Hasil untuk "Hungary"

A. Arneth, Jianguo Liu, J. Razzaque et al.

N. M. S. D. Groot, J. Deanfield

C. Stoate, A. Báldi, P. Beja et al.

Gábor Gyáni

Petra Tozser, Szabina Kádár, Edina Szabó et al.

Background and purpose: The effective transport of an active pharmaceutical ingredient across various membrane systems is critical for enhancing its bioavailability, especially in formulations involving solubilizing agents. This study aims to investigate the permeability differences of carvedilol (CAR) between lipophilic and size-exclusion membranes in the presence of hydroxypropyl-beta-cyclodextrin (HP-β-CD) using in vitro side-by-side diffusion cell assays. Experimental approach: Solubility and permeability assays confirmed that HP-β-CD significantly enhanced the solubility of CAR, while simultaneously decreasing its permeability, indicating an interplay between the two parameters. Key results: A mathematical model based on Fick’s first law of diffusion was developed to describe drug transport across the UWL, and generally through the UWL-membrane system, with a particular focus on the role of solubilizing agents. Conclusion: Results from both the UWL and membrane limited transport conditions demonstrated that the supersaturation ratio (SSR, defined as the ratio of the drug concentration present in solution to its thermodynamic solubility measured in exactly the same media) between donor and acceptor compartments is the real driving force of the transport, when the complexing agent and the drug- HP-β-CD complex does not penetrate the membrane or the permeation of the solubilizing additive through the membrane is relatively slow, so it does not affect the transport of the API substantially.

Károly Mészáros

M. Krupa, A. Balogh-Pécsi

Introduction Following the pandemic, we can find many new communication situations. Social relationships have changed a lot and are developing differently due to digital development, new lifestyles, and the effects of COVID-19. These components: social media, the transformation of interpersonal relationships, and the use of the platforms provided by the internet can lead to addictive disorders as risk factors. Objectives In this presentation, we review studies investigating the relationship between the new digital techniques, social connection, and communication development of adults with addictive disorders. We attempt to provide a summary of new theories and the areas currently being researched around the topic. Another aim of our research is to present the new drama-based therapy theories and methods in adults with addictive disorders. Methods To learn about recent international results, we conducted a literature search in 3 databases (PubMed, Medline, Web of Science) using the following keywords: drama therapy, addiction, emotion regulation, and adults, over the past 5 years. Empirical journal articles in English were used to prepare the literature review. Exclusion criteria were: the appearance publication before the year 2017 and the adolescent population. Results Changes in social behavior, emotion regulation, and addictive disorder were correlated. The studies examined social communications and loneliness in primarily cross-sectional studies design. The escapism from interpersonal relations and low self-esteem is the highest motivation to start regular videogame playing or using social media without control which becomes an addictive disorder. Conclusions Problematic social media use and changes in social connection threaten adults’ mental health. The diagnosis of emotion dysregulation, low self-esteem, and social disconnection is the detection of risk factors for addictive disorders. The new methods and tools of drama-based therapy are new prevention possibilities for these risk factors. In this way, it is a relevant issue in the field of education science. Disclosure of Interest None Declared

Kitti Dióssy

Hungarian Életünk és mindennapjaink egyre nagyobb részére van befolyása a mesterséges intelligenciának (MI). A munkaerőpiacon már jelenlévő Y és Z generáció motivációja és attitűdje hatással van hosszú távon a vállalatok versenyképességére. Az MI előnyeinek felismerése mellett annak alkalmazása és az esetleges hátrányaihoz való alkalmazkodás is jelentős feladat. Kutatásomban arra fókuszálok, hogy feltárjam a fiatal közgazdászok gondolkodásmódját az MI-vel kapcsolatban, anonim kérdőívek segítségével (147 magyar, 105 amerikai válaszadó). Ennek érdekében amerikai (fejlett gazdaság és élen járó az MI-ben) és magyar (fejlett gazdaság, de nem jelentős az MI területén) fiatal közgazdászokat kérdeztem meg. Kutatásomból kiderült, hogy a két nemzet közgazdászainak gondolkodása között nem fedezhető fel szignifikáns különbség. Egyértelműen pozitívan és bizakodóan állnak az MI-hez, valamint annak rövid és hosszú távú hatásához. Érdeklődésük középpontjában azonban még nem szerepel az MI és annak megértése, de izgalmasnak találják. Fontosnak tartják a fejleszthető puha és a nehéz készségeket, amelyekkel felülreprezentált helyzetbe kerülhetünk az MI-vel szemben. A fiatal közgazdászok szerint teljesen nem fog megszűnni az emberi munka, csak átalakul, emiatt sem érzik magukat veszélyeztetve a munkaerőpiacon. English An increasing part of our everyday life is affected by artificial intelligence (AI). The motivation and attitude of Generation Y and Z have a fundamental influence on the competitiveness of companies. Therefore, it is important to recognize, apply, and adapt to the potential drawbacks of AI. In my research, by using an anonymous questionnaire, the focus is laid on how young economists think of the subject. Thus, I interviewed American (a developed economy with a significant role in the field of AI) and Hungarian (a developed economy but not significant role in the field of AI) young economists. My research has shown that no significant difference can be identified between the thinking of economists in the two nations. Young people are unambiguously positive and optimistic about AI and its impact in the short and long term. However, AI and its understanding are not yet at the centre of their interest, though they find it fascinating. Soft- and hard skills that can be developed are considered important, with which they can be in an advantageous position against AI. According to young economists, human work will not completely disappear, it will only alter, and due to this, they do not feel threatened in the labour market.

