Conductive hydrogels that simultaneously exhibit high mechanical robustness, reliable electrical conductivity, and interfacial adhesion are highly desirable for flexible sensing applications; however, achieving these properties in a single system remains challenging due to intrinsic structure–property trade-offs. Herein, a multifunctional conductive hydrogel (ASP hydrogel) is developed based on a polyacrylamide (PAM)/sodium alginate (SA) double-network architecture using a gallic acid (GA)–Fe<sup>3+</sup>–pyrrole (Py) coupling strategy. In this design, GA provides metal-coordination sites for Fe<sup>3+</sup>, while Fe<sup>3+</sup> simultaneously serves as an oxidant to trigger the in situ polymerization of pyrrole, enabling the homogeneous integration of polypyrrole (PPy) conductive networks within the hydrogel matrix. The resulting ASP hydrogel exhibits a markedly enhanced fracture strength of 2.95 MPa compared with PAM (0.26 MPa) and PAM–SA (0.22 MPa) hydrogels, together with stable electrical conductivity and reproducible strain-dependent electrical responses. Moreover, the introduction of dynamic metal–phenolic coordination and hydrogen-bonding interactions endows the hydrogel with intrinsic self-healing capability and strong adhesion to diverse substrates. Rather than relying on simple filler incorporation, this work demonstrates an integrated network design that balances mechanical strength, conductivity, and adhesion, providing a versatile material platform for flexible strain sensors and wearable electronics.
Title: Solidifying the Ephemeral: The Alchemy of the Liquid CanvasArtist-Researcher: Giuseppe Rametta Giusirames1. Professional BiographyGiuseppe Rametta Giusirames is an Italian artist and material researcher whose practice lies at the intersection of contemporary art and chemical experimentation. Rejecting standardized industrial media, he develops proprietary material mixes, treating the creation of the "base" as an integral part of the creative act.His most significant breakthrough is a specialized technique designed to "solidify the sea," transforming the fluid and ephemeral nature of marine environments into a permanent, solid canvas. Through his work, he explores themes of environmental memory, the alchemy of matter, and the tension between natural flux and artistic preservation. His studio is a continuous laboratory where traditional aesthetic values meet innovative material engineering.2. Research Statement This research focuses on the chemical and poetic transformation of natural and volatile elements. The core of the project is the stabilization of fluid environments through a unique technical process.Material Hybridization: Sea, Smoke, and AntisepsisMy investigation extends beyond seawater to the stabilization of other volatile and antiseptic substances: * Seawater: Capturing the essence of the ocean to create a structural canvas. * Amuchina (Chlorine-based solutions): Integrating antiseptic elements to explore the tension between hygiene, sterilization, and nature. * Smoke: Attempting to fix the weightlessness of air and fire into a solid surface.By inventing these material compounds, I investigate how artistic practice can "fix" a moment of environmental flux without losing its vital energy.3. The Poetics of Painting on the Sea For me, painting is not a gesture performed on a surface, but a dialogue with an element. To "paint on the sea" means to accept the fluid’s rebellion before fixing it into eternity.It is a poetic act of translation: capturing the rhythm of waves, the transparency of the water, and the ghost-like presence of smoke within the physical constraints of a canvas. This practice transforms the artwork into a relic of a moment that was, by nature, impossible to grasp.4. Visual Documentation Per le tre foto che mi hai inviato, usa queste descrizioni: * Figure 1 - Organic Textures: A demonstration of how the proprietary mix creates an organic "skin," allowing pigments to settle in a cellular structure. * Figure 2 - Marine Diffusion: The interaction between color and the solidified sea base, mimicking the natural movement of underwater currents. * Figure 3 - The Molecular Membrane: A macro view of the stabilized material. This transparent, alveolate structure proves the successful transition from liquid/volatile states to a solid artistic medium. keywords: Artistic Research, Material Science in Art, Solidification, Proprietary Compounds, Seawater Stabilization, Smoke and Volatile Matter, Chemical Alchemy, Environmental Memory, Fluid Dynamics, Artistic Intelligence
Kais Iben Nassar, Sílvia Soreto Teixeira, Manuel P. F. Graça
