Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study
M. Pollán, B. Pérez-Gómez, Roberto Pastor-Barriuso
et al.
Background Spain is one of the European countries most affected by the COVID-19 pandemic. Serological surveys are a valuable tool to assess the extent of the epidemic, given the existence of asymptomatic cases and little access to diagnostic tests. This nationwide population-based study aims to estimate the seroprevalence of SARS-CoV-2 infection in Spain at national and regional level. Methods 35 883 households were selected from municipal rolls using two-stage random sampling stratified by province and municipality size, with all residents invited to participate. From April 27 to May 11, 2020, 61 075 participants (75·1% of all contacted individuals within selected households) answered a questionnaire on history of symptoms compatible with COVID-19 and risk factors, received a point-of-care antibody test, and, if agreed, donated a blood sample for additional testing with a chemiluminescent microparticle immunoassay. Prevalences of IgG antibodies were adjusted using sampling weights and post-stratification to allow for differences in non-response rates based on age group, sex, and census-tract income. Using results for both tests, we calculated a seroprevalence range maximising either specificity (positive for both tests) or sensitivity (positive for either test). Findings Seroprevalence was 5·0% (95% CI 4·7–5·4) by the point-of-care test and 4·6% (4·3–5·0) by immunoassay, with a specificity–sensitivity range of 3·7% (3·3–4·0; both tests positive) to 6·2% (5·8–6·6; either test positive), with no differences by sex and lower seroprevalence in children younger than 10 years (10%) and lower in coastal areas (<3%). Seroprevalence among 195 participants with positive PCR more than 14 days before the study visit ranged from 87·6% (81·1–92·1; both tests positive) to 91·8% (86·3–95·3; either test positive). In 7273 individuals with anosmia or at least three symptoms, seroprevalence ranged from 15·3% (13·8–16·8) to 19·3% (17·7–21·0). Around a third of seropositive participants were asymptomatic, ranging from 21·9% (19·1–24·9) to 35·8% (33·1–38·5). Only 19·5% (16·3–23·2) of symptomatic participants who were seropositive by both the point-of-care test and immunoassay reported a previous PCR test. Interpretation The majority of the Spanish population is seronegative to SARS-CoV-2 infection, even in hotspot areas. Most PCR-confirmed cases have detectable antibodies, but a substantial proportion of people with symptoms compatible with COVID-19 did not have a PCR test and at least a third of infections determined by serology were asymptomatic. These results emphasise the need for maintaining public health measures to avoid a new epidemic wave. Funding Spanish Ministry of Health, Institute of Health Carlos III, and Spanish National Health System.
1543 sitasi
en
Geography, Medicine
Episodes from the history of infinitesimals
Mikhail G. Katz
Infinitesimals have seen ups and downs in their tumultuous history. In the 18th century, d'Alembert set the tone by describing infinitesimals as chimeras. Some adversaries of infinitesimals, including Moigno and Connes, picked up on the term. We highlight the work of Cauchy, Noël, Poisson and Riemann. We also chronicle reactions by Moigno, Lamarle and Cantor, and signal the start of a revival with Peano.
History-Guided Video Diffusion
Kiwhan Song, Boyuan Chen, Max Simchowitz
et al.
