Hasil untuk "Homeopathy"

Fanglin Duan, Li-Xue Zhang, Muhammad Naveed et al.

Background The Tibetan medicine Ershiwuwei Guijiu Pill (EWGP), a classic Tibetan medicine prescription for the treatment of postmenopausal osteoporosis (PMOP) in the Qinghai–Tibet region, has attracted extensive attention due to its curative effects on gynecological diseases. However, its chemical ingredients and molecular mechanism are still unclear. Aim of the study To analyze the chemical constituents and effective serum chemical metabolites of EWGP and to explore the molecular mechanism of EWGP in treating PMOP through network analysis and experimental validation. Methods The ethanol extract of EWGP and its drug-containing serum were detected by liquid chromatography-mass spectrometry (LC–MS), and the chemical constituents were analyzed and identified. SwissTarget prediction was used to predict the corresponding potential target genes of the identified chemical components. Thereafter, a visualization network of the components and corresponding targets was constructed with Cytoscape software. Moreover, a specific disease database for animals was used to search and filter for osteoporosis (OP) targets, and a drug-disease target protein–protein interaction (PPI) network was constructed. Cytoscape 3.7.0 was used for visualization and cluster analysis, and R Studio was used for GO and KEGG enrichment analysis. AutoDock Tools were applied for molecular docking of the serum metabolites and specific target proteins. The potential mechanism of EWGP in preventing and treating PMOP was predicted by network pharmacology analysis and was experimentally studied and verified in vivo and in vitro . Results A total of 199 chemical substances were identified in the ethanol extract, and 11 were found in the serum. A total of 419 predicted targets and 128 target genes related to osteoporosis were screened. There were 16 common targets identified between the predicted targets and OP genes. Following the enrichment analysis, 16 KEGG signaling pathways and 63 GO biological process items were identified. The results of molecular docking showed that the main active compounds may be Protopine, Hetisine, Piperine, Visaminol, Boldine, and Trigonelline, and the specific targets may be CYP17A1, ESR2, MAPK14, and the vitamin D receptor (VDR). The results of cell and animal experiments showed that EWGP may improve bone metabolism via estrogen and calcium signaling pathways regulated by estrogens and calcium ions. Conclusions EWGP contains multiple herbal drugs and treats PMOP through multiple targets and signaling pathways. We preliminarily tested the chemical compounds of EWGP, especially in the serum, to determine the chemical metabolites of EWGP and revealed the molecular mechanism of EWGP in preventing and treating PMOP; moreover, we used computer-virtual molecular docking and experiments for preliminary verification of the core targets of network pharmacology analysis.

Hinpetch Daungsupawong, Viroj Wiwanitkit

Christian Grah MD, Irina Gatov MS, Shiao Li Oei PhD et al.

Background Sarcoidosis is a chronic, inflammatory, granulomatous, multisystem disease. At the Department of Pneumology of the hospital Gemeinschaftskrankenhaus Havelhöhe, the treatment of sarcoidosis is complemented with a multi-component mixture based on Viscum album L. , mistletoe extracts and Ferrum chloratum according to the Havelhöhe Sarcoidosis Protocol (HSP). The aim of this study was to evaluate the course of disease in sarcoidosis patients treated with HSP. Methods A retrospective cohort study was conducted by evaluating data on clinical progression, pulmonary function, fatigue, and adverse events in a real-world sarcoidosis cohort using descriptive statistics. Results 956 patients with sarcoidosis were treated with HSP between 2003 and 2022 and a total of 124 consenting patients (all stages, 35% multi-organ sarcoidosis, mean age 43 years, 69% female) were evaluated for clinical outcomes over a median follow-up of 23 months. The response rate for controlling pulmonary disease in this study cohort was 69%. At baseline, 81 patients (65%) had clinically relevant fatigue, which improved in 48 patients (59%) during HSP therapy. At the last follow-up visit, 103 (83%) did not need glucocorticosteroids or other medications and were receiving only HSP. Pharmacovigilant monitoring demonstrated a safe HSP therapeutic profile, with only 10 (8%) subjects experiencing grade 1 adverse events. Conclusion The feasibility and safety of complementary HSP therapy in the treatment of sarcoidosis have been demonstrated. These results should be used for the creation of hypotheses and further investigations.

