The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST)
R. Overbeek, R. Olson, G. Pusch
et al.
In 2004, the SEED (http://pubseed.theseed.org/) was created to provide consistent and accurate genome annotations across thousands of genomes and as a platform for discovering and developing de novo annotations. The SEED is a constantly updated integration of genomic data with a genome database, web front end, API and server scripts. It is used by many scientists for predicting gene functions and discovering new pathways. In addition to being a powerful database for bioinformatics research, the SEED also houses subsystems (collections of functionally related protein families) and their derived FIGfams (protein families), which represent the core of the RAST annotation engine (http://rast.nmpdr.org/). When a new genome is submitted to RAST, genes are called and their annotations are made by comparison to the FIGfam collection. If the genome is made public, it is then housed within the SEED and its proteins populate the FIGfam collection. This annotation cycle has proven to be a robust and scalable solution to the problem of annotating the exponentially increasing number of genomes. To date, >12 000 users worldwide have annotated >60 000 distinct genomes using RAST. Here we describe the interconnectedness of the SEED database and RAST, the RAST annotation pipeline and updates to both resources.
4209 sitasi
en
Biology, Computer Science
Time Flies When You're Having Fun: Cognitive Absorption and Beliefs About Information Technology Usage
Ritu Agarwal, Elena Karahanna
4941 sitasi
en
Computer Science, Psychology
Using Technology and Constituting Structures: A Practice Lens for Studying Technology in Organizations
W. Orlikowski
4475 sitasi
en
Computer Science, Sociology
Strategic Alignment: Leveraging Information Technology for Transforming Organizations
J. C. Henderson, N. Venkatraman
4497 sitasi
en
Engineering, Computer Science
Predicting User Intentions: Comparing the Technology Acceptance Model with the Theory of Planned Behavior
Kieran Mathieson
4619 sitasi
en
Computer Science
Studying Information Technology in Organizations: Research Approaches and Assumptions
W. Orlikowski, Jack J. Baroudi
4486 sitasi
en
Sociology, Computer Science
Persuasive technology: using computers to change what we think and do
James Kalbach
4758 sitasi
en
Engineering, Computer Science
A Resource-Based Perspective on Information Technology Capability and Firm Performance: An Empirical Investigation
A. Bharadwaj
5288 sitasi
en
Computer Science, Business
Capturing the Complexity in Advanced Technology Use: Adaptive Structuration Theory
G. DeSanctis, M. S. Poole
4179 sitasi
en
Computer Science
Why Don't Men Ever Stop to Ask for Directions? Gender, Social Influence, and Their Role in Technology Acceptance and Usage Behavior
V. Venkatesh, Michael G. Morris
Using the Technology Acceptance Model (TAM), this research investigated gender differences in the overlooked context of individual adoption and sustained usage of technology in the workplace. User reactions and technology usage behavior were studied over a five-month period among 342 workers being introduced to a new software system. At all three points of measurement, compared to women, men's technology usage deci
4540 sitasi
en
Computer Science, Psychology
A Conceptual and Operational Definition of Personal Innovativeness in the Domain of Information Technology
Ritu Agarwal, J. Prasad
3673 sitasi
en
Computer Science
The Role of the Business Model in Capturing Value from Innovation: Evidence from Xerox Corporation's Technology Spin-Off Companies
H. Chesbrough, R. Rosenbloom
This paper explores the role of the business model in capturing value from early stage technology. A successful business model creates a heuristic logic that connects technical potential with the realization of economic value. The business model unlocks latent value from a technology, but its logic constrains the subsequent search for new, alternative models for other technologies later on--an implicit cognitive dimension overlooked in most discourse on the topic. We explore the intellectual roots of the concept, offer a working definition and show how the Xerox Corporation arose by employing an effective business model to commercialize a technology rejected by other leading companies of the day. We then show the long shadow that this model cast upon Xerox's later management of selected spin-off companies from Xerox PARC. Xerox evaluated the technical potential of these spin-offs through its own business model, while those spin-offs that became successful did so through evolving business models that came to differ substantially from that of Xerox. The search and learning for an effective business model in failed ventures, by contrast, were quite limited. Copyright 2002, Oxford University Press.
Review: Information Technology and Organizational Performance: An Integrative Model of IT Business Value
Nigel P. Melville, K. Kraemer, V. Gurbaxani
3708 sitasi
en
Economics, Computer Science
Shaping Agility through Digital Options: Reconceptualizing the Role of Information Technology in Contemporary Firms
V. Sambamurthy, A. Bharadwaj, V. Grover
Agility is vital to the innovation and competitive performance of firms in contemporary business environments. Firms are increasingly relying on information technologies, including process, knowledge, and communication technologies, to enhance their agility. The purpose of this paper is to broaden understanding about the strategic role of IT by examining the nomological network of influences through which IT impacts firm performance. By drawing upon recent thinking in the strategy, entrepreneurship, and IT management literatures, this paper uses a multitheoretic lens to argue that information technology investments and capabilities influence firm performance through three significant organizational capabilities (agility, digital options, and entrepreneurial alertness) and strategic processes (capability-building, entrepreneurial action, and coevolutionary adaptation). We also propose that these dynamic capabilities and strategic processes impact the ability of firms to launch many and varied competitive actions and that, in turn, these competitive actions are a significant antecedent of firm performance. Through our theorizing, we draw attention to a significant and reframed role of IT as a digital options generator in contemporary firms.
3393 sitasi
en
Business, Computer Science
Open Innovation: The New Imperative for Creating and Profiting from Technology
H. Chesbrough
5161 sitasi
en
Engineering
Internet paradox. A social technology that reduces social involvement and psychological well-being?
Robert E. Kraut, Michael Patterson, Vicki Lundmark
et al.
4606 sitasi
en
Psychology, Medicine
Information Technology Adoption Across Time: A Cross-Sectional Comparison of Pre-Adoption and Post-Adoption Beliefs
Elena Karahanna, D. Straub, N. L. Chervany
3961 sitasi
en
Psychology, Computer Science
Membrane Technology and Applications
R. Baker
Overview of membrane science and technology membrane transport theory membrane and modules concentration polarization reverse osmosis ultrafiltration microfiltration gas separation pervaporation ion exchange membrane processes - electrodialysis carrier facilitated transport medical applications of membranes other membranes processed.
4308 sitasi
en
Materials Science
Why do people use information technology? A critical review of the technology acceptance model
Paul Legris, John Ingham, P. Collerette
4257 sitasi
en
Engineering, Computer Science
Understanding FACTS: Concepts and Technology of Flexible AC Transmission Systems
N. Hingorani, L. Gyugyi
4944 sitasi
en
Engineering, Computer Science