Classifier-free guidance (CFG) is a key technique for improving conditional generation in diffusion models, enabling more accurate control while enhancing sample quality. It is natural to extend this technique to video diffusion, which generates video conditioned on a variable number of context frames, collectively referred to as history. However, we find two key challenges to guiding with variable-length history: architectures that only support fixed-size conditioning, and the empirical observation that CFG-style history dropout performs poorly. To address this, we propose the Diffusion Forcing Transformer (DFoT), a video diffusion architecture and theoretically grounded training objective that jointly enable conditioning on a flexible number of history frames. We then introduce History Guidance, a family of guidance methods uniquely enabled by DFoT. We show that its simplest form, vanilla history guidance, already significantly improves video generation quality and temporal consistency. A more advanced method, history guidance across time and frequency further enhances motion dynamics, enables compositional generalization to out-of-distribution history, and can stably roll out extremely long videos. Project website: https://boyuan.space/history-guidance
From S-matrix theory to strings: Scattering data and the commitment to non-arbitrariness
Robert van Leeuwen
The early history of string theory is marked by a shift from strong interaction physics to quantum gravity. The first string models and associated theoretical framework were formulated in the late 1960s and early 1970s in the context of the S-matrix program for the strong interactions. In the mid-1970s, the models were reinterpreted as a potential theory unifying the four fundamental forces. This paper provides a historical analysis of how string theory was developed out of S-matrix physics, aiming to clarify how modern string theory, as a theory detached from experimental data, grew out of an S-matrix program that was strongly dependent upon observable quantities. Surprisingly, the theoretical practice of physicists already turned away from experiment before string theory was recast as a potential unified quantum gravity theory. With the formulation of dual resonance models (the "hadronic string theory"), physicists were able to determine almost all of the models' parameters on the basis of theoretical reasoning. It was this commitment to "non-arbitrariness", i.e., a lack of free parameters in the theory, that initially drove string theorists away from experimental input, and not the practical inaccessibility of experimental data in the context of quantum gravity physics. This is an important observation when assessing the role of experimental data in string theory.
en
physics.hist-ph, gr-qc
Carlos Ortiz de Landázuri, La vida futura del camino jacobeo, Logroño, [Federación Española Asociaciones Amigos Camino de Santiago], 2022, 325 págs. ISBN: 978-84-73799-70-2.
Antón M. Pazos
A Brief History of Space VLBI
Leonid I. Gurvits
Space Very Long Baseline Interferometry is a radio astronomy technique distinguished by a record-high angular resolution reaching single-digit microseconds of arc. The paper provides a brief account of the history of developments of this technique over the period 1960s-2020s.
Note on episodes in the history of modeling measurements in local spacetime regions using QFT
Doreen Fraser, Maria Papageorgiou
The formulation of a measurement theory for relativistic quantum field theory (QFT) has recently been an active area of research. In contrast to the asymptotic measurement framework that was enshrined in QED, the new proposals aim to supply a measurement framework for measurements in local spacetime regions. This paper surveys episodes in the history of quantum theory that contemporary researchers have identified as precursors to their own work and discusses how they laid the groundwork for current approaches to local measurement theory for QFT.
en
physics.hist-ph, quant-ph
The natural history of symptomatic COVID-19 during the first wave in Catalonia
E. Burn, C. Tebé, S. Fernández-Bertolín
et al.
The natural history of coronavirus disease 2019 (COVID-19) has yet to be fully described. Here, we use patient-level data from the Information System for Research in Primary Care (SIDIAP) to summarise COVID-19 outcomes in Catalonia, Spain. We included 5,586,521 individuals from the general population. Of these, 102,002 had an outpatient diagnosis of COVID-19, 16,901 were hospitalised with COVID-19, and 5273 died after either being diagnosed or hospitalised with COVID-19 between 1st March and 6th May 2020. Older age, being male, and having comorbidities were all generally associated with worse outcomes. These findings demonstrate the continued need to protect those at high risk of poor outcomes, particularly older people, from COVID-19 and provide appropriate care for those who develop symptomatic disease. While risks of hospitalisation and death were lower for younger populations, there is a need to limit their role in community transmission. Establishing the natural history of COVID-19 requires longitudinal data from population-based cohorts. Here, the authors use linked primary care, testing, and hospital data to describe the disease in ~100,000 individuals with a COVID-19 diagnosis among a population of ~5.5 million in Catalonia, Spain.
