Patients with cancer experience a higher burden of SARS-CoV-2 infection, disease severity, complications, and mortality, than the general population. SARS-CoV-2 mRNA vaccines are highly effective in the general population; however, few data are available on their efficacy in patients with cancer. Using a prospective cohort, we assessed the seroconversion rates and anti-SARS-CoV-2 spike protein antibody titers following the first and second dose of BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines in patients with cancer in US and Europe from January to April 2021. Among 131 patients, most (94%) achieved seroconversion after receipt of two vaccine doses. Seroconversion rates and antibody titers in patients with hematological malignancy were significantly lower than those with solid tumors. None of the patients with history of anti-CD-20 antibody in the 6 months before vaccination developed antibody response. Antibody titers were highest for clinical surveillance or endocrine therapy groups and lowest for cytotoxic chemotherapy or monoclonal antibody groups.
This book explains how Roman law worked for those who lived by it, by viewing it in the light of the society and economy in which it operated. Written in an accessible style with the minimum of legal technicality, the book is designed for students and teachers of Roman history as well as interested general readers. Topics covered include the family and inheritance, property and the use of land, business and commercial transactions, and litigation. In this second edition, all chapters have been extensively revised and updated, and a new chapter on crime and punishment has been included. The book ends with an epilogue covering the fate of Roman law in medieval and modern Europe. David Johnston is a lawyer practising in the courts and draws on his experience of law in practice to shape the work and provide new insights for his readers.
Paula López Caballero y Ariadna Acevedo-Rodrigo, Más allá de la identidad indígena. Ciudad de México, Grano de Sal/Universidad Nacional Autónoma de México, 2025.
P. Boffano, A.M. Agnone, Francesca Neirotti
et al.
INTRODUCTION The purpose of this European multicenter study was to describe the general characteristics and risk factors of MRONJ lesions as well as their clinical diagnosis and management at different European Oral and Maxillofacial Surgery centers, in order to minimize selections biases and provide information about the epidemiology, etiopathogenesis, and the current trends in the treatment of MRONJ across Europe. MATERIALS AND METHODS The following data were registered for each patient: gender; age at MRONJ diagnosis; past medical history; indication for antiresorptive or antiangiogenic therapy; type of antiresorptive medication; local risk factor for MRONJ; MRONJ Stage; anatomic location and symptoms; treatment; surgical complications; recurrence. RESULTS A total of 537 patients (375 females, 162 males) with MRONJ were included. Statistically significant associations were found between patients with metastatic bone disease and recurrences (P < 0.0005) and between advanced MRONJ stages (stages 2 and 3) and recurrences (P < 0.005). Statistically significant associations were also found between male gender and recurrences (P < 0.05), and between MRONJ maxillary sites and recurrences (P < 0.0000005). CONCLUSIONS A longer mean duration of antiresorptive medications before MRONJ onset was observed in patients affected by osteoporosis, whereas a shorter mean duration was observed in all metastatic bone cancer patients, and in particular in those affected by prostate cancer with bone metastases or multiple myeloma. Surgery plays an important role for the management of MRONJ lesions.
SETI is not a usual point of departure for environmental humanities. However, this paper argues that theories originating in this field have direct implications for how we think about viable inhabitation of the Earth. To demonstrate SETI's impact on environmental humanities, this paper introduces Fermi paradox as a speculative tool to probe possible trajectories of planetary history, and especially the "Sustainability Solution" proposed by Jacob Haqq-Misra and Seth Baum. This solution suggests that sustainable coupling between extraterrestrial intelligences and their planetary environments is the major factor in the possibility of their successful detection by remote observation. By positing that exponential growth is not a sustainable development pattern, this solution rules out space-faring civilizations colonizing solar systems or galaxies. This paper elaborates on Haqq-Misra's and Baum's arguments, and discusses speculative implications of the Sustainability Solution, thus rethinking three concepts in environmental humanities: technosphere, planetary history, and sustainability. The paper advocates that (1) technosphere is a transitory layer that shall fold back into biosphere; (2) planetary history must be understood in a generic perspective that abstracts from terrestrial particularities; and (3) sustainability is not sufficient vector of viable human inhabitation of the Earth, suggesting instead habitability and genesity as better candidates.
