Hasil untuk "By period"

F. Crews, Jun He, C. Hodge

D. Duffie, Leandro Saita, Ke Wang

Z. J. Huang, A. Kirkwood, T. Pizzorusso et al.

J. Embretson, M. Zupancic, J. Ribas et al.

F. Biering-Sørensen

V. Bhatia, A. Vengsarkar

J. Horne, S. Baliunas

P. Rosenberg, David P. Check, W. Anderson

N. Jaworska, G. MacQueen

I. Lantto, Juuso Heikkinen, T. Flinkkilä et al.

Ladi Alik Kumar, K Sunand, Jitendra Debata et al.

Cancer is a disorder characterized by the abnormal growth of cells that increases uncontrollably over an extended period of time. Treating cancerous brain tumors remains among the most challenging tasks for researchers, as brain tumors are among the hardest cancers to treat. Additionally, the condition often worsens because of the delayed diagnosis caused by the absence of early symptoms. The use of conventional treatment methods, such as radiation, chemotherapy, and surgery, continues to be highly limited. The low solubility, narrow therapeutic index, and limited ability to traverse the blood–brain barrier of most anticancer drugs result in limited therapeutic efficacy. In an attempt to overcome these predicaments, formulation scientists have been considering nanotechnology-based therapeutic solutions, particularly given the increasing rates of brain cancers that have low survivability and the drawbacks of the existing treatment methods. Different nanoplatforms, such as polymeric nanoparticles, nanoliposomes, dendrimers, carbon nanotubes, and magnetic nanoparticles, have been explored. Research has indicated that such nanocarriers can increase the delivery of drugs to cells in brain tumors with a minimal off-target distribution, resulting in minimal adverse effects and optimal treatment. This review presents a summary of nanocarrier-based drug delivery systems that have been reported in recent years for the treatment of brain tumors. In addition, it explains the existing difficulties with the clinical implementation of nanodrug carriers and the perspectives of this field.

Ke-rui Zhang, Yi Yang, Ya-qin Li et al.

Abstract Background Anterior cervical corpectomy and fusion (ACCF) with Traditional Titanium Mesh Cages (TTMCs) can lead to complications such as cage subsidence, dysphagia, and implant-related issues. These complications suggest that the biomechanical stability of ACCF with TTMC may be insufficient. This study aims to evaluate whether a New Assembled Titanium Mesh Cage (NTMC) can improve the biomechanical performance after ACCF. Methods ACCF procedures using both TTMC and NTMC models were constructed and compared. The range of motion (ROM) of the surgical segments and stress peaks in various regions including the endplate, bone-screw interface, facet joints, and adjacent intervertebral discs were analyzed. Results The use of NTMC significantly reduced the postoperative ROM of the surgical segments by 80.7%-82.0% compared to ACCF with TTMC. Additionally, stress peaks at the endplate, bone-screw interface, and facet contact force (FCF) were higher in ACCF with TTMC compared to NTMC. TTMC also induced higher stress peaks in the C3/4 and C6/7 intervertebral discs (ranging from 0.2009–6.961 MPa and 0.2477–4.735 MPa, respectively), followed by the NTMC (ranging from 0.1322–3.820 MPa and 0.2227–4.104 MPa, respectively). Conclusions The utilization of NTMC, which includes enlarged spacers and emulates endplate geometries, effectively reduces the risks of cage subsidence and instrument-related complications in ACCF. Furthermore, ACCF with NTMC also decreases the risks of dysphagia, facet joint degeneration, and adjacent disc degeneration during the follow-up period by altering the fixing method while maintaining construct stability.