Sustainable Tourism, Economic Growth and Employment—The Case of the Wine Routes of Spain
G. Vicente, Víctor Martín Barroso, F. Jiménez
Tourism has become a priority in national and regional development policies and is considered a source of economic growth, particularly in rural areas. Nowadays, wine tourism is an important form of tourism and has become a local development tool for rural areas. Regional tourism development studies based on wine tourism have a long history in several countries such as the US and Australia, but are more recent in Europe. Although Spain is a leading country in the tourism industry, with an enormous wine-growing tradition, the literature examining the economic impact of wine tourism in Spanish economy is scarce. In an attempt to fill this gap, the main objective of this paper is to analyze the impact of wine tourism on economic growth and employment in Spain. More specifically, by applying panel data techniques, we study the economic impact of tourism in nine Spanish wine routes in the period from 2008 to 2018. Our results suggest that tourism in these wine routes had a positive effect on economic growth. However, we do not find clear evidence of a positive effect on employment generation.
Characterizing SOD1 mutations in Spain: The impact of genotype, age and sex in the natural history of the disease
J. Vázquez-Costa, D. Borrego-Hernández, C. Paradas
et al.
The aim of this study was to describe the frequency and distribution of SOD1 mutations in Spain, and to explore factors contributing to their phenotype and prognosis.
The Leuven Gymkhana: Transdisciplinary Action Research Questioning Socially Innovative Multi-Actor Collaborations in COVID Times
Clara Medina-García, Clara Medina-García, Sharmada Nagarajan
et al.
Literatures on social innovation, collective agency and multi-actor collaboration stress the importance of action research and joint problematization to research ongoing processes of collaboration and transformation to advance both theory and practice in these fields. In this paper we analyze our experience building a transdisciplinary action research (TAR) trajectory between 2020 and 2021 to investigate socially innovative multi-actor collaborations (IMACs) and urban governance innovation trajectories in the city of Leuven (Belgium). We specifically focus on (1) how we involved a wide array of researchers, stakeholders and practitioners in the TAR trajectory; (2) how we enacted joint problematization and action, ensuring that all facilitative leadership roles were taken care of; (3) the challenges that the specific COVID context posed on TAR and the innovative tools and approaches we took to adapt under such circumstances; and (4) how our TAR contributed to the ongoing IMACs in Leuven. Discussing our experience in relation to issues raised in action research literature, we summarize key dimensions, roles and tasks necessary in TAR to enable facilitative leadership and multi-actor collaboration and successfully drive joint problematization and transformative change. We conclude that our TAR trajectory in Leuven became a case study of IMAC in itself, and so learnings from our TAR directly dialogue with and inform our empirical analysis of the performance of IMACs too. Through this realization and the analysis of our experience, we get to broader question the role of action research and researchers in urban governance innovation.
Nutrition. Foods and food supply, Food processing and manufacture
A Brief Historical Perspective on the Consistent Histories Interpretation of Quantum Mechanics
Gustavo Rodrigues Rocha, Dean Rickles, Florian J. Boge
It will be presented in this chapter a historical account of the consistent histories interpretation of quantum mechanics based on primary and secondary literature. Firstly, the formalism of the consistent histories approach will be outlined. Secondly, the works by Robert Griffiths and Roland Omnès will be discussed. Griffiths' seminal 1984 paper, the first physicist to have proposed a consistent-histories interpretation of quantum mechanics, followed by Omnès' 1990 paper, were instrumental to the consistent-histories model based on Boolean logic. Thirdly, Murray Gell-Mann and James Hartle's steps to their own version of consistent-histories approach, motivated by a cosmological perspective, will then be described and evaluated. Gell-Mann and Hartle understood that spontaneous decoherence could path the way to a concrete physical model to Griffiths' consistent histories. Moreover, the collective biography of these figures will be put in the context of the role played by the Santa Fe Institute, co-founded by Gell-Mann in 1984 in Santa Fe, New Mexico, where Hartle is also a member of the external faculty.
