Hasil untuk "Dermatology"

Priyanka Sangwan, Priyansh Gupta, Madhusmita Sethy et al.

Bu X, Feng L, Guo J et al.

Xiaolin Bu,1,* Liwei Feng,2,* Jing Guo,3 Rongzhu Yu,2 Xinling Bi4 1Laboratory of Laser and Medical Innovation Application, Department of Dermatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China; 2School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, People’s Republic of China; 3Postgraduate Training Base at Shanghai Gongli Hospital, Ningxia Medical University, Shanghai, People’s Republic of China; 4Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinling Bi, Department of Dermatology, Changhai Hospital, Naval Medical University, 168 Changhai Road, YangPu District, Shanghai, People’s Republic of China, Email bixinling@163.comAbstract: A 65-year-old Asian male presented with a circular skin lesion on the flexor aspect of the right calf that first appeared at age 13 and gradually expanded peripherally. Six months prior to presentation, a dark brown, horn-like keratotic lesion with a hard texture emerged on the annular lesion, growing progressively without pain or pruritus. The cutaneous horn was surgically excised, and the annular lesion underwent biopsy. Pathological findings revealed abundant mucin in dermal collagen, dense histiocyte infiltration, and focal mild collagen degeneration, confirming a diagnosis of granuloma annulare complicated by a cutaneous horn.Keywords: cutaneous horn, granuloma annulare, keratotic

Osorio‐Aragón I. Yolanda, Milián‐Solís Ximena, Berumen‐Glinz Cristina et al.

Abstract We present the case of a 26‐year‐old female with chronic urticaria (CU) with systemic symptoms in whom comprehensive laboratory and imaging studies led to the diagnosis of idiopathic multicentric Castleman disease. Treatment with rituximab induced resolution of CU. The association between these two entities is rare, and common autoimmune and autoinflammatory pathways may be involved in their production. Our case also emphasized the association of CU with an underlying systemic disease.

Daniele Torchia

Mohamed S. Zaky, Rabie B. Atallah, Aya M. Saad Mohyeldeen et al.

Abstract Molluscum contagiosum (MC) is a skin and mucous membrane infection caused by the molluscum virus (MCV). To evaluate safety and efficacy of intralesional injection of tuberculin purified protein derivative (PPD) antigen injection versus MMR (mumps, measles, rubella) antigen for the treatment of molluscum contagiosum (MC). A total of thirty clinically confirmed patients of molluscum were recruited for this trial. Patients who were divided into three groups (A, B and C). Each group consisted of (30) patients. Group (A) subjects received intralesional MMR injections, group (B) subjects received intralesional PPD injection and group (C) received intralesional saline injection. The results of the present study revealed complete clearance of the injected lesions in 12 patients (80%), partial response in 3 patients (20%) of group (A). In group (B), complete clearance of the treated warts was observed in 11 patients (73.3%) and partial response in 4 (26.7%) of patients. In group (C), the majority of patients 8 (53.3%) demonstrated no response while 7 (46.7%) patients showed only partial clearance. We established a good safety and efficacy profile for tuberculin PPD and MMR antigens in treatment of molluscum contagiosum.

Kinga Tyczyńska, Piotr K. Krajewski, Danuta Nowicka-Suszko et al.

