Hasil untuk "physics.acc-ph"

Michael Shatnev

We present a quantum-mechanical calculation of positron channeling radiation in a planar harmonic potential, explicitly accounting for the interference between transition amplitudes from different transverse energy levels. Because the planar channel potential for positrons in diamond~(110) is well approximated by a parabola, the transverse spectrum is equidistant, $\varepsilon_n = Ω(n+\tfrac{1}{2})$, and all $n \to n{-}j$ transitions radiate at the same Doppler-shifted frequency. The entry of the positron into the crystal under the sudden approximation creates a Glauber coherent state with population amplitudes $c_n$. Phase synchronization between the $c_n$ and the dipole matrix elements ensures that all occupied levels contribute constructively to the radiation amplitude, giving an intensity $I_{\rm coh} \propto |A_j|^2$ that exceeds the incoherent (Zhevago--Kumakhov) result by a factor $\mathcal{G} = 12\text{--}31$ for positron energies of $4\text{--}14$~GeV in diamond~(110). Numerical results agree with the experimental peak positions of Avakyan \emph{et al.}~\cite{Avakyan1982}. The enhancement is unique to positrons because their nearly harmonic channel potential is not replicated for electrons. We propose a decisive experimental test of the coherent model based on the predicted nonlinear angular dependence of the peak intensity. The transition from $N$- to $N^2$-scaling of the radiated intensity, driven by quantum coherence, opens a route toward high-intensity monochromatic gamma-ray sources for nuclear physics and materials science.

Jakob M. Grzesik, Aviv Karnieli, Charles Roques-Carmes et al.

We provide a theoretical framework to describe the dynamics of a free-electron beam interacting with quantized bound systems in arbitrary electromagnetic environments. This expands the quantum optics toolbox to incorporate free-electron beams for applications in highly tunable quantum control, imaging, and spectroscopy at the nanoscale. The framework recovers previously studied results and shows that electromagnetic environments can amplify the intrinsically weak coupling between a free-electron and a bound electron to reach previously inaccessible interaction regimes. We leverage this enhanced coupling for experimentally feasible protocols in coherent qubit control and towards the nondestructive readout and projective control of the electron beam's quantum-number statistics. Our framework is broadly applicable to microwave-frequency qubits, optical nanophotonics, cavity quantum electrodynamics, and emerging platforms at the interface of electron microscopy and quantum information.

N. Tripathi, B. Miao, A. Sloss et al.

New techniques for the optical generation of plasma waveguides -- optical fibres for ultra-intense light pulses -- have become vital to the advancement of multi-GeV laser wakefield acceleration. Here, we demonstrate the fabrication and characterization of a transmissive eight-level logarithmic diffractive axicon (LDA) for the generation of meter-scale plasma waveguides. These LDAs enable the formation of a Bessel-like beam with controllable start and end locations of the focal line and near-constant intensity on axis. We present measurements of the Bessel-like focal profile produced by the LDA, and of the leading end of the plasma column generated by it. One important feature is the formation of a funnel-mouthed plasma channel entrance that can act as waveguide coupler. We also compare the diffraction efficiency of our 8-level LDA to 4-level and binary versions, with measurements comparing well to theory.

A. Angella, E. Löfquist, C. Gustafsson et al.

We report the first experimental observation of carrier-envelope phase-driven energy bunching in laser wakefield acceleration. Using a few-cycle (~9 fs), multi-terawatt laser pulse and ionization injection in a helium-nitrogen gas mixture, we observe electron spectra composed of multiple quasi-monoenergetic peaks with regular narrow energy spacing. This comb structure arises from intermittent injection from successive half-cycles of the laser field, enabled by the evolving carrier-envelope phase during propagation in the plasma. These findings establish sub-cycle ionization injection as a potential route to attosecond control in plasma acceleration, enabling injection and beam structuring synchronized to the optical waveform on sub-femtosecond timescales.

