Hasil untuk "cond-mat.soft"

Kevin Thomas, D. French, P. Hayes

E. S. de Villarreal, E. Kellis, W. Kraemer et al.

Kuang-Yung Lee, Ho-Ching Chang, C. Seah et al.

Myotonic dystrophy (Dystrophia Myotonica; DM) is the most common adult-onset muscular dystrophy and its brain symptoms seriously affect patients’ quality of life. It is caused by extended (CTG)n expansions at 3′-UTR of DMPK gene (DM type 1, DM1) or (CCTG)n repeats in the intron 1 of CNBP gene (DM type 2, DM2) and the sequestration of Muscleblind-like (MBNL) family proteins by transcribed (CUG)n RNA hairpin is the main pathogenic mechanism for DM. The MBNL proteins are splicing factors regulating posttranscriptional RNA during development. Previously, Mbnl knockout (KO) mouse lines showed molecular and phenotypic evidence that recapitulate DM brains, however, detailed morphological study has not yet been accomplished. In our studies, control (Mbnl1+/+; Mbnl2cond/cond; Nestin-Cre−/−), Mbnl2 conditional KO (2KO, Mbnl1+/+; Mbnl2cond/cond; Nestin-Cre+/−) and Mbnl1/2 double KO (DKO, Mbnl1ΔE3/ΔE3; Mbnl2cond/cond; Nestin-Cre+/−) mice were generated by crossing three individual lines. Immunohistochemistry for evaluating density and distribution of cortical neurons; Golgi staining for depicting the dendrites/dendritic spines; and electron microscopy for analyzing postsynaptic ultrastructure were performed. We found distributional defects in cortical neurons, reduction in dendritic complexity, immature dendritic spines and alterations of postsynaptic densities (PSDs) in the mutants. In conclusion, loss of function of Mbnl1/2 caused fundamental defects affecting neuronal distribution, dendritic morphology and postsynaptic architectures that are reminiscent of predominantly immature and fetal phenotypes in DM patients.

S. Yuan, X. F. Liu, O. Buzzi

This study focuses on the permeability of saturated Maryland clay, a natural expansive soil that can be found close to the University of Newcastle, Australia. Previous studies on this material cond...

M. Chelly, M. Fathloun, N. Chérif et al.

C. Meylan, D. Malatesta

P. Cormie, J. Mcbride, Grant O. McCaulley

Karel Proesmans, Daan Frenkel

We report a numerical study of thermo-osmotic slip, i.e. the particle flux induced by a thermal gradient along a solid-fluid interface. To facilitate comparison with theory, we consider a model of an ideal but viscous gas. We compare three numerical routes to obtain the slip coefficient: 1. by using the Onsager reciprocity relations 2. by using the appropriate Green-Kubo relation 3. via the excess enthalpy. The numerical results are found to be mutually consistent, and to agree with the theoretical prediction based on the assumption that hydrodynamics and thermodynamics are locally valid.

