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DOAJ Open Access 2025
China precision nutrition biobank: protocol of a prospective cohort study on diet, human phenotype/genotype, and early-onset chronic diseases

Jingjing He, Miao Xie, Jia Liu et al.

Abstract Background The global burden of early-onset chronic diseases, especially early-onset type 2 diabetes, is increasing, particularly in China. Diet is a key factor and emerging evidence highlights substantial inter-individual variability in metabolic responses to diets, highlighting the need for precision nutrition. Methods The China Precision Nutrition Biobank (CPNB) is a prospective, longitudinal, cohort study designed to investigate diet-phenotype/genotype interactions and develop precision dietary strategies for early prevention and intervention of chronic diseases, with a particular focus on early-onset diseases. CPNB consists of three phases: the alpha (pilot cohort), beta (transition cohort), and gamma (main cohort) phases. Approximately 200, 1450, and 20,000 adults aged 18–40 years from urban and rural areas in China including Beijing, one city each in Heilongjiang, Shandong, Zhejiang, Guangxi, and Hainan provinces, and one or more villages each in Henan, Gansu, Sichuan, Zhejiang, and Hunan provinces will be recruited during the alpha, beta, and gamma phases, respectively, between 2025 and 2035. Sociodemographic information, medical records, read-time weighed food records and corresponding continuous glucose monitor (CGM) readings, objective physical activity, food challenges, genes, gut and oral microbiota, metabolites from blood, stool, urine, saliva, and hair, and questionnaires will be collected at baseline survey. The follow-up survey will be conducted every five years to repeat these assessments until participants’ death (the follow-up period may extend up to 80 years). Outcomes of interest are common early- and late-onset chronic diseases and their preclinical stages. Discussion The CPNB data can be used to develop prediction models for personalized metabolic responses and risks of early-onset chronic diseases among Chinese people. It will also provide new evidence on interactions of diet with human phenotypes/genotypes during preclinical stage, onset, and progression of early-onset diseases. CPNB aims to inform the development of precision nutrition strategies aligned with the principles of predictive, personalized, preventive, and participatory medicine in the Chinese population. Trial registration CPNB was registered at Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ ) on June 3rd, 2025, under the registration number ChiCTR2500103621.

Nutrition. Foods and food supply, Nutritional diseases. Deficiency diseases
DOAJ Open Access 2025
Pest categorisation of Lepidosaphes pistaciae

EFSA Panel on Plant Health (PLH), Antonio Vicent Civera, Paula Baptista et al.

Abstract Following the commodity risk assessment of Prunus persica and P. dulcis plants for planting from Türkiye, in which Lepidosaphes pistaciae (Hemiptera: Diaspididae), the pistachio oyster scale or yellow pistachio scale, was identified as a pest of possible concern, the EFSA Panel on Plant Health performed a pest categorisation for the territory of the European Union (EU). L. pistaciae is reported as a polyphagous pest which, however, mainly affects plants of the genus Pistacia. Originating from Asia, it is widely distributed in pistachio producing countries of Central, South and West Asia. Within the EU, the pest has been reported from Cyprus and Greece. However, its precise distribution within Cyprus and Greece is unknown. It completes two generations per year and overwinters as a fully developed adult female. The eggs are hidden under the female's body and hatch around April. First‐instar nymphs, crawlers, move on host plants for a short period of time before becoming permanently settled and initiating feeding, mainly on leaves but also on branches and fruits. Young females appear in early June and mature ones in late June. Plants for planting and fruits provide potential pathways for entry into the EU. Climate suitability suggests that it could further establish in large parts of the EU. In Iran, L. pistaciae is considered a devastating pest for cultivated pistachio. L. pistaciae was detected in Greece over 30 years ago with small population densities and without any records of damage. It was also found in Cyprus in 1967 and nowadays is not considered a major pest. Its ability to cause an impact in the EU is uncertain considering the lack of evidence on impact in Cyprus and Greece. Phytosanitary measures are available to reduce the likelihood of entry. While the fulfilment of the criterion on having an economic or environmental impact in the EU is associated with a key uncertainty, all the other criteria assessed by EFSA for consideration as a potential quarantine pest are met.