Aigerim Assylkhanova, Gyula Nagy, Cezar Morar et al.

The topic of dark tourism emerged in the last three decades as tourism became more accessible. It allows forgotten history to be revised and transferred to the public. This study aims to restructure existing categorization regarding dark tourism and address the research gaps in dark tourism studies. We collected studies from international publication databases – Scopus, Web of Science, and Google Scholar. We pre-processed the following data for each study: topic, authors’ location of university affiliation, study area, year of publication, top-cited articles, top productive journals in publishing dark tourism studies, keywords, and internality/externality of the author from the study area. With the current paper, we analysed review articles published from 1996 to 2024 (first quarter), applying qualitative methods. Based on these, a new analytical framework was generated. Furthermore, the connections between research topics were also analysed. The results of the analysis highlight specific research gaps in the literature on dark tourism and address poorly visible research fields in international journals, e.g. terrorism-related research, social media links of dark tourism, postcolonial contexts, or commemoration of communist past and heritage. Consequently, certain countries and regions are underrepresented in the literature. This critical review offers new research areas but also gives some directions to the theoretical enrichment of the dark tourism concept.

Nezahat Turfan

The objective of this study was to investigate the effect of 10 mM silicon (Si) application on salt stress (50, 100, and 200 mM NaCl) tolerance in Hungarian vetch seedlings (Ege Beyazi-79) based on growth parameters (shoot length and fresh weight, organic dry matter, and moisture), bioactive compounds as chlorophyll, carotenoid, proline, protein, nitrate, and nutrient status. Silicon was applied to the seedlings from the leaves and NaCl from the salt soil, both of which were dissolved in Hoagland solution. The results revealed that the highest shoot length Si+100 mM NaCl was recorded and the highest fresh and dry weight was recorded with length Si+50 mM NaCl. The highest dry matter was obtained from Si and 200 mM NaCl. The highest chlorophyll, carotenoid, proline, protein, and nitrate were obtained from 100 mM NaCl+Si, while the lowest chlorophyll, carotenoid, and nitrate were obtained from 200 mm NaCl and the lowest proline and protein from 100 mM NaCl, respectively. The amount of K, Mg, and S were low in NaCl doses but high in Si and Si + NaCl doses, and P was higher in all groups compared to the control. The content of Na, Co, and Se were high in all groups except Cl 50 NaCl, while Mn, Zn, and Ni were higher in Si and Si + NaCl doses. Silicon content of samples was high at higher NaCl + Si doses. The results provided by this investigating indicated that silicate concentrations positively affected the parameters examined in Hungarian seedlings, and increased the tolerance of seedlings to salt stress.

Mahbod Ebrahimi, Firoozeh Akbari Asbagh, Fatemeh Davari Tanha et al.

Abstract Background: The common causes of infertility in women with endometriosis are folliculogenesis alternation, steroidogenesis and fertilization impairment, oocyte and embryo quality reduction, and implantation defect. Objective: To compare in vitro fertilization (IVF) cycle success rates of women with endometriosis who were treated with letrozole + gonadotropin (LA) vs. placebo + gonadotropin (PA). Materials and Methods: This double-blind, randomized clinical trial study was conducted with 94 infertile women with endometriosis (47 in the LA group and 47 in the PA group) who were candidates for IVF, from April-June 2021. For all participants, the long agonist protocol was applied. In both groups, gonadotropin-releasing hormone agonist was prescribed in the mid-luteal stage and from the third day of the cycle, and gonadotropin was started and its doses were regulated based on the patient's age, serum anti-Mullerian hormone and follicle-stimulating hormone. From the third day of the menstrual cycle, 5 mg of letrozole daily for 5 days was prescribed for the LA group, while the placebo was prescribed for the PA group on the identical days and duration. After embryo transfer, biochemical and clinical pregnancy were measured in the 2 groups. Results: The gonadotropin dosage (p < 0.01) and estradiol level (p = 0.02) on the human chorionic gonadotropin administration day were significantly lower in the LA group compared with in the PA group. Fetus transfer was done for 32 women. No significant differences were detected between the study groups regarding biochemical or clinical pregnancy (p = 0.72 for both). Conclusion: Letrozole as a co-treatment drug in the IVF cycle of women with endometriosis can significantly reduce the gonadotropin dosage and estradiol level with the same pregnancy rates.