Spintronics, an interdisciplinary field merging magnetism and electronics, has attracted considerable interest due to its potential to transform data storage, logic devices, and emerging quantum technologies. Among the materials explored for spintronic applications, metal oxide nanostructures synthesized via sol–gel methods offer a unique combination of low-cost processing, structural tunability, and defect-mediated magnetic control. This comprehensive review presents a critical overview of recent advances in sol–gel-derived magnetic oxides, such as Co-doped ZnO, La<sub>1−x</sub>Sr<sub>x</sub>MnO<sub>3</sub>, Fe<sub>3</sub>O<sub>4</sub>, NiFe<sub>2</sub>O<sub>4</sub>, and transition-metal-doped TiO<sub>2</sub>, with emphasis on synthesis strategies, the dopant distribution, and room-temperature ferromagnetic behavior. Key spintronic functionalities, including magnetoresistance, spin polarization, and magnetodielectric effects, are systematically examined. Importantly, this review differentiates itself from the prior literature by explicitly connecting sol–gel chemistry parameters to spin-dependent properties and by offering a comparative analysis of multiple oxide systems. Critical challenges such as phase purity, reproducibility, and defect control are also addressed. This paper concludes by outlining future research directions, including green synthesis, the integration with 2D materials, and machine-learning-assisted optimization. Overall, this work bridges sol–gel synthesis and spintronic material design, offering a roadmap for advancing next-generation oxide-based spintronic devices.
<i>Hypericum perforatum</i> L. (H.P.) is a species with a well-documented history of use in wound healing practices across the globe. The objective of this study was twofold: firstly, to evaluate the in vivo efficacy of liposomal in situ gel formulations in wound healing, both clinically and histopathologically, and secondly, to determine the physicochemical characterization of liposomal in situ gel formulations. The in vitro studies will be assessed in terms of particle size, zeta potential, release kinetics, rheological behaviors, and antioxidant and antimicrobial properties. The in vivo studies will be evaluated in clinical animal experiments and pathology studies. The in-situ hydrogel formulations were prepared using the physical cross-linking method with Poloxamer 188, Poloxamer 407, Ultrez 21, and Ultrez 30. The liposome formulations phospholipid 90H and lipoid S100 were prepared using the thin film solvent evaporation method. The antioxidant activity of the samples was evaluated through in vitro studies employing the DPPH antioxidant activity, ABTS+ test, and FRAP test. The antimicrobial activity of the samples was evaluated through the determination of MIC and MBC values employing the 96-well plate method. In vivo, 36 male New Zealand rabbits aged 32–36 weeks were utilized, with six rabbits in each group. The groups were composed of six distinct groups, including conventional and in situ gel liposome formulations of HHPM, three different commercial preparations, and a control group (<i>n</i> = 6). The HHPM-LG8 formulation developed in this study was found to be applicable in terms of all its properties. The new liposomal in situ hydrogel formulation demonstrated notable wound healing activity, a result that was supported by the formulation itself.
The paper presents data on fluoride concentrations in the Dniester River and Dubasari reservoir, the waters of which are used for multiple purposes, including use as a source of drinking water. Water samples were taken seasonally from 2011 to 2024. The concentration of fluoride ions was determined photometrically using an acidic solution of zirconyl chloride and alizarin red S. Fluorides ranged from 0.05 to 1.07 mg/L in the Dniester sector from Naslavcea (entry point of the river into the territory of the Republic of Moldova) to Dubasari reservoir, and from 0.05 to 0.93 mg/L downstream of the Dubasari dam. They varied from 0.02 to 0.95 mg/L in the reservoir waters. Mean annual concentrations of fluorides in the entire Dniester River, including the Dubasari reservoir, oscillated from 0.15±0.07 to 0.81±0.10 mg/L during the study period. Concentrations below 0.5 mg/L were recorded in 76.6% of analysed water samples. Higher concentrations were observed during periods of low waters, when the river was predominantly supplied by groundwater. In most cases, due to the modified regime of the Dniester resulting from the river regulation, no clear seasonal dynamics were recorded.