Nutrition. Foods and food supply, Chemical technology
DOAJ Open Access 2025
The impact of flash continuous glucose monitoring and nutrition coaching on dietary self-efficacy and weight management in university students in Korea: a pre-post intervention study

Soojin Park

Objectives This study aimed to evaluate the impact of a 4-week multicomponent intervention combining flash continuous glucose monitoring (flash-CGM), group nutrition education, and personalized nutrition coaching on dietary self-efficacy (DSE) and weight management in healthy university students. Methods A total of 27 university students participated in a pre-post intervention study. The intervention included a single 4-hour group-based nutrition education session, flash-CGM usage (FreeStyle Libre; Abbott Diabetes Care), and weekly one-on-one nutrition coaching. Participants wore the CGM device for 28 days (replaced after 14 days), and were guided in using the FoodLens app (DoingLab) for dietary tracking and a mobile app-linked digital scale for weight monitoring. Outcomes measured before and after the intervention included DSE, body mass index (BMI), nutrition quotient (NQ) and glycemic indicators. Statistical analyses included Wilcoxon signed-rank and Mann-Whitney U-tests with significance set at P < 0.05. Results There was a significant increase in DSE (P < 0.05), particularly in managing eating behavior under stress and fatigue. A modest but significant decrease in BMI was observed in the overall group (P < 0.05), though changes were not significant in the BMI ≥ 23 kg/m2 subgroup. Glycemic indicators showed minimal changes. The overall NQ score improved slightly, with significant increases in fruit intake (P < 0.01) and nutrition label checks (P < 0.05). High satisfaction levels (4.52 ± 0.65 on a 5‑point scale) were reported for device usability and coaching services. Conclusion The multicomponent intervention improved DSE, NQ scores, and supported modest weight reduction among university students. The combined effect of CGM, nutrition education, and coaching appears promising; however, further studies are needed to isolate the effects of each component and evaluate long-term outcomes. Trial Registration: Clinical Research Information Service Identifier: KCT0010255. Trial Registration Clinical Research Information Service Identifier: KCT0010255.

Nutrition. Foods and food supply, Nutritional diseases. Deficiency diseases
DOAJ Open Access 2025
Development of djenkol peel extract-loaded liposome as functional food ingredients: Physicochemical characteristic, antioxidant activities, and cytotoxicity

Lalita Chotphruethipong, Sirima Sinthusamran, Soottawat Benjakul et al.

Djenkol peel is an agricultural by-product containing valuable bioactive compounds. The direct use of its extract faces challenges related to stability and sensory acceptance. This study aimed to investigate the effect of djenkol peel extract (DPE) on the encapsulation efficiency (EE) using liposomes. The physicochemical properties, antioxidant activities, and cytotoxicity of the obtained liposomes were evaluated. DPE (0, 0.25, 0.50, 0.75, and 1.00 %, w/v) was encapsulated using phospholipid/cholesterol as the wall material. The highest EE (66.69 %) was observed in the liposomes loaded with 0.25 % (w/v) DPE (LE-0.25DPE) (P < 0.05). All DPE-loaded liposomes displayed nanometer-scale particle sizes (78.94–135.60 nm) and negative zeta potentials (−52.60 to −57.50 mV). Encapsulation of DPE in liposomes can mask its undesirable color. Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and differential scanning calorimetry (DSC) revealed changes in the physicochemical and thermal properties of LE-0.25DPE. Additionally, LE-0.25DPE showed increased DPPH radical-scavenging activity (DPPH-RSA) and ferric reducing antioxidant power (FRAP) in a dose-dependent manner (250–2000 μg/mL). In vitro Caco-2 cell viability test, LE-0.25DPE at 0.1–1 μg/mL exhibited no cytotoxicity compared to the control (P < 0.05). Thus, DPE-loaded liposomes demonstrate potential as a functional food ingredient with high bioactivity.

Agriculture (General), Nutrition. Foods and food supply
DOAJ Open Access 2024
Using mid-upper arm circumference z-score measurement to support youth malnutrition screening as part of a global sports and wellness program and improve access to nutrition care

Amy R. Sharn, Raissa Sorgho, Suela Sulo et al.

