Hasil untuk "Architecture"

L. Catarinucci, Danilo De Donno, L. Mainetti et al.

C. Partch, C. Green, J. Takahashi

L. Blanchoin, R. Boujemaa-Paterski, C. Sykes et al.

M. Kagey, J. Newman, S. Bilodeau et al.

Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound transcription factors and the transcription apparatus at the core promoter, but this process is not well understood. Here we report that mediator and cohesin physically and functionally connect the enhancers and core promoters of active genes in murine embryonic stem cells. Mediator, a transcriptional coactivator, forms a complex with cohesin, which can form rings that connect two DNA segments. The cohesin-loading factor Nipbl is associated with mediator–cohesin complexes, providing a means to load cohesin at promoters. DNA looping is observed between the enhancers and promoters occupied by mediator and cohesin. Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell.

M. Jinno, H. Takara, B. Kozicki et al.

B. F. Castro

N. Dosenbach, D. Fair, A. Cohen et al.

Erik Lindholm, J. Nickolls, S. Oberman et al.

P. Mattila, P. Lappalainen

J. Broekstra, A. Kampman, F. V. Harmelen

P. Baltes

Tal Garfinkel, M. Rosenblum

J. Lynch

E. Koechlin, Chrystèle Ody, F. Kouneiher

D. X. Wei, Cheng Jin, S. Low et al.

V. Betz, Jonathan Rose, Alexander Marquardt

H. Ramchoun, M. J. Idrissi, Y. Ghanou et al.

— The multilayer perceptron has a large wide of classification and regression applications in many fields: pattern recognition, voice and classification problems. But the architecture choice has a great impact on the convergence of these networks. In the present paper we introduce a new approach to optimize the network architecture, for solving the obtained model we use the genetic algorithm and we train the network with a back-propagation algorithm. The numerical results assess the effectiveness of the theoretical results shown in this paper, and the advantages of the new modeling compared to the previous model in the literature.

Gunasekaran Manogaran, R. Varatharajan, Daphne Lopez et al.

Zhiji Gao, Jin’an Xu, Hanjie Qiu et al.

Granite sawdust is a by-product in the process of stone processing, which is usually piled up, thus easily causing environmental pollution. To achieve resource utilization, granite sawdust was used as a partial substitution of cement in this work. The effects of different sawdust contents (10–50%) were systematically studied on the pore structure and the mechanical properties of its dry powder mortar. Combined with the grey correlation theory, the correlation between pore size distribution and compressive strength was analyzed. The results showed that the consistency and mechanical properties of the mortar gradually decreased along with the increasing sawdust content, while its critical pore-diameter decreased. The mortar performance was the best when its sawdust content is 10%, which meets the M25 technical requirements. When content reaches up to 30%, the mortar still met the strength standard of M20. Compared to fly ash, the mortar with 30% sawdust as the substitution has a higher water retention rate but lower mechanical strength. The grey correlation analysis indicated that the pores with diameters less than 10 nm and greater than 1000 nm had the most significant impact on the compressive strength.