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Menampilkan 20 dari ~1075935 hasil · dari arXiv, CrossRef

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CrossRef Open Access 2022
Glial Contributions to Lafora Disease: A Systematic Review

Stefania Della Vecchia, Maria Marchese, Filippo Maria Santorelli

Background: Lafora disease (LD) is a neurodegenerative condition characterized by the accumulation of polyglucosan bodies (PBs) throughout the brain. Alongside metabolic and molecular alterations, neuroinflammation has emerged as another key histopathological feature of LD. Methods: To investigate the role of astrocytes and microglia in LD, we performed a systematic review according to the PRISMA statement. PubMed, Scopus, and Web-of-Science database searches were performed independently by two reviewers. Results: Thirty-five studies analyzing the relationship of astrocytes and microglia with LD and/or the effects of anti-inflammatory treatments in LD animal models were identified and included in the review. Although LD has long been dominated by a neuronocentric view, a growing body of evidence suggests a role of glial cells in the disease, starting with the finding that these cells accumulate PBs. We discuss the potential meaning of glial PB accumulations, the likely factors activating glial cells, and the possible contribution of glial cells to LD neurodegeneration and epilepsy. Conclusions: Given the evidence for the role of neuroinflammation in LD, future studies should consider glial cells as a potential therapeutic target for modifying/delaying LD progression; however, it should be kept in mind that these cells can potentially assume multiple reactive phenotypes, which could influence the therapeutic response.

arXiv Open Access 2014
On Regularity of J-holomorphic Maps

Max Lipyanskiy

We provide a short proof that an $L^2_1$ and $J$-holomorphic curve is in fact smooth. As an application, we deduce a removal of singularity theorem for curves of finite energy.

en math.SG
arXiv Open Access 2014
Gromov-Uhlenbeck Compactness

Max Lipyanskiy

We develop an analytic framework that combines the compactness theory of Gromov for J-holomorphic curves with that of Uhlenbeck for ASD connections. Compactness, regularity and removal of singularity theorems are discussed.

en math.SG
arXiv Open Access 2014
Fukaya's work on Lagrangian embeddings

Janko Latschev

This is an expository account of some applications of string topology to the study of Lagrangian embeddings into symplectic manifolds, originally due to Fukaya, which was written as a contribution to a book on free loop spaces.

en math.SG

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