ObjectiveHistorically, mid-upper arm circumference (MUAC) has been instrumental to identifying malnutrition in children under 5 years living in resource restricted settings. Less attention is directed to at-risk, school-aged youth. Updated and validated pediatric age- and gender-specific MUAC growth curves expand malnutrition screening opportunities (2 months-18 years) including overweight/obesity. An innovative partnership was created to integrate MUAC z-score measurement trainings and screenings in the Real Madrid Foundation's (RMF) Social Sports Schools (S3) program, which provide sports and wellness programming to under-resourced communities. This work aimed to investigate the feasibility of leveraging non-healthcare professionals (non-HCPs) to identify malnutrition risk as part of RMF S3.MethodsThis global, two-part program on malnutrition risk identification included training adult facilitators and screening children attending RMF S3. RMF facilitators were trained with didactic lectures on malnutrition, and practical hands-on learning of proper MUAC z-score tape measurement. Aggregate data on facilitators and the number of times to correctly administer the MUAC z-tape were recorded. Aggregate data on child malnutrition risk screenings were collected.ResultsNine countries participated representing Europe, Pacific Asia, Africa, Latin America, and North America. In total, 143 RMF facilitators were trained, and 318 children were screened across 11 sites. More than half of facilitators were male (56%, n = 80), and majority were coaches (41.3%, n = 59), followed by staff (25.2%, n = 36), and volunteers (16.1%, n = 23). Facilitator attempts ranged from 1 to 4 times for proper MUAC z-score administration with mean 2.12 (± 0.86). There were no significant differences for attempts among RMF facilitator types (p = 0.10). Sixteen percent (n = 51) of children screened were recommended for HCP referral, with concentrations in Pacific Asia (68%, n = 35), Latin America (24%, n = 12), and Africa (8%, n = 4).ConclusionsFindings from our sample demonstrate that integration of MUAC z-score based malnutrition risk screening within community sports and wellness programming among non-HCPs is feasible, and that some regions with less frequent access to routine health care may experience greater benefit from these programs. Equipping non-HCP facilitators in community sports and wellness programs with training on malnutrition screening provides a means to meet under-resourced families where they live to begin conversations around malnutrition risk with the hope of establishing additional pathways to care.

Nutrition. Foods and food supply
DOAJ Open Access 2024
Sensitive and rapid detection of bisphenol A using signal amplification nanoparticles loaded with anti-bisphenol A monoclonal antibody

Sumei Ling, Aidi Xu, Menghan Sun et al.

Bisphenol A has been reported to be a ubiquitous contaminant, and exposure to this compound can lead to adverse effects in human health. In the study, monoclonal antibody against BPA (anti-BPA mAb) with high affinity (3.74 × 109 L/mol) secreted by cell line 2E3 was successfully screened. Inspired by the signal amplification of nanoparticles, anti-BPA mAbs were labeled with nano-materials including colloidal gold (AuNP) and gold nanoflowers (AuNF) for preparation of immunoprobes and AuNP-/AuNF-based test strips. The developed AuNP- and AuNF-based test strips achieved the rapid and sensitive detection of BPA within 10 min, with the limit of detection (LOD) of 25 μg/mL and 3.125 μg/mL, respectively. The detection result in BPA spiked samples measured by the proposed methods was consistent with that detected by LC-MS method. The preparation process of as-prepared test strip is time-saving and considered as ideal candidates method for rapid screening BPA in real samples.

Nutrition. Foods and food supply, Food processing and manufacture
CrossRef Open Access 2023
Micro, Macro and Home Economics (A comparative analysis)

Mohammad Asad Bin Yousuf

General people often misunderstood the concept of economics and usually relate economics with money. Economics is not only concern about money or financial condition, rather it emphasize on the choice human makes or decision human takes. Economics is an inevitable part of human life mainly concern about making choices. Economics is the submission of all kinds of choices human makes in every day’s life and living. Majority of the daily, weekly, monthly, yearly living and life choices a human made have nothing to do with money but still they are concerning issues of economics. Economics is broadly divided into two categories, Microeconomics and Macroeconomics. Beside these two broad classes, there is another section of economics namely the Home Economics. This article gives a first-hand knowledge and understanding to mass people about the three different sections of economics so that people can make better choices in their life and living.

DOAJ Open Access 2023
Agricultural transformations in the arid, drought-prone region of Kachchh: People-led, market-oriented growth under adverse climatic conditions

Praharsh M. Patel

Water availability, soil suitability, and favorable climate are the primary requirements for stable agricultural production. However, due to erratic rainfall and scarcity of irrigation water, arid regions suffer from volatile conditions for agriculture. For example, Kachchh, the westernmost district of India in Gujarat, has an arid climate, with more than half of the area is either partially inundated by seawater or classified as desert. The remaining landmass experiences low (15 Year Annual Normal = 450 mm) and erratic (45 percent Coefficient of Variation) rainfall rendering agriculture in the region, not a promising occupation. But in recent years, access to irrigation through groundwater, the advent of micro-irrigation practices, and increasing market-oriented crops supported by regular rainfall have led to significant agricultural improvement for the region. As a result, there has been a significant shift toward less water-intensive and high-value horticulture crops. This paper ponders upon drivers of agricultural transformations in Kachchh combining the quantitative observation data and qualitative field insights. It also highlights hurdles to the smooth adoption of drought-resilient and market-oriented agriculture during the adverse climatic conditions.

