arXiv Open Access 2007

Point Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53

Chi-Tin Shih Stephan Roche Rudolf A. Römer

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Abstrak

We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective single-strand or double-strand tight-binding models which simulate hole propagation along the DNA, a statistical analysis of charge transmission modulations associated with all possible point mutations is performed. We find that in contrast to non-cancerous mutations, mutation hotspots tend to result in significantly weaker {\em changes of transmission properties}. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.

Topik & Kata Kunci

q-bio.GN cond-mat.soft q-bio.QM

Penulis (3)

Chi-Tin Shih

Stephan Roche

Rudolf A. Römer

Format Sitasi

APA MLA BibTeX

Shih, C., Roche, S., Römer, R.A. (2007). Point Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53. https://arxiv.org/abs/0708.3181

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Informasi Jurnal

Tahun Terbit: 2007
Bahasa: en
Sumber Database: arXiv
Akses: Open Access ✓