Abstract Introduction Chronic pruritus (CP) is a common symptom defined as a sensation that provokes the desire to scratch and which lasts for at least 6 weeks. CP remains a problem for up to 21.3% of renal transplant recipients (RTRs). Our research aimed to establish the possible association between serum levels of neurotrophin-4 (NT-4) and brain-derived neurotrophic factor (BDNF) and the presence and intensity of CP in RTR. Methods The study was performed on a group of 129 RTRs, who were divided according to the presence or absence of pruritus in the previous 3 days. The assessment of pruritus was performed with the use of a numeric rating scale (NRS), 4-Item Itch Questionnaire (4IIQ), and Itchy Quality of Life (Itchy QoL). A total of 129 blood samples with a volume of 9 ml were drawn from RTRs during the monthly routine control. Serum levels (pg/mL) of NT-4 and BDNF were measured by the ELISA. Results Pruritic RTRs have statistically significantly higher serum concentrations of NT-4 serum level compared to non-pruritic RTRs (229.17 ± 143.86 pg/mL and 153.08 ± 78.19 pg/mL [p = 0.024], respectively). Moreover, a statistically significant difference between pruritic and non-pruritic RTRs with healthy controls was shown (p < 0.001 and p < 0.001, respectively). Although there was a numerically higher serum concentration of BDNF in pruritic RTRs (32.18 ± 7.31 pg/mL vs. 31.58 ± 10.84 pg/mL), the difference did not reach statistical significance. No statistically significant difference was also seen in BDNF serum levels between RTRs and healthy controls. Furthermore, there was a statistically significant, positive correlation between serum concentration of NT-4 and NRS score (p = 0.008, r = 0.357). Conclusions The results indicate higher NT-4 serum concentration in RTRs with pruritus compared to RTRs without pruritus. Furthermore, the study revealed a statistically significant, positive correlation between the serum concentration of NT-4 and NRS score.

Lidia Rudnicka

The Polish Dermatological Society was founded in February 1920 by Franciszek Krzyształowicz (1868–1931), Robert Bernhardt (1874–1950), Roman Leszczyński (1873–1940), Jan Lenartowicz (1877–1959) and Franciszek Walter (1885–1950). For 100 years of the existence of the Polish Dermatological Society, the most important goal was to build cooperation and the best possible, science-based, quality of dermatology in Poland, as well as building a favorable image of Polish dermatology and Polish dermatologists in the world. The Society now has over 2,600 members, the most in the history of our Society. The Polish Dermatological Society, was created by people with a passion for dermatology and cooperation. Now, after it was developed by several generations dermatologists we can look with optimism into the next 100 years.

Jia ZHANG, Kaiyun ZHANG, Tao CHEN et al.

Objective To investigate the differences in the cutaneous microbiome between patients with primary acute guttate psoriasis and healthy controls. Methods We enrolled 18 patients with primary acute guttate psoriasis, including 9 patients with upper respiratory tract infection and 9 patients without upper respiratory tract infection, and 9 healthy controls. Skin swabs were collected from lesional and non-lesional skin of psoriatic patients and healthy controls. The 16S rDNA sequencing was used for analyzing the DNA samples and annotating the sequencing results. The differences in microbial species and community structure among the three groups were determined by bioinformatics and statistics analysis. Results At the Phylum level, the dominant species among the three groups were Firmicutes, Proteobacteria and Actinobacteria. There was no significant difference in α diversity analysis among the three groups (all P>0.05). There were significant differences in the composition of microbial community between the control group and the two groups of patients (both P<0.05). Gammaproteobacteria and Cutibacterium in the primary acute guttate psoriasis without upper respiratory tract infection were lower than those in the normal group (both P<0.05).Campylobacteria, Lawsonella and Actinomyces in the primary acute guttate psoriasis with upper respiratory tract infection were lower than those in the normal group (both P<0.05), but unidentified Weeksellaceae was the opposite (P<0.05). Gammaproteobacteria, Enhydrobacter and Pseudomonas in the primary acute guttate psoriasis without upper respiratory tract infection were lower than that in primary acute guttate psoriasis with upper respiratory tract infection (all P<0.05). Conclusions There are differences in the composition of microbial community among the three groups at the genus level. Upper respiratory tract infection affects the composition of microflora on the skin lesion of acute guttate psoriasis. The pathogenesis of psoriasis is associated with cutaneous microbiome.

Giuseppe Broggi, Anna Elisa Verzì, Rosario Caltabiano et al.

In dermatopathological daily practice, vertical histopathology sections are classically used to analyze skin biopsies. Conversely, horizontal histopathological sections are currently used for the diagnosis of some types of alopecia. In the last years the morphological findings obtained by horizontal histopathology have been correlated to those obtained by in vivo reflectance confocal microscopy which provides the same “point of view” of the skin. This review paper emphasizes the strong matching and correlation between reflectance confocal microscopy images and horizontal histopathology in cutaneous neoplasms, further demonstrating the strong reliability of this innovative, non-invasive technique in the management of skin tumors.

