Abstract Anxiety and depression are significant concerns among antenatal women in Bangladesh. Despite the critical need for tailored mental health care in health facilities, studies on these symptoms in this demographic remain lacking. Therefore, our study aimed to assess the levels, distribution, and associated factors of depressive and anxiety symptoms and their co-occurrence among women seeking antenatal care at a public healthcare facility in Bangladesh. We conducted a cross-sectional study between May 2024, and June 2024, among women seeking antenatal care (ANC) care in Durgapur Upazila Health Complex, a primary-level public health facility in Bangladesh. Among 640 women who received ANC care, 638 participated in the study. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9), and anxiety symptoms were assessed by the Generalized Anxiety Disorder-7 (GAD-7). Bivariate and multivariable logistic regression were conducted to determine factors contributing to depressive and anxiety symptoms. About 39% of participants had depressive symptoms and 50% had anxiety symptoms, with 26% experiencing both simultaneously. No participants had severe overall depressive or anxiety symptoms. PHQ-9 data indicated half experienced daily fatigue, while GAD-7 data showed over half experienced daily nervousness and two-fifths had daily fears. Women in the second and third trimesters had 43% (aOR: 0.57, 95% CI: 0.36–0.89) and 58% (aOR: 0.42, 95% CI: 0.24–0.71) lower odds of depressive symptoms compared to those in the first trimester respectively. Women with 11 years or more education had 40% (aOR: 0.60, 95% CI: 0.38–0.94) lower odds of anxiety. Additionally, women in the second and third trimesters had 40% (aOR: 0.60, 95% CI: 0.37–0.97) and 49% (aOR: 0.59, 95% CI: 0.29–0.91) lower likelihood of co-occurrence compared to those in the first trimester and women with 6–10 years of education had 48% (aOR: 0.52, 95% CI: 0.34–0.79) and those with 11 or more years had 52% (aOR: 0.48, 95% CI: 0.29–0.81) lower likelihood of co-occurring depressive and anxiety symptoms compared to women with 5 years or less education. Our study found a high prevalence of depressive and anxiety symptoms among antenatal care seekers, with notable co-occurrence of these conditions. Given these findings, there is an urgent need for targeted mental health support for these women, especially those in their first trimester and those with limited education.
The city of Medan as the center of government as well as the capital of North Sumatra has an iconic shape that can be developed into three-dimensional souvenir products, such as the shape of historic buildings, past transportation, typical food, and also traditional clothing. However, the iconic forms of the city of Medan are still under-explored to be developed as a reference for three-dimensional souvenir products. This creation aims to examine the potential of the iconic forms of the city of Medan that can be developed as a reference for three-dimensional souvenir products using clay flour. The creation method used refers to Graham Wallas' theory of creativity, where the creation process starts from preparation, incubation, illumination and verification. The results of the creation in the form of souvenir products made from clay are five, each work entitled clay post office, clay water tower, clay bentor Medan, clay mie gomak, and clay malay wedding couple doll. Overall, the results of the creation show that the iconic shapes of the city of Medan have great potential to be used as references in the creation of clay souvenir products that are original, have aesthetic qualities, and are exclusive as tourism souvenirs.Keywords: iconic shapes, souvenir products, clay. AbstrakKota Medan sebagai pusat pemerintahan sekaligus ibu kota Sumatera Utara memiliki bentuk ikonik yang dapat dikembangkan menjadi produk cenderamata tiga dimensional, seperti bentuk bangunan bersejarah, transportasi masa lalu, makanan khas, dan juga busana tradisional. Namun, bentuk-bentuk ikonik kota Medan masih kurang dieksplor untuk dikembangkan sebagai rujukan produk cenderamata tiga dimensional. Penciptaan ini bertujuan untuk mengkaji potensi bentuk-bentuk ikonik kota Medan yang dapat dikembangkan sebagai rujukan produk cenderamata tiga dimensional menggunakan bahan tepung clay. Metode penciptaan yang digunakan mengacu pada teori kreativitas Graham Wallas, dimana proses penciptaan dimulai dari persiapan (preparation), inkubasi (incubation), illuminasi (illumination) dan verifikasi (verivication). Hasil penciptaan berupa produk cenderamata berbahan clay yaitu sebanyak lima, masing-masing karya berjudul clay post office, clay water tower, clay bentor Medan, clay mie gomak, dan clay malay wedding couple doll. Secara keseluruhan, hasil penciptaan menunjukkan bahwa bentuk-bentuk ikonik kota Medan memiliki potensi besar dijadikan rujukan dalam penciptaan produk cenderamata berbahan clay yang orisinal, memiliki kualitas estetis, eksklusif sebagai cenderamata pariwisata.Kata Kunci: bentuk ikonik, produk cenderamata, clay. Authors:Rosnani