Semantic Scholar Open Access 2020 1543 sitasi

Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study

M. Pollán B. Pérez-Gómez Roberto Pastor-Barriuso J. Oteo Miguel A. Hernán +105 lainnya

Lihat Sumber DOI

Abstrak

Background Spain is one of the European countries most affected by the COVID-19 pandemic. Serological surveys are a valuable tool to assess the extent of the epidemic, given the existence of asymptomatic cases and little access to diagnostic tests. This nationwide population-based study aims to estimate the seroprevalence of SARS-CoV-2 infection in Spain at national and regional level. Methods 35 883 households were selected from municipal rolls using two-stage random sampling stratified by province and municipality size, with all residents invited to participate. From April 27 to May 11, 2020, 61 075 participants (75·1% of all contacted individuals within selected households) answered a questionnaire on history of symptoms compatible with COVID-19 and risk factors, received a point-of-care antibody test, and, if agreed, donated a blood sample for additional testing with a chemiluminescent microparticle immunoassay. Prevalences of IgG antibodies were adjusted using sampling weights and post-stratification to allow for differences in non-response rates based on age group, sex, and census-tract income. Using results for both tests, we calculated a seroprevalence range maximising either specificity (positive for both tests) or sensitivity (positive for either test). Findings Seroprevalence was 5·0% (95% CI 4·7–5·4) by the point-of-care test and 4·6% (4·3–5·0) by immunoassay, with a specificity–sensitivity range of 3·7% (3·3–4·0; both tests positive) to 6·2% (5·8–6·6; either test positive), with no differences by sex and lower seroprevalence in children younger than 10 years (10%) and lower in coastal areas (<3%). Seroprevalence among 195 participants with positive PCR more than 14 days before the study visit ranged from 87·6% (81·1–92·1; both tests positive) to 91·8% (86·3–95·3; either test positive). In 7273 individuals with anosmia or at least three symptoms, seroprevalence ranged from 15·3% (13·8–16·8) to 19·3% (17·7–21·0). Around a third of seropositive participants were asymptomatic, ranging from 21·9% (19·1–24·9) to 35·8% (33·1–38·5). Only 19·5% (16·3–23·2) of symptomatic participants who were seropositive by both the point-of-care test and immunoassay reported a previous PCR test. Interpretation The majority of the Spanish population is seronegative to SARS-CoV-2 infection, even in hotspot areas. Most PCR-confirmed cases have detectable antibodies, but a substantial proportion of people with symptoms compatible with COVID-19 did not have a PCR test and at least a third of infections determined by serology were asymptomatic. These results emphasise the need for maintaining public health measures to avoid a new epidemic wave. Funding Spanish Ministry of Health, Institute of Health Carlos III, and Spanish National Health System.

Topik & Kata Kunci

Geography Medicine

Penulis (110)

M. Pollán

B. Pérez-Gómez

Roberto Pastor-Barriuso

J. Oteo

Miguel A. Hernán

M. Pérez-Olmeda

J. L. Sanmartín

Aurora Fernández-García

Israel Cruz

N. Fernández de Larrea

Marta Molina

F. Rodríguez-Cabrera

M. Martín

P. Merino-Amador

José León Paniagua

Juan F. Muñoz-Montalvo

Faustino Blanco

R. Yotti

Faustino Rodrigo Mariano Saturnino Marta Juan F. Matías Jos Blanco Gutiérrez Fernández Martín Mezcua Navarro M

