Hasil untuk "artificial intelligence"

Rohan Gupta, Devesh Srivastava, Mehar Sahu et al.

Drug designing and development is an important area of research for pharmaceutical companies and chemical scientists. However, low efficacy, off-target delivery, time consumption, and high cost impose a hurdle and challenges that impact drug design and discovery. Further, complex and big data from genomics, proteomics, microarray data, and clinical trials also impose an obstacle in the drug discovery pipeline. Artificial intelligence and machine learning technology play a crucial role in drug discovery and development. In other words, artificial neural networks and deep learning algorithms have modernized the area. Machine learning and deep learning algorithms have been implemented in several drug discovery processes such as peptide synthesis, structure-based virtual screening, ligand-based virtual screening, toxicity prediction, drug monitoring and release, pharmacophore modeling, quantitative structure–activity relationship, drug repositioning, polypharmacology, and physiochemical activity. Evidence from the past strengthens the implementation of artificial intelligence and deep learning in this field. Moreover, novel data mining, curation, and management techniques provided critical support to recently developed modeling algorithms. In summary, artificial intelligence and deep learning advancements provide an excellent opportunity for rational drug design and discovery process, which will eventually impact mankind. The primary concern associated with drug design and development is time consumption and production cost. Further, inefficiency, inaccurate target delivery, and inappropriate dosage are other hurdles that inhibit the process of drug delivery and development. With advancements in technology, computer-aided drug design integrating artificial intelligence algorithms can eliminate the challenges and hurdles of traditional drug design and development. Artificial intelligence is referred to as superset comprising machine learning, whereas machine learning comprises supervised learning, unsupervised learning, and reinforcement learning. Further, deep learning, a subset of machine learning, has been extensively implemented in drug design and development. The artificial neural network, deep neural network, support vector machines, classification and regression, generative adversarial networks, symbolic learning, and meta-learning are examples of the algorithms applied to the drug design and discovery process. Artificial intelligence has been applied to different areas of drug design and development process, such as from peptide synthesis to molecule design, virtual screening to molecular docking, quantitative structure–activity relationship to drug repositioning, protein misfolding to protein–protein interactions, and molecular pathway identification to polypharmacology. Artificial intelligence principles have been applied to the classification of active and inactive, monitoring drug release, pre-clinical and clinical development, primary and secondary drug screening, biomarker development, pharmaceutical manufacturing, bioactivity identification and physiochemical properties, prediction of toxicity, and identification of mode of action.

Bas H. M. van der Velden, Hugo J. Kuijf, K. Gilhuijs et al.

With an increase in deep learning-based methods, the call for explainability of such methods grows, especially in high-stakes decision making areas such as medical image analysis. This survey presents an overview of explainable artificial intelligence (XAI) used in deep learning-based medical image analysis. A framework of XAI criteria is introduced to classify deep learning-based medical image analysis methods. Papers on XAI techniques in medical image analysis are then surveyed and categorized according to the framework and according to anatomical location. The paper concludes with an outlook of future opportunities for XAI in medical image analysis.

W. Bi, A. Hosny, M. Schabath et al.

Judgement, as one of the core tenets of medicine, relies upon the integration of multilayered data with nuanced decision making. Cancer offers a unique context for medical decisions given not only its variegated forms with evolution of disease but also the need to take into account the individual condition of patients, their ability to receive treatment, and their responses to treatment. Challenges remain in the accurate detection, characterization, and monitoring of cancers despite improved technologies. Radiographic assessment of disease most commonly relies upon visual evaluations, the interpretations of which may be augmented by advanced computational analyses. In particular, artificial intelligence (AI) promises to make great strides in the qualitative interpretation of cancer imaging by expert clinicians, including volumetric delineation of tumors over time, extrapolation of the tumor genotype and biological course from its radiographic phenotype, prediction of clinical outcome, and assessment of the impact of disease and treatment on adjacent organs. AI may automate processes in the initial interpretation of images and shift the clinical workflow of radiographic detection, management decisions on whether or not to administer an intervention, and subsequent observation to a yet to be envisioned paradigm. Here, the authors review the current state of AI as applied to medical imaging of cancer and describe advances in 4 tumor types (lung, brain, breast, and prostate) to illustrate how common clinical problems are being addressed. Although most studies evaluating AI applications in oncology to date have not been vigorously validated for reproducibility and generalizability, the results do highlight increasingly concerted efforts in pushing AI technology to clinical use and to impact future directions in cancer care.

Andreas Holzinger, G. Langs, H. Denk et al.

