Likelihood-Based Heterogeneity Inference Reveals Non-Stationary Effects in Biohybrid Cell-Cargo Transport
Abstrak
Variability of motility behavior in populations of microbiological agents is a ubiquitous phenomenon even in the case of genetically identical cells. Accordingly, passive objects introduced into such biological systems and driven by them will also exhibit heterogeneous motion patterns. Here, we study a biohybrid system of passive beads driven by active ameboid cells and use a likelihood approach to estimate the heterogeneity of the bead dynamics from their discretely sampled trajectories. We showcase how this approach can deal with information-scarce situations and provides natural uncertainty bounds for heterogeneity estimates. Using these advantages we particularly uncover that the heterogeneity in the system is time-dependent.
Topik & Kata Kunci
Penulis (5)
Jan Albrecht
Lara S. Dautzenberg
Manfred Opper
Carsten Beta
Robert Großmann
Akses Cepat
- Tahun Terbit
- 2025
- Bahasa
- en
- Sumber Database
- arXiv
- Akses
- Open Access ✓