Nutrition. Foods and food supply, Food processing and manufacture
DOAJ Open Access 2022
Consumer Perceptions on Processed Fruit Peels as Dietary Additives

Eridiong O. Onyenweaku, Hema Kesa , Levi U. Akah

Plant foods reduces the risks of both chronic and infectious diseases in humans. Fruit peel is still frowned upon as part of a normal healthy diet. This study aims at ascertaining consumer fruit peel preferences, perceptions and acceptability to enable the production of processed fruit peel sprinkles that will be accepted by consumers as food additives. An online questionnaire was used for this cross-sectional survey and was circulated in South African provinces. Information gathered include sociodemographic data, overall perception/consumer choices of processed fruit peels and factors that influence choices of dietary products. Chi square test was used to check association between some sociodemographic variables and consumer preferences. ‘Sweetened’ was the most suggested flavour for the proposed product, followed by ‘Natural’ i.e. no flavor additives and ‘Chilli’ third most suggested. the participants were interested in processing of fruit peels for consumption. The responses showed general acceptability of the proposed fruit sprinkles, with citrus fruit peels (oranges, grapes and lemons) as most preferred. No association was observed between gender/income and certain consumer preferences for fruit peels. Educational level affected the priority factors of the respondents. Processing and consumption of fruit peels should be encouraged in order to strengthen the immune system especially during this pandemic. Increased consumption of fruit peels will also contribute to a reduction of food waste.

Hospitality industry. Hotels, clubs, restaurants, etc. Food service, Business
DOAJ Open Access 2022
Association between serum 25-hydroxyvitamin-D and Triglycerides-Glucose index among Indian adolescents

Akif Mustafa, Chander Shekhar

Abstract Background Vitamin D deficiency has been found to associated with numerous skeletal and non-skeletal diseases including Diabetes Mellitus. Insulin Resistance (IR) is considered as one of the primary reasons of Type-2 Diabetes Mellitus (T2DM). The association between vitamin D deficiency and IR has been extensively explore in previous studies, but none of them focused on Indian adolescents, and none of them used the TyG index as IR marker. Hence, this population-based cross-sectional study investigates the relationship between insulin resistance (IR) assessed using the Triglycerides Glucose Index (TyG index) and vitamin D measured by serum 25-hydroxyvitamin-D (25(OH)D). Methods For this study, we utilized data from the Comprehensive National Nutrition Survey (CNNS, 2016–18). The study is based on a sample size of 10,167 adolescents aged 10–19 years. The TyG index cut-off value of 4.65 was used to classify IR. We examined associations between the TyG index and serum 25(OH)D using multiple linear regression models adjusted for potential confounders. Odds of Insulin Resistance among vitamin D deficient/insufficient adolescents were assessed using multivariable logistic regression. Results A significant negative association was found between serum 25(OH)D and the TyG index, where a 10% increase in serum 25(OH)D was associated with 0.56 (95% CI = -0.67, -0.45) unit decrement in the TyG index. The odds of having IR were 90% higher among vitamin D deficient adolescents (OR: 1.90; 95% CI = 1.62—2.23) compared to adolescents with adequate levels of vitamin D. The association between vitamin D deficiency and IR was independent of sex; in other words, the association between vitamin D and IR was significant in both the sexes. Conclusion Independent of sex, this study found a significant inverse association between vitamin D and insulin resistance in Indian adolescents. The findings of this study highlight the utility of TyG index and the importance of vitamin D in lowering the risk of T2DM in future generations of the country.

Nutrition. Foods and food supply, Food processing and manufacture
DOAJ Open Access 2021
Effect of a low-FODMAP diet for the management of functional abdominal pain disorders in children: a study protocol for a randomized controlled trial

Agata Stróżyk, Andrea Horvath, Jane Muir et al.

