arXiv Open Access 2016

Signatures of protein structure in the cooperative gating of mechanosensitive ion channels

Osman Kahraman William S. Klug Christoph A. Haselwandter

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Abstrak

Membrane proteins deform the surrounding lipid bilayer, which can lead to membrane-mediated interactions between neighboring proteins. Using the mechanosensitive channel of large conductance (MscL) as a model system, we demonstrate how the observed differences in protein structure can affect membrane-mediated interactions and cooperativity among membrane proteins. We find that distinct oligomeric states of MscL lead to distinct gateway states for the clustering of MscL, and predict signatures of MscL structure and spatial organization in the cooperative gating of MscL. Our modeling approach establishes a quantitative relation between the observed shapes and cooperative function of membrane~proteins.

Topik & Kata Kunci

q-bio.BM cond-mat.soft physics.bio-ph q-bio.SC

Penulis (3)

Osman Kahraman

William S. Klug

Christoph A. Haselwandter

Format Sitasi

APA MLA BibTeX

Kahraman, O., Klug, W.S., Haselwandter, C.A. (2016). Signatures of protein structure in the cooperative gating of mechanosensitive ion channels. https://arxiv.org/abs/1611.00693

Akses Cepat

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Informasi Jurnal

Tahun Terbit: 2016
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