Hasil untuk "math.AP"

Walid Shalata, Muhammed Iraqi, Baisali Bhattacharya et al.

The new era of cancer treatments has made immune checkpoint inhibitors (ICIs) and emerging multikinase inhibitors (TKIs) the standards of care, thus drastically improving patient prognoses. Pembrolizumab is an anti-programmed cell death-1 antibody drug, and lenvatinib is a TKI with preferential antiangiogenic activity. We present, to our knowledge, the first reported series of cases consisting of patients with metastatic non–small cell lung cancer and malignant pleural mesothelioma who were treated with several types of chemotherapy combinations and ICIs followed by disease progression. They were subsequently treated with combined immunotherapy and TKI treatment, resulting in a near complete response within a very short time. Clinical responses were supported by in vitro testing of each patient’s lymphocytic response to pembrolizumab after pre-exposure of target cancer cells to lenvatinib.

Nicolas David Zorzin

Bertram Mapunda

Genuine community participation in research and conservation projects is crucial for sustainable protection, management and development of archaeological sites, especially in sub-Saharan Africa where the scientific value of such resources is less appreciated. Local people often become suspicious of and discontented with field researchers who do not inform them of what they are doing around their courtyard, just as they are displeased with government officials who impose conservation projects upon them. Their discontent often comes for good reasons: either the given research or project is not a priority to them or its objectives differ from theirs. As a result, a conflict of expectations emerges, often leading local communities into disliking the project and hence investing little or just superficial commitment to it. Such feelings may be expressed verbally in formal or informal gatherings or through indifference, resentment, or vandalism, all of which are detrimental to the proper management of the heritage resource in question. Using specific cases of researchers/administrators-villagers differences and conflicts of expectations experienced in various places in Tanzania, the paper discusses causes of such differences, critically examines the Community Participatory technique exposing its strengths and weaknesses, as well as suggests solutions and outlining potential benefits should villagers be genuinely incorporated in such undertakings.

Daniel García Raso

Video games have become a mass culture phenomenon typical of the West Post-Industrial Society as well as an avant-garde narrative medium. The main focus of this paper is to explore and analyze the public image of Archaeology and Prehistory spread by video games and how we can achieve a virtual faithful image of both. Likewise, we are going to proceed to construct an archaeological outline of video games, understanding them as an element of the Contemporary Material Culture and, therefore, subject to being studied by Archaeology.

Emre Özcan

Véronique Bailly, Walter G. Verly