en
physics.hist-ph, quant-ph
A History of Islamic Spain
W. M. Watt, P. Cachia
The period of Muslim occupation in Spain represents the only significant contact Islam and Europe was ever to have on European soil. In this important as well as fascinating study, Watt traces Islam's influence upon Spain and European civilization - from the collapse of the Visigoths in the eighth century to the fall of Granada in the fifteenth, and considers Spain's importance as a part of the Islamic empire. Particular attention is given to the golden period of economic and political stability achieved under the Umayyads. Without losing themselves in detail and without sacrificing complexity, the authors discuss the political, social, and economic continuity in Islamic Spain, or al-Andalus, in light of its cultural and intellectual effects upon the rest of Europe. Medieval Christianity, Watt points out, found models of scholarship in the Islamic philosophers and adapted the idea of holy war to its own purposes while the final reunification of Spain under the aegis of the Reconquista played a significant role in bringing Europe out of the Middle Ages. A survey essential to anyone seeking a more complete knowledge of European or Islamic history, the volume also includes sections on literature and philology by Pierre Cachia. This series of "Islamic surveys" is designed to give the educated reader something more than can be found in the usual popular books. Each work undertakes to survey a special part of the field, and to show the present stage of scholarship here. Where there is a clear picture this will be given; but where there are gaps, obscurities and differences of opinion, these will also be indicated. Full and annotated bibliographies will afford guidance to those who want to pursue their studies further. There will also be some account of the nature and extent of the source material. The series is addressed in the first place to the educated reader, with little or no previous knowledge of the subject; its character is such that it should be of value also to university students and others whose interest is of a more professional kind.
History entanglement entropy
Leonardo Castellani
A formalism is proposed to describe entangled quantum histories, and their entanglement entropy. We define a history vector, living in a tensor space with basis elements corresponding to the allowed histories, i.e. histories with nonvanishing amplitudes. The amplitudes are the components of the history vector, and contain the dynamical information. Probabilities of measurement sequences, and resulting collapse, are given by generalized Born rules: they are all expressed by means of projections and scalar products involving the history vector. Entangled history states are introduced, and a history density matrix is defined in terms of ensembles of history vectors. The corresponding history entropies (and history entanglement entropies for composite systems) are explicitly computed in two examples taken from quantum computation circuits.
The B. B. Newman Spelling Theorem
Carl-Fredrik Nyberg-Brodda
This article aims to be a self-contained account of the history of the B. B. Newman Spelling Theorem, including the historical context in which it arose. First, an account of B. B. Newman and how he came to prove his Spelling Theorem is given, together with a description of the author's efforts to track this information down. Following this, a high-level description of combinatorial group theory is given. This is then tied in with a description of the history of the word problem, a fundamental problem in the area. After a description of some of the theory of one-relator groups, an important part of combinatorial group theory, the natural division line into the torsion and torsion-free case for such groups is described. This culminates in a statement of and general discussion about the B. B. Newman Spelling Theorem and its importance.
José Monteiro da Rocha (1734-1819) and his work of 1782 on the determination of comet orbits
Fernando B. Figueiredo, João M. Fernandes
In 1782 José Monteiro da Rocha, astronomer and professor of the University of Coimbra, presented in a public session of the Royal Academy of Sciences of Lisbon a memoir on the problem of the determination of the comets' orbits. Only in 1799, the "Determinação das Orbitas dos Cometas" (Determination of the orbits of comets) would be published in the Academy's memoires. In that work, Monteiro da Rocha presents a method for solving the problem of the determination of the parabolic orbit of a comet from three observations. Monteiro da Rocha's method is essentially the same method proposed by Olbers and published under von Zach's sponsorship two years before, in 1797. To have been written and published in Portuguese was certainly a hindrance for its dissemination among the international astronomical community. In this article, we intend to present Monteiro da Rocha's method and trying to see to what extent Gomes Teixeira's assertion (Teixeira 1934) that Monteiro da Rocha and Olbers must figure together in the history of astronomy, as the first inventors of a practical and easy method for the determination of parabolic orbits of comets, is justified.