Explainable artificial intelligence (AI) is attracting much interest in medicine. Technically, the problem of explainability is as old as AI itself and classic AI represented comprehensible retraceable approaches. However, their weakness was in dealing with uncertainties of the real world. Through the introduction of probabilistic learning, applications became increasingly successful, but increasingly opaque. Explainable AI deals with the implementation of transparency and traceability of statistical black‐box machine learning methods, particularly deep learning (DL). We argue that there is a need to go beyond explainable AI. To reach a level of explainable medicine we need causability. In the same way that usability encompasses measurements for the quality of use, causability encompasses measurements for the quality of explanations. In this article, we provide some necessary definitions to discriminate between explainability and causability as well as a use‐case of DL interpretation and of human explanation in histopathology. The main contribution of this article is the notion of causability, which is differentiated from explainability in that causability is a property of a person, while explainability is a property of a system

Tanveer Ahmad, Dongdong Zhang, Chao Huang et al.

Abstract The energy industry is at a crossroads. Digital technological developments have the potential to change our energy supply, trade, and consumption dramatically. The new digitalization model is powered by the artificial intelligence (AI) technology. The integration of energy supply, demand, and renewable sources into the power grid will be controlled autonomously by smart software that optimizes decision-making and operations. AI will play an integral role in achieving this goal. This study focuses on the use of AI techniques in the energy sector. This study aims to present a realistic baseline that allows researchers and readers to compare their AI efforts, ambitions, new state-of-the-art applications, challenges, and global roles in policymaking. We covered three major aspects, including: i) the use of AI in solar and hydrogen power generation; (ii) the use of AI in supply and demand management control; and (iii) recent advances in AI technology. This study explored how AI techniques outperform traditional models in controllability, big data handling, cyberattack prevention, smart grid, IoT, robotics, energy efficiency optimization, predictive maintenance control, and computational efficiency. Big data, the development of a machine learning model, and AI will play an important role in the future energy market. Our study’s findings show that AI is becoming a key enabler of a complex, new and data-related energy industry, providing a key magic tool to increase operational performance and efficiency in an increasingly cut-throat environment. As a result, the energy industry, utilities, power system operators, and independent power producers may need to focus more on AI technologies if they want meaningful results to remain competitive. New competitors, new business strategies, and a more active approach to customers would require informed and flexible regulatory engagement with the associated complexities of customer safety, privacy, and information security. Given the pace of development in information technology, AI and data analysis, regulatory approvals for new services and products in the new Era of digital energy markets can be enforced as quickly and efficiently as possible.

Caiming Zhang, Yang Lu

Sofiat Abioye, Lukumon O. Oyedele, L. Àkànbí et al.

The growth of the construction industry is severely limited by the myriad complex challenges it faces such as cost and time overruns, health and safety, productivity and labour shortages. Also, construction industry is one the least digitized industries in the world, which has made it difficult for it to tackle the problems it currently faces. An advanced digital technology, Artificial Intelligence (AI), is currently revolutionising industries such as manufacturing, retail

M. Javaid, Abid Haleem, I. Khan et al.

Hassan Khosravi, S. B. Shum, Guanliang Chen et al.

Marium Malik, M. Tariq, Maira Kamran et al.

M. C. Laupichler, Alexandra Aster, Jana Schirch et al.

Yuchen Jiang, Xiang Li, Hao Luo et al.

The study of artificial intelligence (AI) has been a continuous endeavor of scientists and engineers for over 65 years. The simple contention is that human-created machines can do more than just labor-intensive work; they can develop human-like intelligence. Being aware or not, AI has penetrated into our daily lives, playing novel roles in industry, healthcare, transportation, education, and many more areas that are close to the general public. AI is believed to be one of the major drives to change socio-economical lives. In another aspect, AI contributes to the advancement of state-of-the-art technologies in many fields of study, as helpful tools for groundbreaking research. However, the prosperity of AI as we witness today was not established smoothly. During the past decades, AI has struggled through historical stages with several winters. Therefore, at this juncture, to enlighten future development, it is time to discuss the past, present, and have an outlook on AI. In this article, we will discuss from a historical perspective how challenges were faced on the path of revolution of both the AI tools and the AI systems. Especially, in addition to the technical development of AI in the short to mid-term, thoughts and insights are also presented regarding the symbiotic relationship of AI and humans in the long run.

Mario Krenn, R. Pollice, S. Guo et al.