Ladislav BRIMICH, Martin BEDNÁRIK, Jozef BÓDI et al.

Tidal strain time series recorded at the Vyhne Tidal Station are used to test thirteen different ocean tide loading models. Ten models have been calculated using SPOTL: EOT11a, HAMTIDE11a, OSU.TPXO72atlas, OSU.TPXO72, TPX070, DTU10, CSR4.0, FES2004, FES95.2.1, SCHW1 and three other models were chosen from the Free Ocean Tide Loading Provider (FOTLP) created by Scherneck and Bos: FES2012, FES2014b, GOT00.2. Hourly sampled strain data, corrected for temperature, were subjected to correction for ocean tide loading. The test of models was focused on the diurnal and semi-diurnal tidal harmonic constituents O1, P1, K1 and M2. A negligible difference between the individual global ocean tide loading models was only found mainly due to using different Earth models and Green functions. The amplitude factors for O1, P1, K1 and M2 derived from the measurements are 1.019, 1.226, 0.842 and 1.131, respectively. The average amplitude factors for these tidal components were obtained after ocean load correction using SPOTL routines: 1.121, 1.332, 0.916, 1.283, and in the case of the three models using FOTLP: 1.046, 1.486, 1.067, 1.317. The corrected amplitude factor became closer to the theoretical value only for K1.

Gergő Bendegúz Békési, Lilla Barancsuk, István Táczi et al.

Distribution system state estimation (DSSE) is a valuable step for DSOs toward tackling the challenges of transitioning to a more sustainable energy system and the evolution and proliferation of electric cars and power electronic devices. However, on the LV level, implementation has only taken place in a few pilot projects. In this paper, an LV DSSE method is presented and implemented in four real Hungarian LV supply areas, according to well-defined scenarios. Pseudo-measurement datasets are generated from AACs and SLPs, which have been used in different combinations on networks built with different accuracies in terms of load placement. The paper focuses on the critical aspects of finding accurate and coherent information on network topology with automated management of information systems, real LV network implementation for power flow calculation and managing portions of the network characterized by uncertain or inconsistent line lengths. A refining algorithm is implemented for the integrated network information system (INIS) models. The published method estimates node voltages with a relative error of less than 1% when using AACs, and a meter-placement method to reduce the maximum value of relative errors in future scenarios is also presented. It is shown that the observation of node voltages can be improved with the usage of AACs and SLPs, and with optimal meter placement.

Peter Csiba, László Németh

The Exeter point of a given triangle <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>A</mi><mi>B</mi><mi>C</mi></mrow></semantics></math></inline-formula> is the center of perspective of the tangential triangle and the circummedial triangle of the given triangle. The process of the Exeter point from the centroid serves as a base for defining the Exeter transformation with respect to the triangle <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>A</mi><mi>B</mi><mi>C</mi></mrow></semantics></math></inline-formula>, which maps all points of the plane. We show that a point, its image, the symmedian, and three exsymmedian points of the triangle are on the same conic. The Exeter transformation of a general line is a fourth-order curve passing through the exsymmedian points. We show that each image point can be the Exeter transformation of four different points. We aim to determine the invariant lines and points and some other properties of the transformation.

A.M. Sirunyan, A. Tumasyan, W. Adam et al.

The fiducial cross section for Y(1S) pair production in proton-proton collisions at a center-of-mass energy of 13 TeV in the region where both Y(1S) mesons have an absolute rapidity below 2.0 is measured to be 79±11(stat)±6(syst)±3(B)pb assuming the mesons are produced unpolarized. The last uncertainty corresponds to the uncertainty in the Y(1S) meson dimuon branching fraction. The measurement is performed in the final state with four muons using proton-proton collision data collected in 2016 by the CMS experiment at the LHC, corresponding to an integrated luminosity of 35.9fb−1. This process serves as a standard model reference in a search for narrow resonances decaying to Y(1S)μ+μ− in the same final state. Such a resonance could indicate the existence of a tetraquark that is a bound state of two b quarks and two b¯ antiquarks. The tetraquark search is performed for masses in the vicinity of four times the bottom quark mass, between 17.5 and 19.5 GeV, while a generic search for other resonances is performed for masses between 16.5 and 27 GeV. No significant excess of events compatible with a narrow resonance is observed in the data. Limits on the production cross section times branching fraction to four muons via an intermediate Y(1S) resonance are set as a function of the resonance mass.

