The availability of complete human genome sequences from populations across the world has given rise to new population genetic inference methods that explicitly model ancestral relationships under recombination and mutation. So far, application of these methods to evolutionary history more recent than 20,000–30,000 years ago and to population separations has been limited. Here we present a new method that overcomes these shortcomings. The multiple sequentially Markovian coalescent (MSMC) analyzes the observed pattern of mutations in multiple individuals, focusing on the first coalescence between any two individuals. Results from applying MSMC to genome sequences from nine populations across the world suggest that the genetic separation of non-African ancestors from African Yoruban ancestors started long before 50,000 years ago and give information about human population history as recent as 2,000 years ago, including the bottleneck in the peopling of the Americas and separations within Africa, East Asia and Europe.
M. Jakovljevic, Yan-sui Liu, Arcadio A. Cerda
et al.
Abstract The Global South nations and their statehoods have presented a driving force of economic and social development through most of the written history of humankind. China and India have been traditionally accounted as the economic powerhouses of the past. In recent decades, we have witnessed reestablishment of the traditional world economic structure as per Agnus Maddison Project data. These profound changes have led to accelerated real GDP growth across many LMICs and emerging countries of the Global South. This evolution had a profound impact on an evolving health financing landscape. This review revealed hidden patterns and explained the driving forces behind the political economy of health spending in these vast world regions. The medical device and pharmaceutical industry play a crucial role in addressing the unmet medical needs of rising middle class citizens across Asia, Latin America, and Africa. Domestic manufacturing has only been partially meeting this ever rising demand for medical services and medicines. The rest was complemented by the participation of multinational pharmaceutical industry, whose focus on investment into East Asia and ASEAN nations remains part of long-term market access strategies. Understanding of the past remains essential for the development of successful health strategies for the present. Political economy has been driving the evolution of health financing landscape since the establishment of early modern health systems in these countries. Fiscal gaps these governments face in diverse ways might be partially overcome with the spreading of cost-effectiveness based decision-making and health technology assessment capacities. The considerable remaining challenges ranging from insufficient reimbursement rates, large out-of-pocket spending, and lengthy lag in the introduction of cutting-edge technologies such as monoclonal antibodies, biosimilars, or targeted oncology agents, might be partially resolved only in the long run.
Abstract Seed dispersal is a key process in plant communities and frugivory is very important in vertebrate communities. This paper updates a review of frugivory and seed dispersal by vertebrates in the Oriental Region (tropical and subtropical Asia) published in 1998. The major conclusions remain the same. Small fruits are consumed by a wide range of potential seed dispersal agents, including species that thrive in small forest fragments and degraded landscapes. Larger and larger-seeded fruits are consumed by progressively fewer dispersers, and the largest depend on a few species of mammals and birds which are highly vulnerable to hunting, fragmentation, and habitat loss. Controlling hunting in both forest areas and the agricultural matrix must be a top priority for conservation. A lot more natural history information has been added to the literature since 1998. This reinforces previous evidence for the importance of hornbills, bulbuls, elephants, gibbons, civets, and fruit bats in seed dispersal, and suggests that the roles of green pigeons, macaques, rodents, bears, and deer were previously underestimated. The taxa for which additional natural history observations would be most valuable include fish, pheasants, pigeons, babblers, rodents, and even-toed ungulates. For other animal taxa, future frugivory and seed dispersal studies need to focus more on the fitness consequences for both the plants and the animals.
Ziba Bakhtiar, Ghasem Eghlima, Mehrnaz Hatami
et al.
Abstract Rosa canina L. (Rosaceae), commonly known as the rose hip, is originated from Europe, Africa, and Asia with a long history in medicinal applications. This study aimed to analyze the morphological traits, fatty acids profile, and content of phenolic compounds, anthocyanins, vitamin C, total carotenoid, total phenol, total flavonoid, and antioxidant activity of the fruits of eleven Iranian R. canina ecotypes (RCEs). The highest coefficient of variation was obtained in 1000 seed weight (46.57%). The seed oil varied from 8.08 ± 0.17% to 16.91 ± 0.35%. Linoleic (35.41 ± 0.78% to 49.59 ± 0.96%) and eicosanoic (17.67 ± 0.06% to 25.36 ± 0.54%) acids were the predominant fatty acids in the studied samples. The anthocyanin content in the fruits was ranged from 0.98 ± 0.03 to 4.41 ± 0.04 mg cyanidin 3-glucoside/100 g of dry weight (mg C3G/100 g DW). The high content of vitamin C (103.51 ± 1.24–419.70 ± 3.12 mg/100 g DW), total carotenoid (111.22 ± 0.78–206.98 ± 1.25 mg β-carotene equivalents per g of dry weight (mg β-CARE/g DW)), total phenol (52.87 ± 0.82–104.52 ± 0.23 mg GAE/g DW), and total flavonoid (14.20 ± 0.12–25.18 ± 0.47 mg RE/g DW) were observed in the studied samples. Catechin (20.42 ± 0.47–19.22 ± 0.13 µg/g DW) was the major phenolic compound. The high antioxidant activity in the fruits of the plant was recorded in the studied RCEs (IC50 = 12.54 ± 0.18–26.33 ± 0.13 μg/ml). A significant correlation between some phytochemical compounds (dependent variable) and morphological features (independent variable) was found. Based on our findings, the fruit of the studied ecotypes can be used for future breeding programs and drug development.
