Abstract Hereditary angioedema (HAE), an autosomal dominant disease that may be fatal in the larynx and gastrointestinal tract, can affect the skin and mucosal surfaces. Indium tin oxide-polyethyleneterephthalate (ITO-PET) electrode based on biosensor is put up in this study to detect C1-Inhibitor (C1-INH). The ITO-PET electrodes were surface have undergone a cleaning procedure. Hydroxylation (NH4OH, H2O2, H2O) was applied to the electrode surfaces. The ITO-PET electrode surfaces were then treated with 3-Aminopropyltrimethoxysilane (3-APTES). Crosslinking with glutaraldehyde was the following step. The concentration of 3-APTES, the concentration of anti-C1-INH, and the length of time that C1-INH was incubated were the ideal conditions. It conducted immobilization, optimization, and analysis stlod udies using techniques such as cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The linear range, repeatability, reproducibility, regeneration studies, single frequency studies (SFI), and storage of life of the biosensor were carried out in characterization studies. It was discovered that the linear range of the immunosensor was 2 fg/mL to 1500 fg/mL. It discovered the biosensor's (11 weeks) storage life. The LOD value calculated as a result of the study is 0.23 fg/mL and the LOQ value is 0.26 fg/mL. The biosensor was tested using the (SWV) square wave voltammetry technique (0–1.5 V, equal time: 2, frequency: 25 Hz, pulse size: 25 mV). The interaction between antibody C1-INH and C1-INH antigens was observed using a single frequency technique (SFI).The final stage was testing the biosensor on commercial serum studies.
Chemical technology, Physical and theoretical chemistry
Ruziev I. Kh, N. MukhamadievA., S. KuldoshevaL.
et al.
This article explores modern methods of teaching physical and colloidal chemistry in higher education. Innovative approaches aimed at increasing the effectiveness of learning and active interaction of students with educational material are highlighted. Methods are considered that promote the development of critical thinking, the practical application of theoretical knowledge and the formation of skills in physical and colloidal chemistry. Attention is paid to the use of modern educational technologies, interactive forms of learning and student collaboration in the educational process.
In this study, a novel composite polymer electrolyte consist of 8-arm block liquid crystalline copolymer (8-PEG-MALC), 8-arm poly(ethylene glycol) (8-PEG), polyethylene (glycol) diacrylate (PEGDA) and bistrifluoromethanesulfonimide lithium salt (LiTFSI) was prepared successfully. The branching 8-PEG ensure high ionic conductivity of the all solid state polymer, crosslinking agent PEGDA endow good mechanical property, and 8-arm block liquid crystalline copolymer with a birefringent mesogens to tune the morphology of the composite polymer electrolytes. The polymer electrolytes can form a transparent and flexible film with nanoscale microphase separation structure, which creating well-defined ion conducting channels. The electrochemical properties of composite polymer electrolytes are analyzed and the highest ionic conductivity reaches 6.2 × 10-5 S cm-1 at room temperature after annealed from fixed temperature. It also displays high temperature stability up to 150°C, which is higher than traditional electrolytes. More intriguingly, the assembled LiFePO4/Li cells using the composite polymer electrolytes exhibit good charge/discharge cycles at 95°C. The good electrochemical properties, temperature stability and bendability of the composite polymer electrolytes indicate it potentially as a very promising material for all-solid-state flexible lithium ion batteries.
Industrial electrochemistry, Physical and theoretical chemistry
The affinity of biomolecules, such as peptides and proteins, with inorganic surfaces, is a fundamental topic in biotechnology and bionanotechnology. Amino acids are often used as "model" bits of peptides or proteins for studying their properties in different environments and/or developing functional surfaces. Despite great demand for knowledge about amino acid interactions with metal oxide surfaces, studies on the issue represent a fragmentary picture. In this paper, we describe amino acid adsorption on nanocrystalline anatase systematically at uniform conditions. Analysis of the Gibbs free adsorption energy indicated how the aliphatic, aromatic, polar, and charged side chain groups affect the binding affinity of the amino acids. Thermodynamic features of the l-amino acid adsorption receive thorough interpretation with calculated molecular descriptors. Theoretical modeling shows that amino acids complex with TiO2 nanoparticles as zwitterions via ammonium group.
The unprecedented global warming process causes the shrinking of sea ice in the polar region every year; hence, in order to withstand the harsh environment of this region as well as to reduce the transportation cost, a large number of high-strength steels are required to build icebreakers. The main objective of the present study was to investigate the corrosion behavior of both water-quenched and air-cooled low- carbon steels in 3.5% artificial NaCl solution. It was found that after the corrosion of lamellar ferrites in pearlites and martensites, the remaining cementites aggravated the galvanic corrosion and the pitting corrosion in the matrix. Further, dislocation and the presence of large fractions of cementite in the matrix deteriorated the corrosion resistance property of the directly water-quenched sample. However, the aircooling process significantly improved the corrosion resistance behavior of the sample steel.
Industrial electrochemistry, Physical and theoretical chemistry