Rafeeq P. H. Ahmed, Onur Kanisicak, Perwez Alam

<b>Background</b>: The limited regenerative capacity of adult mammalian cardiomyocytes (CMs) poses a significant challenge for cardiac repair following myocardial infarction. In contrast to adult mammals, CMs in zebrafish and newt hearts retain a lifelong capacity for proliferation and cardiac regeneration. Likewise, neonatal mice exhibit a brief postnatal period, during which CMs retain the ability to proliferate and contribute to myocardial repair, which markedly diminishes within the first week of life. Emerging evidence indicates that adult CM cell cycle progression is critically influenced by oxidative stress. Adult mammalian CMs possess a high mitochondrial content to meet their substantial energy demands. However, this also leads to elevated reactive oxygen species (ROS) production, resulting in DNA damage and subsequent cell cycle arrest. We hypothesize that reducing the mitochondrial content in adult CMs will mitigate ROS production, thereby facilitating cell cycle progression. <b>Methods</b>: Adult CMs were isolated from adult rats (≥12 weeks old). To induce mitophagy, adult CMs were transfected with parkin-expressing plasmid and then treated with carbonyl cyanide 3-chlorophenylhydrazone (CCCP), a mitochondrial protonophore, for 7 days. Post-treatment assessments included the quantification of adult CM proliferation, mitochondrial content, and ROS levels. <b>Results</b>: CCCP-treated adult CMs exhibited a significant increase in proliferation markers, including EdU incorporation, KI67, phospho-histone H3, and Aurora B. Furthermore, CCCP treatment significantly reduced the mitochondrial content, as evidenced by decreased MitoTracker, TMRM, and Tom20 staining compared to controls. This was accompanied by electron microscopy analysis, which showed a significant reduction in the mitochondrial number in the adult CM after CCCP treatment. Moreover, our results also demonstrate a marked reduction in oxidative stress, demonstrated by lower 123-dihydro-rhodamine (123-DHR), CellROX signals, and VDAC. <b>Conclusions</b>: Our findings demonstrate that CCCP-mediated mitochondrial depletion reduces oxidative stress and promotes cell cycle re-entry in adult CM. This study provides direct experimental evidence and substantiates the role of elevated mitochondria and ROS levels in adult CM cell cycle exit.

Manuel Cuerno, Luis Guijarro, Rosa María Arnaldo Valdés et al.

Analyzing flight trajectory data sets poses challenges due to the intricate interconnections among various factors and the high dimensionality of the data. Topological Data Analysis (TDA) is a way of analyzing big data sets focusing on the topological features this data sets have as point clouds in some metric space. Techniques as the ones that TDA provides are suitable for dealing with high dimensionality and intricate interconnections. This paper introduces TDA and its tools and methods as a way to derive meaningful insights from ATM data. Our focus is on employing TDA to extract valuable information related to airports. Specifically, by utilizing persistence landscapes (a potent TDA tool) we generate footprints for each airport. These footprints, obtained by averaging over a specific time period, are based on the deviation of trajectories and delays. We apply this method to the set of Spanish' airports in the Summer Season of 2018. Remarkably, our results align with the established Spanish airport classification and raise intriguing questions for further exploration. This analysis serves as a proof of concept, showcasing the potential application of TDA in the ATM field. While previous works have outlined the general applicability of TDA in aviation, this paper marks the first comprehensive application of TDA to a substantial volume of ATM data. Finally, we present conclusions and guidelines to address future challenges in the ATM domain.

Anja Levis, Markus Huber, Déborah Mathis et al.

Ketone bodies (KBs) are energy-efficient substrates utilized by the heart depending on its metabolic demand and substrate availability. Levels of circulating KBs have been shown to be elevated in acute and chronic cardiovascular disease and are associated with severity of disease in patients with heart failure and functional outcome after myocardial infarction. To investigate whether this pattern similarly applies to patients undergoing cardiac surgery involving cardiopulmonary bypass (CPB), we analysed prospectively collected pre- and postoperative blood samples from 192 cardiac surgery patients and compared levels and perioperative changes in total KBs with Troponin T as a marker of myocardial cell injury. We explored the association of patient characteristics and comorbidities for each of the two biomarkers separately and comparatively. Median levels of KBs decreased significantly over the perioperative period and inversely correlated with changes observed for Troponin T. Associations of patient characteristics with ketone body perioperative course showed notable differences compared to Troponin T, possibly highlighting factors acting as a “driver” for the change in the respective biomarker. We found an inverse correlation between perioperative change in ketone body levels and changes in troponin, indicating a marked decrease in ketone body concentrations in patients exhibiting greater myocardial cell injury. Further investigations aimed at better understanding the role of KBs on perioperative changes are warranted.