This study addresses the unclear mechanisms by which preferential flow channels (PFCs), formed during long-term waterflooding, affect nano-gel microsphere (NGM) flooding efficiency, utilizing CMG reservoir numerical simulation software. A dynamic evolution model of PFCs was established by coupling CROCKTAB (stress–porosity hysteresis) and CROCKTABW (water saturation-driven permeability evolution), and the deep flooding mechanism of NGMs (based on their gel properties such as swelling, elastic deformation, and adsorption, and characterized by a “plugging-migration-replugging” process) was integrated. The results demonstrate that neglecting PFCs overestimates recovery by 8.7%, while NGMs reduce permeability by 33% (from 12 to 8 mD) in high-conductivity zones via “bridge-plug-filter cake” structures, diverting flow to low-permeability layers (+33% permeability, from 4.5 to 6 mD). Field application in a Chang 6 tight reservoir (permeability variation coefficient 0.82) confirms a >10-year effective period with 0.84% incremental recovery (from 7.31% to 8.15%) and favorable economics (ROI ≈ 10:1), providing a theoretical and engineering framework for gel-based conformance control in analogous reservoirs.
River sediments have attracted increasing attention as alternative raw materials for sustainable cementitious materials due to their abundant availability and silica–alumina-rich composition. In this study, a systematic literature search was conducted in Web of Science and Google Scholar using combinations of the keywords “river sediment,” “cementitious materials,” “activation,” and “pozzolanic activity,” covering publications up to July 2025. In addition, a citation network tool (Connected Papers) was employed to trace related works and ensure comprehensive coverage of emerging studies. This review systematically examines the properties of river sediments from diverse regions, along with activation and modification techniques such as alkali/acid activation, thermal calcination, and mechanical milling. Their applications in various cementitious systems are analyzed, with mix design models compared to elucidate the effects of replacing fine aggregates, coarse aggregates, and cement on workability, strength, and durability. Multi-scale characterization via XRD, FTIR, and TG-DSC reveals the mechanisms of C–S–H and C–A–S–H gel formation, pore refinement, and interfacial transition zone densification. The review highlights three key findings: (1) moderate sediment replacement (20–30%) improves strength without compromising flowability; (2) alkali–water glass activation and calcination at 600–850 °C effectively enhance pozzolanic activity; and (3) combining the minimum paste thickness theory with additives such as water reducers, fibers, or biochar enables high-performance and low-carbon concrete design. This review provides a comprehensive theoretical foundation and technical pathway for the high-value utilization of river sediments, carbon reduction in concrete, and sustainable resource recycling.
Kai Müller, Christian Scherdel, Stephan Vidi
et al.
This study explores the impact of pore volume distribution on the structural, thermal, and mechanical properties of spinodal phase-separated silica gels synthesized with poly(ethylene oxide) as a phase-separating agent. By systematically varying gelation temperatures between 20 and 60 °C, we investigate how reaction kinetics influence the resulting pore architecture, thermal conductivity, and elasticity. Nitrogen sorption, mercury intrusion porosimetry, and SEM analysis reveal a transformation from a bimodal pore structure at low temperatures, featuring interconnected macropores, to a predominantly mesoporous network with loss of bimodality. This shift in the diameter of the macropores significantly impacts the thermal insulation properties of the gels as thermal conductivity decreases from 68 to 27 mW (m·K)<sup>−1</sup> due to reduced macroporosity, enhanced mesoporosity, and the Knudsen effect. Mechanical testing revealed a substantial decline in Young’s modulus with increasing gelation temperature. These changes are attributed to the interplay of mesoscale structural differences and density variations, driven by increasing gelation temperatures. While higher temperatures lead to reduced strut thickness and the loss of interconnected macropores, the substantial decline in Young’s modulus highlights the critical role of mesoscale structural integrity in maintaining mechanical stability. The findings underscore the importance of an optimized pore volume distribution in tailoring pore structure and performance characteristics, providing a pathway for optimizing silica gels for applications in thermal insulation, filtration, and catalysis.
