Hasil untuk "Special types of environment"

Yajing Liu, Yuhan Cui, Yingjie Xu et al.

Aromatic amines (AAs), widely distributed in the environment, have raised global concerns due to their carcinogenic risks. However, existing studies mainly focus on individual compounds or cancer types, with limited exploration of the carcinogenic potential of their oxidative products. To comprehensively evaluate human carcinogenic risks, this study selected 100 representative AAs and constructed adverse outcome pathways (AOPs) for bladder, colorectal, and pancreatic cancers. Additionally, 400 oxidative metabolites were generated through reactions with reactive oxygen species (ROO·, HO·, O₂·⁻, and O₃). A multi-indicator evaluation framework was established by integrating molecular docking, ADMET prediction, entropy weighting, coefficient of variation, CRITIC, and subjective weighting methods to quantify the overall carcinogenic risk. Target-specific analyses revealed that cytochrome P450 (CYP450) plays a critical role across AOPs, while O₃-induced metabolites show higher carcinogenic potential. A prioritization list was developed using the TOPSIS method combined with standard deviation classification, identifying 5 AAs of “special concern,” 21 of “high concern,” 51 of “moderate concern,” and 23 of “low concern.” Structural feature and residue-level interaction analyses indicated that AAs with complex architectures, multiple aromatic rings, bulky substituents, or the ability to form electrophilic metabolites exhibited higher risks. Electrostatic interactions were identified as the primary driving force for AA–CYP450 binding, and a greater number of amino acid binding sites enhanced binding affinity and carcinogenic risk. Overall, this study proposes a systematic risk grading framework, establishes a prioritization strategy for AAs control, and elucidates structural and mechanistic determinants contributing to carcinogenic risk heterogeneity.

Liubov I. Iakovleva

The article analyzes architecture as a special interface, presenting the concept of interface through the functions of linking and separating. These functions manifest themselves in various types of architectural space organization: firstly, as intermediary connecting residents with their culture and living space, and secondly, in the image of a smart home connecting the body, imagination, and technologies of the house into a single, continuous network. The article offers a critique of the logic of the interface, which assumes transparency and the effect of direct access to the image of a controlled and perfect life. To conduct a critical analysis, the problem of breakdown is introduced as a necessary condition for the existence of technologies and the material environment of human habitation. Based on the research of N. Thrift, the concepts of uninhabited space by G. Agamben and C. Boano, the processes of rupture and destruction of the material, and the ways of interaction of residents of crisis areas with their homes are analyzed as an alternative to the invisible interface of the smart home. Confrontation with biopolitical control mechanisms is a condition for a critical attitude to the treatment of the living space of the house. Alongside crisis housing forms, Diller and Scofidio’s project is considered to further critique smart home architecture as an invisible interface closely linked to the power of visuality in a given space. In the conclusion of the article, an inference is made about the role and function of architectural interfaces in organizing life and the possible strategies for critiquing the space of interfaces.