The yeast Saccharomyces cerevisiae has been an essential component of human civilization because of its long global history of use in food and beverage fermentation. However, the diversity and evolutionary history of the domesticated populations of the yeast remain elusive. We show here that China/Far East Asia is likely the center of origin of the domesticated populations of the species. The domesticated populations form two major groups associated with solid- and liquid-state fermentation and appear to have originated from heterozygous ancestors, which were likely formed by outcrossing between diverse wild isolates primitively for adaptation to maltose-rich niches. We found consistent gene expansion and contraction in the whole domesticated population, as well as lineage-specific genome variations leading to adaptation to different environments. We show a nearly panoramic view of the diversity and life history of S. cerevisiae and provide new insights into the origin and evolution of the species. An understanding of the domestication of the yeast Saccharomyces cerevisiae has important implications for studying its evolution and diversity. Here, the authors show that Far East Asia is likely the center of origin of the domesticated populations of the yeast based on genomic and phenotypic characterization of a large collection of isolates.
Inflammatory bowel disease (IBD) has increased in incidence and prevalence in Asian countries since the end of the 20th century. Moreover, differences in the cause, phenotypes, and natural history of IBD between the East and West have been recognized. Therefore, the Asian Organization for Crohn's and Colitis and the Asia Pacific Association of Gastroenterology have established recommendations on medical management of IBD in Asia. Initially, the committee members drafted 40 recommendations, which were then assessed according to Grading of Recommendations Assessment, Development and Evaluation. Eight statements were rejected as this indicated that consensus had not been reached. The recommendations encompass pretreatment evaluation; medical management of active IBD; medical management of IBD in remission; management of IBD during the periconception period and pregnancy; surveillance strategies for colitis‐associated cancer; monitoring side effects of thiopurines and methotrexate; and infections in IBD.
This article deals with some issues regarding masculinity in contemporary India, focusing on popular culture, the clothing semiotics, and the media discourse on masculinity, referred to Prime Minister Narendra Modi, leader of the Hindu nationalist party Bharatiya Janata Party (BJP). Modi has manipulated many figures from the nationalist past in order to build an image of himself as “the real man,” reaffirming the mandate of masculinity in order to lead the nation into the new millennium.
1.Introduction
Islamic texts have a more or less pessimistic view of the history and culture of Parthians. Based on these texts, one can obtain scattered insights about the Parthian history. One of the notable points in this text is the Parthian military confrontation with the Seleucids and the Romans. These insights include three main reports. The first report is about the military confrontation of Parthians with Romans during the Achaemenid Empire. The second battle involves the campaign of Gooderz Bin Ash for Palestine. The Blashe war with Romans is the last battle mentioned in the reports. This study attempts to reconstruct the exact details of these wars in the real history of the Parthian Empire.
2.Methodology
In this study, we will reconstruct these battles through a comparative study of the Parthian battles with the Seleucids and then Romans in historical accounts of the Islamic period with real reports such as coins, archaeological sources and Greek and Roman sources. By refining and categorizing these reports and excluding duplicate reports, usually adapted from earlier sources, one can benefit from the capacity of Islamic sources to reconstruct Iran's political and military history in the Parthian era. This research is written in such an approach.