Attila Farkas

A tanulmányban a magyar médiavilágot elemzem, három 2018 őszén megjelent politikai ügy kapcsán. Az Orbán–Simicska-konfliktust követően jelentős változások történtek a médiavilágban. Több új médiumot ekkor alapítottak meg a Fideszhez informálisan kapcsolódó üzletemberek, miközben más médiumok hirtelen gyorsasággal megszűntek. 2018 őszére a Simicska -birodalom lényegében felmorzsolódott. Ezzel ellentétben a Fideszhez informálisan kapcsolódó médiumok száma megugrott. Hipotézisem szerint az átalakulás következtében a magyar médiavilág továbbra is polarizált képet mutat. Az őszi ügyeket háromféle módszerrel vizsgáltam. Először a leíró statisztika elemzéséből kiderült, hogy a kormánypárti és nem kormánypárti médiumok napirendje jelentős eltérést mutat. Másodszor az egyes ügyekben megjelent tudósításokat szisztematikus tartalomelemzésnek vetettem alá, amelynek eredménye azt mutatja, hogy a két csoport tartalmi értelemben polarizált. Végül a médiumok egymás közötti interakciói révén hálózatokat hoztam létre. Ellentétben az első két módszerrel a hálózatelemzés nem erősítette meg a polarizáció tézisét.

Abdul Rahman Jazieh, Elena Pizzo, Laszlo Gulacsi et al.

Introduction: Cancer care is a major challenge to health care and for optimal outcomes, health systems need to align policy across many areas of public life. The recognition that even the wealthiest nations can fail optimum outcomes indicates a need for increased efficiency in cancer control programs. Fundamental to this is the efficient direction of resources––a process that can be optimized through economic measures. This article contains expert recommendations on how decision makers can implement pharmacoeconomic principles at national level in developing countries. Methods: A multidisciplinary panel of 10 experts was formed of oncologists, clinical pharmacists, health economists, and chronic disease control and public health experts from different countries and health-care sectors. The panel developed consensus recommendations for different stakeholders using a framework analysis method. Results: Recommendations were categorized as national level, hospital level, industry level, and public-community level to support decision makers in implementing pharmacoeconomic principles in a systematic way. The recommendations included having proper well-structured, data-driven processes with a specific role for each stakeholder. We proposed required structures and processes in such a way that they can be customized based on individual country plans. Conclusion: The expert panel recommendations will serve as a guide to relevant stakeholders at a national level. Adaptation of these recommendations to each setting is important to accommodate the situation and needs of each country.

Kata Csizér, G. Lukacs

Ugo Merlone, Daren R. Sandbank, Ferenc Szidarovszky

The purpose of this study is to present an analysis of the applicability of an analytical solution to the N−person social dilemma game. Such solution has been earlier developed for Pavlovian agents in a cellular automaton environment with linear payoff functions and also been verified using agent based simulation. However, no discussion has been offered for the applicability of this result in all Prisoners' Dilemma game scenarios or in other N−person social dilemma games such as Chicken or Stag Hunt. In this paper it is shown that the analytical solution works in all social games where the linear payoff functions are such that each agent's cooperating probability fluctuates around the analytical solution without cooperating or defecting with certainty. The social game regions where this determination holds are explored by varying payoff function parameters. It is found by both simulation and a special method that the analytical solution applies best in Chicken when the payoff parameter S is slightly negative and then the analytical solution slowly degrades as S becomes more negative. It turns out that the analytical solution is only a good estimate for Prisoners' Dilemma games and again becomes worse as S becomes more negative. A sensitivity analysis is performed to determine the impact of different initial cooperating probabilities, learning factors, and neighborhood size.

Zoran Simonović, Drago Cvijanović

The authors in this paper talk about the use of state-owned agricultural land under the new Agricultural Land Law. The law gives new solutions on the method of renting agricultural land in state ownership. These solutions also caused some of the remarks that relate primarily to the leasing of state-owned agricultural land. At the end of the work some of the experiences of the countries in the region in the first place of Hungary, Slovenia and Croatia regarding the leasing of state-owned agricultural land are given.