Pemphigoid diseases, such as bullous pemphigoid and epidermolysis bullosa acquisita, are severe organ-specific autoimmune diseases characterized by subepidermal skin blistering with increasing incidence in recent years. Although there have been substantial advances in understanding the pathomechanism of these diseases in the last decades, and the first specific therapy targeting the IL-4 and IL-13 pathway (dupilumab) has been approved by the FDA for bullous pemphigoid, further research is needed to eventually improve patient care. The characteristics of pemphigoid diseases include the formation of immune complexes and their recognition by Fcγ-receptors, as well as the development of a characteristic inflammatory cytokine microenvironment in the skin of the affected patients. Several non-receptor tyrosine kinases are involved in these events, playing a very important role in various signaling processes of immune cells. While certain Src-family kinases and the Syk tyrosine kinase play a very important role in signaling by Fcγ-receptors, JAK-family kinases are crucial players in the signaling of various cytokine receptors including, among others, the receptors of IL-4 and IL-13. The inhibition of these tyrosine kinases with small molecule inhibitors is an emerging therapeutic option in the treatment of an increasing number of immune-mediated diseases. Moreover, numerous studies have been conducted to examine proteins (including PLCγ2 and CARD9) in signal transduction following Fcγ-receptor activation in in vitro and in vivo experimental pemphigoid models, and an increasing number of case studies involving JAK inhibitors report the successful application of these drugs in various pemphigoid diseases. This review summarizes our current understanding of the therapeutically most promising tyrosine kinase signaling pathways in the pathogenesis of pemphigoid diseases.
Mirzayusup Rustambaev, Govkherjan Yuldasheva, Roza Azkhodjaeva
et al.
This article examines migrant victimization as a structural outcome of migration governance systems in developed countries. This study demonstrates that variations in enforcement intensity, labor-market segmentation, and procedural safeguards explain cross-regional differences in exposure to harm and access to justice, thereby reframing migrant victimization as a governance-dependent outcome rather than an individual-level vulnerability. Criminal victimization remains an under-explored facet of migration dynamics in developed countries, despite migrants’ overrepresentation as victims. Legal scholarship on this topic is exceptionally limited and primarily focused on refugee protection. The victimization of migrants at the hands of individuals, groups, and authorities is therefore examined with the aim of informing research agendas, policy debates, and international cooperation. The assessment proceeds in six steps. First, migrant victimization patterns are outlined according to crime type, drawing on the European Union, the United States, and the Global South as contextual frames. Next, legal definitions and protections are distinguished from victimization levels, with the international legal framework and the concept of safe access to justice underscored. Then, broader systemic drivers and comparative factors influencing victimization patterns are investigated, again through the lens of the European Union, North America, Western Europe, and Oceania. Fourth, considerations relevant to the study of migrant victimization are reviewed, including methodological challenges, variations in legal terminology, underlying fieldwork orientations, and the availability of prior research. This study argues that migrant victimization is best understood as a structural product of migration governance regimes, where enforcement design, legal stratification, and labor-market segmentation systematically shape exposure to harm and access to justice.
K.B. Makhanov, A.A. Khitakhunov, Z. Zhanaltay
et al.
This study analyzes changes in the spatial distribution of the rural population in post-Soviet Kazakhstan using census data from 1989 to 2024. While the total rural population has remained stable, over 27% of rural settlements have been eliminated during the sample period. Applying a proximity-based framework, the research shows that districts near major cities have experienced rural population growth and resilience, while remote areas face sharp decline and village abandonment. The findings reveal a selective spatial reorganization of the rural landscape, with populations concentrating in fewer, larger settlements located within accessible distance of major urban centers. These dynamics reflect not only rural decline, but also broader structural changes aligned with Kazakhstan’s ongoing urbanization. The observed patterns are closely tied to Kazakhstan’s broader urbanization process in a way that cities have become a key factor shaping rural viability, reinforcing demographic and spatial reorganization across the country. Overall, the findings align with broader research on rural transformation, providing a detailed case of how proximity to urban centers has shaped rural population patterns and settlement structures in post-Soviet Kazakhstan over time, reflecting enduring trends of spatial concentration and selective territorial development.