Maria Juda

The history of publishing in Poland encompasses many issues associated with the emergence and dissemination of printed books. Of fundamental significance to the study of these issues are the records of the publishing output: while we have nearly complete, though still underexamined, records of this output for the period from the 15th to the 18th century, documented in bibliographies and catalogues, the situation is worse when it comes to the 19th and 20th centuries, until the outbreak of the Second World War. In this respect, what we need is not only a continuation, but a radical intensification of bibliographic work. This concerns works published in the Latin, Cyrillic, Hebrew and Greek scripts, as well as musical notation. Polish book scholars have devoted a lot of attention to the beginnings of printing in Poland. The historiography concerning various typographic workshops located in the former Polish-Lithuanian Commonwealth is rich; however, it still requires further extensive studies. Scholars have also been interested in phenomena influ- encing the content structure of printed publications, such as publishing privileges (in the former Polish-Lithuanian Commonwealth), censorship and restrictions imposed by the partitioning powers and later by Poland’s communist authorities, as a result of which Polish publications had to be printed abroad and an independent publishing movement emerged. The scholars’ research interests have also focused on books as products of printers and publishers and on the publication of written works. Scholars have examined both the various components of the book (title page, printer’s signet, stemmata, etc.) and its editorial composition as a whole. Their undoubted achievements in the studies of the history of publishing in Poland are significant, yet in many areas they need to be continued and expanded (one important task is the edition of sources for the study of the history of Polish publishing) and to investigate the phenomena that stem from developmental tendencies in modern book studies.

Z. Kozinszky, R. Dudas

ReJoyce Green, Anna E. Kirkland, Brittney D. Browning et al.

OBJECTIVES/GOALS: Adolescence represents a critical period for substance use initiation. Various factors may contribute to trying a sip or single puff of a substance, that could lead to more frequent use. However, less is known about how predictors from multiple domains converge to impact risk for general substance use initiation. METHODS/STUDY POPULATION: The Adolescent Brain Cognitive Development (ABCD) study is a multi-site longitudinal study following youth into early adulthood. The present study included 7,644 ABCD children who reported no lifetime substance use (including any experimentation) at baseline (ages 9–10). Our primary aim was to use a random forest classification model to predict binary substance use initiation, defined as trying any non-prescribed substance (e.g., alcohol, tobacco, cannabis, non-prescribed medications), during a 2-year follow-up after baseline. A total of 402 variables from the following categories were examined as predictors: demographics, peer substance use and availability, mental and physical health, culture and environment, biospecimens, neurocognitive functioning, and structural neuroimaging variables. RESULTS/ANTICIPATED RESULTS: Over a two-year follow-up, 751 (9.8%) of substance-naïve children reported trying a substance by age 11. The most common substance was alcohol, followed by cannabis and tobacco. Mean Decrease Accuracy (MDA) values were used to assess the relative importance of each predictor. The overall accuracy of the model in accurately predicting group membership (no substance use initiation vs. substance use initiation) was 57.66%. Of the top 5 predictors, the most important predictor was intent to use alcohol (MDA = .002). The following top predictors were structural neuroimaging variables: volume and surface area of right lateral occipital lobe (MDA = .0009 and .0008, respectively), surface area of right inferior temporal lobe (MDA = .0007), and surface area of left superior frontal lobe (MDA = .0007). DISCUSSION/SIGNIFICANCE: A combination of intent to use alcohol and structural neuroimaging indices were among the top predictors of substance use initiation. Understanding predictors of early substance use experimentation is important for identifying at-risk youth that may require targeted intervention approaches.

A. Sanders

Z. M. Leão, R. Kikuchi, B. Ferreira et al.

Os recifes de coral do Brasil formam estruturas significativamente diferentes dos modelos conhecidos: (i) possuem uma forma de crescimento de pinaculos coralineos em forma de cogumelo, chamados "chapeiroes", (ii) sao construidos por uma fauna coralinea com baixa diversidade e rica em especies endemicas, sendo grande parte destas formas reliquias do periodo Terciario e (iii) os recifes costeiros estao num ambiente dominado por sedimentos siliciclasticos. Os recifes estao distribuidos em quatro areas ao longo da costa brasileira: regioes norte, nordeste, leste, e nas ilhas oceânicas, mas especies isoladas de coral podem ser encontradas em aguas mais quentes nas enseadas da regiao sul. Diferentes tipos de banco recifais, recifes em franja, "chapeiroes" isolados e um atol estao presentes ao longo da costa brasileira. Corais, milleporideos e algas coralinas incrustantes constroem a estrutura rigida dos recifes. As areas em que ocorrem os maiores recifes de coral correspondem as regioes nas proximidades de centros urbanos que estao experimentando crescimento acelerado e rapido desenvolvimento do turismo. Os principais efeitos antropogenicos sobre o ecossistema recifal estao associados, essencialmente ao aumento da sedimentacao devido a remocao da mata atlântica e as descargas de efluentes industriais e urbanos. Os efeitos do aquecimento das aguas oceânicas que vem afetando varias areas de recifes, com alta intensidade de branqueamento de coral, nao causaram mortalidade em massa nos recifes brasileiros ate o evento de 2010.