Hasil untuk "Medicine"

Chuanjiang He, S. Zheng, Yan Luo et al.

Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules, such as lipids, proteins, and nucleic acids. Exosomes are derived from cells through exocytosis, are ingested by target cells, and can transfer biological signals between local or distant cells. Exosome secretion is a constitutive phenomenon that is involved in both physiological and pathological processes and determines both the exosomal surface molecules and the contents. Hence, we can exploit exosomes as biomarkers, vaccines and drug carriers and modify them rationally for therapeutic interventions. However, it is still a challenge to identify, isolate and quantify exosomes accurately, efficiently and selectively. Further studies on exosomes will explore their potential in translational medicine and provide new avenues for the creation of effective clinical diagnostics and therapeutic strategies; the use of exosomes in these applications can be called exosome theranostics. This review describes the fundamental processes of exosome formation and uptake. In addition, the physiological and pathological roles of exosomes in biology are also illustrated with a focus on how exosomes can be exploited or engineered as powerful tools in translational medicine.

I. König, Oliver Fuchs, G. Hansen et al.

The term “precision medicine” has become very popular over recent years, fuelled by scientific as well as political perspectives. Despite its popularity, its exact meaning, and how it is different from other popular terms such as “stratified medicine”, “targeted therapy” or “deep phenotyping” remains unclear. Commonly applied definitions focus on the stratification of patients, sometimes referred to as a novel taxonomy, and this is derived using large-scale data including clinical, lifestyle, genetic and further biomarker information, thus going beyond the classical “signs-and-symptoms” approach. While these aspects are relevant, this description leaves open a number of questions. For example, when does precision medicine begin? In which way does the stratification of patients translate into better healthcare? And can precision medicine be viewed as the end-point of a novel stratification of patients, as implied, or is it rather a greater whole? To clarify this, the aim of this paper is to provide a more comprehensive definition that focuses on precision medicine as a process. It will be shown that this proposed framework incorporates the derivation of novel taxonomies and their role in healthcare as part of the cycle, but also covers related terms. Precision medicine is defined as a process involving the derivation of novel taxonomies based on deep phenotyping http://ow.ly/WHna30dNNOZ

Thomas Dt, K. A. Erdman, Louise M. Burke

D. Wishart

Yuping Han, Xue-zhou Li, Yanbo Zhang et al.

In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules, they are not detected by immune surveillance and do not lead to graft rejection after transplantation. These properties make them competent biomedical candidates, especially in tissue engineering. We present a brief overview of MSC extraction methods and subsequent potential for differentiation, and a comprehensive overview of their preclinical and clinical applications in regenerative medicine, and discuss future challenges.

Haiyu Xu, Yan-Qiong Zhang, Zhenming Liu et al.

Abstract Traditional Chinese medicine (TCM) is not only an effective solution for primary health care, but also a great resource for drug innovation and discovery. To meet the increasing needs for TCM-related data resources, we developed ETCM, an Encyclopedia of Traditional Chinese Medicine. ETCM includes comprehensive and standardized information for the commonly used herbs and formulas of TCM, as well as their ingredients. The herb basic property and quality control standard, formula composition, ingredient drug-likeness, as well as many other information provided by ETCM can serve as a convenient resource for users to obtain thorough information about a herb or a formula. To facilitate functional and mechanistic studies of TCM, ETCM provides predicted target genes of TCM ingredients, herbs, and formulas, according to the chemical fingerprint similarity between TCM ingredients and known drugs. A systematic analysis function is also developed in ETCM, which allows users to explore the relationships or build networks among TCM herbs, formulas,ingredients, gene targets, and related pathways or diseases. ETCM is freely accessible at http://www.nrc.ac.cn:9090/ETCM/. We expect ETCM to develop into a major data warehouse for TCM and to promote TCM related researches and drug development in the future.

Y. Xiang, Zimu Guo, Pengfei Zhu et al.

Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer. In this review, we sought to summarize the molecular and cellular mechanisms underlying the chemopreventive and therapeutic activity of TCM, especially that of the Chinese herbal medicine‐derived phytochemicals curcumin, resveratrol, and berberine. Numerous genes have been reported to be involved when using TCM treatments and so we have selectively highlighted the role of a number of oncogene and tumor suppressor genes in TCM therapy. In addition, the impact of TCM treatment on DNA methylation, histone modification, and the regulation of noncoding RNAs is discussed. Furthermore, we have highlighted studies of TCM therapy that modulate the tumor microenvironment and eliminate cancer stem cells. The information compiled in this review will serve as a solid foundation to formulate hypotheses for future studies on TCM‐based cancer therapy.