Keywords: rural population, population geography, urbanization, migration, post-Soviet Kazakhstan.
This qualitative exploratory investigation provides a review of relevant EU and national legislation on official translations in Hungary and Poland. In relation to the legal instruments, the following research questions are raised: 1) How does different legislation on official translations affect the Polish community in Hungary? 2) How is the legislation on official translations reflected in civil registration procedures in Hungary? To operationalize the research questions, a sample source of official Polish and Hungarian websites was created. The collected legal instruments and official websites were systematized, examined, and compared using documentary research (Scott and Marshall 2005: 164) and qualitative document analysis (Bowen 2009: 32). The study concludes that Hungarian registry offices and Polish authorities mostly rely on national legislation when defining translation requirements on their websites. Furthermore, the results suggest that notable differences may exist between rules set by laws and real-life practices, which can potentially create uncertainty among persons engaged in mobility.
The study examines the evolution of the proportions of the aristocrats in a well-defined group within the political elite in Dualist-era Hungary, the lord-lieutenant corps, and the reasons behind it. It explores the territorial distribution of aristocratic lord-lieutenants and the role of land ownership in this context. This involves investigating the extent to which the land structure correlated with the proportion of aristocratic lord-lieutenants. It also analyzes the extent of land ownership among these lord-lieutenants, the size and temporal changes of estates and how their land holdings correlated with the counties they were appointed to lead. The proportion of nobility in the lord-lieutenants’ ranks during the Dual Monarchy era, although showing some fluctuations, significantly decreased. Not only did their distribution differ over time, but there were also significant regional variations. The proportion of aristocrats did not show any significant correlation with the land structure (in terms of overall large estates, aristocratic large estates, or estates over 100 acres), the proportion of different ethnicities, or the spatial distribution of the titled persons. The aristocratic lord-lieutenants’ landholdings underwent however significant changes during the dualist period. While at the beginning of the era, one-third of them had landholdings over 10,000 acres, by the turn of the century, only a few of them retained such extensive estates, and increased the number of smaller landowners. The lord-lieutenants still formed the most conservative group within the political-administrative elite, and they largely preserved their homogeneity.
We present a new family of exact solutions of dissipative fireball hydrodynamics for arbitrary bulk and shear viscosities. The main property of these solutions is a spherically symmetric, Hubble flow field. The motivation of this paper is mostly academic: we apply non-relativistic kinematics for simplicity and clarity. In this limiting case, the theory is particularly clear: the non-relativistic Navier–Stokes equations describe the dissipation in a well-understood manner. From the asymptotic analysis of our new exact solutions of dissipative fireball hydrodynamics, we can draw a surprising conclusion: this new class of exact solutions of non-relativistic dissipative hydrodynamics is asymptotically perfect.
This study reveals the behavior of resorcinol, phloroglucinol and pyrogallol in several non-aqueous solvents (acetonitrile, acetone, dimethyl sulphoxide, dimethyl formamide, nitrobenzene, nitromethane, dichloromethane, methanol). The voltammetric curves showed that the results obtained with the outlined compounds depend strongly on the solvent used. Resorcinol and phloroglucinol undergo some fouling during their electrooxidation while pyrogallol gave reproducible voltammograms in many solvents. The optimal solvent was chosen then for the determination of pyrogallol in cooking oil taking into consideration the antifouling, miscibility, permittivity and viscosity effects with steady-state voltammetry by using microelectrode.
The colloidal stability of sulfate (SL) and polyimidazolium-modified sulfate (SL-IP-2) latex particles was studied in an ionic liquid (IL) of ethylammonium nitrate (EAN) and its water mixtures. Aggregation rates were found to vary systematically as a function of the IL-to-water ratio. Repulsive electrostatic interactions between particles dominated at low IL concentrations, while they were significantly screened at intermediate IL concentrations, leading to destabilization of the dispersions. When the IL concentration was further increased, the aggregation of latex particles slowed down due to the increased viscosity and finally, a striking stabilization was observed in the IL-rich regime close to the pure IL solvent. The latter stabilization is due to the formation of IL layers at the interface between particles and IL, which induce repulsive oscillatory forces. The presence of the added salt in the system affected differently the structure of the interfaces around SL and SL-IP-2 particles. The sign of the charge and the composition of the particle surfaces were found to be the most important parameters affecting the colloidal stability. The nature of the counterions also plays an important role in the interfacial properties due to their influence on the structure of the IL surface layers. No evidence was observed for the presence of long-range electrostatic interactions between the particles in pure ILs. The results indicate that the presence of even low concentrations of water and salt in the system (as undesirable impurities) can strongly alter the interfacial structure and thus, the aggregation mechanism in particle IL dispersions.