Serhii Kvasha, Vitalii Vakulenko, Oleksiy Pavlenko

The theoretical and methodological basis of the research presented in the scientific paper is based on the solution of the problem of the effective functioning of the market environment, agricultural market infrastructure in Ukraine, problems and prospects that Ukrainian agrarian modernity has today in the development of global food markets. An important block of issues is also the role of the state in building new mechanisms of restrictions and incentives, implementation of the whole set of regulatory policies during the war in the context of global political, economic, food and financial challenges. The purpose of the study is to improve scientific approaches and practical recommendations for solving the problem of ensuring the organisational and economic foundations of the functioning of the agrarian market in Ukraine under martial law. In order to achieve this goal, a wide range of research methods was used, the most important of which were the methods of generalisation and synthesis, scientific abstraction, analytical diagnostics, descriptive statistics. The methodical basis of the research were general and special methods, namely: system analysis - in order to comprehensively characterise the strategic potential of agricultural development; statistical analysis (method of standard deviation) of the dynamics of gross production by main types of agricultural products, generalisation and synthesis - in order to examine the legislative and regulatory bases in the direction of diagnosis of the potential of the agricultural sector to ensure the sustainability of national food security. The dialectical method of understanding socio-economic processes, the formal-logical method and the method of system analysis have been applied in order to better understand the processes of the country's food supply, the formation of food independence from imports, the identification of the regularities of the processes of food self-sufficiency, as well as to take into account the influence of macroeconomic factors on the improvement of the level of national food supply and food security. The main set of indicators and factors (conditions) of national food security and the set of indicators of national food security were formed to address important issues of food supply in accordance with the country's potential capabilities in the production, storage, processing of agricultural products to provide food for all categories of the population with appropriate levels of consumption, as well as food of adequate quality and safety. The study determines that the economic focus of regulatory measures on the food sector, on the protection of domestic consumers, will lead to the provision of agricultural producers with the necessary and optimal level of income, and will help to increase the competitiveness of the agricultural sector as a whole. It has been proved that solving the problem of improving the organisational and economic foundations of functioning of the agrarian market of Ukraine under martial law will generally contribute to ensuring the level of national food security, which will further give a powerful impetus to the State-building in Ukraine under martial law.

O. E. Shults, G. M. Pervova, S. V. Motov

The features of the nonverbal side of communication in teaching English at a language university are considered. The basic postulates of linguocognitive science are given, justifying the importance of attention not only to language, but also extralinguistic means of communication in a foreign language lesson. The main obstacles that do not allow to focus properly on the nonverbal aspect of communication in English classes in the university environment are indicated. The close connection of gestures, facial expressions, body movements with the linguistic and cultural space within which they exist is substantiated. Classifications of such extralinguistic means are given with special emphasis on various types of gestures. Based on the analysis of a wide range of scientific papers on the problem of research, two large groups of functions of nonverbal communication tools and a number of private functions included in them are identified. The possible roles of extralinguistic means of communication in foreign language classes and scenarios of their use are determined. The possibility of widespread use of video materials, in particular, authentic Englishlanguage feature films for teaching students of a language university the non-verbal side of communication is substantiated. An example of one of the possible sequences of such training in extralinguistic means of communication on a linguocognitive basis is given.

Soloviev Vyacheslav, Korchagin Alexey, Miller Viktor

The article presents the results of the analysis of the problems of regional investment in terms of determining the volume of investment costs in capital construction projects. The purpose of the study is to determine the relationship of the state's pricing policy in the construction industry to the process of allocating investments for the construction of infrastructure facilities in the regional context. The signs of uneven possibilities of budgets of different regions are highlighted. Pricing factors for construction products, in particular, due to the regulatory framework, are identified as local reasons for differences in capabilities. The types of construction objects with characteristic qualities for carrying out such an analysis are determined. Research methods are based on a piecemeal comparison of linear models of direct costs and cost conversion indices in territorial standards. Differentiation of state pricing standards is considered on the example of special types of work in the construction of urban infrastructure facilities. The estimation of the difference in the cost indicators of territorial standards is used in the assessment of the investment potential of the region. The results obtained show a multiple difference in the cost of construction resources in neighboring regions without proper justification. This makes it possible to determine the volume and cost parameters of construction projects, the creation of which is possible within the framework of the current regional budget. The proposed three-dimensional model of the timing, cost and risks of the project provides grounds for calculating the qualitative indicator when choosing objects of investment programs of the regions. It is concluded that there is a need to move from a system of loosely interconnected territorial and sectoral budget and regulatory bases to a unified information environment.

Nemanja Mišljenović, Matej Žnidarec, Goran Knežević et al.

