Hasil untuk "Life"

Mehak Pant, Lubna Salman, Anupama V. Betigeri et al.

Background: Students belong to the most significant groups of individuals that use technology. Screen time impacts several factors including health and behavior. It is still mostly unknown how physical activity and screen-grounded programming interact to affect health-related quality of life. Methods: The study had been carried out as a crossed sectional survey. (google form survey circulated to participating university students). The student selection for this cross-sectional survey, included all undergraduate students aged 18–30 years, studying in MRIIRS, Faridabad. Participants-100, inclusion criteria age: 18–30 years university students exclusion criteria age: below 18 years. Results and Conclusion: The findings indicated that the combination of excessive screen time and no physical activity had the biggest detrimental effect on “health-related quality of life”.

Valerio Aversano, Ellen Van Stichel

In recent decades, a novel right-wing nationalist and populist tendency has emerged on a global scale, frequently framing Christian identity as one of its central pillars. This article explores the relationship between right-wing populism and Christianity, by addressing how populism considers the role of religion on the one hand, and how Christianity position itself in relation to populism on the other hand, with a specific focus on Pope Francis’s social thought Although the relationship between right-wing populism and Christianity appears to be ambivalent, the response of Pope Francis, as elaborated in the encyclical _Fratelli Tutti_, is not. In the section entitled “A Better Kind of Politics,” the distinction between the “popular” and “populist leader” is employed as a hermeneutical tool to investigate current political developments. Furthermore, it enables us to respond to the allegation that Francis himself could be considered a populist, as some claim, referring to his alleged affinities with the political culture associated with Peronism. In his interpretation of the notion of political love as delineated in _Fratelli Tutti_, Francis leaves us with a legacy regarding the ethical response of Christians to populism, promoting instead a “culture of encounter” and a “better kind of politics.”

Corey M. Abramson

This chapter demonstrates how computational social science (CSS) tools are extending and expanding research on aging. The depth and context from traditionally qualitative methods such as participant observation, in-depth interviews, and historical documents are increasingly employed alongside scalable data management, computational text analysis, and open-science practices. Machine learning (ML) and natural language processing (NLP), provide resources to aggregate and systematically index large volumes of qualitative data, identify patterns, and maintain clear links to in-depth accounts. Drawing on case studies of projects that examine later life--including examples with original data from the DISCERN study (a team-based ethnography of life with dementia) and secondary analyses of the American Voices Project (nationally representative interview)--the chapter highlights both uses and challenges of bringing CSS tools into more meaningful dialogue with qualitative aging research. The chapter argues such work has potential for (1) streamlining and augmenting existing workflows, (2) scaling up samples and projects, and (3) generating multi-method approaches to address important questions in new ways, before turning to practices useful for individuals and teams seeking to understand current possibilities or refine their workflow processes. The chapter concludes that current developments are not without peril, but offer potential for new insights into aging and the life course by broadening--rather than replacing--the methodological foundations of qualitative research.

Erwan Plantec, Gautier Hamon, Mayalen Etcheverry et al.

Central to the artificial life endeavour is the creation of artificial systems spontaneously generating properties found in the living world such as autopoiesis, self-replication, evolution and open-endedness. While numerous models and paradigms have been proposed, cellular automata (CA) have taken a very important place in the field notably as they enable the study of phenomenons like self-reproduction and autopoiesis. Continuous CA like Lenia have been showed to produce life-like patterns reminiscent, on an aesthetic and ontological point of view, of biological organisms we call creatures. We propose in this paper Flow-Lenia, a mass conservative extension of Lenia. We present experiments demonstrating its effectiveness in generating spatially-localized patters (SLPs) with complex behaviors and show that the update rule parameters can be optimized to generate complex creatures showing behaviors of interest. Furthermore, we show that Flow-Lenia allows us to embed the parameters of the model, defining the properties of the emerging patterns, within its own dynamics thus allowing for multispecies simulations. By using the evolutionary activity framework as well as other metrics, we shed light on the emergent evolutionary dynamics taking place in this system.

Michael Safo Oduro, Eniola Fasola, Prince Peprah et al.