Abstract Background Evidence from studies in adults documents that fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) may be triggers of symptoms in individuals with functional abdominal pain disorders (FAPDs). However, in children, the evidence is very limited. We aim to assess the effects of a low-FODMAP diet compared with a regular diet for the management of children with FAPDs. Methods We will perform a randomized, quadruple-blinded, controlled trial. Seventy-four children aged 8 to 18 years with a FAPD (Irritable Bowel Syndrome or Functional Abdominal Pain-Not Otherwise Specified), diagnosed according to the Rome IV criteria, will be randomly allocated to receive either a low-FODMAP diet or a regular diet for 4 weeks. The primary outcome will be the percentage of the responders, defined as the participants who have at least 30% improvement in abdominal pain intensity on a Visual Analogue Scale (VAS) during the last week of the trial compared with baseline, that is at least equal to the Reliable Change Index (≥ 25 mm change on VAS). Other outcomes will include changes in stool consistency, abdominal pain frequency, total scores on the Gastrointestinal Symptom Rating Scale, KIDSCREEN-10 Index and World Health Organization Five Well-Being Index, child’s school attendance and parents’ work absenteeism, and BMI-for-age z-score. Compliance, tolerability of the low-FODMAP diet, and adverse events also will be evaluated. Each FAPD subtype will be assessed separately. Discussion There is a need for high-quality evidence regarding the dietary management of children with FAPDs. This randomized controlled trial (RCT) of rigorous methodological design will help to establish the effectiveness, if any, of a low-FODMAP diet for the management of FAPDs in the pediatric population. The findings of this RCT will assist with the development of guidelines and influence the direction of further research. Trial registration NCT04528914 Data and protocol version identifier: 24/08/2020

Nutrition. Foods and food supply, Nutritional diseases. Deficiency diseases
DOAJ Open Access 2020
Safety of lacto‐N‐neotetraose (LNnT) produced by derivative strains of E. coli BL21 as a novel food pursuant to Regulation (EU) 2015/2283

EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Jacqueline Castenmiller et al.

Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the change in the production process and specifications of lacto‐N‐neotetraose (LNnT) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human‐identical milk oligosaccharide (HiMO) LNnT but also contains lactose, lacto‐N‐triose II (LNT II), para‐lacto‐N‐neo‐hexaose (para‐LNnH) and other related carbohydrates. The NF is produced by fermentation with two genetically modified strains of Escherichia coliBL21. LNnT when chemically synthesised or produced by microbial fermentation using another E. coli strain (K‐12) is already authorised and included in the EU list of NFs. This application is limited to a change in the manufacturing process and specifications while target population, uses and use levels and consequently the anticipated intake do not change. The information provided on the manufacturing process, including the absence of DNA from the producing microorganisms, composition, identity and specifications of the NF do not raise safety concerns. Particularly, the proposed changes in the specifications are limited to a slightly higher ash content and limits for the presence of yeast and moulds, while specifications for methanol and LNnT fructose isomer have been removed. Food supplements are not intended to be used if other foods with the added NF or breast milk for young children are consumed on the same day. The Panel concludes that lacto‐N‐neotetraose (LNnT) as a NF when produced by fermentation with two genetically modified strains of E. coliBL21 is safe under the proposed conditions of use.

Nutrition. Foods and food supply, Chemical technology
DOAJ Open Access 2019
Safety assessment of the process PETman, based on Starlinger Decon technology, used to recycle post‐consumer PET into food contact materials

EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera et al.

Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process PETman (EU register number RECYC163) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid‐state polycondensation (SSP) in a continuous reactor at high temperature under vacuum and gas flow. Having examined the challenge test provided, the Panel concluded that the preheating (step 2) and the decontamination in the continuous SSP reactor (step 3) are the critical steps that determine the decontamination efficiency of the process. The operating parameters to control the performance of these critical steps are temperature, pressure, residence time and gas flow. It was demonstrated that this recycling process is able to ensure that the level of migration of potential unknown contaminants into food is below the conservatively modelled migration of 0.1 μg/kg food. Therefore, the Panel concluded that the recycled PET obtained from this process is not considered of safety concern, when used at up to 100% for the manufacture of materials and articles for contact with all types of foodstuffs for long‐term storage at room temperature, with or without hotfill. Trays made of this recycled PET are not intended to be used in microwave and conventional ovens and such use is not covered by this evaluation.

