Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
Abstrak
New paradigm in cancer pathogenesis revealed that microenvironmental conditions significantly contribute to cancer. Hence, Warburg stated that cancer is a metabolic disease. Chlorogenic acid (CGA) is a polyphenol that is found abundantly in coffee. This compound has proven ability in ameliorating some metabolic diseases through various pathways. This article will elaborate the potency of CGA as a chemosensitizer in suppressing tumor growth through a metabolic pathway. AMPK pathway is the main cell metabolic pathway that is activated by CGA in some studies. Moreover, CGA inhibited EGFR/PI3K/mTOR, HIF, VEGF pathways and MAPK/ERK pathway that may suppress tumor cell growth. Furthermore, CGA induced intracellular DNA damage and topoisomerase I- and II-DNA complexes formation that plays a key role in apoptosis. Conclusively, based on the ability of CGA in activate and inhibit some important pathways in cancer metabolism, it may act as a chemosensitizing agent leading to cancer growth suppression.
Topik & Kata Kunci
Penulis (3)
Mifetika Lukitasari BSN, MSc
Dwi Adi Nugroho MD, MSc
Nashi Widodo PhD
Akses Cepat
- Tahun Terbit
- 2018
- Sumber Database
- DOAJ
- DOI
- 10.1177/2515690X18789628
- Akses
- Open Access ✓