A. S. Dyatlov, D. M. Dolgintsev, V. V. Gerasimov et al.

The generation of relativistic vortex electron beams via photoemission requires ultraviolet laser beams with well-controlled orbital angular momentum (OAM) and compatibility with radio-frequency (RF) photoinjector drive-laser systems. High-OAM vortex beams at a wavelength of 266 nm are generated using three fabricated diffractive optical elements integrated into an operational photoinjector beamline: a reflective fork grating, a high-topological-charge spiral phase plate, and binary axicons. The spiral phase plate produces a high-purity Laguerre-Gaussian mode with an OAM of l = 64 and a conversion efficiency of 80%, whereas binary axicons generate low-divergence quasi-Bessel beams forming a superposition of multiple OAM states with a finite OAM bandwidth imposed by their binary phase structure. Fork gratings provide flexible access to lower OAM values and enable robust modal diagnostics. The generated beams are characterized using cylindrical-lens mode conversion and radial intensity analysis, demonstrating practical control of both the OAM content and spectral bandwidth of ultraviolet structured light for accelerator-based applications.

Andrei Lunin, Mustafa Bal, Akshay Murthy et al.

The Josephson junction and shunt capacitor form a transmon qubit, which is the cornerstone of modern quantum computing platforms. For reliable quantum computing, it is important how long a qubit can remain in a superposition of quantum states, which is determined by the coherence time (T1). The coherence time of a qubit effectively sets the "lifetime" of usable quantum information, determining how long quantum computations can be performed before errors occur and information is lost. There are several sources of decoherence in transmon qubits, but the predominant one is generally considered to be dielectric losses in the natural oxide layer formed on the surface of the superconductor. In this paper, we present a numerical study of microwave surface losses in planar superconducting antennas of different transmon qubit designs. An asymptotic method for estimating the energy participation ratio in ultrathin films of nanometer scales is proposed, and estimates are given for the limits of achievable minimum RF losses depending on the electrical properties of the surface oxide and the interface of the qubit with the substrate material.

Benjamin Sims, David Sims, Sergey V. Baryshev et al.

We present the design and characterization of a dual-mode radiofrequency (rf) cavity, a novel electromagnetic structure with potential benefits such as compactness, efficiency, cost reduction and multifunctionality. The cavity was designed to balance the dual-mode structure considering several factors, such as mode frequencies, quality factor (Q-factor), and minimizing cross talk between couplers. We preformed various tests to verify that this cavity preformed as expected compared to simulated results. As exampled here, a combination of the the fundamental mode TM 010 and the TM 011 mode, tuned to a harmonic of the fundamental, was realized to linearize the off-crest electric field, thereby enabling concurrent bunching and acceleration of charged particle (e.g. electrons) beam in high power systems. The reduction in the number of cavities required to bunch and accelerate promises cost and space savings over conventional approaches. This research lays the foundation for further exploration of multi-mode cavity applications and optimization for specific use cases, with potential implications for a wide range of fields including quantum information platforms.

J. Lawson, R. Veech

The observed equilibrium constants (Kobs) of the creatine kinase (EC 2.7.3.2), myokinase (EC 2.7.4.3), glucose-6-phosphatase (EC 3.1.3.9), and fructose-1,6-diphosphatase (EC 3.1.3.11) reactions have been determined at 38 degrees C, pH 7.0, ionic strength 0.25, and varying free magnesium concentrations. The equilibrium constant (KCK) for the creatine kinase reaction defined as: KCK = [sigma ATP] [sigma creatine] divided by ([sigma ADP] [sigma creatine-P] [H+]) was measured at 0.25 ionic strength and 38 degrees C and was shown to vary with free [Mg2+]. The value was found to be 3.78 x 10(8) M-1 at free [Mg2+] = 0 and 1.66 x 10(9) M-1 at free [Mg2+] = 10(-3) M. Therefore, at pH 7.0, the value of Kobs, defined as Kobs = KCK[H+] = [sigma ATP] [sigma creatine] divided by ([sigma ADP] [sigma creatine-P] was 37.8 at free [Mg2+] = 0 and 166 at free [Mg2+] = 10(-3) M. The Kobs value for the myokinase reaction, 2 sigma ADP equilibrium sigma AMP + sigma ATP, was found to vary with free [Mg2+], being 0.391 at free [Mg2+] = 0 and 1.05 at free [Mg2+] = 10(-3) M. Taking the standard state of water to have activity equal to 1, the Kobs of glucose-6-P hydrolysis, sigma glucose-6-P + H2O equilibrium sigma glucose + sigma Pi, was found not to vary with free [Mg2+], being 110 M at both free [Mg2+] = 0 and free [Mg2+] = 10(-3) M. The Kobs of fructose-1,6-P2 hydrolysis, sigma fructose-1,6-P2 equilibrium sigma fructose-6-P + sigma Pi, was found to vary with free [Mg2+], being 272 M at free [Mg2+] = 0 and 174 M at free [Mg2+] = 0.89 x 10(-3) M.