Abstract Background There is a dearth of studies focused on the impact of self-rated health on life satisfaction among large-bodied adolescents, as well as the moderating role of physical activity in this relationship. Large-bodied adolescents refers to young people (usually aged 10–19 years) whose body size falls within the overweight or obese range as defined by the World Health Organisation’s Growth Reference, based on age- and sex-specific body mass index (BMI) percentiles. This study aimed to address the gap in research by examining the association between self-rated health and life satisfaction in a diverse sample of large-bodied adolescents from 39 countries and regions in Europe and North America. The moderating role of physical activity in the association was also examined. Methods The study analysed data from the Health Behaviour in School-aged Children (HBSC) survey, involving a sample of 24,839 large-bodied adolescents. Three sequential binary mixed effects logit models were fitted: the first assessing self-rated health alone, the second adjusting for multiple covariates, and the third incorporating an interaction term between physical activity and self-rated health. The analysis was performed using R Software (v4.1.2), with significance determined at a level of 0.05. Results The results show that adolescents who rated their health as “poor” were a little more than six times (AOR = 6.32, 95%CI: 5.30–7.54, p < 0.001) as likely to report lower life satisfaction compared to those who rated their health as “excellent”. Those who rated their health as “good” had 1.71 times higher odds (AOR = 1.71, 95%CI: 1.44–2.04, p < 0.001) of reporting lower life satisfaction compared to those who rated their health as “excellent”. The analysis further indicated that physical activity plays a partial moderating role in the relationship between self-rated health and life satisfaction. Participants who considered themselves “somewhat active” reported higher life satisfaction compared to their “inactive” peers (AOR = 0.58, p = 0.031, 95% CI: 0.36–0.95). Conclusions The study supports the hypothesis that poorer self-rated health is associated with lower life satisfaction among large-bodied adolescents. It further suggests that increased physical activity can ‘partly’ buffer the negative effects of poor self-rated health on life satisfaction. These findings emphasise the importance of interventions promoting physical activity and positive self-care to improve general well-being in large-bodied adolescents.

Tian Jiang, Lei Zhao, Xu Zhang et al.

Species of <i>Craterellus</i> are interesting and important due to their mycorrhizal properties, medicinal value, and edibility. Despite extensive research on <i>Craterellus</i> in China, its taxonomy remains inadequately understood. This study presents three newly described species of <i>Craterellus</i>, namely <i>C. albimarginatus</i>, <i>C. involutus</i>, and <i>C. longitipes</i>, identified through morphological and phylogenetic analyses, with the goal of refining the taxonomy of Chinese <i>Craterellus</i>.

Guillaume Barbalat, Ariane Guilbert, Lucie Adelaïde et al.

Abstract Background A number of negative developmental outcomes in response to extreme temperature have been documented. Yet, to our knowledge, environmental research has left the question of the effect of temperature on human neurodevelopment largely unexplored. Here, we aimed to investigate the effect of ambient temperature on linguistic development at the age of 2 years-old. Methods We used data from the prospective national French birth cohort ELFE (N = 12,163) and highly-resolved exposure models with daily temporal resolution and 200 m to 1 km spatial resolution. We investigated the effect of weekly averages of overall, daytime and night-time temperature in the prenatal (first 30 weeks of gestation) and postnatal (91 weeks after birth) period on vocabulary production scores from the MacArthur-Bates Communicative Development Inventories (MB-CDI) at 2 years-old. Exposure-response and lag-response relationships were modeled with confounder-adjusted distributed lag non-linear models. Results Scores at the MB-CDI decreased by 3.2% (relative risk (RR) 0.968, 95% confidence interval (CI): 0.939–0.998) following exposure to severe night-time heat of 15.6 °C (95th percentile) vs. 8.3 °C (median) throughout gestational weeks 14 to 19. In the postnatal period, scores at the MB-CDI decreased by 14.8% (RR 0.852; 95% CI: [0.756–0.96]) for severe overall heat of 21.9 °C (95th percentile) vs. 11.5 °C (median) throughout weeks 1 to 28. Consistent results were found for daytime and night-time heat. We observed positive effects of overall and night-time heat in the first few weeks of pregnancy. Night-time cold in the pre-natal period also resulted in improved scores at the MB-CDI. Adjusting our models for air pollutants (PM2.5, PM10 and NO2) tended to confirm these observations. Finally, there were no significant differences in temperature effects between boys and girls. Conclusion In this large cohort study, we showed a negative impact of hot temperatures during pregnancy and after birth on language acquisition. Positive associations observed in the first few weeks of pregnancy are likely the results of methodological artifacts. Positive associations with night-time cold during the prenatal period are likely truly protective, as colder temperatures may encourage staying indoors at a comfortable temperature. Policymakers should consider neurodevelopment impairments as a deleterious effect of climate change.