Dionysios Tsintzas, George Vithoulkas

Background: Fractures of the proximal humerus are the third commonest fracture category in the elderly, comprising 4%–5% of all fractures affecting this population after low-energy trauma. Despite the fact that for stable and minimally displaced fractures recent guidelines recommend conservative treatment with immobilization of the upper limb, for unstable three- or four-part fractures, surgery with open reduction and internal fixation is the treatment of choice. Case Report: A case of a comminuted subcapital fracture of the humerus for which the initial conservative treatment with immobilization did not yield any radiological improvement during the first 3 weeks of treatment is presented. The patient is a 53-year-old woman who presented to the clinic after a fall. After 3 weeks of treatment with sling immobilization, there were no signs of callus formation. The subsequent treatment of the fracture with the help of classical homeopathy yielded very fast results, both in relation to the radiological picture of the fracture as well as in relation to the patient’s mobilization and function. The remedy chosen, according to the relevant repertorization, was Symphytum officinale, 1M initial potency, followed by 30 CH daily, for 3 weeks. Conclusions: Individualized classical homeopathy offers powerful assistance to the treating physician in the treatment of complex bone fractures of the human body that are difficult to treat with standard conservative methods. A series of experimental and clinical findings require the continuation of scientific research in this particular field.

Călin I. Hulea, Romeo T. Cristina

This review is about acupuncture defining elements as one of the safest methods that can be used also in veterinary therapy. In the past 20 years many veterinarians in Europe started to practice in their offices only in animal acupuncture. Acupuncture is a complex system of diagnosis, treatment and diseases prevention, based on body’s reflex action, due to the skin’s stimulation with needles. Treatment involves precise points (acupoints) influencing on skin’s surface in conjunction with certain internal organs and body functions. The aim is to strengthen and stimulate body’s own homeostatic mechanisms. Knowing the acupoints and at what level can act in good sense, results can lead to eg.: pain inhibition, increased cardiac output, cough reflex suppression, bone healing and others causing therapeutic effects in a great variety of animal diseases. The indications of acupuncture are as: primary therapy, adjunctive therapy support, or back-up therapy, as alternative one, when allopathic treatments are insufficient. Acupuncture can be used simultaneously with traditional therapies being compatible with non-traditional and holistic veterinary approaches (eg. homeopathy, chiropractic). Aplicability of acupuncture is presented from Asian and Western perspective, are presented acupuncture’s current theories (eg electrical, humoral, neurophysiological), directions, main indications, limitations vs. indications, advantages, disadvantages etc.

Abdullah Shaikh, Pranjali Guhathakurata, Partha Chakraborty et al.

Animal (dog, cat, and rodent) bite injuries in neonates are common in developing countries, especially when the mother leaves the baby at the side of the field in which she is working. A wide spectrum of rat-bite injuries is described in the literature. Disease following the bite of a rat has been known for many years and has been described as rat-bite fever. We report a case of a 17-day-old female neonate who presented with a severe rat-bite injury to the face, with consequent problems in management.

Chakariya Lin, Junya Pattraraachachai, Kammal K. Pawa et al.

