Dennis Ogiermann, Abdulaziz Mohamed, Luigi E. Perotti
et al.
Piezo1 ion channels are voltage-modulated, stretch-activated ion channels involved in a variety of important physiological and pathophysiological processes, as for example cardiovascular development and homeostasis. Since its discovery, it has been known that this type of ion channel desensitizes when exposed to stretch. However, recent experiments on Piezo1 ion channels have uncovered that their stretch response is qualitatively different when exposed to positive electrochemical driving forces, where the desensitization is reset. In this work, we propose a novel voltage-modulated mathematical model of Piezo1 based on a continuous-time Markov chain. We show that our Piezo1 model is able to quantitatively reproduce a wide range of experimental observations. Furthermore, we integrate our new ion channel model into the Mahajan-Shiferaw ventricular cardiomyocyte model to study the effect of electromechanical pacing at the cellular scale. This integrated cell model is able to qualitatively reproduce some aspects of the experimental observations regarding the rate-dependence of electromechanical pacing protocols. Our studies suggest that the Piezo1 ion channel is an important component that significantly contributes to the electromechanical coupled response of cardiomyocytes.
The distribution of particles inside hadronic jets produced in the decay of boosted W and Z bosons can be used to discriminate such jets from the continuum background. Given that a jet has been identified as likely resulting from the hadronic decay of a boosted W or Z boson, this paper presents a technique for further differentiating Z bosons from W bosons. The variables used are jet mass, jet charge, and a b-tagging discriminant. A likelihood tagger is constructed from these variables and tested in the simulation of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$W'\rightarrow WZ$$\end{document}W′→WZ for bosons in the transverse momentum range 200 GeV \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<p_\text {T}<$$\end{document}<pT< 400 GeV in \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\sqrt{s}=8$$\end{document}s=8 TeV pp collisions with the ATLAS detector at the LHC. For Z-boson tagging efficiencies of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\epsilon _Z=90$$\end{document}ϵZ=90, 50, and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$10\,\%$$\end{document}10%, one can achieve \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$W^+$$\end{document}W+-boson tagging rejection factors (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$1/\epsilon _{W^+}$$\end{document}1/ϵW+) of 1.7, 8.3 and 1000, respectively. It is not possible to measure these efficiencies in the data due to the lack of a pure sample of high \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p_\text {T}$$\end{document}pT, hadronically decaying Z bosons. However, the modelling of the tagger inputs for boosted W bosons is studied in data using a \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$t\bar{t}$$\end{document}tt¯-enriched sample of events in 20.3 fb\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${}^{-1}$$\end{document}-1 of data at \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\sqrt{s}=8$$\end{document}s=8 TeV. The inputs are well modelled within uncertainties, which builds confidence in the expected tagger performance.
Abstract Friction stir processing (FSP) is applied to modify the surface microstructure of cast AZ91 magnesium alloy. The electrochemical and hydrogen evolution measurements reveal that the corrosion rate of processed alloy in 3.5 wt% NaCl solution is significantly decreased. This is mainly attributed to the alteration of corrosion process induced by modification on the morphology and distribution of β-Mg17Al12 phase via FSP. It is originally reported that the formation of a compact and continuous β phase layer on the FSPed surface owing to the segregation of fine β phase effectively enhances the stability and passivity of corrosion product film.
We report a measurement of electron antineutrino oscillation from the Daya Bay Reactor Neutrino Experiment with nearly 4 million reactor ν[over ¯]_{e} inverse β decay candidates observed over 1958 days of data collection. The installation of a flash analog-to-digital converter readout system and a special calibration campaign using different source enclosures reduce uncertainties in the absolute energy calibration to less than 0.5% for visible energies larger than 2 MeV. The uncertainty in the cosmogenic ^{9}Li and ^{8}He background is reduced from 45% to 30% in the near detectors. A detailed investigation of the spent nuclear fuel history improves its uncertainty from 100% to 30%. Analysis of the relative ν[over ¯]_{e} rates and energy spectra among detectors yields sin^{2}2θ_{13}=0.0856±0.0029 and Δm_{32}^{2}=(2.471_{-0.070}^{+0.068})×10^{-3} eV^{2} assuming the normal hierarchy, and Δm_{32}^{2}=-(2.575_{-0.070}^{+0.068})×10^{-3} eV^{2} assuming the inverted hierarchy.