Natalya Weber, Christian Guckelsberger, Tom Froese

The Self-Optimization (SO) model can be considered as the third operational mode of the classical Hopfield Network, leveraging the power of associative memory to enhance optimization performance. Moreover, it has been argued to express characteristics of minimal agency, which renders it useful for the study of artificial life. In this article, we draw attention to another facet of the SO model: its capacity for creativity. Drawing on creativity studies, we argue that the model satisfies the necessary and sufficient conditions of a creative process. Moreover, we show that learning is needed to find creative outcomes above chance probability. Furthermore, we demonstrate that modifying the learning parameters in the SO model gives rise to four different regimes that can account for both creative products and inconclusive outcomes, thus providing a framework for studying and understanding the emergence of creative behaviors in artificial systems that learn.

Julio C. Rangel, Tarcisio Mendes de Farias, Ana Claudia Sima et al.

The recent success of Large Language Models (LLM) in a wide range of Natural Language Processing applications opens the path towards novel Question Answering Systems over Knowledge Graphs leveraging LLMs. However, one of the main obstacles preventing their implementation is the scarcity of training data for the task of translating questions into corresponding SPARQL queries, particularly in the case of domain-specific KGs. To overcome this challenge, in this study, we evaluate several strategies for fine-tuning the OpenLlama LLM for question answering over life science knowledge graphs. In particular, we propose an end-to-end data augmentation approach for extending a set of existing queries over a given knowledge graph towards a larger dataset of semantically enriched question-to-SPARQL query pairs, enabling fine-tuning even for datasets where these pairs are scarce. In this context, we also investigate the role of semantic "clues" in the queries, such as meaningful variable names and inline comments. Finally, we evaluate our approach over the real-world Bgee gene expression knowledge graph and we show that semantic clues can improve model performance by up to 33% compared to a baseline with random variable names and no comments included.

Ana Glidden, Sara Seager, Janusz J. Petkowski et al.

Isotopologue ratios are anticipated to be one of the most promising signs of life that can be observed remotely. On Earth, carbon isotopes have been used for decades as evidence of modern and early metabolic processes. In fact, carbon isotopes may be the oldest evidence for life on Earth, though there are alternative geological processes that can lead to the same magnitude of fractionation. However, using isotopologues as biosignature gases in exoplanet atmospheres presents several challenges. Most significantly, we will only have limited knowledge of the underlying abiotic carbon reservoir of an exoplanet. Atmospheric carbon isotope ratios will thus have to be compared against the local interstellar medium or, better yet, their host star. A further substantial complication is the limited precision of remote atmospheric measurements using spectroscopy. The various metabolic processes which cause isotope fractionation cause less fractionation than anticipated measurement precision (biological fractionation is typically 2 to 7%). While this level of precision is easily reachable in the laboratory or with special in situ instruments, it is out of reach of current telescope technology to measure isotope ratios for terrestrial exoplanet atmospheres. Thus, gas isotopologues are poor biosignatures for exoplanets given our current and foreseeable technological limitations.

Koma Akim

The objective of the study is to demonstrate the significance of damage control surgery in saving lives and possibly preventing permanent disability in a resource poor environment. This is because in resource limited settings, advanced treatment modalities such as external fixation and angiography with embolization are not available. Moreover, besides being expensive, these treatment methods for pelvic fractures require training and skills to perform. The retroperitoneal pelvic packing is easy to learn and, thus can be used in an emergency to save lives and prevent long-term problems in patients who have sustained life threatening pelvic injuries and severe haemorrhage. Therefore, specialist surgeons, especially those working in low- and middle-income countries, should be encouraged to learn and consider retroperitoneal pelvic packing as a stabilization and definitive treatment in some cases of pelvic fractures.