Abstract Background The traditional Thai polyherbal formulation “Sao Thong Tai” (STT) contains four medicinal plants, namely Boesenbergia rotunda (L.) Mansf., Sida acuta Burm.f., Dactyloctenium aegyptium (L.) Willd., and Oryza sativa L. and it is considered an aphrodisiac and remedy for the effective treatment of decreased male libido in Thai traditional medicine and it may ameliorate erectile function. This pilot study was carried out to investigate the efficacy and safety of the polyherbal STT for mild to moderate erectile dysfunction in a small group of elderly men in Thailand in a double-blind, randomized controlled trial. Methods This research is a preliminary study. Fifty-four elderly males aged 50-69 years who had been diagnosed with mild to moderate ED were randomized into two groups of equal size: an STT group (n=27) and a placebo control group (n=27). The patients received either an 800 mg dose of STT extract or a lactose placebo twice a day for the eight-week treatment period, after which they were followed up for four weeks. Erectile function, sexual activity, self-reported attitudes toward sexual dysfunction, and partner-reported sexual dysfunction were investigated to confirm the efficacy of the polyherbal preparation. The International Index of Erectile Function (IIEF-5) and the Scale for Quality of Sexual Function (QSF) were used for primary outcome assessment. Results The IIEF-5 scores of the STT group were significantly increased compared with those of the placebo group (p<0.001). The severity of ED decreased from "mild" or "mild to moderate" to normal in 88.9% of the STT group vs. 0% of the placebo group, and the QSF score increased in the STT group (p<0.001). Sexual activity, self-reported views of sexual dysfunction, and partners’ views of sexual dysfunction showed significant improvement in the STT group, and there was no significant difference in psychosomatic quality of life. No adverse events were observed in either group. Conclusion Compared with a placebo, an oral aqueous extract of STT taken daily at a dose of 1,600 mg for eight weeks can effectively treat mild to moderate ED in elderly men. The preparation was also shown to be safe with respect to all parameters assessed. This finding demonstrates that STT can be used for the effective treatment of decreased male libido in Thai traditional medicine and may ameliorate ED. Trial registration TCTR/20180126001 033/2560. Registered 16 January 2018, Thai Clinical Trials Registry http://www.thaiclinicaltrials.org/

Emmanuelle Lüthi, Manuel Diezi, Nadia Danon et al.

Abstract Background The prevalence of complementary and alternative medicine (CAM) use and the modalities used by pediatric oncology patients vary widely across studies. In addition, the changes in the use of CAM over the course of treatment are understudied. Thus, this study aimed to explore (1) CAM use by pediatric oncology patients in relation to specific time intervals and (2) communication about CAM use between parents and oncologists. Methods This retrospective cross-sectional study was conducted among parents of children diagnosed with cancer at a Swiss pediatric hematology-oncology center by means of an online questionnaire. Questions were related to their child’s CAM use over different time intervals, sources of information about CAM use, and communication with the oncologists. Results Among 140 respondents, CAM was used by 54.3% of patients before diagnosis and 69.3% of patients after diagnosis. During each defined time interval, between 50 and 58.8% of the patients used at least one CAM. Homeopathy was the most popular CAM modality used during oncology treatment, during the first year after treatment, and between 1 and 5 years after the end of treatment. Osteopathy was the most popular CAM ≥5 years after the end of oncology treatment. Forty percent of respondents did not discuss CAM with their oncologist. Conclusions The high prevalence of CAM use and the different trends of use during the oncology care pathway and afterward underline the need to increase communication about CAM in the pediatric oncology setting, notably regarding benefits and risks of interaction with oncology treatment.

Dimitris Kalliantas, Meletia Kallianta, Konstantinos Kordatos et al.

The fact that many patients all over the world use homeopathic ultra high diluted succussed medicinal products, makes very interesting an explanation about the structure of them since until now only unconfirmed hypotheses are made. The present study focuses on the still unanswered questions about what happens with the chemical composition and the physicochemical properties of these products using Hypericum Perforatum L as a representative paradigm. All samples were prepared according to manufacturing procedures described mainly in S. Hahnemann's “Organon” and were examined by SEM, XRD, FTIR, DLS micro Mastersizer, DLS nano Zetasizer, UV-Vis and TEM. Measurements of electrical conductivity and pH were effectuated by the appropriate devices. During trituration of source material in alpha-lactose monohydrate some functional chemical groups present in source material disappeared and some others new ones came in view at the end of the process. A differentiation upon physicochemical properties between the source material and final triturating product was viewed, as well as micro-nanoparticles in colloidal form in all potencies derived trituration or extraction origin were present. The findings showed that the whole preparation process leads to the creation of micro nanoparticles something that for solid origin these products are created by trituration and for extract origin products these nanoparticles exist from the beginning.