Faustino Blanco

Rodrigo Gutiérrez Fernández

M. Martín

Saturnino Mezcua Navarro

Marta Molina

Juan F. Muñoz-Montalvo

Matías Salinero Hernández

J. L. Sanmartín

M. Cuenca‐Estrella

R. Yotti

José León Paniagua

N. Fernández de Larrea

P. Fernández-Navarro

Roberto Pastor-Barriuso

B. Pérez-Gómez

M. Pollán

A. Avellón

G. Fedele

Aurora Fernández-García

Jesus Oteo Iglesias

M. T. Pérez Olmeda

Israel Cruz

M. E. Fernandez Martinez

F. Rodríguez-Cabrera

Miguel A. Hernán

S. Padrones Fernández

J. Rumbao Aguirre

J. M. Navarro Mari

B. Palop Borrás

A. P. Pérez Jiménez

M. Rodríguez-Iglesias

A. C. Calvo Gascón

M. L. Lou Alcaine

I. Donate Suárez

Óscar Suárez Álvarez

M. Rodríguez Pérez

Margarita Cases Sanchís

C. J. Villafáfila Gomila

L. Carbo Saladrigas

A. Hurtado Fernández

A. Oliver

Elías Castro Feliciano

M. N. González Quintana

J. M. Barrasa Fernández

M. A. Hernández Betancor

M. Hernández Febles

L. Martín Martín

L. López López

Teresa Ugarte Miota

Inés De Benito Población

M. S. Celada Pérez

M. N. Vallés Fernández

Tomás Maté Enríquez

Miguel Villa Arranz

Marta Domínguez-Gil González

I. Fernández-Natal

Gregoria Megías Lobón

J. L. Muñoz Bellido

P. Ciruela

Ariadna Mas i Casals

Maria Doladé Botías

M. Á. Marcos Maeso

D. Pérez Del Campo

Antonio Félix de Castro

Ramón Limón Ramírez

M. F. Elías Retamosa

M. Rubio González

M. S. Blanco Lobeiras

Alberto Fuentes Losada

A. Aguilera

G. Bou

Yolanda Caro

Noemí Marauri

L. M. Soria Blanco

I. del Cura González

M. Hernández Pascual

R. Alonso Fernández

P. Merino-Amador

N. Cabrera Castro

Aurora Tomás Lizcano

Cristóbal Ramírez Almagro

M. Segovia Hernández

N. Ascunce Elizaga

M. Ederra Sanz

Carmen Ezpeleta Baquedano

Ana Bustinduy Bascaran

Susana Iglesias Tamayo

Luis Elorduy Otazua

Rebeca Benarroch Benarroch

Jesús Lopera Flores

A. Vázquez de la Villa

Format Sitasi

APA MLA BibTeX

Pollán, M., Pérez-Gómez, B., Pastor-Barriuso, R., Oteo, J., Hernán, M.A., Pérez-Olmeda, M. et al. (2020). Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. https://doi.org/10.1016/S0140-6736(20)31483-5

@article{pollán2020, author = {M. Pollán and B. Pérez-Gómez and Roberto Pastor-Barriuso and J. Oteo and Miguel A. Hernán and M. Pérez-Olmeda and J. L. Sanmartín and Aurora Fernández-García and Israel Cruz and N. Fernández de Larrea and Marta Molina and F. Rodríguez-Cabrera and M. Martín and P. Merino-Amador and José León Paniagua and Juan F. Muñoz-Montalvo and Faustino Blanco and R. Yotti and Faustino Rodrigo Mariano Saturnino Marta Juan F. Matías Jos Blanco Gutiérrez Fernández Martín Mezcua Navarro M and Faustino Blanco and Rodrigo Gutiérrez Fernández and M. Martín and Saturnino Mezcua Navarro and Marta Molina and Juan F. Muñoz-Montalvo and Matías Salinero Hernández and J. L. Sanmartín and M. Cuenca‐Estrella and R. Yotti and José León Paniagua and N. Fernández de Larrea and P. Fernández-Navarro and Roberto Pastor-Barriuso and B. Pérez-Gómez and M. Pollán and A. Avellón and G. Fedele and Aurora Fernández-García and Jesus Oteo Iglesias and M. T. Pérez Olmeda and Israel Cruz and M. E. Fernandez Martinez and F. Rodríguez-Cabrera and Miguel A. Hernán and S. Padrones Fernández and J. Rumbao Aguirre and J. M. Navarro Mari and B. Palop Borrás and A. P. Pérez Jiménez and M. Rodríguez-Iglesias and A. C. Calvo Gascón and M. L. Lou Alcaine and I. Donate Suárez and Óscar Suárez Álvarez and M. Rodríguez Pérez and Margarita Cases Sanchís and C. J. Villafáfila Gomila and L. Carbo Saladrigas and A. Hurtado Fernández and A. Oliver and Elías Castro Feliciano and M. N. González Quintana and J. M. Barrasa Fernández and M. A. Hernández Betancor and M. Hernández Febles and L. Martín Martín and L. López López and Teresa Ugarte Miota and Inés De Benito Población and M. S. Celada Pérez and M. N. Vallés Fernández and Tomás Maté Enríquez and Miguel Villa Arranz and Marta Domínguez-Gil González and I. Fernández-Natal and Gregoria Megías Lobón and J. L. Muñoz Bellido and P. Ciruela and Ariadna Mas i Casals and Maria Doladé Botías and M. Á. Marcos Maeso and D. Pérez Del Campo and Antonio Félix de Castro and Ramón Limón Ramírez and M. F. Elías Retamosa and M. Rubio González and M. S. Blanco Lobeiras and Alberto Fuentes Losada and A. Aguilera and G. Bou and Yolanda Caro and Noemí Marauri and L. M. Soria Blanco and I. del Cura González and M. Hernández Pascual and R. Alonso Fernández and P. Merino-Amador and N. Cabrera Castro and Aurora Tomás Lizcano and Cristóbal Ramírez Almagro and M. Segovia Hernández and N. Ascunce Elizaga and M. Ederra Sanz and Carmen Ezpeleta Baquedano and Ana Bustinduy Bascaran and Susana Iglesias Tamayo and Luis Elorduy Otazua and Rebeca Benarroch Benarroch and Jesús Lopera Flores and A. Vázquez de la Villa}, title = {Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study}, year = {2020}, journal = {Semantic Scholar}, doi = {10.1016/S0140-6736(20)31483-5}, url = {https://www.semanticscholar.org/paper/0739f687a2ef85ac4556238e4b6e1e01c4d05535}, }

Akses Cepat

Lihat di Sumber doi.org/10.1016/S0140-6736(20)31483-5

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 1543×
Sumber Database: Semantic Scholar
DOI: 10.1016/S0140-6736(20)31483-5
Akses: Open Access ✓