Adrian Tantau, András Puskás-Tompos, Costel Stanciu
et al.
Consumer behaviour in the energy field is playing a more important role in the new approach dominated by the proliferation of renewable energy sources. In this new context, the grid has to balance the intermittent and uncertain renewable energy generated, and find solutions, also, on the consumer side for increasing the stability and reliability of the energy system. The main de-mand response solutions are price and incentive based, but there is a need to identify the main factors which can influence their efficiency due to the fact that there is a lack of knowledge about the preferences of consumers. The main goal of this article is to identify the main demand response solutions and the related key factors which influence the participation of consumers in demand response programs and may contribute to the spread of renewable energy sources. For this research, semi-structured interviews were organised with experts in energy from Romania, Hungary and Serbia, as well as workshops with experts in energy, and an online survey with customers for electricity. This article reduces the gap between the results of technical studies, related in demand response programs, and their practical implementations, where the consumer behaviour and its social dimensions are neglected even though, in reality, they are playing the main role. The results suggest that the consumer’s participation in demand response programs is highly influenced by different aspects related to the promotion of the renewable energy and the reduction of CO<sub>2</sub> emissions and the global warming impact.
Ildikó Línzembold, Dalma Czett, Katalin Böddi
et al.
Flavonoids and carotenoids possess beneficial physiological effects, such as high antioxidant capacity, anticarcinogenic, immunomodulatory, and anti-inflammatory properties, as well as protective effects against UV light. The covalent coupling of hydrophobic carotenoids with hydrophilic flavonoids, such as daidzein and chrysin, was achieved, resulting in new amphipathic structures. 7-Azidohexyl ethers of daidzein and chrysin were prepared in five steps, and their azide-alkyne [4 + 2] cycloaddition with pentynoates of 8′-apo-β-carotenol, zeaxanthin, and capsanthin afforded carotenoid−flavonoid conjugates. The trolox-equivalent antioxidant capacity against ABTS<sup>•+</sup> radical cation and self-assembly of the final products were examined. The 1:1 flavonoid−carotenoid hybrids generally showed higher antioxidant activity than their parent flavonoids but lower than that of the corresponding carotenoids. The diflavonoid hybrids of zeaxanthin and capsanthin, however, were found to exhibit a synergistic enhancement in antioxidant capacities. ECD (electronic circular dichroism) and UV-vis analysis of zeaxanthin−flavonoid conjugates revealed that they form different optically active J-aggregates in acetone/water and tetrahydrofuran/water mixtures depending on the solvent ratio and type of the applied aprotic polar solvent, while the capsanthin derivatives showed no self-assembly. The zeaxanthin bis-triazole conjugates with daidzein and with chrysin, differing only in the position of a phenolic hydroxyl group, showed significantly different aggregation profile upon the addition of water.
Gábor Bíró, Gergely Gábor Barnaföldi, Gábor Papp
et al.
The non-extensive statistical description of the identified final state particles measured in high energy collisions is well-known by its wide range of applicability. However, there are many open questions that need to be answered, including but not limited to, the question of the observed mass scaling of massive hadrons or the size and multiplicity dependence of the model parameters. This latter is especially relevant, since currently the amount of available experimental data with high multiplicity at small systems is very limited. This contribution has two main goals: On the one hand we provide a status report of the ongoing tuning of the soon-to-be-released HIJING++ Monte Carlo event generator. On the other hand, the role of multiplicity dependence of the parameters in the non-extensive hadronization model is investigated with HIJING++ calculations. We present cross-check comparisons of HIJING++ with existing experimental data to verify its validity in our range of interest as well as calculations at high-multiplicity regions where we have insufficient experimental data.