Vasyl Popovych, Ivana Koshel, Yulia Haman et al.

Abstract Background COVID19 is a high burden for medicine and society as still no specific therapy exists. Most patients depend on symptomatic treatment, comparable to the symptomatic treatment in common respiratory infection e.g., Acetaminophen or Ibuprofen. Many cases of COVID19 show mild forms without need of hospitalization. In this randomized, open-label, multicentre, comparative trial we analysed the efficacy, safety, and tolerability of the herbal medicinal product BNO 1030 in mild cases of COVID-19 to offer an additional symptomatic relive. Methods The study was designed as an open label randomized, prospective, multicentred clinical trial. Out of 133 screened outpatients aged 18 to 70 with mild COVID-19 symptoms 120 patients were randomised (1:1) in 2 parallel groups. The main group received BNO 1030 in addition to symptomatic therapy (acetaminophen or ibuprofen). The control group got a symptomatic therapy only. The patients with laboratory proven COVID 19 were included for the final analyses: 47 – in the main group and 46 – in the control one. The evaluation criteria were dynamics of the symptoms: hyperthermia, myalgia, nasal congestion, nasal discharge, coughing, anosmia, rhinolalia, sore throat, duration of the use of antipyretics (clinically significant fever). These symptoms were assessed during the physician’s visit on a 4-point scale (0 — absent, 1 — insignificant, 2 — moderate, 3 — strong/pronounced) and self- assessed via ten-point visual analogue scale (VAS) daily in a patient’s diary. The primary endpoint was the decrease of the average score compared to the baseline defined as “therapeutic benefit” from the usage of BNO 1030. Results In the comparison of both groups over the treatment time, the main group (n = 47) showed a greater decrease in the severity of symptoms of fever, myalgia, nasal congestion, coughing, anosmia and rhinolalia, assessed by the doctor on a 4-point scale on V2 (4th day) and V3 (14th day) compared to those on V1, as well as a reduction of the antipyretics intake duration (p < 0.05). Significant differences of the main group were obtained, too, based on the results of symptoms self-assessment by the patient. The “therapeutic benefit from the use of BNO 1030 was 3 days. There is an increase in the number of recovered patients from 73.9–96.6 % according to the average symptom score, and a decrease in the number of hospitalized patients from 8.6–4.4 % in the main group., as compared to the data of the control group (p < 0.05). All patients tolerated the herbal medicine well, with no adverse drug reactions being reported. Conclusions BNO 1030 (Imupret®) offers a safe and effective treatment benefit in patients with mild forms of diagnosed COVID-19 aged 18–70 in addition to symptomatic treatment with acetaminophen or NSAIDs. COVID 19 positive patients treated with Imupret showed an earlier relive of symptoms when being treated with BNO 1030. Trial registration This trial was registered in ClinicalTrial.gov: NCT04797936 .

Ehigbai I. Oikeh, Faith E. Oviasogie, Ehimwenma S. Omoregie

Abstract Background Citrus sinensis is one of the most abundant citrus species consumed. Orange peels are a waste by-product of the fruit and may potentially contain useful phytonutrients with biological relevance. Methods Fresh and dry peels of sweet orange were subjected to Soxhlet extraction and then concentrated using a rotary evaporator. Total phenolic, flavonoid and tannin content were determined using standard methods. Antimicrobial activities against five (5) bacterial strains (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhimurium) and three (3) fungal strains (Candida albicans, Aspergillus niger and Penicillium notatum) was carried out by observing the zone of inhibition using disc diffusion method. Results The total phenolic, flavonoid and tannin content was higher in the fresh peel extract compared to the dry peel extract. Antimicrobial activities revealed that the fresh peel extract had better antibacterial activities against all bacterial strains and one fungal strain studied compared to the dry peel extract. Growth of Aspergillus niger and Penicillium notatum were however better inhibited by the dry peel extract than the fresh peel extract. Conclusion This study investigated the phenolic content and antimicrobial activities of fresh and dry Citrus sinensis peel extracts. The results from the study conclude that the fresh Citrus sinensis peel extract contains more phenolics and possesses better antimicrobial activities against the studied microbial strains compared to the dry peel extract. The findings in this study suggest that drying plant parts before extraction for phytonutrients may lead to loss of active components.