Anne Niknejad, Christopher J. Mungall, David Osumi-Sutherland et al.

With the new era of genomics, an increasing number of animal species are amenable to large-scale data generation. This had led to the emergence of new multi-species ontologies to annotate and organize these data. While anatomy and cell types are well covered by these efforts, information regarding development and life stages is also critical in the annotation of animal data. Its lack can hamper our ability to answer comparative biology questions and to interpret functional results. We present here a collection of development and life stage ontologies for 21 animal species, and their merge into a common multi-species ontology. This work has allowed the integration and comparison of transcriptomics data in 52 animal species.

Jiankui Liu, Jiankui Liu, Jiankui Liu et al.

The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens causing substantial economic losses to the Chinese swine industry. In this study, we analyzed the complete genome sequences of four PRRSV isolates (PRRSV2/CN/SS0/2020, PRRSV2/CN/SS1/2021, PRRSV2/CN/L3/2021, and PRRSV2/CN/L4/2020) isolated from a single pig farm from 2020 to 2021. The genomes of the four isolates were 14,962–15,023 nt long, excluding the poly (A) tails. Comparative analysis of the genome sequences showed that the four isolates shared 93.2–98.1% homology and they had no close PRRSV relatives registered in the GenBank (&lt;92%). Furthermore, PRRSV2/CN/SS0/2020 and PRRSV2/CN/SS1/2021 had characteristic 150-aa deletions (aa481+aa537-566 +aa628–747) that were identical to the live attenuated virus vaccine strain TJM-F92 (derived from the HP-PRRSV TJ). Further analysis of the full-length sequences suggests that the four isolates were natural recombinant strains between lineages 1 (NADC30-like), 3 (QYYZ-like), and 8.7 (JXA1-like). Animal experiments revealed discrepancies in virulence between PRRSV2/CN/SS0/2020 and PRRSV2/CN/L3/2021. The strain with high homology to HP-PRRSV demonstrates higher pathogenicity for pigs than the other isolate with low homology to HP-PRRSV. Taken together, our findings suggest that PRRSVs have undergone genome evolution by recombination among field strains/MLV-like strains of different lineages.

J. Holler, P. Kedron

Reproducible open science with FAIR data sharing principles requires research to be disseminated with open data and standardised metadata. Researchers in the geographic sciences may benefit from authoring and maintaining metadata from the earliest phases of the research life cycle, rather than waiting until the data dissemination phase. Fully open and reproducible research should be conducted within a version-controlled executable research compendium with registered pre-analysis plans, and may also involve research proposals, data management plans, and protocols for research with human subjects. We review metadata standards and research documentation needs through each phase of the research process to distil a list of features for software to support a metadata-rich open research life cycle. The review is based on open science and reproducibility literature and on our own work developing a template research compendium for conducting reproduction and replication studies. We then review available open source geographic metadata software against these requirements, finding each software program to offer a partial solution. We conclude with a vision for software-supported metadata-rich open research practices intended to reduce redundancies in open research work while expanding transparency and reproducibility in geographic research.

Lisa Argnani, Anna Zanetti, Anna Zanetti et al.

Background: Rheumatoid arthritis (RA) is associated with an increase in cardiovascular (CV) risk. This issue maybe not only explained by a genetic component, as well as by the traditional CV risk factors, but also by an underestimation and undertreatment of concomitant CV comorbidities.Method: This was a retrospective matched-cohort analysis in the Italian RA real-world population based on the healthcare-administrative databases to assess the CV risk factors and incidence of CV events in comparison with the general population. Persistence and adherence to the CV therapy were also evaluated in both groups.Results: In a RA cohort (N = 21,201), there was a greater prevalence of hypertension and diabetes with respect to the non-RA subjects (N = 249,156) (36.9 vs. 33.4% and 10.2 vs. 9.6%, respectively), while dyslipidemia was more frequent in the non-RA group (15.4 vs. 16.5%). Compared with a non-RA cohort, the patients with RA had a higher incidence of atrial fibrillation (incidence rate ratio, IRR 1.28), heart failure (IRR 1.53), stroke (IRR 1.19), and myocardial infarction (IRR 1.48). The patients with RA presented a significantly lower persistence rate to glucose-lowering and lipid-lowering therapies than the controls (odds ratio, OR 0.73 [95% CI 0.6–0.8] and OR 0.82 [0.8–0.9], respectively). The difference in the adherence to glucose-lowering therapy was significant (OR 0.7 [0.6–0.8]), conversely no statistically significant differences emerged regarding the adherence to lipid-lowering therapy (OR 0.89 [95% CI 0.8–1.0]) and anti-hypertensive therapy (OR 0.96 [95% CI 0.9–1.0]).Conclusion: The patients with RA have a higher risk of developing CV events compared with the general population, partially explained by the excess and undertreatment of CV risk factors.

Ashenafi Zemed, Kalkidan Nigussie Chala, Getachew Azeze Eriku et al.

<h4>Introduction</h4>Evidence on a patient-centered assessment of outcome among patients with stroke is limited in Ethiopia. Therefore, this study aimed to assess the level of health-related quality of life (HRQOL) and associated factors in Ethiopia's tertiary level hospitals.<h4>Methods</h4>A cross-sectional study was conducted at three tertiary level hospitals (Felege Hiwot comprehensive specialized hospital, University of Gondar comprehensive specialized hospital, and Dessie referral hospital) from April 1 to May 31, 2019. A total of 180 patients with stroke were included, and a consecutive sampling method was employed to recruit the participants. RAND 36-Item Health Survey was used to measure the HRQOL. A generalized linear model with a gamma distribution and log-link function was used to investigate potential predictors, and variables with a P value of <0.05 were considered statistically significant.<h4>Results</h4>Out of the participants, 50.56% were female. The average age and average duration of illness were 59.04 (12.71) and 1.5 (1.46) years, correspondingly. The physical health domain score was higher than the mental health domain score. Education (P = 0.041), social support (P = 0.050), disability (P <0.001), co-morbidity (P = 0.011), depression (P = 0.015) and income (<1000 ETB P = 0.002; 1000-4000 ETB P = 0.009) were associated with physical health domain. Whereas, ischemic stroke (P = 0.014), education (P = 0.020), disability (P <0.001), and depression (P <0.001) were associated with the mental health domain.<h4>Conclusion</h4>The HRQOL of the patients was low. Social support and lower disability status were associated with higher HRQOL, whereas disability and depression were associated with higher HRQOL. Therefore, attention should be given to strengthening social support; health professionals should focus on reducing disability/physical dependency and depression, as these are vital factors for improving HRQOL.

V. N. B. KOLYCH, N. V. HUDZ

A pathological autopsy was performed on 6 corpses of piglets during the first week of their life who died from mycoplasmosis. Examination of the visible mucous membranes revealed hyperemia of the mucous membrane of the nasal cavity and thymus. Simultaneous lesions of the pharyngeal, parotid, cervical and mandibular lymph nodes were noted. They were slightly enlarged, from dark pink to dark red. The heart is irregularly shaped due to the expansion of the right ventricle or the diffuse expansion of all departments. Lungs have doughy consistency, uneven color. In some cases, there are diffuse red areas covering the entire lobe of the lungs, in other cases, there are lesions of small areas. The liver has a smooth surface, soft or pasty consistency, the parenchyma pattern is slightly smoothed in section. The color of the liver is different: dark red areas without clear boundaries turn into creamyclay. A characteristic feature was flatulence of the stomach and intestines. Catarrhal enteritis was registered in animals, which manifested itself in the form of moderate hyperemia of the intestinal mucosa and serous membranes. Microscopically, there is a significant blood supply to the vessels in the lungs. Alveoli are half fall down, in the form of slit-like lumens. In areas of tissue infiltration by inflammatory infiltrate, the alveolar wall is thickened, alveolocytes are in a state of turbid swelling and vacuolar dystrophy, they are impregnated with erythrocytes. Peribronchial pneumonia of lymphocytic character is observed. The liver is in a state of acute venous hyperemia. The central and intraparticle capillaries are sharply dilated and filled with blood in some lobes, and the hepatic beams are compressed accordingly. In the center of other lobes, diffuse infiltration of liver tissue by erythrocytes as a consequence of diapedesis is noted. Hepatocytes are in a state of granular dystrophy. Destructive changes are strongly expressed in the mucous membrane of the small intestine: desquamation of the epithelium, necrosis of epitheliocytes and villi, destruction of crypts. In the brain tissue, there is dilation of the lumens of large and small blood vessels, extracellular and perivascular edema, areas of reactive necrosis

Sanjay Bhalchandra Londhe, Ravi Vinod Shah, Meghana Patwardhan et al.

Abstract Purpose The aim of this prospective study was to understand the fear and apprehension factors that play on patient’s mind before total knee arthroplasty. Methods This retrospective cohort study included 500 consecutive patients (375 females and 125 males) who were scheduled to undergo total knee arthroplasty the next day. The patients were asked to list the most important fear in their mind regarding the operation in descending order of importance. They were given a questionnaire form which contained several capture points, including age, gender, educational background, occupation, and provision of help at home. Preoperative pain was measured by using the visual analog score, and its influence on the patients’ fear and apprehension factors was also measured. Results In this study, 58% of patients (50 males, 40%; 240 females, 64%) were fearful of the pain that they would experience after surgery and during the postoperative physiotherapy. The female patients showed more fear of pain than their male counterparts (P < 0.05). 18% of the patients (40 males, 32%; 50 females, 13%) listed whether they will be able to walk and perform activities of daily living after surgery as the most important fear. The male patients had more fear of returning to normal walking (P < 0.05). 20% of the patients (30 males, 24%; 70 females, 19%) were fearful about getting adequate home help after discharge from hospital (P > 0.05). 4% of patients were concerned about withstanding such a major operation. There was no difference between male and female patients (P > 0.05). Conclusion The majority of the patients experience apprehension of pain in the perioperative period of TKA. Preoperative counseling benefits pain management by alleviating the patient’s concerns about the fear of postoperative pain and apprehension of returning to normal walking.

Iulia-Cristina Stanica, Florica Moldoveanu, Giovanni-Paul Portelli et al.

As life expectancy is mostly increasing, the incidence of many neurological disorders is also constantly growing. For improving the physical functions affected by a neurological disorder, rehabilitation procedures are mandatory, and they must be performed regularly. Unfortunately, neurorehabilitation procedures have disadvantages in terms of costs, accessibility and a lack of therapists. This paper presents Immersive Neurorehabilitation Exercises Using Virtual Reality (INREX-VR), our innovative immersive neurorehabilitation system using virtual reality. The system is based on a thorough research methodology and is able to capture real-time user movements and evaluate joint mobility for both upper and lower limbs, record training sessions and save electromyography data. The use of the first-person perspective increases immersion, and the joint range of motion is calculated with the help of both the HTC Vive system and inverse kinematics principles applied on skeleton rigs. Tutorial exercises are demonstrated by a virtual therapist, as they were recorded with real-life physicians, and sessions can be monitored and configured through tele-medicine. Complex movements are practiced in gamified settings, encouraging self-improvement and competition. Finally, we proposed a training plan and preliminary tests which show promising results in terms of accuracy and user feedback. As future developments, we plan to improve the system's accuracy and investigate a wireless alternative based on neural networks.

Joris H. J. van Sadelhoff, Selma P. Wiertsema, Johan Garssen et al.

Breastfeeding is indicated to support neonatal immune development and to protect against neonatal infections and allergies. Human milk composition is widely studied in relation to these unique abilities, which has led to the identification of various immunomodulating components in human milk, including various bioactive proteins. In addition to proteins, human milk contains free amino acids (FAAs), which have not been well-studied. Of those, the FAAs glutamate and glutamine are by far the most abundant. Levels of these FAAs in human milk sharply increase during the first months of lactation, in contrast to most other FAAs. These unique dynamics are globally consistent, suggesting that their levels in human milk are tightly regulated throughout lactation and, consequently, that they might have specific roles in the developing neonate. Interestingly, free glutamine and glutamate are reported to exhibit immunomodulating capacities, indicating that these FAAs could contribute to neonatal immune development and to the unique protective effects of breastfeeding. This review describes the current understanding of the FAA composition in human milk. Moreover, it provides an overview of the effects of free glutamine and glutamate on immune parameters relevant for allergic sensitization and infections in early life. The data reviewed provide rationale to study the role of free glutamine and glutamate in human milk in the protection against neonatal allergies and infections.