Ashley T. Ng, BS, Richard L. Tower, Beth A. Drolet

Vascular anomalies comprise an array of congenital developmental disorders that can lead to significant disfigurement and physiologic disarray. The vast multitude of clinical phenotypes has inherently led to misdiagnosis and patients and families enduring long diagnostic odysseys of medical care. Although the observed variation in disease manifestations remains poorly understood, targeted next-generation sequencing has pivoted our understanding of the pathobiology of vascular anomalies and, for the first time, uncovered potential pharmacologic targets for these disorders. In this review article, we highlight current and developing targeted therapies for vascular anomalies, namely phosphoinositide 3-kinase and mitogen-activated protein kinase pathway inhibitors, and discuss the future directions of targeted therapies.

Junjun Zhang, Ruwen Zhou, Yiming Mi et al.

Background: IgA nephropathy (IgAN) is characterized by the mesangial deposition of pathogenic IgA. We previously detected the deposition of pathogenic secretory IgA (SIgA) in the mesangium of about one-third of IgAN patients. Tubulointerstitial injury has an important role in the development of IgAN. However, the relationship between SIgA and tubulointerstitial damage is currently unclear. In this work, the role of the mesangial-tubular crosstalk was explored in the tubulointerstitial damage in SIgA-induced IgAN. Methods: SIgA deposition in renal tissues of IgAN patients was detected by immunofluorescence. Flow cytometry was used to assess the binding of SIgA to human renal mesangial cells (HRMC) and human proximal tubule epithelial (HK-2) cells. HK-2 was co-cultured with HRMC added with SIgA isolated from patients or normal volunteers. Protein synthesis and gene expressions of TNF-α, TGF-β1, and MCP-1 were determined by ELISA and PCR, respectively. The expressions of the above cytokines in renal tissues of patients and normal controls were detected by immunohistochemistry. Results: Twenty-nine of 96 patients had SIgA deposition in the mesangium, but SIgA was rarely detected in the tubulointerstitium. The binding rate of SIgA to HK-2 (2.79%) was significantly lower than that of HRMC (81.6%) (p &#x3c; 0.001). The expressions of TNF-α, TGF-β1, and MCP-1 in HRMC were significantly higher than in SIgA-stimulated HK-2 (p &#x3c; 0.05), and their expressions were significantly higher in the SIgA-stimulated co-culture group compared with SIgA-stimulated HRMC (p &#x3c; 0.05). The expressions of the above cytokines were mainly detected in tubulointerstitium of IgAN patients with positive and negative SIgA deposition, without significant difference between the 2 groups, but to a significantly higher level than that in normal controls, and their expressions positively correlated with tubulointerstitial injury. Conclusion: Inflammatory factors released from the mesangium after SIgA deposition might mediate tubulointerstitial damage via mesangial-tubular crosstalk in IgAN.

Yican Wang, Meng Huang, Xin Du et al.

Trichloroethylene (TCE) hypersensitivity syndrome (THS), called occupational medicamentosa-like dermatitis due to TCE (OMDT) in China, is a fatal occupational disorder caused by TCE exposure. Visceral damage, including kidney injury, is one of the major complications. Necroptosis is a regulated cell death form linked to local inflammatory response. This study aimed to investigate whether renal cell necroptosis was involved in TCE-induced kidney injury. A Balb/c mouse model of TCE sensitization was utilized to study mechanisms of modulation of TCE-induced renal necroptosis. Renal histology (using light and transmission electron microscopy) and renal tubular impairment indexes, including α1-microglobulin (α1-MG), and β2-microglobulin (β2-MG), were evaluated. In addition, tissue expression of necroptosis-related proteins, including tumor necrosis factor (TNF)-α, TNF receptor 1 (TNFR1), receptor-interacting protein kinase 3 (RIPK3), p-RIK3, mixed lineage kinase domain-like protein (MLKL), and p-MLKL, were also evaluated. The study here confirmed TCE sensitization caused damage to renal tubules and renal tubular epithelial cell (RTEC) necroptosis. In mice treated with R7050 (a specific TNFα antagonist), it was also seen that inhibition of TNFα expression could effectively inhibit RTEC necroptosis and improve renal function in the TCE-sensitized mice. Taken together, these results help to define a novel mechanism by which RTEC necroptosis plays a key role in TCE-induced kidney damage.