CS : Universitas Negeri MedanZulkifli : Universitas Negeri Medan References:Bangun, N. B., & Silaban, B. (2017). Analisis Cenderamata Kerajinan Ukir Kayu Di Pasar Buah Berastagi Ditinjau Dari Prinsip-Prinsip Desain. Gorga: Jurnal Seni Rupa, 6(2), 125-140.Budiman, K. (2011). Semiotika Visual: Konsep, Isu, dan Problem Ikonisitas. Yogyakarta: Jalasutra.Damajanti, I. (2013). Psikologi Seni. Bandung: PT Kiblat Buku Utama.Kamal, R. (2019). Pemanfaatan Sisik Ikan untuk Kerajinan Souvenir. Jurnal Ilmiah Mahasiswa Pendidikan Kesejahteraan Keluarga, 4(2).Restiana, V., & Lutfiati, D. (2020). Pemanfaatan Clay Tepung Sebagai Aksesoris Rambut. JBC: Journal of Beauty and Cosmetology, 1(2), 13-24.Saragih, L. A., & Zulkifli, Z. (2018). Analisis Kerajinan Souvenir Diorama Berbahan Limbah pada Pengrajin Dikraf Berdasarkan Prinsip-Prinsip Desain. Gorga: Jurnal Seni Rupa, 8(1), 272-278.Setiasih, N. W., & Setiawan, G. H. (2020). IRT Kerajinan Tangan Clay Oleh-Oleh Khas Bali. WIDYABHAKTI Jurnal Ilmiah Populer, 3(1), 1-5.Sihombing, R. D., & Erdansyah, F. (2020). Penerapan WPAP dengan Corel Draw pada Gantungan Kunci Berbahan Resin di Kelompok UKM Sumatera Utara. Gorga: Jurnal Seni Rupa, 9(2), 430-437.Siregar, S. R., & Wiratma, S. (2016). Penerapan Ikon Medan sebagai Cindramata pada Baju Kaos dengan Teknik Sablon Kuas Ditinjau dari Prinsip-Prinsip Estetika. Gorga: Jurnal Seni Rupa, 5(2).Suryani, S., & Misgiya, M. (2017). Tinjauan Elemen Hias Kerajinan Keramik Menggunakan Cat Tembok di Sentra Kerajinan “Karya Cipta Lestari” Tanjung Morawa, Deli Serdang Tahun 2016. Gorga: Jurnal Seni Rupa, 6(2), 158-176.Yumielda, V. D., & Zulkifli, Z. (2022). Kajian Semiotika Peirce Pada Karya Seni Lukis di Sanggar Seni Rupa Simpassri. Visual Heritage: Jurnal Kreasi Seni dan Budaya, 5(1), 28-38.Zulkifli, Z., Ibrahim, A., Pasaribu, M., & Amal, B. K. (2021). The Revitalization of Iconic Shapes through the Creation of Relief Dimensional Paintings as Tourism Software Products (Case Study in Medan City, Indonesia). Randwick International of Social Science Journal, 2(4), 450-460.
CS Mohanty, Chaitanya Kodange, Sourabh Bhutani
et al.
Introduction: Metabolic syndrome refers to a clustering of metabolic risk factors including central obesity, glucose intolerance, low high-density lipoprotein (HDL) cholesterol, high triglycerides, and hypertension. In the naval setting, some occupational characteristics of submariners such as long work hours, lack of physical activity, disturbed circadian rhythm, and stress have a negative influence on the health status of individuals. It is worth speculating that the occupational factors might also influence the development of clinical conditions related to a greater cardiovascular risk such as metabolic syndrome. Materials and Methods: A cross-sectional study was conducted over a period of 2 years. Submariners posted onboard an operational submarine for the past 1 year in the age group 18–45 years and willing to participate in the study were included in the study. Shore-based personnel in the similar age group posted in shore billet for at least 1 year were taken as control. Universal sampling technique was used for selection of subjects. A total of 250 submariners and 250 age-matched shore-based naval personnel were enrolled in the study. The study group was assessed for prevalence and risk factors of metabolic syndrome using national cholesterol education program adult treatment panel III criteria. Results: The mean age of submariners and shore-based personnel was 29.7 ± 4.9 years and 29.3 ± 5.3 years, respectively (P = 0.77). 20.8% of the submariners had a body mass index (BMI) more than 25 kg/m2 compared to 16.8% in the shore-based group. BMI was higher for the submariners compared to shore-based personnel but the difference was not statistically significant (P = 0.097). The prevalence of systolic and diastolic hypertension in submariners was 16.8%–15.2% compared to 11.6% and 10.4% in shore-based group (P > 0.05). Fasting blood sugar levels >100 mg/dl was observed in 14% submariners compared to 8.4% shore-based personnel (P > 0.05). Triglyceride levels of >150 mg/dl was observed in 22.4% submariners compared to 16% shore-based personnel (P = 0.085). HDL level of <40 mg/dl was observed in 13.6% submariners compared to 8.8% in shore-based personnel (P = 0.12). The prevalence of risk factors such as alcohol consumption (34% vs. 26%) and smoking (3.6% vs. 1.1%) and low physical activity (30% vs. 21.2%) were higher in the submariners as compared to the shore-based personnel though the difference was not statistically significant. The prevalence of metabolic syndrome was 9.2% in submariners compared to 6.4% in shore-based personnel. The difference was not statistically significant (P = 0.31). The overall prevalence of metabolic syndrome among submariners was higher than shore-based personnel but it was less compared to studies conducted on the Indian general population in urban areas. Conclusion: There is a need for preventive and/or therapeutic programs focused on cardiovascular and metabolic health for submariners.