This review provides the state of the art of energy management systems (EMS) and organizational structures of prosumers. Integration of renewable energy sources (RES) into the household brings new challenges in optimal operation, power quality, participation in the electricity market and power system stability. A common solution to these challenges is to develop an EMS with different prosumer organizational structures. EMS development is a multidisciplinary process that needs to involve several aspects of observation. This paper provides an overview of the prosumer organizational and control structures, types and elements, prediction methods of input parameters, optimization frameworks, optimization methods, objective functions, constraints and the market environment. Special attention is given to the optimization framework and prediction of input parameters, which represents room for improvement, that mitigate the impact of uncertainties associated with RES-based generation, consumption and market prices on optimal operation.

mehdi mohammadiraz, maryam sharif nejad, Mohammad Hassan Fotros

Among the growth and development of businesses, managing financial flows and increasing its effectiveness is an important achievement that causes value stability, efficiency of systems and procedures throughout the chains of Business. Therefore, paying attention to uncontrollable and controllable variables that lead to value creation is inevitable. The purpose of this study is to study the impact of social and biological factors (production and recycling of polymer parts) of environment on the value creation of the company along the supply chain. Also the key role of financial ratios has also been considered in this regard.The present research is of quantitative and applied types and is based on mathematical modeling. It is the result of a combination of genetic algorithms and Simulated Annealing. The financial analysis parameters of the model include current ratios, debt to equity, Instantaneous ratio, net profit margin, cash ratio and rate of return.The analysis of the results shows that considering financial goals and indicators leads to improved profitability and by removing financial indicators from the model, profitability is reduced. Therefore,this is means that the environmental and social performance of the supply chain is improved.Companies can pay special attention to social issues and environmental factors along with their profitability Increase their economic value. Profitability can also be improved by exposing social responsibilities and the mission of environmental protection.

Narimane Lammari, Ouahida Louaer, Abdeslam Hassen Meniai et al.

The last decade has witnessed a burgeoning global movement towards essential and vegetable oils in the food, agriculture, pharmaceutical, cosmetic, and textile industries thanks to their natural and safe status, broad acceptance by consumers, and versatile functional properties. However, efforts to develop new therapy or functional agents based on plant oils have met with challenges of limited stability and/or reduced efficacy. As a result, there has been increased research interest in the encapsulation of plant oils, whereby the nanocarriers serve as barrier between plant oils and the environment and control oil release leading to improved efficacy, reduced toxicity and enhanced patient compliance and convenience. In this review, special concern has been addressed to the encapsulation of essential and vegetable oils in three types of nanocarriers: polymeric nanoparticles, liposomes and solid lipid nanoparticles. First, the chemical composition of essential and vegetable oils was handled. Moreover, we gather together the research findings reported by the literature regarding the different techniques used to generate these nanocarriers with their significant findings. Finally, differences and similarities between these nanocarriers are discussed, along with current and future applications that are warranted by their structures and properties.

L. K. Goni, M. A. Jafar Mazumder, M. Quraishi et al.

Corrosion is a risky phenomenon that devastatingly affects innovative, industrial, and mechanical applications, especially in the oil and gas industries. The corrosion conceivably influences industrial equipment; it deteriorates the environment and lessens the equipment/infrastructure's lifetime. Considering the significant impact of corrosion in our daily lives, this review article aims to briefly discuss the significance of corrosion and different control methods with special attention on corrosion inhibitors. The classification of corrosion inhibitors based on types and their advantage/limitations, and heterocyclic compounds as potential corrosion inhibitors, mainly nitrogen-based compounds (pyridine (1N), pyrimidine (2N), and triazines (3N) fused ring benzimidazole, etc.), and their biological significance has been discussed in detail. The mechanism, challenges, and applications of heterocyclic compounds as corrosion inhibitors in various industrial relevant corrosive environments such as acid pickling, descaling operation in the desalination plant, oil gas industry, etc., have also been highlighted in the review.