Johanna Andrae, R. Gallini, C. Betsholtz

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in gastrulation and in the development of the cranial and cardiac neural crest, gonads, lung, intestine, skin, CNS, and skeleton. Similarly, roles for PDGFR-beta signaling have been established in blood vessel formation and early hematopoiesis. PDGF signaling is implicated in a range of diseases. Autocrine activation of PDGF signaling pathways is involved in certain gliomas, sarcomas, and leukemias. Paracrine PDGF signaling is commonly observed in epithelial cancers, where it triggers stromal recruitment and may be involved in epithelial-mesenchymal transition, thereby affecting tumor growth, angiogenesis, invasion, and metastasis. PDGFs drive pathological mesenchymal responses in vascular disorders such as atherosclerosis, restenosis, pulmonary hypertension, and retinal diseases, as well as in fibrotic diseases, including pulmonary fibrosis, liver cirrhosis, scleroderma, glomerulosclerosis, and cardiac fibrosis. We review basic aspects of the PDGF ligands and receptors, their developmental and pathological functions, principles of their pharmacological inhibition, and results using PDGF pathway-inhibitory or stimulatory drugs in preclinical and clinical contexts.

M. C. Catoira, L. Fusaro, Dalila Di Francesco et al.

Hydrogels from different materials can be used in biomedical field as an innovative approach in regenerative medicine. Depending on the origin source, hydrogels can be synthetized through chemical and physical methods. Hydrogel can be characterized through several physical parameters, such as size, elastic modulus, swelling and degradation rate. Lately, research is focused on hydrogels derived from biologic materials. These hydrogels can be derived from protein polymers, such as collage, elastin, and polysaccharide polymers like glycosaminoglycans or alginate among others. Introduction of decellularized tissues into hydrogels synthesis displays several advantages compared to natural or synthetic based hydrogels. Preservation of natural molecules such as growth factors, glycans, bioactive cryptic peptides and natural proteins can promote cell growth, function, differentiation, angiogenesis, anti-angiogenesis, antimicrobial effects, and chemotactic effects. Versatility of hydrogels make possible multiple applications and combinations with several molecules on order to obtain the adequate characteristic for each scope. In this context, a lot of molecules such as cross link agents, drugs, grow factors or cells can be used. This review focuses on the recent progress of hydrogels synthesis and applications in order to classify the most recent and relevant matters in biomedical field.

W. Haskell, I. Lee, R. Pate et al.

Y. Mintz, Ronit Brodie

Abstract The term Artificial Intelligence (AI) was coined by John McCarthy in 1956 during a conference held on this subject. However, the possibility of machines being able to simulate human behavior and actually think was raised earlier by Alan Turing who developed the Turing test in order to differentiate humans from machines. Since then, computational power has grown to the point of instant calculations and the ability evaluate new data, according to previously assessed data, in real time. Today, AI is integrated into our daily lives in many forms, such as personal assistants (Siri, Alexa, Google assistant etc.), automated mass transportation, aviation and computer gaming. More recently, AI has also begun to be incorporated into medicine to improve patient care by speeding up processes and achieving greater accuracy, opening the path to providing better healthcare overall. Radiological images, pathology slides, and patients’ electronic medical records (EMR) are being evaluated by machine learning, aiding in the process of diagnosis and treatment of patients and augmenting physicians’ capabilities. Herein we describe the current status of AI in medicine, the way it is used in the different disciplines and future trends.

Xiao-Hua Zhou, N. Obuchowski, D. McClish

C. Hennekens, J. Buring, S. Mayrent

A. Dragun, P. Schilling, T. Speer et al.

R. Langer, D. Tirrell

D. Fabricant, N. Farnsworth

In this review we describe and discuss several approaches to selecting higher plants as candidates for drug development with the greatest possibility of success. We emphasize the role of information derived from various systems of traditional medicine (ethnomedicine) and its utility for drug discovery purposes. We have identified 122 compounds of defined structure, obtained from only 94 species of plants, that are used globally as drugs and demonstrate that 80% of these have had an ethnomedical use identical or related to the current use of the active elements of the plant. We identify and discuss advantages and disadvantages of using plants as starting points for drug development, specifically those used in traditional medicine.

