Rheology of mixed motor ensembles
Abstrak
The rheology of biological cells is not only determined by their cytoskeletal networks, but also by the molecular motors that crosslink and contract them. Recently it has been found that the assemblies of myosin II molecular motors in non-muscle cells are mixtures of fast and slow motor variants. Using computer simulations and an analytical mean field theory of a crossbridge model for myosin II motors, here we show that such motor ensembles effectively behave as active Maxwell elements. We calculate storage and loss moduli as a function of the model parameters and show that the rheological properties cross over from viscous to elastic as one increases the ratio of slow to fast motors. This suggests that cells tune their mechanical properties by regulating the composition of their myosin assemblies.
Topik & Kata Kunci
Penulis (2)
Justin Grewe
Ulrich S. Schwarz
Akses Cepat
- Tahun Terbit
- 2020
- Bahasa
- en
- Sumber Database
- arXiv
- Akses
- Open Access ✓