Mifetika Lukitasari BSN, MSc, Dwi Adi Nugroho MD, MSc, Nashi Widodo PhD

New paradigm in cancer pathogenesis revealed that microenvironmental conditions significantly contribute to cancer. Hence, Warburg stated that cancer is a metabolic disease. Chlorogenic acid (CGA) is a polyphenol that is found abundantly in coffee. This compound has proven ability in ameliorating some metabolic diseases through various pathways. This article will elaborate the potency of CGA as a chemosensitizer in suppressing tumor growth through a metabolic pathway. AMPK pathway is the main cell metabolic pathway that is activated by CGA in some studies. Moreover, CGA inhibited EGFR/PI3K/mTOR, HIF, VEGF pathways and MAPK/ERK pathway that may suppress tumor cell growth. Furthermore, CGA induced intracellular DNA damage and topoisomerase I- and II-DNA complexes formation that plays a key role in apoptosis. Conclusively, based on the ability of CGA in activate and inhibit some important pathways in cancer metabolism, it may act as a chemosensitizing agent leading to cancer growth suppression.

Alshymaa A.-R. Gomaa, Mamdouh N. Samy, Samar Y. Desoukey et al.

Abstract Background Many plants of genus Abutilon are traditionally used for treatment of inflammation, bronchitis, piles, gonorrhea, diabetes and fever. Abutilon hirtum is traditionally used to ease the pain of kidney gravel, to treat diarrhoea, cough and toothache, to cure bladder inflammations, wounds and ulcers and as an antipyretic, demulcent, diuretic and mouth wash. The aim of the study is to evaluate the anti-inflammatory, analgesic, antipyretic and antidiabetic effects of the total ethanolic extract and different fractions of Abutilon hirtum (Lam.) Sweet leaves. Methods Air dried powder of A. hirtum leaves were extracted using 95% ethanol and fractionated successively with petroleum ether, chloroform and finally with ethyl acetate. The extracts were concentrated to afford petroleum ether, chloroform, ethyl acetate and aqueous fractions and were investigated for their anti-inflammatory, analgesic, antipyretic and antidiabetic activities using carrageenan-induced paw edema, hot plate, yeast -induced pyrexia and streptozotocin-induced hyperglycemia methods, respectively. Results The total ethanolic extract and the chloroform fraction exhibited the highest anti-inflammatory activity with a percentage of inhibition 50.8% which is close to that of indomethacin (52.4%). The aqueous extract exhibited the maximum analgesic activity (216.6%) with a rapid onset and a longer duration followed by petroleum ether and chloroform fractions and total extract (189.8, 186.9 and 183.0%, respectively), which is almost similar to that of acetylsalicylic acid (186.4%). The total ethanolic extract showed higher activity compared to the used standard acetylsalicylic acid with a rapid onset (30 min) and a longer duration exhibiting the maximum activity. The crude polysaccharides fraction showed a significant lowering in blood glucose level (81.08%). The total extract and petroleum ether, chloroform, ethyl acetate and aqueous fractions exhibited a significant anti-diabetic activity after 5 h (47.49, 47.79, 50.04, 49.80 and 46.36%, respectively) compared with that of metformin (55.45%). Conclusion Abutilon hirtum extract and fractions exhibited anti-inflammatory analgesic, antipyretic and antipyretic activities which may be attributed by the presence of active phytoconstituents.

Abhirup Basu, A. Suresh, S. Kane et al.

