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DOAJ Open Access 2024
Insertion Results and Hearing Outcomes of a Slim Lateral Wall Electrode

Sini Sipari, Matti Iso-Mustajärvi , Pia Linder et al.

BACKGROUND: The clinical outcomes of cochlear implantation vary for several reasons. It is necessary to study the different electrodes and variables for further development. The aim of this study is to report the clinical outcomes of a new slim lateral wall electrode (SlimJ). METHODS: Data of 25 cochlear implantations in 23 patients with the SlimJ electrode were retrospectively collected. The insertion results were assessed by image fusion of the preoperative computed tomography (CT), magnetic resonance imaging (MRI), and postoperative cone-beam CT. The hearing outcomes were evaluated by the improvement of speech recognition in noise, measured preoperatively and at follow-up. Postoperative pure-tone thresholds were obtained in cases with preoperative functional low frequency hearing [PTA (0.125-0.5 kHz) ≤ 80 dB HL]. RESULTS: The preoperative mean speech reception threshold (SRT) was +0.6 dB signal-to-noise ratio (SNR) (SD ± 4.2 dB) and the postoperative −3.5 dB SNR (SD ± 2.3 dB). The improvements between the preoperative and postoperative SRT levels ranged from 0.0 to 15.1 dB, with a mean improvement of 4.2 dB (SD ± 3.6 dB). Residual hearing in low frequencies (mean PTA(125-500 Hz)) was preserved within 30 dB HL in 70% and within 15 dB HL in 40% of patients who had preoperatively functional low frequency hearing. Mean insertion depth angle (IDA) was 401° (SD ± 41°). We observed scalar translocations from scala tympani to scala vestibuli in 2 ears (9%). CONCLUSION: The relatively atraumatic insertion characteristics make the SlimJ array feasible for hearing preservation cochlear implantation. The hearing outcomes are comparable to those reported for other electrodes and devices

Otorhinolaryngology
DOAJ Open Access 2024
Assessment of sensory impairment in older adults with dementia

Nikol Gottfriedová, Martina Kovalová, Eva Mrázková et al.

Background: Over 55 million people worldwide are living with dementia. The rate of cognitive decline increases with age, and loss of senses may be a contributing factor. Objectives: This study aimed to analyze hearing, olfactory function, and color vision in patients with dementia. Materials and methods: The sample comprised 40 patients with dementia and 37 cognitively normal controls aged 41–85 years. All participants underwent conventional pure-tone audiometry and a screening version of the Hearing Handicap Inventory for Adults, the Odorized Markers Test of olfactory function and the Ishihara color vision test. The effects of comorbidities and lifestyle factors were also assessed. Results: Patients with dementia had significantly worse hearing at almost all frequencies tested and significantly greater olfactory impairment than cognitively normal controls. Color vision impairment was found in less than 8% of the sample, with no significant difference between the groups. Impairment of two senses (hearing and olfaction) was significantly more common in patients with dementia than in controls. Conclusion: Individuals with dementia were found to have sensory decline, namely hearing and olfactory impairment. Color vision was rarely impaired in the sample. Participants with dementia tended to have more multisensory impairments than controls.

Otorhinolaryngology
DOAJ Open Access 2024
A Study On The Histopathological Analysis Of Nasal Masses Among Patients Attending The Ent Department Of Pakistan Institute Of Medical Sciences, Islamabad

Malik Jawad Faisal, Muhammad Arshad, Moniba Zafar et al.

Objective: The study was conducted to understand the different histopathological patterns, the classification of nasal tumours, and the relative distribution of the various lesions by age and sex. Method: In this study, 80 patients admitted to our hospital with nasal weights and numerous clinical presentations were selected. The study period is 2 years. This study was conducted in the Department of Otorhinolaryngology/ ENT and Histopathology department of the Pakistan Institute of Medical Sciences and AFIP for a two-year duration from April 2019 to April 2021. Results: The most numerous groups of changes were non-cancerous nasal growth; 55 cases (68.25%), then 25 cases (32.25%) of nasal tumours, 16 benign, and 9 malignant cases in cancerous tumours. Conclusion: Nasal obstruction and rhinorrhea are the most commonly encountered symptoms in our community, with simple inflammatory nasal polyps being the predominant histological pattern. Surgical intervention is considered the optimal treatment modality.

DOAJ Open Access 2024
Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism

Zhongkui Wang, Fuquan Zhang, Chengpei Zhu et al.