Eszter Prépost,1 Zoltán Tóth,1 David S Perlin,2 Rudolf Gesztelyi,3 Gábor Kardos,1 Renátó Kovács1,4 Fruzsina Nagy,1 Lajos Forgács,1 László Majoros11Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; 2Public Health Research Institute, New Jersey Medical School-Rutgers, Newark, NJ, USA; 3Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; 4Faculty of Pharmacy, University of Debrecen, Debrecen, HungaryBackground: Echinocandins are the first-line therapy for treatment of invasive Candida infections, but the mortality rate remains high, calling for novel strategies. Giving single larger echinocandin doses infrequently is an alternative regimen. Our aim was to test this novel approach in a neutropenic murine model.Materials and methods: We compared the in vivo efficacy of single 10 and 40 mg/kg of caspofungin (2.5× and 10× the normal humanized dose) to that of the same cumulative doses of daily 2 and 8 mg/kg doses for 5 days against 2 each of wild-type C. albicans and C. dubliniensis as well as echinocandin resistant C. albicans. As a comparator, we tested daily 1 mg/kg amphotericin B.Results: In lethality experiments, all caspofungin and amphotericin B regimens improved survival against wild-type C. albicans and C. dubliniensis clinical isolates (P<0.0001) and decreased the mean fungal kidney burdens of both species compared to controls. However, fungal kidney burden decreases were not always statistically significant, especially with single 10 or 40 mg/kg caspofungin doses. Amphotericin B was the least active drug against wild-type C. albicans. Against echinocandin-resistant strains, monodose 40 mg/kg caspofungin and 1 mg/kg of daily amphotericin B were effective in lethality experiments. Although, significant kidney CFU decreases were never found, except for amphotericin B against one of the isolates (p<0.05 at day 3 and p<0.001 at day 6).Conclusion: Single 40 mg/kg caspofungin and 1 mg/kg amphotericin B proved to be effective in the lethality experiments against wild-type and echinocandin-resistant C. albicans and wild-type C. dubliniensis. This was not always shown regarding fungal tissue burdens. Single caspofungin doses used in mice in this study are attainable in humans as well, suggesting a potential place of this dosing strategy not only in prevention but also in curative treatment of evolved invasive Candida infections.Keywords: humanized caspofungin doses, intermittent dosing regimen of echinocandins, Candida albicans complex, fungal tissue burden, echinocandin resistance
Varga Veronika, Bélafi-Bakó Katalin, Vozik Dávid
et al.
Itaconic acid is an organic acid produced mainly for non-food purposes. It can be manufactured by biotechnological synthesis using various strains which results in the salt form of the acid. In this work, the separation of sodium itaconate by electrodialysis was studied. Homopolar cation- and anion-selective membranes were applied and the module was operated under a constant voltage. The transport of the acid was followed by on-line ultraviolet and visible absorption spectroscopy, where the detector was installed in the system. The experiments with models of aqueous solutions confirmed that the technique is suitable for the effective recovery of itaconic acid.
Jaime Franco, Florencia Sardi, László Szilágyi
et al.
With the aim to develop compounds able to target multiple metabolic pathways and, thus, to lower the chances of drug resistance, we investigated the anti-trypanosomal activity and selectivity of a series of symmetric diglycosyl diselenides and disulfides. Of 18 compounds tested the fully acetylated forms of di-β-D-glucopyranosyl and di-β-D-galactopyranosyl diselenides (13 and 15, respectively) displayed strong growth inhibition against the bloodstream stage of African trypanosomes (EC50 0.54 μM for 13 and 1.49 μM for 15) although with rather low selectivity (SI < 10 assayed with murine macrophages). Nonacetylated versions of the same sugar diselenides proved to be, however, much less efficient or completely inactive to suppress trypanosome growth. Significantly, the galactosyl (15), and to a minor extent the glucosyl (13), derivative inhibited glucose catabolism but not its uptake. Both compounds induced redox unbalance in the pathogen. In vitro NMR analysis indicated that diglycosyl diselenides react with glutathione, under physiological conditions, via formation of selenenylsulfide bonds. Our results suggest that non-specific cellular targets as well as actors of the glucose and the redox metabolism of the parasite may be affected. These molecules are therefore promising leads for the development of novel multitarget antitrypanosomal agents. Keywords: Glutathione, Redox biosensor, Selenosugar, Trypanosome inhibition, Selenium NMR
Bence Mátyás, Gabriela Bautista, Máté Szarka
et al.
