Hasil untuk "physics.space-ph"

R. Laureijs, J. Amiaux, S. Arduini et al.

Euclid is a space-based survey mission from the European Space Agency designed to understand the origin of the Universe's accelerating expansion. It will use cosmological probes to investigate the nature of dark energy, dark matter and gravity by tracking their observational signatures on the geometry of the universe and on the cosmic history of structure formation. The mission is optimised for two independent primary cosmological probes: Weak gravitational Lensing (WL) and Baryonic Acoustic Oscillations (BAO). The Euclid payload consists of a 1.2 m Korsch telescope designed to provide a large field of view. It carries two instruments with a common field-of-view of ~0.54 deg2: the visual imager (VIS) and the near infrared instrument (NISP) which contains a slitless spectrometer and a three bands photometer. The Euclid wide survey will cover 15,000 deg2 of the extragalactic sky and is complemented by two 20 deg2 deep fields. For WL, Euclid measures the shapes of 30-40 resolved galaxies per arcmin2 in one broad visible R+I+Z band (550-920 nm). The photometric redshifts for these galaxies reach a precision of dz/(1+z) < 0.05. They are derived from three additional Euclid NIR bands (Y, J, H in the range 0.92-2.0 micron), complemented by ground based photometry in visible bands derived from public data or through engaged collaborations. The BAO are determined from a spectroscopic survey with a redshift accuracy dz/(1+z) =0.001. The slitless spectrometer, with spectral resolution ~250, predominantly detects Ha emission line galaxies. Euclid is a Medium Class mission of the ESA Cosmic Vision 2015-2025 programme, with a foreseen launch date in 2019. This report (also known as the Euclid Red Book) describes the outcome of the Phase A study.

Y. Surendranath, M. Kanan, D. Nocera

A. Pezzulo, X. Tang, M. J. Hoegger et al.

Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and the resulting inflammation cause most of the morbidity and mortality, how the loss of CFTR function first disrupts airway host defence has remained uncertain. To investigate the abnormalities that impair elimination when a bacterium lands on the pristine surface of a newborn CF airway, we interrogated the viability of individual bacteria immobilized on solid grids and placed onto the airway surface. As a model, we studied CF pigs, which spontaneously develop hallmark features of CF lung disease. At birth, their lungs lack infection and inflammation, but have a reduced ability to eradicate bacteria. Here we show that in newborn wild-type pigs, the thin layer of airway surface liquid (ASL) rapidly kills bacteria in vivo, when removed from the lung and in primary epithelial cultures. Lack of CFTR reduces bacterial killing. We found that the ASL pH was more acidic in CF pigs, and reducing pH inhibited the antimicrobial activity of ASL. Reducing ASL pH diminished bacterial killing in wild-type pigs, and, conversely, increasing ASL pH rescued killing in CF pigs. These results directly link the initial host defence defect to the loss of CFTR, an anion channel that facilitates HCO3− transport. Without CFTR, airway epithelial HCO3− secretion is defective, the ASL pH falls and inhibits antimicrobial function, and thereby impairs the killing of bacteria that enter the newborn lung. These findings suggest that increasing ASL pH might prevent the initial infection in patients with CF, and that assaying bacterial killing could report on the benefit of therapeutic interventions.

S. Shiratori, M. Rubner

Jinyuan Zhou, J. Payen, David A Wilson et al.

Saba M. Ali, G. Yosipovitch

The "acid mantle" is a topic not only of historical interest, but also of clinical significance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent basic science investigations into skin pH, discuss skin disorders characterized by aberrant pH, and finally discuss practical application for preservation of the acid mantle. Recognizing factors that alter skin pH and selecting products that preserve the acid mantle is of prime importance in treating dermatologic patients.

Hai‐Long Jiang, Dawei Feng, Kecheng Wang et al.

Jianquan Luo, Y. Wan

Qunpeng Duan, Yu Cao, Yan Li et al.