Mehdi Salehi MD, Mohammad Setayesh MD, Roshanak Mokaberinejad MD, PhD

Infertility is a medical and psychosocial problem with a high prevalence. There are different treatments for this problem in Iranian traditional medicine. A 28-year-old woman presented with the complaints of 4 emergency operations of the left ovarian cyst during 4 years and infertility. Diagnostic laparoscopy showed an ovarian cyst, adhesion, and endometriosis. Hysteroscopy was unremarkable. After 2 months of letrozole administration, the ovarian cyst ruptured again. Considering the failure of conventional treatments, Iranian traditional medicine products were administered to the patient. After 3 months, the patient conceived and delivered a healthy boy through normal vaginal delivery. These compounds may help with pregnancy as a uterine tonic, vitalizer, and aphrodisiac with brain and cardiac tonic properties.

Young-Chang Arai MD, Shuichi Aono PhD, Izumi Makino PhD et al.

Blood stasis is a very important pathophysiological concept not only in Kampo but also in traditional Chinese medicine. Blood stasis indicates severe disease. Fuku shin (the abdominal exam) and Zetsu shin (the tongue exam) are the most important approaches of the 4 diagnostic procedures in Kampo . Tenderness of the lower abdominal region ( Sho fuku koh man ) and distended sublingual veins have been mentioned as typical signs of blood stasis in Kampo or traditional Chinese medicine. The aim of the present study was to determine the association between Sho fuku koh man and distended sublingual veins. An appearance of sublingual veins and a level of Sho fuku koh man showed a significant and positive correlation ( r s = .5248; n = 279; P < .0001). In conclusion, the relationship between the appearance of sublingual veins and the level of Sho fuku koh man showed a significant and positive correlation.

Yu-Hsin Lin PhD, Tzong-Shiun Li MD, PhD

Far-infrared (FIR) radiation therapy has been used for soothing effect in wound treatment. Studies have shown that FIR could enhance wound healing processes in rat models. Although these research results supported that FIR may play an important for wound healing, it had no consensus in clinical practices. It is suggested that more persuasive systemic clinical researches are needed to explore the effectiveness of FIR therapy for wound healing.

S. Jyoti, S. Tandon

Sandeep Murgi Babukumar, Vishwanth Kumbar, Gouri Kaveriappa et al.

An elderly male came with h/o loss of appetite and weight loss since 3 months. On evaluation, prothrombin time (PT), activated partial thromboplastin time (aPTT), and international normalized ratio (INR) values were high. Hepatitis B surface antigen (HbSAg) screening was reactive and serum alfa-fetoprotein (AFP) was raised. Ultrasound examination revealed a hepatic mass with inferior vena caval extension and direct invasion of the right atrium. Computed tomography (CT) scan of the lower thorax and abdomen was performed, which confirmed the ultrasound diagnosis. The patient had a brief stay in the hospital and got discharged against medical advice; he was not available for follow-up. Hepatocellular carcinomas (HCCs) commonly metastasizes to the lung, bone, brain, and adrenal glands. About 70% of the patients with HCCs have hepatic and portal vein invasions but encroachment into the right atrium is very rare. The most common symptoms of cardiac metastasis include asymptomatic cases, bilateral lower leg edema, and exertional dyspnea in that order. Typical complications of intravascular tumor extension lead to secondary Budd-Chiari syndrome, right heart insufficiency, or massive pulmonary embolism. The prognosis of HCC with atrial invasion is poor, with median survival ranging from 1 month to 4 months. HCC in these cases may be more aggressive, with a shorter doubling time. The risk for cardiopulmonary collapse is higher, with heart failure or sudden death. Surgical interventions as well as nonsurgical approaches have been used in the treatment of patients with symptomatic inferior vena cava (IVC)/right atrial tumor thrombi. There are few reports of en bloc hepatectomy and resection of the right atrial thrombus under cardiopulmonary bypass. Routine screening in patients with HCC, such as including chest imaging as part of surveillance computed tomographic scans, may facilitate earlier detection and treatment.

Subrata Chakrabarti