The genetic architecture of type 2 diabetes
C. Fuchsberger, J. Flannick, T. Teslovich
et al.
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups. To increase statistical power, we expanded the sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes.
A time delay neural network architecture for efficient modeling of long temporal contexts
Vijayaditya Peddinti, Daniel Povey, S. Khudanpur
1076 sitasi
en
Computer Science
Making: Anthropology, Archaeology, Art and Architecture
T. Ingold
Wireless Information and Power Transfer: Architecture Design and Rate-Energy Tradeoff
Xun Zhou, Rui Zhang, Chin Keong Ho
Simultaneous information and power transfer over the wireless channels potentially offers great convenience to mobile users. Yet practical receiver designs impose technical constraints on its hardware realization, as practical circuits for harvesting energy from radio signals are not yet able to decode the carried information directly. To make theoretical progress, we propose a general receiver operation, namely, dynamic power splitting (DPS), which splits the received signal with adjustable power ratio for energy harvesting and information decoding, separately. Three special cases of DPS, namely, time switching (TS), static power splitting (SPS) and on-off power splitting (OPS) are investigated. The TS and SPS schemes can be treated as special cases of OPS. Moreover, we propose two types of practical receiver architectures, namely, separated versus integrated information and energy receivers. The integrated receiver integrates the front-end components of the separated receiver, thus achieving a smaller form factor. The rate-energy tradeoff for the two architectures are characterized by a so-called rate-energy (R-E) region. The optimal transmission strategy is derived to achieve different rate-energy tradeoffs. With receiver circuit power consumption taken into account, it is shown that the OPS scheme is optimal for both receivers. For the ideal case when the receiver circuit does not consume power, the SPS scheme is optimal for both receivers. In addition, we study the performance for the two types of receivers under a realistic system setup that employs practical modulation. Our results provide useful insights to the optimal practical receiver design for simultaneous wireless information and power transfer (SWIPT).
1873 sitasi
en
Computer Science, Mathematics
Architecture of graphdiyne nanoscale films.
Guoxing Li, Yuliang Li, Huibiao Liu
et al.
2327 sitasi
en
Medicine, Materials Science
Stability of Ecological Communities and the Architecture of Mutualistic and Trophic Networks
Élisa Thébault, C. Fontaine
1638 sitasi
en
Biology, Medicine
A data-oriented (and beyond) network architecture
T. Koponen, Mohit Chawla, Byung-Gon Chun
et al.
1708 sitasi
en
Computer Science
Intrinsic functional architecture in the anaesthetized monkey brain
Justin L. Vincent, G. Patel, M. Fox
et al.
1841 sitasi
en
Biology, Medicine
Microservices Architecture Enables DevOps: Migration to a Cloud-Native Architecture
Armin Balalaie, A. Heydarnoori, Pooyan Jamshidi
678 sitasi
en
Computer Science
Distortion Invariant Object Recognition in the Dynamic Link Architecture
M. Lades, J. Vorbrüggen, J. Buhmann
et al.
2117 sitasi
en
Computer Science
The software radio architecture
J. Mitola
2131 sitasi
en
Computer Science
Modeling and rendering architecture from photographs: a hybrid geometry- and image-based approach
P. Debevec, C. J. Taylor, Jitendra Malik
2244 sitasi
en
Computer Science
Principled design of the modern Web architecture
R. Fielding, R. Taylor
1815 sitasi
en
Computer Science
Architecture and algorithms for an IEEE 802.11-based multi-channel wireless mesh network
Ashish Raniwala, T. Chiueh
1738 sitasi
en
Computer Science
GATE: an Architecture for Development of Robust HLT applications
H. Cunningham, D. Maynard, Kalina Bontcheva
et al.
In this paper we present GATE, a framework and graphical development environment which enables users to develop and deploy language engineering components and resources in a robust fashion. The GATE architecture has enabled us not only to develop a number of successful applications for various language processing tasks (such as Information Extraction), but also to build and annotate corpora and carry out evaluations on the applications generated. The framework can be used to develop applications and resources in multiple languages, based on its thorough Unicode support.
1764 sitasi
en
Computer Science
Service Oriented Architecture Concepts Technology And Design
Christina Kluge
648 sitasi
en
Computer Science
A cloud-scale acceleration architecture
Adrian M. Caulfield, Eric S. Chung, Andrew Putnam
et al.
599 sitasi
en
Computer Science
The Origins Of Genome Architecture
E. Kaestner
575 sitasi
en
Computer Science
PRIME: A Novel Processing-in-Memory Architecture for Neural Network Computation in ReRAM-Based Main Memory
Ping Chi, Shuangchen Li, Cong Xu
et al.
549 sitasi
en
Computer Science
SpArch: Efficient Architecture for Sparse Matrix Multiplication
Zhekai Zhang, Hanrui Wang, Song Han
et al.
Generalized Sparse Matrix-Matrix Multiplication (SpGEMM) is a ubiquitous task in various engineering and scientific applications. However, inner product based SpGEMM introduces redundant input fetches for mismatched nonzero operands, while outer product based approach suffers from poor output locality due to numerous partial product matrices. Inefficiency in the reuse of either inputs or outputs data leads to extensive and expensive DRAM access. To address this problem, this paper proposes an efficient sparse matrix multiplication accelerator architecture, SpArch, which jointly optimizes the data locality for both input and output matrices. We first design a highly parallelized streaming-based merger to pipeline the multiply and merge stage of partial matrices so that partial matrices are merged on chip immediately after produced. We then propose a condensed matrix representation that reduces the number of partial matrices by three orders of magnitude and thus reduces DRAM access by 5.4x. We further develop a Huffman tree scheduler to improve the scalability of the merger for larger sparse matrices, which reduces the DRAM access by another 1.8x. We also resolve the increased input matrix read induced by the new representation using a row prefetcher with near-optimal buffer replacement policy, further reducing the DRAM access by 1.5x. Evaluated on 20 benchmarks, SpArch reduces the total DRAM access by 2.8x over previous state-of-the-art. On average, SpArch achieves 4x, 19x, 18x, 17x, 1285x speedup and 6x, 164x, 435x, 307x, 62x energy savings over OuterSpace, MKL, cuSPARSE, CUSP, and ARM Armadillo, respectively.
280 sitasi
en
Computer Science