ground-telescope photometry from Las Cumbres and Sierra Nevada observatories. We aim to explore the presence of small planets in tight orbits using the spectroscopic radial velocity technique. We obtained 159 and 70 radial velocity measurements of GJ338B and A, respectively, with the CARMENES visible channel. We also compiled additional relative radial velocity measurements from the literature and a collection of astrometric data that cover 200 a of observations to solve for the binary orbit. We found dynamical masses of 0.64$\pm$0.07M$_\odot$ for GJ338B and 0.69$\pm$0.07M$_\odot$ for GJ338A. The CARMENES radial velocity periodograms show significant peaks at 16.61$\pm$0.04 d (GJ338B) and 16.3$^{+3.5}_{-1.3}$ d (GJ338A), which have counterparts at the same frequencies in CARMENES activity indicators and photometric light curves. We attribute these to stellar rotation. GJ338B shows two additional, significant signals at 8.27$\pm$0.01 and 24.45$\pm$0.02 d, with no obvious counterparts in the stellar activity indices. The former is likely the first harmonic of the star's rotation, while we ascribe the latter to the existence of a super-Earth planet with a minimum mass of 10.27$^{+1.47}_{-1.38}$$M_{\oplus}$ orbiting GJ338B. GJ338B b lies inside the inner boundary of the habitable zone around its parent star. It is one of the least massive planets ever found around any member of stellar binaries. The masses, spectral types, brightnesses, and even the rotational periods are very similar for both stars, which are likely coeval and formed from the same molecular cloud, yet they differ in the architecture of their planetary systems.
Large amplitude whistler waves at frequencies of 0.2 to 0.4 times electron cyclotron frequency are frequently observed in the solar wind. The waves are obliquely propagating close to the resonance cone, with significant electric fields parallel to the background magnetic field, enabling strong interactions with electrons. Propagation angles are distinctly different from whistlers usually observed in the solar wind, and amplitudes are significantly larger. Waves occur most often in association with stream interaction regions (SIRs), and are often close-packed. 68 percent of the 54 SIRs had narrowband whistler groups; 33 percent of the nine interplanetary coronal mass ejections had coherent groups. Although wave occurrence as a function of the electron temperature anisotropy and parallel beta is constrained by the thresholds for the whistler temperature anisotropy and firehose instabilities, neither is consistent with observed wave properties. We show for the first time that comparisons of wave data to thresholds for the electron beam driven instability (beam speed greater than twice the electron Alfven speed) and to the whistler heat flux fan instability indicate that either might destabilize the narrowband waves. In contrast, the less coherent waves, on average, are associated with zero or near zero heat flux and much higher electron Alfven speeds, without higher energy beams. This suggests that the less coherent waves may be more effective in regulating the electron heat flux, or that the scattering and energization of solar wind electrons by the narrowband waves results in broadening of the waves. The highly oblique propagation and large amplitudes of both the narrowband and less coherent whistlers enable resonant interactions with electrons over a broad energy range, and, unlike parallel whistlers does not require that the electrons and waves counter-propagate.
An accurate and efficient method dealing with the few-body dynamics is important for simulating collisional N-body systems like star clusters and to follow the formation and evolution of compact binaries. We describe such a method which combines the time-transformed explicit symplectic integrator (Preto & Tremaine 1999; Mikkola & Tanikawa 1999) and the slow-down method (Mikkola & Aarseth 1996). The former conserves the Hamiltonian and the angular momentum for a long-term evolution, while the latter significantly reduces the computational cost for a weakly perturbed binary. In this work, the Hamilton equations of this algorithm are analyzed in detail. We mathematically and numerically show that it can correctly reproduce the secular evolution like the orbit averaged method and also well conserve the angular momentum. For a weakly perturbed binary, the method is possible to provide a few order of magnitude faster performance than the classical algorithm. A publicly available code written in the c++ language, SDAR, is available on GitHub (https://github.com/lwang-astro/SDAR). It can be used either as a stand alone tool or a library to be plugged in other $N$-body codes. The high precision of the floating point to 62 digits is also supported.
The ability for citizen scientists to analyze image data and search for exoplanets using images from small telescopes has the potential to greatly accelerate the search for exoplanets. Recent work on the Exoplanet Transit Interpretation Code (EXOTIC) enables the generation of high-quality light curves of exoplanet transits given such image data. However, on large image datasets, the photometric analysis of the data and fitting light curves can be a time-consuming process. In this work, we first optimize portions of the EXOTIC codebase to enable faster image processing and curve fitting. Specifically, we limited repetitive computation on fitting centroids with various apertures and annuli. Moreover, this speedup is scaled linearly based on the number of FITS files. After testing on existing HAT-P-32 b data and newer HAT-P-23 b data, our best demonstration was approximately a 5x speedup, though that factor increases given a larger number of FITS files. Utilizing the accelerated code, we analyzed transits of HAT-P-23 b, Qatar-1 b, WASP-2 b, and WASP-33 b using data captured by the 16" SRO telescope operated by Boyce-Astro.
After a decade of design and construction, South Africa's SKA-MID precursor MeerKAT has begun its science operations. To make full use of the widefield capability of the array, it is imperative that we have an accurate model of the primary beam of its antennas. We have used an available L-band full-polarization astro-holographic observation and electromagnetic simulation to create sparse representations of the beam using principal components and Zernike polynomials. The spectral behaviour of the spatial coefficients has been modelled using discrete cosine transform. We have provided the Zernike-based model over a diameter of 10 degrees in an associated software tool that can be useful for direction dependent calibration and imaging. The model is more accurate for the diagonal elements of the beam Jones matrix and at lower frequencies. As we get more accurate beam measurements and simulations in the future, especially for the cross-polarization patterns, our pipeline can be used to create more accurate sparse representations of MeerKAT beam.
Radiotherapy is a fundamental component of treatment for the majority of patients with cancer. In recent decades, technological advances have enabled patients to receive more targeted doses of radiation to the tumor, with sparing of adjacent normal tissues. There had been hope that the era of precision medicine would enhance the combination of radiotherapy with targeted anticancer drugs; however, this ambition remains to be realized. In view of this lack of progress, the FDA–AACR–ASTRO Clinical Development of Drug–Radiotherapy Combinations Workshop was held in February 2018 to bring together stakeholders and opinion leaders from academia, clinical radiation oncology, industry, patient advocacy groups, and the FDA to discuss challenges to introducing new drug–radiotherapy combinations to the clinic. This Perspectives in Regulatory Science and Policy article summarizes the themes and action points that were discussed. Intelligent trial design is required to increase the number of studies that efficiently meet their primary outcomes; endpoints to be considered include local control, organ preservation, and patient-reported outcomes. Novel approaches including immune-oncology or DNA-repair inhibitor agents combined with radiotherapy should be prioritized. In this article, we focus on how the regulatory challenges associated with defining a new drug–radiotherapy combination can be overcome to improve clinical outcomes for patients with cancer.