3.Discussion
In some Islamic texts, the first Parthian confrontation with Romans occurred during the reign of Ash kingdom. Some of these texts describe Ashk as the eldest child who provided an army and went to the battle of Antiches and seized his kingdom (Tabari, 1974, 2/496; Balami, 2001, 499; Gardizi, 1985, 59-60; Balkhi , 1985, 59; Mostofi, 2008, 99). Isfahani Hamza mentions this war during the reign of Shapur ibn Ash Ash ibn Azar (Isfahani, 1968, 41-42). Various reports of Islamic sources have attributed the Parthian king's war against Antiches to the time of the Ash Kingdom, Shapur bin Ash , and Euphorshah. It seems that this war can be traced back to the actual Parthian history at the time of the first Ash (247 BC - 217 BC).At the time of Antiochus II's reign (246BC- 261BC ), Arsaces defeated Andragoras and gained dominion over Parth (Strootman, 2015b; Schippmann, 2012: 525-526). After Antiochus II, Seleucus II succeeded to the throne In 246 BC. With the onset of the Seleucus II campaign in the eastern regions, Arsaces retreated to the Apacak region (Strabo, 1928: 269; trootman, 2015b; Shipman, 2005: 28; Wolski, 2004: 81). In later battles with the second Seleucus, Arsaces achieved victory (Justin, 1994: 256). The Seleucid king was forced to return because of the unrest in Asia Minor. But before his retreat, he recognized the rule of Ash over Parthia and Hircania as the Sultans of the Seleucids (Strootman, 2015b; Fry, 2006: 293; Shipman, 2005: 28). It may be argued that the Ash-and-Antiochus war in Islamic history is a reflection of the battles between Ash I the founder of the Parthian kingdom and of Antiochus II and Seleucus and illustrates his efforts to drive the Seleucids out of the Iranian borders and establish the Parthian dynasty. In the history of the Islamic era, there have been reports of the attack on Palestine by Goderz bin Ash. In these reports, Guderz bin Ashq is the one who, when the Jews of the Israelites killed YahyaBenzaria (AS), destined that he would attack Yahya (AS) in revenge and kill the Jews (Tabari, 1352: 2/496; Isfahani, 1346: 42; Thalabi, 1372: 226; Gardizi, 1363: 60-61; Balkhi, 1363: 18; Mostofi, 1383: 101). In a solid account of the kingdom of Godezerz, his attack on Palestine heralds the beginning of Goderzez's reign and speaks in detail of the king's glory and highness. (Thaleb, 1372: 226). In national and epic narratives we find the name of Goderz. In these narratives, Goodarz, the son of Kashvad, is considered one of the greatest Iranian heroes. (Yarshater, 1392: 569; Safa, 1333: 574). Gooderz's name in national stories can be a reflection of Gooderz I the Parthian king. In spite of the similarity between the name of Goderz in the Islamic narrative with the Parthian king Goderz I, the insights in the Islamic texts lead us to the view that this Goderz should be regarded as the son of Ered II (37-37 BC). Labinius, the Roman commander, also accompanied him during the Pakistani invasion of Syria and Palestine. With the victory of Parthians in Syria, the way to Pakur came to the southern states of the Levant. Due to the turbulent conditions in Palestine, Pakor succeeded in conquering Jerusalem (Josphous, 1934: 126-127; Voleski, 2004: 156; Du Boaz, 1342: 92). It can be concluded that the Godarz raid on Palestine in the narratives of Islamic historians is a reflection of the Pakor army, the Parthian prince in the West Euphrates in 51 BC. Blash is the third Parthian king to be found in his scattered references to his war with the Romans in Islamic texts. Some Islamic historians make no mention of this war in the name of Blash. For example, in his report, Balami named the Ashq (Balami, 2001: 449-500), and Hamdollah Mostofi attributes it to the time of Nursi ibn Godarz ibn Balash (Mostofi, 1387: 102). According to historical reports of the Islamic period, Blush son of Khosro reported that the Romans had come to seek revenge on Antiochus and to avenge his blood on the Iranian war (Tabari, 1352: 2/497; Isfahani, 1346: 42-43). Blash asked for help from neighboring Malkovtiev. Each king provided the military and financial power to the extent of his ability. (Tabari, 1352: 2/497: Isfahani, 1346: 43-42; see also Nak; Balami, 1380: 500-449; Mostofi, 1387: 102). Concerning the Blash war and its reconciliation with the Parthian history, we may be able to cautiously date this war at the time of the fifth Blashe (191-208 AD). in the evidence provided by the Islamic texts about this war are references to the beginning of the war by the Romans. After the death of Blush IV (192/1923 - 191/1990), his son replaced him. Coinciding with the beginning of the reign of the fifth Blach, the Parthians were attacked by Septemus Soros in northern Mesopotamia. The fifth blast calls on the rulers of the provinces of Oserouen and Adiabon, whose lands were near the Roman borders, to oppose Roman siege and besiege Rome (Dio cassius, 1957: 217-218; Chaumont, 1988: 57 579; Voleski, 2004: 210; Shipman, 2005: 75). Eventually, however, the Roman troops, during their retreat, faced resistance from the city's defenders and withdrew. As the siege ended, the campaign ended. (Dio cassius, 1957: 221-222; Chaumont, 1988: 579; Voleski, 1383: 212; Shipman, 1383: 76; Duobey, 1342: 233.(