Resumen El artículo analiza la vida, el exilio y la obra artística del pintor republicano José Luis Fernández Martínez (pintor Sarralde-“Pasajes”) bajo el gobierno republicano y el sucesivo régimen franquista. Alistado como voluntario en el ejército de la República, fue afectado en la Sección de Cultura del Comisariado General de Guerra trabajando codo a codo con otros artistas; sobrevivió a los vencedores enmascarando su pasado durante la posguerra y haciendo frente a los estragos de una España ennegrecida durante la etapa del primer franquismo. Tuvo la suerte de viajar a América muy pronto, en 1945, y la osadía, de cara al gobierno franquista, de entablar amistad con exiliados republicanos en México, en donde se casó y formó familia. Desde entonces y durante largos años residió entre las dos orillas. Su pincel retrató a ilustres personajes del ámbito de la cultura y política durante el gobierno republicano, el régimen franquista y la república de México; pero también aquellos otros exiliados republicanos o personajes afines a la causa en América. Fue único en conectar uno y otro mundo, tan distintos, gracias a su arte.
The paper deals with the publishing history in the post-Soviet era of three very prominent works in Gulag literature in Italian translation – Life and Fate by Vasilij Grossman, Kolyma Tales by Varlam Šalamov and The Gulag Archipelago by Aleksandr Solženicyn – in order to reconstruct their Italian reception in the years 1991-2022. The controversies surrounding the publication of these works in Italy are also discussed, and it is noted how the Italian press has paid particular attention to them, with major Italian writers reviewing the editions and contributing to their Italian reception. Finally, the lack of critical reflection by Italian Russianists on Gulag literature is discussed.
History of Eastern Europe, Slavic languages. Baltic languages. Albanian languages
The codification attempts of Criminal Law in the time of the Enlightenment of the 1790 s and the liberalism of the 1830s and 1840s are the focal points of the study. In order to draft bills to reform the feudal state based on customary law and privileges without changing the basic public law framework, nine so-called national regular committees were set up by Article 67 of Act 1791. The committees completed their work and sent their drafts, known as operatives, to the king between 1792 and 1795. After all, the completed operatives were not put on the agenda of the Parliament due to changes in the domestic and foreign policy status quo. They could find a way out from the archives of the Chancellery only thanks to the committees set up by Article 8 of Act 1827. These committees were responsible for reviewing the „forgotten“ operatives, which were finally printed and sent to the counties for comments. The Hungarian liberal noble opposition was organised first as a movement and then as a party during these county debates (1831–1832) in order to replace the feudal system by manifesting the basic principles of the civil transition in the so-called laws of April.
History (General) and history of Europe, History of Law
The aim of this article is to examine the role of Catholic political thought in relation to the history of European integration and show how the shift away from this communitarian tradition by mainstream social democratic and conservative parties can help explain the rise of populism. The idea of Europe as a unified entity has always been grounded in its Christian character, and this was the basis of the Christian Democratic pan-European project of the EU’s ‘founding fathers’ in the mid-twentieth century. The rise of both social and economic liberalism in the ensuing years led to a disconnect between the political establishment – who remain largely supportive of the project – and growing numbers of disaffected citizens. A refocusing of the political narrative in relation to European integration on the continent’s communitarian and Christian (and Social) Democratic traditions could halt the advance of populist-nationalism and Eurosceptic parties.
Ebele, E. Nnadozie, Obinna O. Ike, Ngozi U. Chuke
et al.
The study investigated the influence of psychological ownership on the association between satisfaction with work-family balance and intention to stay in the profession in South-Eastern Nigerian public hospitals. An exploratory research design was adopted for a study that was conducted among 389 nurses recruited from public hospitals in South-eastern Nigeria (females: 373 (96 %); males: 16(4 %); mean age: 37.40 years; SD = 6.33). Participants completed self-report measures of satisfaction with work-family balance, psychological ownership, and intention to stay. Regression analyses showed that work-family balance and psychological ownership positively correlated with nurses' intention to stay. Psychological ownership also moderated the relationship between satisfaction with work-family balance and intention to stay. These findings indicated that psychological ownership and satisfaction with work-family balance are necessary preconditions for striking a balance between job demands and employees’ responsibilities to encourage intention to stay and improve commitment and productivity. Thus, the current findings help hospital managements comprehend and appreciate the critical roles of psychological ownership and satisfaction with work-family balance in enhancing nurses’ intention to stay.