Abstract Peripheral blood cells from nine patients with B-chronic lymphocytic leukemia (B-CLL) were treated in vitro with bryostatin 1 (a macrocyclic lactone derived from a marine invertebrate). Like the phorbol ester 12- 0-tetradecanoyl-phorbol 13-acetate (TPA), bryostatin 1 activates protein kinase C (PKC), which plays a central role in the phosphatidylinositol signal transduction pathway. The effects of bryostatin 1 alone and in combination with TPA or with the calcium mobilizing ionophore A23187 were assessed by morphological appearance, cell adherence and aggregation, RNA and DNA synthesis, and immunoglobulin (Ig) production. While eight of nine B-CLL cultures remained proliferatively inert, bryostatin 1 could effectively trigger activation and differentiation of B-CLL cells in all cases as inferred by the induction of morphological changes, RNA synthesis, and monotypic Ig production. Addition of calcium ionophore A23187 to bryostatin 1- exposed cells resulted in significantly increased values for RNA synthesis and Ig production and in the acquisition of plasmacytoid morphology. Bryostatin 1 and the dual signal of bryostatin 1 plus A23187 mimicked the stimulatory action of TPA and the combination of TPA plus A23187, respectively. Overall, bryostatin 1 was less active than equivalent concentrations of TPA. This lesser efficacy may, however, reflect a quantitative rather than qualitative difference. Bryostatin 1 partially antagonized TPA-mediated effects on B-CLL cells suggesting different modes of action by the two activators. These studies indicate that bryostatin 1 has effective differentiation- inducing properties on B-CLL cells that can differentiation-inducing properties on B-CLL cells that can be accentuated by a calcium ionophore.
Peripheral blood cells from nine patients with B-chronic lymphocytic leukemia (B-CLL) were treated in vitro with bryostatin 1 (a macrocyclic lactone derived from a marine invertebrate). Like the phorbol ester 12- 0-tetradecanoyl-phorbol 13-acetate (TPA), bryostatin 1 activates protein kinase C (PKC), which plays a central role in the phosphatidylinositol signal transduction pathway. The effects of bryostatin 1 alone and in combination with TPA or with the calcium mobilizing ionophore A23187 were assessed by morphological appearance, cell adherence and aggregation, RNA and DNA synthesis, and immunoglobulin (Ig) production. While eight of nine B-CLL cultures remained proliferatively inert, bryostatin 1 could effectively trigger activation and differentiation of B-CLL cells in all cases as inferred by the induction of morphological changes, RNA synthesis, and monotypic Ig production. Addition of calcium ionophore A23187 to bryostatin 1- exposed cells resulted in significantly increased values for RNA synthesis and Ig production and in the acquisition of plasmacytoid morphology. Bryostatin 1 and the dual signal of bryostatin 1 plus A23187 mimicked the stimulatory action of TPA and the combination of TPA plus A23187, respectively. Overall, bryostatin 1 was less active than equivalent concentrations of TPA. This lesser efficacy may, however, reflect a quantitative rather than qualitative difference. Bryostatin 1 partially antagonized TPA-mediated effects on B-CLL cells suggesting different modes of action by the two activators. These studies indicate that bryostatin 1 has effective differentiation- inducing properties on B-CLL cells that can differentiation-inducing properties on B-CLL cells that can be accentuated by a calcium ionophore.