Purpose This study aimed to explore the value of preoperative total parathyroid volume (TPV) as a marker for predict recurrence of renal secondary hyperparathyroidism (SHPT).Methods We identified 28 patients with recurrence and 128 without recurrence who underwent total parathyroidectomy with autotransplantation (tPTX + AT) at our institution between 2015 and 2022. The TPV and postoperative recurrence information of the patients were recorded. Within the intergroup comparison, data obtained from the recurrence and non-recurrence groups were evaluated using the t-test. Univariate and multivariate analyses were performed according to the regression model to determine factors that were significant in predicting postoperative recurrence. The cutoff value of TPV was determined using a receiver operating characteristic (ROC) curve.Results The mean TPV of recurrence and no-recurrence groups were 2.99 ± 1.52 cm3 and 1.73 ± 1.19 cm3, respectively (p = 0.007). In univariate analysis, female sex, total parathyroid volume > 1.99 cm3, serum PTH > 928.37 pg/mL and p > 1.59 mmol/L were independent factors for SHPT recurrence. In multivariable analysis, TPV > 1.99 cm3, serum parathyroid hormone (PTH) > 928.37 pg/mL and p > 1.59 mmol/L were independent factors for SHPT recurrence. The ability of TPV to distinguish between recurrence and non-recurrence was evaluated using the ROC curve. The cutoff value of TPV was estimated as 2.65 cm3. With this value, sensitivity was found as 60.70%, specificity was 89.80%, and AUC was 0.80 (p < 0.001, confidence interval =0.719–0.882).Conclusion According to the data in this study, it can be said that TPV can be used to distinguish recurrence from no-recurrence. Most importantly, TPV can be used to identify SHPT recurrence.

DOAJ Open Access 2024
Evaluation and Treatment of Dysphagia in Public and Private Intensive Care Units (ICUs) in Greece

Soultana L. Papadopoulou, Evangelia Kitsanou, Ermioni Brahimi et al.

Introduction Dysphagia is a significant but underrecognized clinical issue in the intensive care unit (ICU), and it is associated with various complications. Despite its clinical importance, there is limited research and no Greek ICU-specific guidelines for managing dysphagic patients. Additionally, only a few ICUs in Greece have dysphagia specialists, specifically speech-language pathologists (SLPs) providing their expertise.

Medicine, Otorhinolaryngology
DOAJ Open Access 2024
Phenotypic and genotypic characterization of Staphylococcus aureus strains isolated from otitis externa: Emergence of CC30-spa t019-SCCmec IV carrying PVL as major genotype

Zahra Rahmani, Sareh Sadat Hosseini, Parmida Bagheri et al.

The increasing emergence of Staphylococcus aureus as the primary causative agent of otitis externa has been noted; however, detailed information regarding the molecular characteristics of these strains in Iran remains scarce. The current study aims to investigate both genotypic and phenotypic attributes of S. aureus strains implicated in ear infections. In the present work, we analyzed 60 S. aureus strains isolated from cases of otitis externa over a period of 45 months. The resistance patterns were determined using disk diffusion and microbroth dilution methods. All S. aureus isolates were confirmed by the nucA polymerase chain reaction assay, and their biofilm production was assessed by a microtiter plate assay. Molecular characterization of the isolates was performed using the staphylococcal cassette chromosome mec, multilocus sequence typing, and staphylococcus protein A typing methods. Overall, the results indicated that 44 out of 60 S. aureus isolates (73.3 %) were methicillin-resistant Staphylococcus aureus. Resistance to mupirocin and vancomycin was observed in 13.3 % and 1.7 % of the tested isolates, respectively. Furthermore, out of the 60 S. aureus isolates, 56 strains (93.4 %) were classified as positive biofilm strains at different levels. Twelve distinct clonal lineages were identified. The vast majority of S. aureus isolates belonged to CC30/ST30-MRSA IV/t019 (41.7 %). Among the 31 strong biofilm producers, the majority (64.5 %) belonged to CC30/ST30-MRSA IV/t019 clone. Biofilm negative isolates belonged to CC22/ST22 (2 isolates), CC8/ST585 (one isolate), and CC8/ST8 (one isolate). Our result revealed that about three-quarters of PVL-positive strains belonged to CC30/ST30. Our data confirmed the presence of MSSA strains among CC30/ST30 and CC22/ST22 isolates. The mupirocin resistant isolates (n = 8) belonged to CC8/ST585-MRSA III/t713 (37.5 %), CC8/ST239-MRSA III/t030 (25 %), CC8/ST8-MRSA IV/t008 (12.5 %), CC8/ST239-MRSA III/t037 (12.5 %), and CC22/ST22-MRSA IV/t790 (12.5 %) lineages. The VRSA strain belonged to the CC8/ST8-MRSA IV/t008 lineage, carrying the vanA determinant. iMLSB phenotypes (n = 14) were distributed across different lineages, including CC30/ST30-MRSA IV/t019 (21.5 %), CC30/ST30-MSSA/t021 (21.5 %), CC22/ST22-MSSA/t005 (14.3 %), CC8/ST239-MRSA III/t030 (14.3 %), CC22/ST22-MSSA/t1869 (7.1 %), CC22/ST22-MRSA IV/t790 (7.1 %), CC8/ST239-MRSA III/t037 (7.1 %), and CC1/ST772-MRSA IV/t10795 (7.1 %). These findings highlight significant genotypic diversity and high biofilm formation among our isolates. The frequent occurrence of the CC/ST30 clone in S. aureus strains isolated from otitis externa reflects the emergence of these lineages as a predominant clone in Iran, posing a significant public health concern.

