DOAJ Open Access 2021

C-type lectin binds envelope protein of white spot syndrome virus and induces antiviral peptides in red swamp crayfish

Jie Gao Bing-Jie Ren Ping-Ping Liu Xian-Wei Wang

Abstrak

Previously a pattern recognition receptor (PRR) from kuruma shrimp was found able to recognize bacterial glycans by the C-type lectin domain (CTLD) and to interact with Jak/Stat receptor Domeless by the interleukin-like coiled coil (cc) region. In the current study, its homolog, namely Pc-ccCL, was found important in the antiviral response in red swamp crayfish Procambarus clarkii. This PRR plays a role by inhibiting white spot syndrome virus (WSSV) infection in a Jak/Stat dependent manner. The CTLD can bind the viral envelope protein VP28, while the cc region determines the dependence on Jak/Stat pathway. Two anti-lipopolysaccharides factors were identified as the downstream antiviral peptides. This study provides new insights into the antiviral signaling in invertebrates. Furthermore, the mechanism that a PRR recognizes virus and directly activates Jak/Stat pathway and antiviral-effector expression represents a simple but fast antiviral strategy in crustaceans.

Topik & Kata Kunci

Zoology

Penulis (4)

Jie Gao

Bing-Jie Ren

Ping-Ping Liu

Xian-Wei Wang

Format Sitasi

APA MLA BibTeX

Gao, J., Ren, B., Liu, P., Wang, X. (2021). C-type lectin binds envelope protein of white spot syndrome virus and induces antiviral peptides in red swamp crayfish. https://doi.org/10.1016/j.fsirep.2021.100027

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.1016/j.fsirep.2021.100027
Akses: Open Access ✓