Richa Mishra, Ashish Kumar, Harshad Ingle et al.

MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection. In the last decade, multiple DNA and RNA viruses have been shown to produce miRNAs known as viral miRNAs (v-miRNAs) so as to evade the host immune response. In this review, we highlight the origin and biogenesis of viral miRNAs during the viral lifecycle. We also explore the role of viral miRNAs in immune evasion and hence in maintaining chronic infection and disease. Finally, we offer insights into the underexplored role of viral miRNAs as potential targets for developing therapeutics for treating complex viral diseases.

M. V. Zhuchkov, Yu. S. Bychkova, M. A. Tarasova

This article provides a clinical observation of paraneoplastic syndrome of a patient with basal cell carcinoma of skin. Authors present clinical features of the described for the first time, paraneoplastic retentional follicular hyperkeratosis of facial area.

Reena Rai

Reza Yaghoobi, Karan Lal, Amir Feily

Thorakkal Shamim

Paula Maio, Diogo Bento, Raquel Vieira et al.

Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.<br>Os linfomas citot&#243;xicos compreendem um espectro de linfomas de c&#233;lulas T perif&#233;ricos e linfomas Natural Killer que podem ter express&#227;o cut&#226;nea prim&#225;ria ou secund&#225;ria. Descrevemos o caso de um homem com 46 anos de idade, natural de Cabo Verde,com dermatose envolvendo a face e tronco constitu&#237;da por p&#225;pulas monomorfas superf&#237;cie lisa e polineuropatia sensitivo motora.A hip&#243;tese de Hansen&#237;ase foi colocada suportada por achados histopatol&#243;gicos sugestivos sendo o doente referenciado &#224; consulta de Doen&#231;a de Hansen do nosso hospital. Em biopsia de pele e de g&#226;nglio identificou-se prolifera&#231;&#227;o linfocit&#225;ria cujo estudo imunohistoqu&#237;mico permitiu o diagn&#243;stico de linfoma T com express&#227;o de marcadores citot&#243;xicos. Iniciou quimioterapia verificando-se inicialmente remiss&#227;o parcial das les&#245;es cut&#226;neas mas posteriormente a progress&#227;o da doen&#231;a sist&#233;mica.

N. Cassano, C. Foti, S. Centofanti et al.

The symptoms of irritant contact dermatitis (ICD) are often controlled by topical corticosteroids, which, however, are not suitable for the long-term management owing to the risk of side effects. Moisturizers can be used to prevent ICD and to treat lesions of mild to moderate severity. In this study we want to assess the effectiveness and tolerability of a cosmetic cream (Efaderm® cream), containing a mixture of substances with moisturizing, anti-inflammatory and antioxidant effects ( borago officinalis oil, soy sterol, urea, lithium glycyrrethinate, carbocysteine, tocopheryl acetate, coenzyme Q10, allantoin), in the treatment of ICD. Three hundred and twelve patients with ICD entered the study. ICD was induced by either occupational or non-occupational factors, affected various skin sites, especially the hands, and was characterized by a subacute, recurrent or chronic course in the majority of cases. The cream was applied on lesionai skin twice a day, or more frequently if needed, for approximately 4 weeks. Most patients (n. 179) did not adopt preventive measures (e.g., irritant avoidance, suspension of working activities, use of protective gloves). After treatment, there was a significant improvement (P<0.001) of symptoms and signs of ICD (erythema, scaling/dryness, oozing/crusting, excoriations/fissuring, pruritus/burning), independently on the use of prevention. Patient's assessment of overall effectiveness was positive in the majority of cases.

Bernardo Gontijo, Sílvio Alencar Marques, Everton Siviero do Vale