An oracle that correctly predicts the outcome of every particle physics experiment, the products of every possible chemical reaction or the function of every protein would revolutionize science and technology. However, scientists would not be entirely satisfied because they would want to comprehend how the oracle made these predictions. This is scientific understanding, one of the main aims of science. With the increase in the available computational power and advances in artificial intelligence, a natural question arises: how can advanced computational systems, and specifically artificial intelligence, contribute to new scientific understanding or gain it autonomously? Trying to answer this question, we adopted a definition of ‘scientific understanding’ from the philosophy of science that enabled us to overview the scattered literature on the topic and, combined with dozens of anecdotes from scientists, map out three dimensions of computer-assisted scientific understanding. For each dimension, we review the existing state of the art and discuss future developments. We hope that this Perspective will inspire and focus research directions in this multidisciplinary emerging field. Scientific understanding is one of the main aims of science. This Perspective discusses how advanced computational systems, and artificial intelligence in particular, can contribute to driving scientific understanding.

A. Zador, Sean Escola, B. Richards et al.

One of the ambitions of computational neuroscience is that we will continue to make improvements in the field of artificial intelligence that will be informed by advances in our understanding of how the brains of various species evolved to process information. To that end, here the authors propose an expanded version of the Turing test that involves embodied sensorimotor interactions with the world as a new framework for accelerating progress in artificial intelligence. Neuroscience has long been an essential driver of progress in artificial intelligence (AI). We propose that to accelerate progress in AI, we must invest in fundamental research in NeuroAI. A core component of this is the embodied Turing test, which challenges AI animal models to interact with the sensorimotor world at skill levels akin to their living counterparts. The embodied Turing test shifts the focus from those capabilities like game playing and language that are especially well-developed or uniquely human to those capabilities – inherited from over 500 million years of evolution – that are shared with all animals. Building models that can pass the embodied Turing test will provide a roadmap for the next generation of AI.

M. M. Civaner, Y. Uncu, Filiz Bulut et al.

Background As the information age wanes, enabling the prevalence of the artificial intelligence age; expectations, responsibilities, and job definitions need to be redefined for those who provide services in healthcare. This study examined the perceptions of future physicians on the possible influences of artificial intelligence on medicine, and to determine the needs that might be helpful for curriculum restructuring. Methods A cross-sectional multi-centre study was conducted among medical students country-wide, where 3018 medical students participated. The instrument of the study was an online survey that was designed and distributed via a web-based service. Results Most of the medical students perceived artificial intelligence as an assistive technology that could facilitate physicians’ access to information (85.8%) and patients to healthcare (76.7%), and reduce errors (70.5%). However, half of the participants were worried about the possible reduction in the services of physicians, which could lead to unemployment (44.9%). Furthermore, it was agreed that using artificial intelligence in medicine could devalue the medical profession (58.6%), damage trust (45.5%), and negatively affect patient-physician relationships (42.7%). Moreover, nearly half of the participants affirmed that they could protect their professional confidentiality when using artificial intelligence applications (44.7%); whereas, 16.1% argued that artificial intelligence in medicine might cause violations of professional confidentiality. Of all the participants, only 6.0% stated that they were competent enough to inform patients about the features and risks of artificial intelligence. They further expressed that their educational gaps regarding their need for “knowledge and skills related to artificial intelligence applications” (96.2%), “applications for reducing medical errors” (95.8%), and “training to prevent and solve ethical problems that might arise as a result of using artificial intelligence applications” (93.8%). Conclusions The participants expressed a need for an update on the medical curriculum, according to necessities in transforming healthcare driven by artificial intelligence. The update should revolve around equipping future physicians with the knowledge and skills to effectively use artificial intelligence applications and ensure that professional values and rights are protected.

A. Fedyk, James Hodson, Natalya Khimich et al.

How does artificial intelligence (AI) impact audit quality and efficiency? We explore this question by leveraging a unique dataset of more than 310,000 detailed individual resumes for the 36 largest audit firms to identify audit firms’ employment of AI workers. We provide a first look into the AI workforce within the auditing sector. AI workers tend to be male and relatively young and hold mostly but not exclusively technical degrees. Importantly, AI is a centralized function within the firm, with workers concentrating in a handful of teams and geographic locations. Our results show that investing in AI helps improve audit quality, reduces fees, and ultimately displaces human auditors, although the effect on labor takes several years to materialize. Specifically, a one-standard-deviation change in recent AI investments is associated with a 5.0% reduction in the likelihood of an audit restatement, a 0.9% drop in audit fees, and a reduction in the number of accounting employees that reaches 3.6% after three years and 7.1% after four years. Our empirical analyses are supported by in-depth interviews with 17 audit partners representing the eight largest U.S. public accounting firms, which show that (1) AI is developed centrally; (2) AI is widely used in audit; and (3) the primary goal for using AI in audit is improved quality, followed by efficiency.

D. Gašević, G. Siemens, Shazia Sadiq

N. Yüksel, H. R. Börklü, H. K. Sezer et al.

Jasmin Praful Bharadiya