P. Comfort, Thomas Dos’Santos, Christopher Thomas et al.

Abstract Comfort, P, Dos'Santos, T, Thomas, C, McMahon, JJ, and Suchomel, TJ. An investigation into the effects of excluding the catch phase of the power clean on force-time characteristics during isometric and dynamic tasks: an intervention study. J Strength Cond Res 32(8): 2116–2129, 2018—The aims of this study were to compare the effects of the exclusion or inclusion of the catch phase during power clean (PC) derivatives on force-time characteristics during isometric and dynamic tasks, after two 4-week mesocycles of resistance training. Two strength matched groups completed the twice-weekly training sessions either including the catch phase of the PC derivatives (Catch group: n = 16; age 19.3 ± 2.1 years; height 1.79 ± 0.08 m; body mass 71.14 ± 11.79 kg; PC 1 repetition maximum [1RM] 0.93 ± 0.15 kg·kg−1) or excluding the catch phase (Pull group: n = 18; age 19.8 ± 2.5 years; height 1.73 ± 0.10 m; body mass 66.43 ± 10.13 kg; PC 1RM 0.91 ± 0.18 kg·kg−1). The Catch and Pull groups both demonstrated significant (p ⩽ 0.007, power ≥0.834) and meaningful improvements in countermovement jump height (10.8 ± 12.3%, 5.2 ± 9.2%), isometric mid-thigh pull performance (force [F]100: 14.9 ± 17.2%, 15.5 ± 16.0%, F150: 16.0 ± 17.6%, 16.2 ± 18.4%, F200: 15.8 ± 17.6%, 17.9 ± 18.3%, F250: 10.0 ± 16.1%,10.9 ± 14.4%, peak force: 13.7 ± 18.7%, 9.7 ± 16.3%), and PC 1RM (9.5 ± 6.2%, 8.4 ± 6.1%), before and after intervention, respectively. In contrast to the hypotheses, there were no meaningful or significant differences in the percentage change for any variables between groups. This study clearly demonstrates that neither the inclusion nor exclusion of the catch phase of the PC derivatives results in any preferential adaptations over two 4-week, in-season strength and power, mesocycles.

P. P. Gorman, R. Butler, Phillip J. Plisky et al.

V. Manzi, S. D'Ottavio, F. Impellizzeri et al.

D. Dwyer, T. Gabbett

J. S. Langer

Results of recent large-scale molecular dynamics simulations of dislocation-mediated solid plasticity are campared with predictions of the statistical thermodynamic theory of these phenomena. These computational and theoretical analyses are in substantial agreement with each other in both their descriptions of strain-rate dependent steady plastic flow and of a transient stress peak associated with initially small densities of dislocations. The comparisons between the numerical simulations and basic theory reveal inconsistencies in some conventional phenomenological descriptions of solid plasticity.

Kai-Wen Lan

Helena Andersson, M. Randers, Anja Heiner-Møller et al.

D. Hackett, N. Johnson, C. Chow

N. Souissi, H. Chtourou, Asma Aloui et al.

M. Reggiani, S. Quanz, M. Meyer et al.

We present L′- and J-band high-contrast observations of HD 169142, obtained with the Very Large Telescope/NACO AGPM vector vortex coronagraph and the Gemini Planet Imager, respectively. A source located at 0.″156 ± 0.″032 north of the host star (P.A. = 7.°4 ± 11.°3) appears in the final reduced L′ image. At the distance of the star (∼145 pc), this angular separation corresponds to a physical separation of 22.7 ± 4.7 AU, locating the source within the recently resolved inner cavity of the transition disk. The source has a brightness of L′ = 12.2 ± 0.5 mag, whereas it is not detected in the J band (J >13.8 mag). If its L′ brightness arose solely from the photosphere of a companion and given the J − L′ color constraints, it would correspond to a 28–32 MJupiter object at the age of the star, according to the COND models. Ongoing accretion activity of the star suggests, however, that gas is left in the inner disk cavity from which the companion could also be accreting. In this case, the object could be lower in mass and its luminosity enhanced by the accretion process and by a circumplanetary disk. A lower-mass object is more consistent with the observed cavity width. Finally, the observations enable us to place an upper limit on the L′-band flux of a second companion candidate orbiting in the disk annular gap at ∼50 AU, as suggested by millimeter observations. If the second companion is also confirmed, HD 169142 might be forming a planetary system, with at least two companions opening gaps and possibly interacting with each other.

Zahra Fazli, Ali Najafi

Based on a microscopic model, we develop a continuum description for a suspension of microscopic self propelled particles. With this continuum description we study the role of long-range interactions in destabilizing macroscopic ordered phases that are developed by short-range interactions. Long-wavelength fluctuations can destabilize both isotropic and also symmetry broken polar phase in a suspension of dipolar particles. The instabilities in a suspension of pullers (pushers) arise from splay (bend) fluctuations. Such instabilities are not seen in a suspension of quadrupolar particles.

S. Freitas, P. Mil‐homens