4.Conclusion
In Islamic sources, we find only three cases of the Parthian-Roman wars. First is the Ashq war with Antiches. The victory of Ashq in this battle led to the establishment of the Parthian dynasty. Greek and Roman sources and recent research can partly trace the date of this war to the actual Parthian history at the time of the first Ashq (247 BC - 217 BC). Among these evidences are the first Ashq battles with the Seleucid kings and stories related to the beginning of the Parthian dynasty. Given the coincidence of the reign of Antiochus II (261 BC - 246 BC) and Seleucus II (246 BC - 225 BC), the Ashq's wars are more likely to date in this period. The reference to Antiochus in historical accounts of the Islamic period may be the same as Antiochus II of Seleucid king. The second battle is the Godarz onslaught on Palestine. Evidence from Islamic reports and its concordance with new research suggests that the attack of Godarz Bin Ash to Palestine by Prince Pakour's son Ard II (57 BC - 37 BC) could be countered by Jerusalem and the conquest of the land. The Blashe war with the Romans is the last battle mentioned in reports of the Islamic era. According to the reports of the Islamic writers about the war of Balash and its reconciliation with the history of the Parthians, this war can be dated with prudence at the time of the fifth Balash (208-201 AD). Comparing the evidence of Islamic texts with Greek and Roman sources and new research indicates that this war is a reflection of the onslaught of Emperor Septimius Soros on the lands of northern Mesopotamia during the fifth Blashe, when Islamic historians combined reports of this war with the events of the Sassanid era.
Organizational behaviour, change and effectiveness. Corporate culture, Fine Arts
This article questions new issues and actors in the reconfiguration of national religious spaces after a new religious policy was implemented in the 1990s. It focuses on the worship of Mother-Goddesses (Đạo Mẫu) which has taken a long time to become part of the national politico-religious space and is fully in keeping with the rise of Vietnam’s cultural nationalism. Beyond mere state nationalism, this cult has developed as a result of effective liberalization of the cult market on the one hand and struggle for official recognition as national religion on the other hand. The dynamic of worship advocacy is examined through the dispute between Mother-Goddesses followers and Buddhists, which appeared and evolved exclusively on the Internet between 2017 and 2018. My data come from YouTube videos, in which discourses of protagonists on both sides are produced. This study aims to trace the history and grasp the issues of this controversy.
В статье рассматривается вопрос о текстах из разряда дхарани, включенных в 108-томный канонический свод Ганджур на монгольском языке. Ксилографическое издание Монгольского Ганджура было привезено из экспедиций в Китай индийским ученым Рагхувирой и в последующем использовано для повторного издания в серии «Шата-питака» (Śata-Piṭaka Series) Локешом Чандра. Экземпляр этого 108-томного серийного издания был приобретен через бурятские дацаны калмыцким гелюнгом Тугмюд-гавджи (О. М. Дорджиевым) (1887‒1980) и ныне составляет ценную часть коллекции старописьменных источников Научного архива КалмНЦ РАН. Анализ оглавлений, которые предваряют каждый из томов издания Л. Чандра, а также текстов свода показал, что сочинения из разряда дхарани представлены в ряде томов, соответственно в разных разделах, преимущественно в разделах «Dandr-a» («Тантра») и «Eldeb» («Собрание сутр»), причем отдельные тома включают единичные тексты, а в каких-то других томах они приводятся единым блоком (подборками). Один из текстов дхарани — сочинение из 23-го тома «Дхарани, именуемая „Сердце-сущность Святого, [обладающего] безграничной жизнью и знанием“» представлен в данной публикации в виде транслитерации и комментированного перевода. Цель статьи — дать обзор сочинений жанра дхарани в составе Монгольского Ганджура по известным материалам и представить перевод одной из дхарани, привлекших наше внимание. Материалы и методы — сравнительно-текстологическое исследование состава Ганджура по изданию Локеша Чандра с обращением к другим изданиям этого свода и попыткой рассмотрения специфики состава разных изданий Ганджура и ее причины. Результаты и выводы: очевидно, исследуемый свод Ганджура составлялся из разных источников, и в его составлении участвовали разные переводчики. История составов разных изданий монгольского Ганджура весьма сложна и требует дальнейших исследований как самого свода, так и отдельных входящих в него текстов.
