DOAJ Open Access 2020

The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection

Richa Mishra Ashish Kumar Harshad Ingle Himanshu Kumar Himanshu Kumar

Abstrak

MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection. In the last decade, multiple DNA and RNA viruses have been shown to produce miRNAs known as viral miRNAs (v-miRNAs) so as to evade the host immune response. In this review, we highlight the origin and biogenesis of viral miRNAs during the viral lifecycle. We also explore the role of viral miRNAs in immune evasion and hence in maintaining chronic infection and disease. Finally, we offer insights into the underexplored role of viral miRNAs as potential targets for developing therapeutics for treating complex viral diseases.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (5)

Richa Mishra

Ashish Kumar

Harshad Ingle

Himanshu Kumar

Format Sitasi

APA MLA BibTeX

Mishra, R., Kumar, A., Ingle, H., Kumar, H., Kumar, H. (2020). The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection. https://doi.org/10.3389/fimmu.2019.03079

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Informasi Jurnal

Tahun Terbit: 2020
Sumber Database: DOAJ
DOI: 10.3389/fimmu.2019.03079
Akses: Open Access ✓