K. Ivanov, D. Gorlova, I. Tsymbalov et al.

The simultaneous laser-driven acceleration and angular manipulation of the fast electron beam is experimentally demonstrated. The bunch of multi-MeV energy charged particles is generated during the propagation of the femtosecond laser pulse through the near-critical plasma slab accompanied by plasma channeling. Plasma is formed by the controlled breakdown of a thin-tape target by a powerful nanosecond prepulse. The electron beam pointing approach is based on the refraction of a laser pulse in the presence of a strong radial density gradient in the breakdown of the tape with a small displacement of the femtosecond laser beam relative to the breakdown symmetry axis. A shift of several micrometers makes it possible to achieve beam deflection by an angle up to 10 degrees with acceptable beam charge and spectrum conservation. This opens up opportunities for in-situ applications for scanning objects with an electron beam and the multistage electron beam energy gain in consecutive laser accelerators without bulk magnetic optics for particles. Experimental findings are supported by numerical Particle-In-Cell calculations of laser-plasma acceleration and hydrodynamic simulations.

L. Tronstad, J. Andreasen, G. Hasselgren et al.

F. Maxfield

It has been shown that endocytic vesicles in BALB/c 3T3 cells have a pH of 5.0 (Tycko and Maxfield, Cell, 28:643-651). In this paper, a method for measuring the effect of various agents, including weak bases and ionophores, on the pH of endocytic vesicles is presented. The method is based on the increase in fluorescein fluorescence with 490-nm excitation as the pH is raised above 5.0. Intensities of cells were measured using a microscope spectrofluorometer after internalization of fluorescein-labeled alpha 2-macroglobulin by receptor-mediated endocytosis. The increase in endocytic vesicle pH was determined from the increase in fluorescence after addition of various concentrations of the test agents. The following agents increased endocytic vesicle pH above 6.0 at the indicated concentrations: monensin (6 microM), FCCP (10 microM), chloroquine (140 microM), ammonia (5 mM), methylamine (10 mM). The ability of many of these agents to raise endocytic vesicle pH may account for many of their effects on receptor-mediated endocytosis. Dansylcadaverine caused no effect on vesicle pH at 1 mM. The observed increases in vesicle pH were rapid (1-2 min) and could be reversed by removal of the perturbant. This reversibility indicates that the vesicles themselves contain a mechanism for acidification. The increase in vesicle pH due to these treatments can be observed visually using an SIT video camera. Using this method, it is shown that endocytic vesicles become acidic at very early times (i.e., within 5-7 min of continuous uptake at 37 degrees C).

G. Wiener, J. Richter, J. Copper et al.

A. A. Baulin

This research considers potential dose increase in target due to cisplatin (Pt) concentration and radiation type. Cisplatin concentrations from 0.003 to 120 mM were used. Monte-Carlo simulation of Linear accelerator (Elekta Synergy) and X-ray tube (Xstrahl300) was carried out using Geant4 and PClab. As the first step of this research, we performed simulation of energy spectrum from radiotherapy units (spectrum model). The next step was the modeling of linear accelerator head and X-ray tube, and the distribution of dose in the water phantom (PDD model). At the second stage, dose changes were investigated in the presence of cisplatin in the target (CIS model). The simulation results showed that the dose escalation can be caused by photon-capture therapy (PCT). There is a dose enhancement in the volume where cisplatin is accumulated. Then higher is concentration, then higher is the effect. However, the photon energy increase from 60 to 250 kV and increase of depth of target reduces the effect of PCT due the decrease of the photoelectric effect cross-section. Should be noticed, that the orthovoltage X-rays energy, listed in the table with results shows higher dose enhancement, than the megavoltage photon beam generated from linear acceleration sources. In addition, that the dose enhancement factors (DEF) are higher in linac without flattening filter, than in linac with flattening filter.