Nutrition. Foods and food supply, Chemical technology
DOAJ Open Access 2019
Factors Affecting Sustainable Market Acceptance of Residential Microgeneration Technologies. A Two Time Period Comparative Analysis

Spyridon Karytsas, Ioannis Vardopoulos, Eleni Theodoropoulou

On a global scale, the residential sector is responsible for a significant part of consumed energy, of which the major part is dependent upon fossil fuels. A solution for the reduction of fossil fuel use is the application of residential microgeneration technologies. The present study examines the market acceptance factors of such systems in Greece, as well as how these factors change over time, based on real decisions made by consumers. In this context, two surveys applying a common questionnaire were performed in 2012 and 2019 in order to examine the effects of (a) socioeconomic, residence, and spatial characteristics, (b) environmental awareness and behavior, and (c) factors related to consumer behavior, attitudes, and system attribute preferences. Factors affecting the installation of a microgeneration system are gender, age, income, residence type, ownership and size, environmental behavior, use of a subsidy program, as well as views on costs and market-related issues. When evaluating the effect of these factors over time, socioeconomic and residence characteristics, as well as environmental behavior, seem to have a fixed effect to the installation of residential microgeneration systems, with market acceptance fluctuations being related mainly to market conditions, including existing subsidy programs, expectations on fuel prices, and legislation.

DOAJ Open Access 2018
What about the other 50 percent of the Canadian population? Food allergies ignored in national policy plan

Susan Elliott, Francesca Cardwell

Food allergy is a growing public health epidemic in Canada, affecting 50 percent of Canadian households either directly or indirectly. Despite the physical, psychosocial and quality of life impacts to those affected, food allergy has recently been ignored in the Canadian policy context. While the complete etiology of food allergy remains unknown, we have enough information to make strong policy choices that can maximize choice and minimize risk for affected Canadians, and place Canada at the forefront of food allergy management and research. Policy recognizing food allergy as a chronic health issue that represents a significant public health problem in Canada is critical.

Nutrition. Foods and food supply, Social Sciences
DOAJ Open Access 2018
Cloudy wheat beer enriched with okra [Abelmoschus esculentus (L.) Moench]: Effects on volatile compound and sensorial attributes

Kang Xu, Mengmeng Guo, Jinhua Du et al.

In order to explore the effect of okra on the cloudy and flavor characteristics of wheat beer, fresh okra and dried okra were added separately into boiling wort. The beer without okra was used as control sample. Aroma characteristics were analyzed using gas chromatography (GC), high-performance liquid chromatography, headspace–solid-phase microextraction–GC–mass spectrometry (HS-SPME-GC-MS), and electronic nose. The results showed that okra addition significantly increased the turbidity and viscosity. Principal components analysis reflected that three beers were apart from each other. After adding okra, the higher alcohols decreased, while the esters increased. In conclusion, okra can be used to improve stability and aroma characteristics.

Nutrition. Foods and food supply, Food processing and manufacture
DOAJ Open Access 2017
Scientific Opinion on Flavouring Group Evaluation 302 (FGE.302): N‐(2‐methylcyclohexyl)‐2,3,4,5,6‐pentafluoro‐benzamide from Chemical Group 30

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), Vittorio Silano, Claudia Bolognesi et al.

Abstract The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids was requested to evaluate N‐(2‐methylcyclohexyl)‐2,3,4,5,6‐pentafluoro‐benzamide [FL‐no: 16.119] in the Flavouring Group Evaluation 302, using the Procedure in Commission Regulation (EC) No 1565/2000. The substance is intended to be used as a flavour modifier and the current evaluation is only applicable to this use. Information on the ratios of diastereoisomers of the substance has been provided (cis 20–40% and trans 60–80%). Information on the ratio of enantiomers is lacking. The available data on genotoxicity do not preclude the evaluation of the candidate substance [FL‐no: 16.119] through the Procedure. The substance was evaluated through the B‐side of the Procedure. A ‘No Observed Adverse Effect Level’ (NOAEL) of 55 mg/kg body weight (bw) per day could be derived for [FL‐no: 16.119] from a 90‐day subchronic toxicity study in rats. This NOAEL provides an adequate margin of safety of 1.4 × 106, based on the ‘Maximised Survey‐Derived Daily Intake’ (MSDI) of 2.4 μg/capita per day. Based on the ‘modified Theoretical Added Maximum Daily Intake’ (mTAMDI) approach, the Panel concluded that more information is needed on use and use levels. Besides the safety assessment of this flavouring substance, the specifications for the material of commerce have also been considered. Additional information on the stereoisomeric composition of the flavouring substance is required.

Nutrition. Foods and food supply, Chemical technology

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