T. Yu. Bespalova

Listeria (L.) monocytogenes is an intracellular food pathogen that causes listeriosis in mammals in the form of sporadic cases or large outbreaks with a high mortality rate among humans and domestic ruminants. The determination of the sequence type (ST) and the clonal complex (CC) by multilocus sequencing (MLST) and other methods in L. monocytogenes strains from different sources allowed us to establish the existence of strains with organ tropism and causing forms of listeriosis common to humans and ruminants. The purpose of the review was to generalize the available data on the distribution and genotypic diversity of L. monocytogenes strains isolated during neurolisteriosis and abortions, their adaptation in the environment to determine a possible link between listeriosis of ruminants and humans. In general, the analysis of the differential distribution of STs/CCs of L. monocytogenes associated with humans and ruminants showed their significant variation, as well as the predominance of CCs (CC1, CC2, CC4, CC6, CC7, CC8, CC14, CC29, CC37, etc.) common to the studied host groups. Neurolisterioses in humans are mainly associated with hypervirulent CC1, CC6, CC4, CC2, in ruminants - CC1 and CC4, as well as CC8-16 and CC412. A special association of ST1 (CC1) with human and bovine neurolisteriosis has been determined, indicating increased neurotropism of ST1. In small ruminants (goats, sheep), neurolisterioses are associated with various STs from phylogenetic lineages I and II. Most of L. monocytogenes strains isolated from abortions belonged to CC1, CC2, CC4, CC6, CC7, CC14 in humans and CC1, CC6, CC4-217, CC37 in ruminants. The detection of common isolates CC1, CC4-CC217, CC6, CC18, CC37 in ruminants and in their natural environment indicates that the farm environment is a reservoir for L. monocytogenes strains. In the Russian Federation, the prevalence of SТ7 isolates among all types of sources obtained on the territory of the country was noted. Future research should be aimed at studying the pathogenicity of L. monocytogenes strains with an increased tendency to cause diseases in humans and ruminants for better understanding the mechanisms of infection and strengthening the control over the spread of the pathogen in various ecological niches.

Daniela Ullmann, Julian Kreimeier, Harald Kipke

To achieve the 1.5-degree target of the Paris Climate Agreement, it is of great importance to promote environmentally friendly means of transport. In urban areas, shifting motorized trips to active transport modes (i.e., walking and cycling) is essential. Therefore, knowledge of walking and cycling is indispensable for planning and policy, which is the basis for targeted promotion of active forms of mobility. This paper aims to identify factors that specifically influence cycling and to derive recommendations for action for planning and policy in a virtual testbed. Specifically, the influence of traffic planning measures (i.e., structural infrastructure facilities for stationary and moving traffic as well as traffic regulations) and urban design measures (i.e., the design of public space) on the promotion of cycling will be shown. For this purpose, a virtual reality simulation was used, independent of different external conditions during field surveys and the necessity of time-, cost- and regulation-intensive structural changes. Using an improved bicycle simulator, 93 people cycled through 20 variations of an approximately 680 m long road section, surveying the effect of selected traffic planning and urban design parameters. Special attention was paid to the subjective safety of the cyclists and the attractiveness of the urban environment. Furthermore, three types of infrastructure were differentiated: No bicycle infrastructure (riding on the roadway), a bicycle lane, and a structurally separated cycle path next to the sidewalk. The virtual road section represented a real location. In addition to the findings gained from the physiological optimization of the simulator, the results show that roadside greenery had the highest effectiveness in terms of subjective safety and attractiveness. Other factors with a high influence were a speed reduction from 50 to 30 km/h when riding on the roadway with cars and the red coloring of the bicycle lane, each increasing the perception of safety. In contrast, a lack of a boundary line between the cycle path and the sidewalk was unsettling for those who rarely or never ride bicycles in their daily lives. In addition, restaurant and recreation areas increased the attractiveness of the road section, although entailing a lower perception of safety. Other factors, such as motor vehicle traffic volume or vehicles parked at the roadside, showed no significant effects on the evaluation of cycling.With the help of these findings, the consequences of traffic planning and urban design measures can be better assessed in subsequent virtual testbeds. Also, initial trends can be identified as to which planning instruments should be used as a priority to promote cycling in urban areas. Future work should validate the transfer of these insights into physical urban spaces to support further the mid-term transformation towards sustainable urban mobility using scientific evidence.

