Hasil untuk "Maps"

S. Lim, M. Ashby

J. Eells, L. Lemaire

M. Ashby

O. Vingsbo, S. Söderberg

M. Gäumann, C. Bezençon, P. Canalís et al.

W. Fulton, R. Pandharipande

These are notes from a jointly taught class at the University of Chicago and lectures by the first author in Santa Cruz. Topics covered include: construction of moduli spaces of stable maps, Gromov-Witten invariants, quantum cohomology, and examples. These notes will appear in the proceedings of the 1995 Santa Cruz conference.

M. A. Ruiz-Primo, R. Shavelson

Aaron W. F. Lee, W. Sweldens, P. Schröder et al.

S. Lincoln

E. Zerubavel

T. Malzbender, Dan Gelb, H. Wolters

S. Eickhoff, S. Heim, K. Zilles et al.

Michael T. Gastner, M. Newman

B. Hewitson, R. Crane

D. Wood, John Fels, J. Krygier

Geongyu Lee, Joonho Lee, Tae-Yeong Kwak et al.

Abstract Accurate prediction of the likelihood of recurrence is important in the selection of postoperative treatment for patients with early-stage breast cancer. In this study, we investigated whether deep learning algorithms can predict patients’ risk of recurrence by analyzing the pathology images of their cancer histology. We analyzed 125 hematoxylin and eosin-stained whole slide images (WSIs) from 125 patients across two institutions (National Cancer Center and Korea University Medical Center Guro Hospital) to predict breast cancer recurrence risk using deep learning. Sensitivity reached 0.857, 0.746, and 0.529 for low, intermediate, and high-risk categories, respectively, with specificity of 0.816, 0.803, and 0.972, and a Pearson correlation of 0.61 with histological grade. Class activation maps highlighted features like tubule formation and mitotic rate, suggesting a cost-effective approach to risk stratification, pending broader validation. These findings suggest that deep learning models trained exclusively on hematoxylin and eosin stained whole slide images can approximate genomic assay results, offering a cost-effective and scalable tool for breast cancer recurrence risk assessment. However, further validation using larger and more balanced datasets is needed to confirm the clinical applicability of our approach.

Veysel Oğulcan Kaya, Ogün Adebali

Abstract While it is well-established that UV radiation threatens genomic integrity, the precise mechanisms by which cells orchestrate DNA damage response and repair within the context of 3D genome architecture remain unclear. Here, we address this gap by investigating the UV-induced reorganization of the 3D genome and its critical role in mediating damage response. Employing temporal maps of contact matrices and transcriptional profiles, we illustrate the immediate and holistic changes in genome architecture post-irradiation, emphasizing the significance of this reconfiguration for effective DNA repair processes. We demonstrate that UV radiation triggers a comprehensive restructuring of the 3D genome organization at all levels, including loops, topologically associating domains and compartments. Through the analysis of DNA damage and excision repair maps, we uncover a correlation between genome folding, gene regulation, damage formation probability, and repair efficacy. We show that adaptive reorganization of the 3D genome is a key mediator of the damage response, providing new insights into the complex interplay of genomic structure and cellular defense mechanisms against UV-induced damage, thereby advancing our understanding of cellular resilience.

Philine Guckelberger, Leah Haut, Rosaria Tornisiello et al.

Abstract DNA methylation regulation involves multi-layered chromatin interactions that require remodeling proteins like the helicase, lymphoid-specific (HELLS). Here, we generate HELLS and DNA methyltransferase 3A and B (DNMT3A/B) knockout human pluripotent stem cells and report telomere-to-telomere maps of whole genome bisulfite sequencing data combined with ATAC-sequencing. Disrupting HELLS induces a global loss of DNA methylation that is distinct from the DNMTs, in particular over peri/centromeric satellite repeats as defined in the telomere-to-telomere genome assembly. However, HELLS appears dispensable for local enhancer remodeling and the potential to differentiate into the three embryonic germ layers. Taken together, our results further clarify the genomic targets and role of HELLS in human cells.

Ferris Moser

We investigate phase space transport in a two-dimensional stretched caldera potential using the Origin-Fate Map (OFM) framework, complemented by Lagrangian Descriptor (LD) analysis. The caldera potential, a model for reaction dynamics with multiple exit channels, is adjusted by a stretching factor lambda that controls the directional bias of the four-saddle landscape. Several OFMs are constructed for two Poincare surfaces of section using forwards and backwards symplectic integration to assign each initial condition a channel of origin and fate. Our results reproduce the highly symmetric lambda = 1.0 patterns reported in Hillebrand et al. (Phys. Rev. E 108, 024211, 2023), and reveal, for smaller lambda, pronounced channel imbalance, figure-eight transport loops, and complex mixed-channel chaotic regions. Long-time integrations show a reduction of trapped regions with boundaries that exhibit self-similarity under deep zoom, revealing fractal-like structures. High-resolution OFMs and LD gradient maps uncover lobe dynamics and manifold structures that govern transport, showing near-perfect alignment between LD ridges and OFM boundaries.

H. Moel, J. Alphen, J. Aerts

Abstract. To support the transition from traditional flood defence strategies to a flood risk management approach at the basin scale in Europe, the EU has adopted a new Directive (2007/60/EC) at the end of 2007. One of the major tasks which member states must carry out in order to comply with this Directive is to map flood hazards and risks in their territory, which will form the basis of future flood risk management plans. This paper gives an overview of existing flood mapping practices in 29 countries in Europe and shows what maps are already available and how such maps are used. Roughly half of the countries considered have maps covering as good as their entire territory, and another third have maps covering significant parts of their territory. Only five countries have very limited or no flood maps available yet. Of the different flood maps distinguished, it appears that flood extent maps are the most commonly produced floods maps (in 23 countries), but flood depth maps are also regularly created (in seven countries). Very few countries have developed flood risk maps that include information on the consequences of flooding. The available flood maps are mostly developed by governmental organizations and primarily used for emergency planning, spatial planning, and awareness raising. In spatial planning, flood zones delimited on flood maps mainly serve as guidelines and are not binding. Even in the few countries (e.g. France, Poland) where there is a legal basis to regulate floodplain developments using flood zones, practical problems are often faced which reduce the mitigating effect of such binding legislation. Flood maps, also mainly extent maps, are also created by the insurance industry in Europe and used to determine insurability, differentiate premiums, or to assess long-term financial solvency. Finally, flood maps are also produced by international river commissions. With respect to the EU Flood Directive, many countries already have a good starting point to map their flood hazards. A flood risk based map that includes consequences, however, has yet to be developed by most countries.