J. Jiang, Yujing Zhang, Kaimin Li et al.

D. Wencel, T. Abel, C. McDonagh

D. O'Hanlon, T. Moench, R. Cone

Lactic acid at sufficiently acidic pH is a potent microbicide, and lactic acid produced by vaginal lactobacilli may help protect against reproductive tract infections. However, previous observations likely underestimated healthy vaginal acidity and total lactate concentration since they failed to exclude women without a lactobacillus-dominated vaginal microbiota, and also did not account for the high carbon dioxide, low oxygen environment of the vagina. Fifty-six women with low (0-3) Nugent scores (indicating a lactobacillus-dominated vaginal microbiota) and no symptoms of reproductive tract disease or infection, provided a total of 64 cervicovaginal fluid samples using a collection method that avoided the need for sample dilution and rigorously minimized aerobic exposure. The pH of samples was measured by microelectrode immediately after collection and under a physiological vaginal concentration of CO2. Commercial enzymatic assays of total lactate and total acetate concentrations were validated for use in CVF, and compared to the more usual HPLC method. The average pH of the CVF samples was 3.5 ± 0.3 (mean ± SD), range 2.8-4.2, and the average total lactate was 1.0% ± 0.2% w/v; this is a five-fold higher average hydrogen ion concentration (lower pH) and a fivefold higher total lactate concentration than in the prior literature. The microbicidal form of lactic acid (protonated lactic acid) was therefore eleven-fold more concentrated, and a markedly more potent microbicide, than indicated by prior research. This suggests that when lactobacilli dominate the vaginal microbiota, women have significantly more lactic acid-mediated protection against infections than currently believed. Our results invite further evaluations of the prophylactic and therapeutic actions of vaginal lactic acid, whether provided in situ by endogenous lactobacilli, by probiotic lactobacilli, or by products that reinforce vaginal lactic acid.

Mehdi Damaghi, Jonathan W. Wojtkowiak, R. Gillies

Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH sensors. These sensors have the ability to recognize and induce cellular responses to maintain the pHi, often at the expense of acidifying the extracellular pH. In turn, extracellular acidification impacts cells via specific acid-sensing ion channels (ASICs) and proton-sensing G-protein coupled receptors (GPCRs). In this review, we will discuss some of the major players in proton sensing at the plasma membrane and their downstream consequences in cancer cells and how these pH-mediated changes affect processes such as migration and metastasis. The complex mechanisms by which they transduce acid pH signals to the cytoplasm and nucleus are not well understood. However, there is evidence that expression of proton-sensing GPCRs such as GPR4, TDAG8, and OGR1 can regulate aspects of tumorigenesis and invasion, including cofilin and talin regulated actin (de-)polymerization. Major mechanisms for maintenance of pHi homeostasis include monocarboxylate, bicarbonate, and proton transporters. Notably, there is little evidence suggesting a link between their activities and those of the extracellular H+-sensors, suggesting a mechanistic disconnect between intra- and extracellular pH. Understanding the mechanisms of pH sensing and regulation may lead to novel and informed therapeutic strategies that can target acidosis, a common physical hallmark of solid tumors.

D. Ling, W. Park, Sin‐jung Park et al.

S. Percival, Sara M. McCarty, J. Hunt et al.

Sharmila Baliga, Sangeeta Muglikar, Rahul Kale

Objectives: Saliva contains a variety of host defense factors. It influences calculus formation and periodontal disease. Different studies have been done to find exact correlation of salivary biomarkers with periodontal disease. With a multitude of biomarkers and complexities in their determination, the salivary pH may be tried to be used as a quick chairside test. The aim of this study was to analyze the pH of saliva and determine its relevance to the severity of periodontal disease. Study Design: The study population consisted of 300 patients. They were divided into three groups of 100 patients each: Group A had clinically healthy gingiva, Group B who had generalized chronic gingivitis and Group C who had generalized chronic periodontitis. The randomized unstimulated saliva from each patient was collected and pH was tested. Data was analyzed statistically using analysis of variance technique. Results: The salivary pH was more alkaline for patients with generalized chronic gingivitis as compared with the control group (P = 0.001) whereas patients with generalized chronic periodontitis had more acidic pH as compared with the control group (P = 0.001). Conclusion: These results indicate a significant change in the pH depending on the severity of the periodontal condition. The salivary pH shows significant changes and thus relevance to the severity of periodontal disease. Salivary pH may thus be used as a quick chairside diagnostic biomarker.