O. G. Motovilin, E. N. Saverskaya, R. R. Khairov

Diabetes mellitus (DM) in children has an impact on the social world of the child, changing his environment and his own role. A comprehensive approach to the treatment of diabetes in childhood involves taking into account the characteristics of a growing organism, analyzing socio-psychological factors and individual personality traits. The article analyzes the significant social spheres in which a child's relationships are built: family, non-family environment (peers and other children, educators, teachers, doctors). Special attention is paid to the negative impact of the Internet and social networks on the formation of opinions and attitudes of a child with diabetes and his parents to doctors and treatment. One of the tasks of DM therapy is to create a social situation that will contribute to the formation of personal qualities in a child that are necessary for managing the disease and maintaining psychological well-being. The tools for implementing this direction are both traditional diabetes schools and promising types of programs with the creation of groups of children involved in active joint activities: artistic, sports, dance, intellectual, etc. As an example of an innovative approach to teaching, adaptation and inclusion of children with diabetes in society, the social health and educational program “Diabetes. Dances. Children”, which has been implemented since 2020 in Moscow. The program is attended by 15 children and adolescents with diabetes (5-15 years), diabetes experience from 2 months to 10 years. The features of the program consist in the adaptation of dance and physical activities to the glycemic indices of children in dynamics; participation in the program of children, their family environment and friends; accompanying endocrinologists and clinical psychologists; conducting seminars for children and parents as part of an educational marathon; participation of children in dance competitions and festivals, video filming and various creative events.

Huajun Yu, W. Xie, Lan Yang et al.

Payments for ecosystem services (PES) is an effective policy in conserving ecosystem services and is increasingly applied globally. The concept of PES was firstly defined in 2005, researches with various terminologies, concepts, and practices emerged since then. This paper analyzed the research patterns of PES studies through bibliometric methods, with a special focus on the trends of terminology, location (geographical research hotspot), types of PES, and PES effectiveness evaluation based on author keywords analysis. The results showed that PES started to receive considerable academic attentions from 2005, and the number of PES publications have relatively kept an increasing trend since then. The most influential journal, country, research organization, and author were Ecological Economics, USA, Chinese Academy of Sciences (CAS, China), and Dr. Wunder. Further analysis revealed that there were various terminologies in PES studies, notably "ecological compensation" and "eco-compensation" (EC) were primarily adapted by Chinese research community. China was the geographical research hotspot and developing countries (Vietnam, Mexico, and Brazil) have received growing academic interests in last decade. "Forest and Carbon" PES was the most concerned types of PES in last five years. There were 125 articles evaluated the effectiveness of empirical PES initiatives, and the majority focused on the social aspect. We proposed two suggestions for future research: (1) adapting EC as an alternative term for PES studies because of its inclusiveness and representation of empirical practices; (2) enhancing integrated evaluation of PES programs to achieve multiple benefits.

N. Kazanskiy, M. A. Butt, S. Degtyarev et al.

Optical sensors are widely used in the biomedical, chemical and food industries. They provide high sensitivity to changes in the refractive index of the environment due to a specific distribution of resonances across the field. The sensitivity of the sensor is highly dependent on its material and structure. In this review, we focused on the analysis of silicon waveguides as a promising component for optical sensor miniaturization, and plasmon refractive index sensors without fluorescent labeling. We presented the latest developments of special types of plasmon structures, such as metal-insulator-metal waveguides, and their application in refractive index sensors. We analyzed numerous types of plasmon waveguides, their geometry, materials and manufacturing processes, as well as possible energy losses. A discussion of the spectral characteristics of recently proposed refractive index sensors, with an emphasis on their sensitivity and quality indicators, is an important part of the review.

F. Costa, A. Lago, Verónica Rocha et al.

Over the last decades, the production and consumption of pharmaceuticals and health care products grew manifold, allowing an increase in life expectancy and a better life quality for humans and animals, in general. However, the growth in pharmaceuticals production and consumption comes with an increase in waste production, which creates a number of challenges as well as opportunities for the waste management industries. The conventional current technologies used to treat effluents have shown to be inefficient to remove or just to reduce the concentrations of these types of pollutants to the legal limits. The present review provides a thorough state-of-the-art overview on the use of biological processes in the rehabilitation of ecosystems contaminated with the pharmaceutical compounds most commonly detected in the environment and eventually more studied by the scientific community. Among the different biological processes, special attention is given to biosorption and biodegradation.

