Semantic Scholar Open Access 2020 116 sitasi

Biocatalysis in drug discovery and development.

A. Fryszkowska Paul N. Devine

Abstrak

Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is beginning to transform chemical synthesis in the pharmaceutical industry. This review presents recent examples of the creative use of biocatalysis to enable drug discovery and development. We illustrate how increased access to novel biotransformations and the rise of cascade biocatalysis allowed fundamentally new syntheses of novel medicines, representing progress toward more sustainable pharmaceutical manufacturing. Finally, we describe the opportunities and challenges the industry must address to ensure the reduction to practice of biotechnological innovations to develop new therapies in a faster, more economical, and environmentally benign way.

Topik & Kata Kunci

Medicine Engineering

Penulis (2)

A. Fryszkowska

Paul N. Devine

Format Sitasi

APA MLA BibTeX

Fryszkowska, A., Devine, P.N. (2020). Biocatalysis in drug discovery and development.. https://doi.org/10.1016/j.cbpa.2020.01.012

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Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 116×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.cbpa.2020.01.012
Akses: Open Access ✓