Science (General), Social sciences (General)
DOAJ Open Access 2023
Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

Wenshi Liu, Xiao Cui, Yifan Zhong et al.

Polyphenols, also known as phenolic compounds, are chemical substances containing aromatic rings as well as at least two hydroxyl groups. Natural phenolic compounds exist widely in plants, which protect plants from ultraviolet radiation and other insults. Phenolic compounds have superior pharmacological and nutritional properties (antimicrobial, antibacterial, antiviral, anti-sclerosis, antioxidant, and anti-inflammatory activities), which have been paid more and more attention by the scientific community. Phenols can protect key cellular components from reactive free radical damage, which is mainly due to their property to activate antioxidant enzymes and alleviate oxidative stress and inflammation. It can also inhibit or isolate reactive oxygen species and transfer electrons to free radicals, thereby avoiding cell damage. It has a regulatory role in glucose metabolism, which has a promising prospect in the prevention and intervention of diabetes. It also prevents cardiovascular disease by regulating blood pressure and blood lipids. Polyphenols can inhibit cell proliferation by affecting Erk1/2, CDK, and PI3K/Akt signaling pathways. Polyphenols can function as enhancers of intrinsic defense systems, including superoxide dismutase (SOD) and glutathione peroxidase (GPX). Simultaneously, they can modulate multiple proteins and transcription factors, making them promising candidates in the investigation of anti-cancer medications. This review focuses on multiple aspects of phenolic substances, including their natural origins, production process, disinfection activity, oxidative and anti-inflammatory functions, and the effects of different phenolic substances on tumors.

Therapeutics. Pharmacology
DOAJ Open Access 2022
The anatomy of the foramina and efferent nerve fibers from the pterygopalatine ganglion in posterolateral nasal wall

Kazuhiro Ogi, Rowan Valentine, Masanobu Suzuki et al.

Abstract Background The advance of endoscopic surgery has enabled selective section of the postganglionic nerve branches from pterygopalatine ganglion (PPG) as a modification of the vidian neurectomy. Recent microanatomic studies have suggested that the nasal mucosa is also innervated by multiple efferent rami associated with the sphenopalatine artery (SPA) in the procedure “posterior nasal neurectomy.” This anatomic cadaveric study aims to identify all postganglionic nerve fibers in the lateral nasal wall which should inform future surgical procedures aimed at interrupting these nerve fibers. Methods Two cadaver heads, with a total of three individual sides, were dissected. All neurovascular structures penetrating the vertical plate of palatine bone were carefully identified following meticulous removal of the overlying mucosa layers. The efferent nerve fibers were identified and dissected back to their origin—the PPG or greater palatine nerve. Results Several foramina with efferent PPG nerves were identified on the vertical plate of the palatine bone and medial pterygoid plate. The superior, middle, and inferior turbinates (IT) were innervated by efferent nerves from the PPG via the anterior region of the SPA. The IT was innervated from nerves originating from behind the SPA through bony foramina. The lateral wall of inferior meatus was innervated by efferent nerves that originated from greater palatine nerve and pharyngeal nerve. Conclusion This study demonstrated the anatomical positions of the postganglionic nerves that innervate the lateral nasal wall. These nerves are located anterior to the SPA as well as posterior to the SPA, where they penetrate the palatine bone. Level of evidence: NA.