Chaosheng Zhang, L. Liu, Mei-hua Zhao et al.

N. Massari, Melisa B. Nicoud, V. Medina

In the present review, we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different neoplasias including gastric, colorectal, oesophageal, oral, pancreatic, liver, lung, skin, blood and breast cancers will be reviewed. The expression of histamine receptor subtypes, with special emphasis on the histamine H4 receptor, in different cell lines and human tumours, the signal transduction pathways and the associated biological responses as well as the in vivo treatment of experimental tumours with pharmacological ligands will be described. The presented evidence demonstrates that histamine regulates cancer‐associated biological processes during cancer development in multiple cell types, including neoplastic cells and cells in the tumour micro‐environment. The outcome will depend on tumour cell type, the level of expression of histamine receptors, signal transduction associated with these receptors, tumour micro‐environment and histamine metabolism, reinforcing the complexity of cancer disease. Findings show the pivotal role of H4 receptors in the development and progression of many types of cancers, and considering its immunomodulatory properties, the H4 receptor appears to be the most promising molecular therapeutic target for cancer treatment within the histamine receptor family. Furthermore, the H4 receptor is differentially expressed in tumours compared with normal tissues, and in most cancer types in which data are available, H4 receptor expression is associated with clinicopathological characteristics, suggesting that H4 receptors might represent a novel cancer biomarker.

Natalya Chernenko, Tetiana Moiseienko, Olena Korohodova et al.

This paper studies the dynamics and trends in processes of mergers and acquisitions in a highly competitive and global economic environment. The aim of this study is to analyse and divide into periods M&A agreements in the global economy. The study produces a precise definition and discusses benefits and drawbacks of such horizontal and vertical agreements. The authors discuss historical waves of mergers and acquisitions processes and present 11 individual periods containing special aspects and description of types of the agreements, as well as supplement the periods with COVID-19 pandemic flow for 2020-2021. A polynomial regression analysis is used to predict the mechanism, results and magnitude of mergers and acquisitions. Furthermore, a discrete time model enables studying behaviour pattern of mergers and acquisitions happened during 2009-2020. The results demonstrate that transnational companies are greatly attributed to economic growth through mergers and acquisitions despite their rather high preparation and implementation costs. It may be expected an escalation of capital redistribution among pharmaceutical and bioengineering companies in a post-pandemic period due to increased M&A agreements.

Tiroyaone Shimane Tshikantwa, M. W. Ullah, Feng He et al.

For a long time, it was considered that interactions between microbes are only inhibitory in nature. However, latest developments in research have demonstrated that within our environment, several classes of microbes exist which produce different products upon interaction and thus embrace a wider scope of useful and potentially valuable aspects beyond simple antibiosis. Therefore, the current review explores different types of microbial interactions and describes the role of various physical, chemical, biological, and genetic factors regulating such interactions. It further explains the mechanism of action of biofilm formation and role of secondary metabolites regulating bacteria-fungi interaction. Special emphasis and focus is placed on microbial interactions which are important in medicine, food industry, agriculture, and environment. In short, this review reveals the recent contributions of microbial interaction for the benefit of mankind.

L. Bode, E. Vraga

High quality cross-platform research is difficult and expensive to perform in political communication. Yet studying media platforms in isolation ignores the realities of the contemporary media experience. As platforms multiply, the media environment itself has become more complicated, as classic understandings of media ecology give way to a growing recognition of the hybrid media system. In studying political communication across platforms, we can better understand what types of experiences and effects are universal, and which are specific to a particular platform. This special issue highlights the diverse methods needed to study a complex media environment and the nuance and richness of understanding we gain by doing so. We urge researchers to extend their research outside of a single platform, to consider the context and affordances of multiple platforms, and to focus on a more ecological approach to the modern media environment.