Databases which store and manage long-term scientific information related to life science are used to store huge amount of quantitative attributes. Introduction of a new entity attribute requires modification of the existing data tables and the programs that use these data tables. A feasible solution is increasing the virtual data tables while the number of screens remains the same. The main objective of the present study was to introduce a logic called Joker Tao (JT) which provides universal data storage for cloud-based databases. It means all types of input data can be interpreted as an entity and attribute at the same time, in the same data table.
The Standard Model is one of the main intellectual achievements for about the last 50 years, a result of many theoretical and experimental studies. In this lecture a brief introduction to the electroweak part of the Standard Model is given. Since the Standard Model is a quantum field theory, some aspects for understanding of quantization of abelian and non-abelian gauge theories are also briefly discussed. It is demonstrated how well the electroweak Standard Model works in describing a large variety of precise experimental measure- ments at lepton and hadron colliders.
The final product of a post-volcanic activity is the exhalation of low-temperature (<100°C) gases containing mostly carbon dioxide. The phenomenon is called mofettes, which are often used for therapeutic treatments in the form of dry CO2 spas. Along its pathway to the surface, the deep origin gas also intakes different radon isotopes from the rocks and soils; therefore, the risks associated with radon exposures should also be a concern. In this work, we have found that the 222Rn activity concentration in the mofette gas of Mátraderecske is particularly high; it is in the order of 200 kBq·m−3. However, owing to the carefully designed flow pattern of mofette gas and fresh air, the radon level is about 1 kBq·m−3 at the breath level of the staff, accompanying the treatment, which is the radon reference level for workers in Hungary. We have also found that in this dry spa, radon is a good tracer of CO2; therefore, it can be used to monitor the CO2 distribution in the treatment pools.
Bacterial blight is one of the most serious diseases affecting Persian walnut (Juglans regia L.). Susceptibility to this disease was evaluated by artificial inoculation in an in vitro experiment for cultivars developed in Hungary and for selections from Transylvania. Thirty pieces of immature fruit of 11 walnut cultivars and 10 selections were inoculated by punction using a suspension containing a mixture of Xaj-isolates of controlled virulence. As control, a moderate resistant (mR) ‘Pedro’ and a highly susceptible (hS) ‘Milotai intenzív’ cultivars were used. After ten days the diameter of the necrotic area around the inoculation points was measured and the disease rate (DR) was noted. For the calculation of indexes it was taken the structure of the lesions (diffuse or defined margin) into consideration. None of the 21 cultivars/selections analysed were found to be hardly resistant, although all of them showed a higher degree of resistance than the susceptible control (‘Milotai intenzív’). The majority of the analysed cultivars fit into the moderate susceptible (mS) and moderate resistant (mR) group. ‘Milotai kései’ and SZEN-10, had a notable reaction as considered to be moderate resistant (mR), showed a similar degree of resistance compared to the control cultivar ‘Pedro’. It was concluded that these cultivars, based on their resistance to Xanthomonas arboricola pv. juglandis, could be proposed as resistance gene sources, as well as for production purposes in the environmental conditions of the Carpathian Basin.
J. Austin Harris, W. Raphael Hix, Merek A. Chertkow
et al.
We investigate core-collapse supernova (CCSN) nucleosynthesis in polar axisymmetric simulations using the multidimensional radiation hydrodynamics code CHIMERA. Computational costs have traditionally constrained the evolution of the nuclear composition in CCSN models to, at best, a 14-species $α$-network. Such a simplified network limits the ability to accurately evolve detailed composition, neutronization and the nuclear energy generation rate. Lagrangian tracer particles are commonly used to extend the nuclear network evolution by incorporating more realistic networks in post-processing nucleosynthesis calculations. Limitations such as poor spatial resolution of the tracer particles, estimation of the expansion timescales, and determination of the "mass-cut" at the end of the simulation impose uncertainties inherent to this approach. We present a detailed analysis of the impact of these uncertainties on post-processing nucleosynthesis calculations and implications for future models.