Marlene E Noack, Florian Tietjens, U. Latacz-Lohmann
After three decades of orienting agriculture towards ecological and social sustainability goals, the Ukraine war catapulted productivity and supply goals back onto the political agenda. Against this background, the present study aimed to establish how farmers and food consumers envision the future of agriculture. Application of Q-Methodology revealed three opinion groups for both farmers and consumers. In conclusion, the Ukraine war has not significantly shifted the balance between old and new societal demands on agriculture. Old discrepancies in the views of farmers and the non-farming population persist. While among the farmers surveyed the group of those who adhere to “business as usual” predominates, there is no group among the consumers surveyed who share this view. Rather, there is a majority desire among consumers for the sector to continue to be aligned with sustainability goals. Security of supply is only an issue for a small proportion of the consumers surveyed.
In this work, we consider an extension of symmetric teleparallel gravity, namely, f(Q) gravity, where the fundamental block to describe spacetime is the nonmetricity, Q. Within this formulation of gravitation, we perform an observational analysis of several modified f(Q) models using the redshift approach, where the f(Q) Lagrangian is reformulated as an explicit function of the redshift, f(z). Various different polynomial parametrizations of f(z) are proposed, including new terms which would allow for deviations from the Λ Cold Dark Matter model. Given a variety of observational probes, such as the expansion rate data from early type galaxies, type Ia supernovae, quasars, gamma ray bursts, baryon acoustic oscillations data, and cosmic microwave background distance priors, we have checked the validity of these models at the background level in order to verify if this new formalism provides us with plausible alternative models to explain the late time acceleration of the Universe. Indeed, this novel approach provides a different perspective on the formulation of observationally reliable alternative models of gravity.
Abstract This study proposes a cooperative multi-agent system for managing the energy of a stand-alone microgrid. The multi-agent system learns to control the components of the microgrid so as this to achieve its purposes and operate effectively, by means of a distributed, collaborative reinforcement learning method in continuous actions-states space. Stand-alone microgrids present challenges regarding guaranteeing electricity supply and increasing the reliability of the system under the uncertainties introduced by the renewable power sources and the stochastic demand of the consumers. In this article we consider a microgrid that consists of power production, power consumption and power storage units: the power production group includes a Photovoltaic source, a fuel cell and a diesel generator; the power consumption group includes an electrolyzer unit, a desalination plant and a variable electrical load that represent the power consumption of a building; the power storage group includes only the Battery bank. We conjecture that a distributed multi-agent system presents specific advantages to control the microgrid components which operate in a continuous states and actions space: For this purpose we propose the use of fuzzy Q-Learning methods for agents representing microgrid components to act as independent learners, while sharing state variables to coordinate their behavior. Experimental results highlight both the effectiveness of individual agents to control system components, as well as the effectiveness of the multi-agent system to guarantee electricity supply and increase the reliability of the microgrid.
Optical microresonators are essential to a broad range of technologies and scientific disciplines. However, many of their applications rely on discrete devices to attain challenging combinations of ultra-low-loss performance (ultrahigh Q) and resonator design requirements. This prevents access to scalable fabrication methods for photonic integration and lithographic feature control. Indeed, finding a microfabrication bridge that connects ultrahigh-Q device functions with photonic circuits is a priority of the microcavity field. Here, an integrated resonator having a record Q factor over 200 million is presented. Its ultra-low-loss and flexible cavity design brings performance to integrated systems that has been the exclusive domain of discrete silica and crystalline microcavity devices. Two distinctly different devices are demonstrated: soliton sources with electronic repetition rates and high-coherence/low-threshold Brillouin lasers. This multi-device capability and performance from a single integrated cavity platform represents a critical advance for future photonic circuits and systems. Using silicon nitride waveguides processed by plasma-enhanced chemical vapour deposition, full integration of ultrahigh-Q resonators with other photonic devices is now possible, representing a critical advance for future photonic circuits and systems.
In this paper, two new approaches have been presented to view q‐rung orthopair fuzzy sets. In the first approach, these can viewed as L‐fuzzy sets, whereas the second approach is based on the notion of orbits. Uncertainty index is the quantity HA(x)=1−(A+(x))q−(A−(x))q , which remains constant for all points in an orbit. Certain operators can be defined in q‐ROF sets, which affect HA(x) when applied to some q‐ROF sets. Operators Iδ , Mδ,ν , and Kδ,ν have been defined. It is studied that how these operators affect HA(x) when applied to some q‐ROF set A.
Traditional Chinese medicine (TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic “multicomponent and multitarget” feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as “herbal medicine” or “natural product”, and the pharmacopoeia quality monographs are actually chemical-markers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of “quality marker” (Q-marker), following the “property-effect-component” theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics, pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM. This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples.