This is the first meta-analysis of the pooled prevalence of insomnia in the general population of China. A systematic literature search was conducted via the following databases: PubMed, PsycINFO, EMBASE and Chinese databases (China National Knowledge Interne (CNKI), WanFang Data and SinoMed). Statistical analyses were performed using the Comprehensive Meta-Analysis program. A total of 17 studies with 115,988 participants met the inclusion criteria for the analysis. The pooled prevalence of insomnia in China was 15.0% (95% Confidence interval [CI]: 12.1%-18.5%). No significant difference was found in the prevalence between genders or across time period. The pooled prevalence of insomnia in population with a mean age of 43.7 years and older (11.6%; 95% CI: 7.5%-17.6%) was significantly lower than in those with a mean age younger than 43.7 years (20.4%; 95% CI: 14.2%-28.2%). The prevalence of insomnia was significantly affected by the type of assessment tools (Q = 14.1, P = 0.001). The general population prevalence of insomnia in China is lower than those reported in Western countries but similar to those in Asian countries. Younger Chinese adults appear to suffer from more insomnia than older adults. Trial Registration: CRD 42016043620
Emanuela Longo, Elena Giuliano, Agnese Gagliardi
et al.
In ophthalmology, developing effective drug delivery systems is crucial to overcome anatomical and physiological barriers, such as rapid tear turnover and blinking, which limit the efficacy of conventional formulations like eye drops. Poloxamers, especially the derivatives 407 (P407) and 188, are amphiphilic triblock copolymers characterized by an intriguing thermo-reversible behavior, making them ideal candidates for the development of in situ hydrogels for ocular applications. Various thermo-sensitive poloxamer-based hydrogels were designed to be easily instilled as liquids at room temperature, gelling promptly upon contact with the corneal surface. These systems promoted a controlled release of active compounds, significantly improving their adhesion to the ocular surface. This review discusses the most relevant scientific literature on the topic, with particular attention to studies published in recent years. The results demonstrated that poloxamer formulations are capable of overcoming typical ocular barriers, thereby increasing drug bioavailability. The intrinsic biocompatibility of poloxamers contributes to the safety and tolerability of the system. Furthermore, P407 showed additional wound healing features. The combination of biocompatibility and thermo-reversible behavior makes poloxamer-based hydrogels a promising platform for the development of innovative ocular drug delivery systems able to enhance therapeutic efficacy and patient comfort.
The present study aimed to update the literature review on the prevalence of fibromyalgia (FM) published in 2006. A bibliographical survey was carried out from 2005 to 2014 in the MEDLINE, Web of Science, Embase, LILACS and SciELO databases and 3274 records were identified. Five researchers selected the studies, following the inclusion criteria: studies that obtained the prevalence of FM. FM studies in associated diseases were excluded. When screening by title and abstract, 2073 irrelevant articles were excluded. The full texts of 210 articles were evaluated for eligibility and this review included 39 studies, described in 41 articles. The selected studies were grouped into four categories: a) prevalence of FM in the general population; B) prevalence of FM in women; C) prevalence of FM in rural and urban areas; D) prevalence of FM in special populations. The literature shows values of FM prevalence in the general population between 0.2 and 6.6%, in women between 2.4 and 6.8%, in urban areas between 0.7 and 11.4%, in rural areas between 0.1 and 5.2%, and in special populations values between 0.6 and 15%. This literature review update shows a significant increase in FM prevalence studies in the world. The new 2010 American College of Rheumatology criteria have not been widely used yet and the COPCORD (Community-oriented program for control of Rheumatic Diseases) methodology has increased the quality of studies on the prevalence of rheumatic diseases in general.
It has been proposed that the flat rotation curves observed at large radii in disk galaxies can be interpreted as an effect of General Relativity (GR) instead of the presence of dark matter (DM) halos in Newtonian gravity. In Ciotti (2022) the problem is rigorously explored in the special setting of the weak-field, low-velocity gravitomagnetic limit of GR. The rotation curves are obtained for purely baryonic disk models with realistic density profiles, and compared with the predictions of Newtonian gravity for the same disks, in absence of DM. The rotation curves are indistinguishable, with percentual GR corrections at all radii of the order of $\approx 10^{-6}$ or less, so that DM halos are required in gravitomagnetism as in Newtonian gravity. From a more general point of view, a list of the most urgent problems that must be addressed by any proposed GR-based alternative to the existence of DM, is given.