History of Asia, Political institutions and public administration - Asia (Asian studies only)
Austronesian languages are spread across half the globe, from Easter Island to Madagascar. Evidence from linguistics and archaeology indicates that the ‘Austronesian expansion,’ which began 4,000–5,000 years ago, likely had roots in Taiwan, but the ancestry of present-day Austronesian-speaking populations remains controversial. Here, we analyse genome-wide data from 56 populations using new methods for tracing ancestral gene flow, focusing primarily on Island Southeast Asia. We show that all sampled Austronesian groups harbour ancestry that is more closely related to aboriginal Taiwanese than to any present-day mainland population. Surprisingly, western Island Southeast Asian populations have also inherited ancestry from a source nested within the variation of present-day populations speaking Austro-Asiatic languages, which have historically been nearly exclusive to the mainland. Thus, either there was once a substantial Austro-Asiatic presence in Island Southeast Asia, or Austronesian speakers migrated to and through the mainland, admixing there before continuing to western Indonesia. Populations speaking Austronesian languages are numerous and widespread, but their history remains controversial. Here, the authors analyse genetic data from Southeast Asia and show that all populations harbour ancestry most closely related to aboriginal Taiwanese, while some also contain a component closest to Austro-Asiatic speakers.
This article aims to describe and analyze the functions of Bagas Godang and Sopo Godang as a source of learning the local history of students in the School. Basically the function of Bagas Godang and Sopo Godang is an identical symbol of civilized society as a center of government, and custom development, as well as education and character building centers Naposo Nauli Bulung (youth and young women) in the Land of Mandailing. The existence of the functions of Bagas Godang and Sopo Godang as culture heritage Mandailing plays an important role in the transformation of the philosophical values of Dalihannatolu in Naposo Nauli Bulung (youth and young women) in the context of Globalization Now. The method used in this study is the Historical method through several stages, namely: (1) Heuristics, (2) criticism, (3) interpretation, (4) Historiography. While the techniques used to obtain data through field studies are interviews in a structured and in-depth manner, analyzing various source books, newspapers, and archival material related to the issues discussed. The results showed that the content and constants of Bagas Godang and Sopo Godang were relevant as sources of learning local history in schools. Through the contextualization of learning as follows: first, the utilization of the functions of Bagas Godang and Sopo Godang as culture heritage in learning the local history of students through field studies, secondly, the Constellation of the functions of Bagas Godang and Sopo Godang in learning local history through the use of used goods as an integrated creative media character values, third digitizing the function of Bagas Godang and Sopo Godang as a heritage culture in learning the history of local students in high school.
S. V. Rasskazov, I. S. Chuvashova, Т. A. Yasnygina
et al.
The modern theory of the evolving Earth is based on integrated isotopic data obtained for the accessible part of the planet and cosmic bodies, in which the U–Pb isotope system plays a key role. The theory is tested by the isotope systematics of oceanic basalt sources. The origin of continental volcanic rocks is often interpreted in terms of the isotopic systematics of oceanic basalts. However, such interpretations, as a rule, reveal contradictions arising from differences in the history and current mantle dynamics of oceans and continents. Under the oceans, a mantle material has long lost connection with the accessible Earth tectonic units; under the continents such a connection is often established. The nature of the evolution of deep‐seated processes under the continents remains uncertain and, by analogy with the oceans, requires deciphering in terms of the components of the mantle sources for volcanic rocks. In modern lithospheric plates of the Earth, there are regions ranging in width from hundreds to thousands of kilometers, which are characterized by high strain rates and, consequently, at least one to two orders of magnitude lower viscosity relative to that of the internal stable parts of the plates. This gives them a special structural status of “dispersed plate boundaries”. The isotope‐geochemical studies of volcanic rocks from regions of the unstable Asia revealed the different nature of components in sources, for which particular interpretations have been proposed. In this paper, a general systematics of sources is defined for volcanic rocks of the latest geodynamic stage in Asia through estimating the incubation time on the 207Pb/204Pb versus 206Pb/204Pb diagram. Two domains are designated: (1) low 238U/204Pb (LOMU) derived from the viscous protomantle (VIPMA), and (2) elevated 238U/204Pb (ELMU). The mantle domains evolved from the Earth's primary material between 4.51 and 4.36 Gyr ago, 4.0 and 3.7 Gyr ago, 2.9 and 2.6 Gyr ago, 2.0 and 1.8 Gyr ago, about 0.66 Gyr ago and <0.09 Gyr ago. Melting anomalies of ELMU sources characterize the unstable mantle of Southern Asia, and those of LOMU sources belong to the Japan‐Baikal geodynamic corridor of the transitional region between the unstable mantle of Asia and its stable core. The Late Cenozoic evolution of the Japan‐Baikal geodynamic corridor resulted in cutting the LOMU domain by the Jeju‐Vitim ELMU source line.