The article presents the meaning of the principle of separation of Church and state in the European context. Christian teaching distinguishes between the secular and the spiritual sphere. In European society, such a division is accepted, but questions about the correct relationship between the Church and the state have been arising throughout history. The Church and the state seldom lived in a peaceful coexistence, and the state often interfered with the Church and vice versa. The correct understanding of the separation of Church and state means that spiritual leaders should not act as state leaders and that state leaders should not express their opinions on spiritual and moral matters. Church and state must work together for the welfare and progress of both the entire community and the individual.
History and principles of religions, Practical Theology
In this paper we describe the history of the LHCb experiment over the last three decades, and its remarkable successes and achievements. LHCb was conceived primarily as a b-physics experiment, dedicated to CP violation studies and measurements of very rare b decays, however the tremendous potential for c-physics was also clear. At first data taking, the versatility of the experiment as a general-purpose detector in the forward region also became evident, with measurements achievable such as electroweak physics, jets and new particle searches in open states. These were facilitated by the excellent capability of the detector to identify muons and to reconstruct decay vertices close to the primary pp interaction region. By the end of the LHC Run 2 in 2018, before the accelerator paused for its second long shut down, LHCb had measured the CKM quark mixing matrix elements and CP violation parameters to world-leading precision in the heavy-quark systems. The experiment had also measured many rare decays of b and c quark mesons and baryons to below their Standard Model expectations, some down to branching ratios of order 10-9. In addition, world knowledge of b and c spectroscopy had improved significantly through discoveries of many new resonances already anticipated in the quark model, and also adding new exotic four and five quark states.
Poszczególne inicjatywy archiwów składające się na ich ofertę edukacyjną,
aby cieszyły się zainteresowaniem i wysoką frekwencją, powinny być właściwie promowane wśród społeczeństwa. Nie ma wątpliwości, że do głównych odbiorców takiej aktywności należą szkoły, przede wszystkim w kontekście edukacji historycznej. Kluczowym zatem wydaje się pytanie, w jaki sposób polskie archiwa informują nauczycieli o swojej ofercie edukacyjnej i zachęcają do korzystania z niej. Zbadania wymaga problem uwzględniania archiwów jako instytucji o charakterze edukacyjnym w uniwersyteckim kształceniu nauczycieli historii. Przede wszystkim należy zastanowić się, w jaki sposób informacje o działaniach edukacyjnych archiwów trafiają do szkół. Wydaje się, że archiwa wykazują się tutaj znaczącą biernością, poprzestając na publikowaniu wiadomości o jednostkowych wydarzeniach (np. wystawach, konkursach itp.) na własnych stronach internetowych. Niekiedy informacje te mają charakter bardziej systemowy – na witrynie archiwum znajduje się zakładka na temat oferty edukacyjnej, w której są zamieszczane np. scenariusze lekcji czy materiały dla nauczyciela. Niektóre placówki są w tym obszarze bardziej proaktywne, np. poprzez warsztaty czy publikacje adresowane do nauczycieli, których celem jest zachęcanie pedagogów do nawiązywania kontaktów z archiwami. Niekiedy przedsięwzięcia te organizowane są wspólnie z ośrodkami metodycznymi i kuratoriami oświaty. Warto zatem przyjrzeć się także współpracy archiwów z wymienionymi podmiotami. Duże znaczenie mają też prywatne, rodzinne i towarzyskie kontakty pomiędzy archiwistami i nauczycielami – te wydają się być najistotniejsze w promowaniu działań edukacyjnych archiwów.
History (General) and history of Europe, Education
Nobility of the Kievan palatinate and the problems of judicial organization in the second half of the 17th century
The Polish-Lithuanian Commonwealth’s nobility attached great importance to the proper functioning of the judicial system, and the administrative issues of the justice system were among the principal matters discussed in the dietines. They were of particular importance to the Kievan nobility during their exile in the second half of the 17th century. The article discusses the statutes aimed at providing them relief during that period. The one of major importance was the act of 1683 that established county courts in the Owrucz and Żytomierz counties. The latter was carried into execution only in 1701. The same statute also prescribed the duties of the castle officials responsible for holding courts in Żytomierz and Owrucz. The article also discusses the issues of judicial administration in the Kievan palatinate and the proposals for the judicial reform raised by the dietines (especially between 1661 and 1667), which were only carried out in 1684, when the Kievan and Owrucz sheriffs were sworn in.