en
physics.hist-ph, astro-ph.EP
Widening Perspectives: The Intellectual and Social Benefits of Astrobiology, Big History, and the Exploration of Space
Ian Crawford
Astrobiology is the field of science devoted to searching for life elsewhere in the Universe. It is inherently interdisciplinary, integrating results from multiple fields of science, and in this respect has strong synergies with 'big history'. I argue that big history and astrobiology are both acting to widen human perspectives in intellectually and socially beneficial directions, especially by enhancing public awareness of cosmic and evolutionary worldviews. I will further argue that these perspectives have important implications for the social and political organisation of humanity, including the eventual political unification of our planet. Astrobiology and big history are also concerned with the future of humanity, and I will argue that this future will be culturally and intellectually enriched if it includes the exploration of the universe around us.
A Changing Dichotomy: The Conception of the "Macroscopic" and "Microscopic" Worlds in the History of Physics
Zhixin Wang
This short essay traces the conceptual history of micro- and macroscopicity in the context of physical science. By focusing on three distinct episodes spanning five centuries, we show the scientific and philosophical meanings of this antonym pair, despite never being far from "the small" and "the large," have been evolving as the frontier of science advances. We analyze the intellectual and material impetus for these movements, and conclude that this conceptual history reflects the changing interaction between the natural world and humankind.
en
physics.hist-ph, physics.pop-ph
Early virtual reality adopters in Spain: sociodemographic profile and interest in the use of virtual reality as a learning tool
Roberto Sánchez-Cabrero, Óscar Costa-Román, Francisco Javier Pericacho-Gómez
et al.
This study describes the social and demographic profile of the first generation of users of marketed virtual reality (VR) viewers in Spain and, subsequently, it assesses the interest in its use as a learning tool. For that purpose, an online questionnaire created ad hoc was administered to a sample of 117 participants. The relationship between twelve variables was analysed comparing means through the Snedecor's F distribution and the contingency tables through the Chi-squared test and Somers' D. Among other issues, it was concluded that the virtual reality user profile at present corresponds to a person older than 36, mainly men, with higher education and having acquired their viewer no longer than one year ago. Concerning the interests of virtual reality users as a learning tool, only a few of them currently use virtual reality for this aim, but they mainly show an interest in using the virtual reality as a learning method and they feel optimism regarding the future use of this technology as a learning tool. However, this is not the case among users of video game consoles (PSVR), who are mainly men not interested in their use as a learning tool at present. Finally, it can be stated that current use as a learning tool among teachers and students is occasional and preferably via smartphones.
Science (General), Social sciences (General)
Femmes et conflits dans l’imaginaire historié de la Rome des Valois
Pierre Pretou
The reception and appropriation of Roman history under the Valois through copies and translations of luxurious manuscripts owned by these kings, their relatives and great officers, connect the medieval imaginary of antiquity to this dynasty. French political iconography of the 14th and 15th centuries combines the governance of the City of Rome with the origins of the kingdom since the translation of Ab Urbe Condita of Tite-Live by Pierre Bersuire, the copies of Jean Mansel's Fleurs des histoires, the translations of De Civitate Dei by Raoul de Presles and the vernacular translation of the writings of Valère Maxime by Simon de Hesdin and Nicolas de Gonesse. By thousands, these miniatures on a universe of men and cities, order and disorder, peace and revenge, concord and discord, identify the public space, the speech, the just power, the contestation, the tyranny, the circulation pacificator of the law, but rarely give way to women, except to associate them with bloody scenes. The serial analysis of the narrow corpus of female representation shows that the appropriation of the image of Roman history gives a singular place to the genre in the representation of conflicts and their resolution in urban areas. The painted women who emerge from Roman stories of the late Middle Ages French escort a world of ancient men experiencing the soothing role of law. Can we conclude for these rare women who accompany scenes of conflict and peace that the painter gives them a historical role as mediators and reinterprets the actions of Roman women? Does he reconsider the construction of public order at the end of the French Middle Ages or is it first of all the historized formulation of a political theory of marriage?
History (General) and history of Europe, History of Spain