V. Destefano, Salaar Khan, Alonzo Tabada

Polylactic acid (PLA) is a versatile biopolymer. PLA is synthesized with ease from abundant renewable resources and is biodegradable. PLA has shown promise as a biomaterial in a plethora of healthcare applications such as tissue engineering or regenerative medicine, cardiovascular implants, dental niches, drug carriers, orthopedic interventions, cancer therapy, skin and tendon healing, and lastly medical tools / equipment. PLA has demonstrated instrumental importance as a three-dimensionally (3D) printable biopolymer, which has further been bolstered by its role during the Coronavirus Disease of 2019 (Covid-19) global pandemic. As an abundant filament, PLA has created desperately needed personal protective equipment (PPE) and ventilator modifications. As polymer chemistry continues to advance, so too will the applications and continued efficacy of PLA-based modalities.

Hua Luo, C. Vong, Hanbin Chen et al.

Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

P. Kokol, Helena Blažun Vošner, J. Završnik

BACKGROUND The application of bibliometrics in medicine enables one to analyse vast amounts of publications and their production patterns on macroscopic and microscopic levels. OBJECTIVES The aim of the study was to analyse the historical perspective of research literature production regarding application of bibliometrics in medicine. METHODS Publications related to application of bibliometrics in medicine from 1970 to 2018 were harvested from the Scopus bibliographic database. Reference Publication Year Spectroscopy was triangulated with the VOSViewer to identify historical roots and evolution of topics and clinical areas. RESULTS The search resulted in 6557 publications. The literature production trend was positive. Historical roots analysis identified 33 historical roots and 16 clinical areas where bibliometrics was applied. DISCUSSION The increase in productivity in application of bibliometrics in medicine might be attributed to increased use of quantitative metrics in research evaluation, publish or perish phenomenon and the increased use of evidence-based medicine. CONCLUSION The trend of the literature production was positive. Medicine was in the forefront of knowledge development in bibliometrics. reference publication year spectroscopy proved to be an accurate method which was able to identify most of the historical roots.

M. Beeson, Rahul G Bhat, J. Broder et al.

Laura Oh, MD , ‡ , ∗∗∗ Viral Patel, MD , ††† Loren Touma, DO , ‡‡‡ , §§§ Melissa A. Barton, M.D. , ∗ and Julia N. Keehbauch ∗, 2022 EM Model Review Task Force; Melissa A. Barton, M.D. ∗, and Julia N. Keehbauch ∗ , American Board of Emergency Medicine ∗ American Board of Emergency Medicine, East Lansing, Michigan, ∗American Board of Emergency Medicine, East Lansing, Michigan, † Summa Health, Akron, Ohio, ‡ American College of Emergency Physicians, Irving, Texas, §Medstar Washington Hospital Center, Georgetown University School of Medicine, Washington, District of Columbia, ||Society for Academic Emergency Medicine, Des Plaines, Illinois, ¶Duke University School of Medicine, Durham, North Carolina, #New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, ∗∗Accreditation Council for Graduate Medical Education, Chicago, Illinois, †† Emergency Medicine Residents’ Association, Irving, Texas, ‡‡ Hennepin County Medical Center, Minneapolis, Minnesota, §§American Academy of Emergency Medicine, Milwaukee, Wisconsin, ||||Sentara Norfolk General Hospital, Eastern Virginia Medical School, Norfolk, Virginia, ¶¶Council of Residency Directors in Emergency Medicine, Irving, Texas, ##Virginia Commonwealth University School of Medicine, Richmond, Virginia, ∗∗∗Emory University, Atlanta, Georgia, ††† UMass Chan Medical School, Worcester, Massachusetts, ‡‡‡ American Academy of Emergency Medicine Resident and Student Association, Milwaukee, Wisconsin, and §§§Jefferson Health Northeast Emergency Medicine, Philadelphia, Pennsylvania Reprint Address: Julia N. Keehbauch, American Board of Emergency Medicine, 3000 Coolidge Road, East Lansing, MI 48823