Environmental knowledge has been established as a behavior-distal, but necessary antecedent of pro-environmental behavior. The magnitude of its effect is difficult to estimate due to methodological deficits and variability of measures proposed in the literature. This paper addresses these methodological issues with an updated, comprehensive and objective test of environmental knowledge spanning a broad variety of current environment related topics. In a multivariate study (n = 214), latent data modeling was employed to explore the internal factor structure of environmental knowledge, its relationship with general knowledge and explanatory power on pro-environmental behavior. We tested competing factor models and uncovered a general factor of environmental knowledge. The main novel finding of the study concerns its relationship with general knowledge. Employing an established test of general knowledge to measure crystallized intelligence revealed a near perfect relationship between environmental and general knowledge. This general knowledge (including the environmental domain) accounted for 7% of the variance in environmentally significant behavior. Age, additionally to acquired education, emerged as a common predictor for both general knowledge and environmentally significant behavior. We discuss the consequences of the strong relation between general and environmental knowledge and provide a possible explanation for the positive age-environmental conservation relationship reported in the literature.
The article examines the tension between the individual and the collective in current mainstream photographic practice, which is considered within the long-term historical context of commercial portraiture. The individualizing tendencies of this representational tradition as well as its status as (auto)biographical fiction were astutely analyzed by the Russian avant-garde thinkers Alexander Rodchenko and Osip Brik. Criticizing the persistence of “painterly” clichés in studio photography of their time, they saw these conventional elements as something that obscures and distorts reality, substituting for it a beautiful picture. For these leftist theorists, reality was primarily defined by the interplay of social forces, and isolating the subject within the picture frame was sufficient grounds for their disapproval. Taking up their notion of cliché applied particularly to posing, this article proposes to view it, instead, as an entry point into the usually invisible collective dimension of each individual portrait. The first section of the article discusses historical precedents to current mainstream photographic portraiture in terms of class- and gender-specific pressures on the sitters which have contributed to the homogenization of the genre’s visual canon. The suggestion to view stylistically similar images of individuals as expressing a latent collectivity is developed in the second part of the article, which analyzes Jana Romanova’s photographic series W through the theoretical framework borrowed from Lauren Berlant (“intimate public”, “female complaint”) and Gayle Letherby (“auto/biography”).
Alberto Borboni, Roberto Pagani, Samuele Sandrini
et al.
Safety plays a key role in human–robot interactions in collaborative robot (cobot) applications. This paper provides a general procedure to guarantee safe workstations allowing human operations, robot contributions, the dynamical environment, and time-variant objects in a set of collaborative robotic tasks. The proposed methodology focuses on the contribution and the mapping of reference frames. Multiple reference frame representation agents are defined at the same time by considering egocentric, allocentric, and route-centric perspectives. The agents are processed to provide a minimal and effective assessment of the ongoing human–robot interactions. The proposed formulation is based on the generalization and proper synthesis of multiple cooperating reference frame agents at the same time. Accordingly, it is possible to achieve a real-time assessment of the safety-related implications through the implementation and fast calculation of proper safety-related quantitative indices. This allows us to define and promptly regulate the controlling parameters of the involved cobot without velocity limitations that are recognized as the main disadvantage. A set of experiments has been realized and investigated to demonstrate the feasibility and effectiveness of the research by using a seven-DOF anthropomorphic arm in combination with a psychometric test. The acquired results agree with the current literature in terms of the kinematic, position, and velocity aspects; use measurement methods based on tests provided to the operator; and introduce novel features of work cell arranging, including the use of virtual instrumentation. Finally, the associated analytical–topological treatments have enabled the development of a safe and comfortable measure to the human–robot relation with satisfactory experimental results compared to previous research. Nevertheless, the robot posture, human perception, and learning technologies would have to apply research from multidisciplinary fields such as psychology, gesture, communication, and social sciences in order to be prepared for positioning in real-world applications that offer new challenges for cobot applications.