P. O. Kazinski, G. Yu. Lazarenko

The explicit expression for the inclusive probability to record a photon created in transition radiation from a one Dirac particle wave packet traversing an ideally conducting plate is derived in the leading order of perturbation theory. The anomalous magnetic moment of the Dirac particle is taken into account. It is shown that the quantum corrections to transition radiation from an electrically charged particle give rise to production of photons with polarization vector orthogonal to the reaction plane ($E$-plane). These corrections result from both the quantum recoil and the finite size of a wave packet. As for transition radiation produced by a neutron falling normally onto the conducting plate, the probability to detect a photon with polarization vector lying in the reaction plane does not depend on the observation angle and the energy of the incident particle. The peculiarities of transition radiation stemming from different shapes of the particle wave packet are investigated. In particular, the transition radiation produced by the wave packet of one twisted Dirac particle is described. The comparison with classical approach to transition radiation is given and the quantum formula for the inclusive probability to detect a photon radiated by the $N$-particle wave packet is derived.

L. Brannon-Peppas, N. Peppas

Z. Wang, R. Delaune, W. H. Patrick et al.

Feng Xu

The electronic absorption spectrum, susceptibility to fluoride inhibition, redox potential, and substrate turnover of several fungal laccases have been explored as a function of pH. The laccases showed a single spectrally detectable acid-base transition at pH 6-9 and a fluoride inhibition that diminished by increased pH (indicating a competition with hydroxide inhibition). Relatively small changes in the redox potentials (≤0.1 V) of laccase were observed over the pH 2.7-11. Under the catalysis of laccase, the apparent oxidation rates (kcat and kcat/Km) of two nonphenolic substrates, potassium ferrocyanide and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid),decreased monotonically as the pH increased. In contrast, the apparent oxidation rates (kcat and kcat/Km) of three 2,6-dimethoxyphenols (whose pKa values range from 7.0 to 8.7) exhibited bell-shaped pH profiles whose maxima were distinct for each laccase but independent of the substrate. By correlating these pH dependences, it is proposed that the balance of two opposing effects, one generated by the redox potential difference between a reducing substrate and the type 1 copper of laccase (which correlates to the electron transfer rate and is favored for a phenolic substrate by higher pH) and another generated by the binding of a hydroxide anion to the type 2/type 3 coppers of laccase (which inhibits the activity at higher pH), contributes to the pH activity profile of the fungal laccases.

I. J. Buerge, S. Hug

M. Dockal, D. Carter, F. Rüker

Human serum albumin (HSA) is a protein of 66.5 kDa that is composed of three homologous domains, each of which displays specific structural and functional characteristics. HSA is known to undergo different pH-dependent structural transitions, the N-F and F-E transitions in the acid pH region and the N-B transition at slightly alkaline pH. In order to elucidate the structural behavior of the recombinant HSA domains as stand-alone proteins and to investigate the molecular and structural origins of the pH-induced conformational changes of the intact molecule, we have employed fluorescence and circular dichroic methods. Here we provide evidence that the loosening of the HSA structure in the N-F transition takes place primarily in HSA-DOM III and that HSA-DOM I undergoes a structural rearrangement with only minor changes in secondary structure, whereas HSA-DOM II transforms to a molten globule-like state as the pH is reduced. In the pH region of the N-B transition of HSA, HSA-DOM I and HSA-DOM II experience a tertiary structural isomerization, whereas with HSA-DOM III no alterations in tertiary structure are observed, as judged from near-UV CD and fluorescence measurements.

D. Sifrim, R. Holloway, J. Silny et al.