This study utilized the Schiff base reaction as a chemical bonding method to successfully graft 2-aminopyridine onto oxidized sodium alginate, resulting in the formation of modified sodium alginate (OSM). Subsequently, the OSM/polyacrylic acid (OSM/PAA) hydrogel was synthesized via a thermally initiated free radical polymerization process and evaluated as an adsorbent for the removal of heavy metal ions from wastewater. Comprehensive characterization of the prepared samples was performed using FT-IR, SEM, and TGA. The influence of temperature, pH, adsorbent dosage, contact time, and heavy metal ion concentration on the adsorption capacity of the OSM/PAA adsorbent in simulated wastewater was thoroughly investigated. Additionally, a detailed analysis of the adsorption thermodynamics, kinetics, and mechanisms was conducted. Experimental results indicated that at 25 °C, pH 5.0, and an adsorbent dosage of 0.4 g/L, the maximum adsorption capacities of the OSM/PAA hydrogel for Cu(II), Zn(II), and Ni(II) were 367.64 mg/g, 398.4 mg/g, and 409.83 mg/g, respectively. These findings suggest that the adsorption of heavy metal ions by OSM/PAA is a spontaneous, heterogeneous chemical process with significant potential for practical applications in wastewater treatment.
Background First contact physiotherapy practitioners (FCPPs) are embedded within general practice, providing expert assessment, diagnosis, and management plans for patients with musculoskeletal disorders (MSKDs), without the prior need for GP consultation. Aim To determine the clinical effectiveness and costs of FCPP models compared with GP-led models of care. Design and setting Multiple site case-study design of general practices in the UK. Method General practice sites were recruited representing the following three models: 1) GP-led care; 2) FCPPs who could not prescribe or inject (FCPPs-standard [St]); and 3) FCPPs who could prescribe and/or inject (FCPPs-additional qualifications [AQ]). Patient participants from each site completed outcome data at baseline, 3 months, and 6 months. The primary outcome was the SF-36 Physical Component Summary (PCS) score. Healthcare usage was collected for 6 months. Results In total, 426 adults were recruited from 46 practices across the UK. Non-inferiority analysis showed no significant difference in physical function (SF-36 PCS) across all three arms at 6 months (P = 0.667). At 3 months, a significant difference in numbers improving was seen between arms: 54.7% (n = 47) GP consultees, 72.4% (n = 71) FCPP-St, and 66.4% (n = 101) FCPP-AQ (P = 0.037). No safety issues were identified. Following initial consultation, a greater proportion of patients received medication (including opioids) in the GP-led arm (44.7%, n = 42), compared with FCPP-St (18.4%, n = 21) and FCPP-AQ (24.7%, n = 40) (P<0.001). NHS costs (initial consultation and over 6-month follow-up) were significantly higher in the GP-led model (median £105.5 per patient) versus FCPP-St (£41.0 per patient) and FCPP-AQ (£44.0 per patient) (P<0.001). Conclusion FCPP-led models of care provide safe, clinically effective patient management, with cost-benefits and reduced opioid use in this cohort.
Roxana Elena Gheorghita, Ancuta Veronica Lupaescu, Anca Mihaela Gâtlan
et al.