Vadim Roytershteyn, Lynn B. Wilson, Li-Jen Chen et al.

Large-amplitude electrostatic fluctuations are routinely observed by spacecraft upon traversal of collisionless shocks in the heliosphere. Kinetic simulations of shocks have struggled to reproduce the amplitude of such fluctuations, complicating efforts to understand their influence on energy dissipation and shock structure. In this paper, 1D particle-in-cell simulations with realistic proton-to-electron mass ratio are used to show that in cases with upstream electron temperature $T_e$ exceeding the ion temperature $T_i$, the magnitude of the fluctuations increases with the electron plasma-to-cyclotron frequency ratio $ω_{pe}/Ω_{ce}$, reaching realistic values at $ω_{pe}/Ω_{ce} \gtrsim 30$. The large-amplitude fluctuations in the simulations are shown to be associated with electrostatic solitary structures, such as ion phase-space holes. In the cases where upstream temperature ratio is reversed, the magnitude of the fluctuations remains small.

D. A. Semyonov, A. A. Semyonova

Humanity must solve the problems that threaten human health during long-term space flight. An unexpected solution is suggested by an experiment on people staying in a closed life support system model, conducted more than 50 years ago in Krasnoyarsk. The high level of carbon dioxide established after the start of the experiment changed the metabolism of the inhabitants. We present the interpretation of the results of the Krasnoyarsk experiment through understanding the effect of hypercapnia on metabolism for the first time in this work. Hypercapnia suppressed the possibility of developing metabolic acidosis and activated fat oxidation. The change in the respiratory quotient caused by hypercapnia stabilized the composition of the gas mixture in the closed life support system and ensured the stability of the system.

Leonor Cui Domingo Centeno, Víctor Puente García

During the propagation of a tsunami, gravity and sound waves can be produced, spreading from its source to the ionosphere's upper layers, thus generating perturbed electron densities in its E and F regions. These ionospheric disturbances can be studied in detail using measurements of the ionosphere's Total Electron Content (TEC), registered by permanent GNSS stations. In this contribution, the foundations of the VARION method (Variometric Approach for Real-time Ionosphere Observation) are described in order to obtain TEC's temporal variations with the aim of detecting such ionospheric disturbances. Moreover, the numerical results obtained after applying this method to real cases of tsunamis monitored by those satellites whose Ionospheric Pierce Points (IPPs) are closest to the tsunami source are presented. Lastly, based on these ionospheric perturbations reflected in the signals emitted by the satellites, a preliminary design is described for its potential integration into a Tsunami early Warning System (TWS) for the Iberian Peninsula.

Enrico Camporeale, George J. Wilkie, Alexander Drozdov et al.

Real-time prediction of the dynamics of energetic electrons in Earth's radiation belts incorporating incomplete observation data is important to protect valuable artificial satellites and to understand their physical processes. Traditionally, reduced models have employed a diffusion equation based on the quasilinear approximation. Using a Physics-Informed Neural Network (PINN) framework, we train and test a model based on Van Allen Probe data. We present a recipe for gleaning physical insight from solving the ill-posed inverse problem of inferring model coefficients from data using PINNs. With this, it is discovered that the dynamics of "killer electrons" is described more accurately instead by a drift-diffusion equation. A parameterization for the diffusion and drift coefficients, which is both simpler and more accurate than existing models, is presented.