arXiv Open Access 2025

On Assessing Overall Survival (OS) in Oncology Studies

Jason C. Hsu

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Abstrak

In assessing Overall Survival (OS) in oncology studies, it is essential for the efficacy measure to be Logic-respecting, for otherwise patients may be incorrectly targeted. This paper explains, while Time Ratio (TR) is Logic-respecting, Hazard Ratio (HR) is not Logic-respecting. With Time Ratio (TR) being recommended, a smooth transitioning strategy is suggested. The conclusion states: Logicality requires, and Subgroup Mixable Estimation (SME) delivers, an efficacy assessment for the overall population within the range of minimum and maximum efficacy in the subgroups, no matter how outcome is measured, whichever logic-respecting efficacy measure is chosen, the same efficacy assessment regardless of how subgroups are stratified.

Topik & Kata Kunci

stat.ME stat.AP

Penulis (1)

Jason C. Hsu

Format Sitasi

APA MLA BibTeX

Hsu, J.C. (2025). On Assessing Overall Survival (OS) in Oncology Studies. https://arxiv.org/abs/2510.07122

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Informasi Jurnal

Tahun Terbit: 2025
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