The present study focused on the development of gel-based capsules from sodium alginate and the fresh juice from different berries: chokeberry, sea buckthorn, and blueberry. Obtained through the extrusion method, the macrocapsules were added into yogurt, a well-known and consumed dairy product. In order to establish the changes that can occur for the food product, the samples were tested over 7 and 15 days of storage in refrigeration conditions. According to the results, the antioxidant activity increased during storage and gels can represent a good option for bioactive substances’ encapsulation. Sensorial analysis performed indicated that consumers are open to consuming yogurt berry capsules and, according to the results observed in the scientific literature, they no longer rejected the product due to the bitterness and sourness of sea buckthorn or aronia. Sea buckthorn capsules were brighter (<i>L</i>*) than chokeberry and blueberry capsules due to carotene content and dark colors. Minimal diameter variations and small standard deviations (SD = 0.25/0.33) suggest that extrusion methods and the Caviar box are good for gel capsule development. Yogurt luminosity varied with capsules; control had the highest, followed by sea buckthorn yogurt. Samples with chokeberry and blueberry (dark) capsules had lower luminosity. Over 8 and 15 days, luminosity slightly decreased, while <i>a</i>* and <i>b</i>* (hue and saturation) increased. Post-storage, the sample with chokeberry capsules showed a light purple color, indicating color transfer from capsules, with increased antioxidant activity. Differences between the samples and control were less pronounced in the sample with sea buckthorn capsules. Values for color differences between yogurt samples during the storage period revealed the most significant difference during the first storage period (day 1–8), with blueberries showing the lowest difference, indicating the stability of the blueberry capsules’ wall during storage.
Converting solar energy into fuels/chemicals through photochemical approaches holds significant promise for addressing global energy demands. Currently, semiconductor photocatalysis combined with redox techniques has been intensively researched in pollutant degradation and secondary energy generation owing to its dual advantages of oxidizability and reducibility; however, challenges remain, particularly with improving conversion efficiency. Since graphene’s initial introduction in 2004, three-dimensional (3D) graphene-based photocatalysts have garnered considerable attention due to their exceptional properties, such as their large specific surface area, abundant pore structure, diverse surface chemistry, adjustable band gap, and high electrical conductivity. Herein, this review provides an in-depth analysis of the commonly used photocatalysts based on 3D graphene, outlining their construction strategies and recent applications in photocatalytic degradation of organic pollutants, H<sub>2</sub> evolution, and CO<sub>2</sub> reduction. Additionally, the paper explores the multifaceted roles that 3D graphene plays in enhancing photocatalytic performance. By offering a comprehensive overview, we hope to highlight the potential of 3D graphene as an environmentally beneficial material and to inspire the development of more efficient, versatile graphene-based aerogel photocatalysts for future applications.
Nowadays, the protection of wood is becoming more important with the increasing demand for durable wood, in addition to its limited accessibility. One possible way to increase the durability is the use of nanoparticles, which can be effective even with a low intake of active ingredients. However, avoiding their leaching is a challenge. A possible solution to leaching is the use of silica aerogel as a fixative. This study investigated the use of mesoporous silica aerogel against the leaching of different nanoparticles under laboratory conditions. Tests were performed involving beech (<i>Fagus sylvatica</i>) and Scots pine (<i>Pinus sylvestris</i>) sapwood, using <i>Trametes versicolor</i> as a white rot and <i>Coniophora puteana</i> as a brown rot fungus. The results show that the subsequent treatment of the wood with mesoporous silica aerogel effectively fixed the nanoparticles in wood. The durability of the samples without aerogel significantly decreased as a result of leaching, whereas the resistance of the samples treated with aerogel decreased only slightly. However, the silica aerogel modification itself caused the leaching of silver nanoparticles, which is a limitation in the use of this method for the fixation of nanoparticles.
Ion Călina, Maria Demeter, Gabriela Crăciun
et al.
The present work discusses the influence of the structural architecture of sodium alginate–co-acrylic acid–poly(ethylene) oxide hydrogels, crosslinked through electron beam (e-beam) radiation processing. The most important properties of the hydrogels were studied in detail to identify a correlation between the architecture of the hydrogels and their properties. Furthermore, the effect of sodium alginate (NaAlg) concentration, the amounts of the polymer blend, and the size of the samples on hydrogel properties were investigated. The results show that the hydrogels cross-linked (0.5% and 1% NaAlg) with 12.5 kGy exhibit improved physicochemical properties. High gel fraction levels (exceeding 83.5–93.7%) were achieved. Smaller hydrogel diameter (7 mm) contributed to a maximum swelling rate and degree of 20.440%. The hydrogel network was dependent on the hydrogels’ diameter and the amount of polymer blend used. The hydrogels best suited the first-order rate constants and exhibited a non-Fickian diffusion character with diffusion exponent values greater than 0.5. This study indicates that the cross-linked hydrogel has good properties, particularly because of its high degree of swelling and extensive stability (more than 180 h) in water. These findings show that hydrogels can be effectively applied to the purification of water contaminated with metals, dyes, or even pharmaceuticals, as well as materials with a gradual release of bioactive chemicals and water retention.
Background Patients suffering from severe mental disorders, including schizophrenia, major depression and bipolar disorders, have a reduced life expectancy compared to the general population of up to 10–25 years. This mortality gap requires urgent actions from a public health perspective in order to be reduced. Main text Factors associated with the high mortality rates in patients with severe mental disorders can be grouped into four groups: those related to the patients, to psychiatrists, to other non-psychiatrist medical doctors and to the healthcare system. Each of these factors should become the target of specific and dedicated interventions, in order to reduce the morbidity and mortality rate in patients with severe mental disorders. All these elements contribute to the neglect of physical comorbidity in patients with severe mental. In particular, the long-standing separation of psychiatry from other branches of medicine and the lack of specific training on this issue further contribute to the poor attention dedicated to management of physical comorbidities. Recently, several professional associations have invited national bodies regulating education of healthcare professionals to include the management of physical health of people with severe mental disorders in undergraduate and postgraduate educational programs. Conclusions The premature mortality in patients with severe mental disorders is a complex phenomenon resulting by the interaction of several protective and risk factors. Therefore, a multilevel approach is needed, in which the different stakeholders involved in health care provision establish workforces for the long-term management of physical and mental health conditions.
Background Family environments can shape children’s personalities and social networks, rendering distinguishing adverse childhood experiences (ACEs) from family and society essential, but related evidence remains limited. Aims This cross-sectional study aimed to investigate the correlations between intrafamilial and social ACEs, their associations with depressive symptoms and cognitive impairment and the (education-moderated) mediating role of social ACEs. Methods Data for this cross-sectional study were from the China Health and Retirement Longitudinal Study. Nine intrafamilial (0, 1, 2, 3, and 4 or more) and three social (0, 1, and 2 or more) ACEs were identified. Depressive symptoms were assessed using the 10-item Center for Epidemiological Studies Depression Scale. Global cognition, including episodic memory and mental intactness, was calculated as z scores. Binary and ordered logistic regressions, generalised linear models with Gaussian family and identity link, and mediation analysis were used. Results 13 435 participants aged 59.0 (51.0–66.0) were included. Compared with participants with no intrafamilial ACEs, those with 1, 2, 3, and 4 or more intrafamilial ACEs tended to develop more social ACEs, with odds ratios (ORs) of 1.55 (95% confidence interval (CI): 1.36 to 1.76), 2.36 (95% CI: 2.08 to 2.68), 3.46 (95% CI: 3.02 to 3.96) and 6.10 (95% CI: 5.30 to 7.02), respectively. Both intrafamilial and social ACEs were associated with depressive symptoms (OR >3 for four or more intrafamilial ACEs and two or more social ACEs) and global cognition (β=−0.26 for four or more intrafamilial ACEs and β=−0.29 for two or more social ACEs). Social ACEs mediated the associations of intrafamilial ACEs with depressive symptoms and global cognition by 12.3% and 13.1%, respectively. Furthermore, as education levels increased, the impact of intrafamilial ACEs on depressive symptoms was increasingly mediated through social ACEs, while the mediating role of social ACEs between intrafamilial ACEs and cognitive impairment gradually diminished. Conclusions Improving children’s social environments and elevating general education can prevent later-life depressive symptoms and cognitive impairment attributed to ACEs in China.