Otorhinolaryngology, Surgery
DOAJ Open Access 2022
Otoneurologia Geriátrica: Conceitos antigos, desafios atuais

Clara Serdoura Alves, Mariline Santos, Ângela Reis Rego et al.

Objetivo: determinar o impacto das queixas otoneurológicas na referenciação de idosos à consulta de otorrinolaringologia. Métodos: Estudo retrospetivo observacional incluindo doentes com idade igual ou superior a 65 anos, referenciados dos Cuidados de Saúde Primários para Otorrinolaringologia durante 2019 e 2020. Informação relativa aos sintomas subjacentes à referenciação foi colhida do P1. Resultados: 1304 doentes foram incluídos neste estudo. 65% (n= 852) referiu sintomatologia otoneurológica como um dos motivos para a referenciação. A hipoacusia foi o sintoma mais reportado (69%, n=592), seguida de acufeno (36%, n=304) e vertigem/tontura/desequilíbrio (25%, n=213). Objetivou-se uma associação estatisticamente significativa entre hipoacusia e idade (p< 0.001) e entre o género feminino e vertigem (p< 0.001) e acufeno (p= 0.007). Entre todos os doentes, a presbiacusia foi o diagnóstico mais comum. Conclusões: Este estudo solidifica as queixas otoneurológicas como centrais nesta população, destacando a importância da preparação dos profissionais para a abordagem destes sintomas.

Otorhinolaryngology
DOAJ Open Access 2021
Treinamento auditivo acusticamente controlado como opção de intervenção em transtorno do processamento auditivo central em perda auditiva unilateral severa/profunda

Márcia Ribeiro Vieira Yamamoto, Liliane Desgualdo Pereira

RESUMO Objetivo Verificar a efetividade do treinamento auditivo acusticamente controlado em pessoas com distúrbio do processamento auditivo central e perda auditiva unilateral de grau severo a profundo. Métodos Participaram do estudo 16 indivíduos, de 13 a 21 anos de idade, diagnosticados com perda auditiva unilateral de grau severo a profundo e transtorno do processamento auditivo central, divididos em dois grupos, com oito indivíduos cada, pareados por idade, sexo e escolaridade: grupo estudo, submetido ao programa de treinamento auditivo acusticamente controlado, em oito sessões, realizadas uma vez por semana; grupo comparação, que não foi submetido a nenhum tipo de intervenção. Ao final de oito semanas, os grupos foram reavaliados quanto ao potencial evocado auditivo de longa latência (P300) e quanto às habilidades auditivas alteradas, observadas nos testes Localização Sonora, Identificação de Sentenças Sintéticas, Fala no Ruído e Randon Gap Detection Test. Resultados Não houve influências do lado da perda auditiva na avaliação inicial, para nenhum dos grupos. Na avaliação final, verificou-se, somente no grupo estudo, aprimoramento de todas as habilidades auditivas, diminuição da latência e aumento da amplitude no P300. Indivíduos com perda auditiva à direita apresentaram maior aumento da amplitude do P300. Não foram observadas modificações no grupo comparação. Conclusão O treinamento auditivo acusticamente controlado foi eficaz, pois possibilitou o aprimoramento das habilidades auditivas e a modificação na atividade neurobiológica quanto à velocidade de processamento auditivo. Sugere-se essa opção de intervenção em pessoas com transtorno do processamento auditivo central e perda auditiva unilateral.

Otorhinolaryngology
DOAJ Open Access 2020
microRNA-139-3p Inhibits Malignant Behaviors of Laryngeal Cancer Cells via the KDM5B/SOX2 Axis and the Wnt/&beta;-Catenin Pathway

Ma Y, Chen Z, Yu G

Yifei Ma,1,2,* Zili Chen,3,* Guodong Yu2 1School of Clinical Medicine, Guizhou Medical University, Guiyang 550004, Guizhou, People&rsquo;s Republic of China; 2Department of Otorhinolaryngology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, People&rsquo;s Republic of China; 3Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, People&rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Guodong Yu Tel/Fax +86-851-86855119Email GuodongYU453@163.comBackground: Laryngeal cancer (LCA) is a common head and neck cancer. Lysine demethylase 5B (KDM5B) knockdown is expected as a new target for cancer prevention. We investigated the molecular mechanism of KDM5B in LCA.Materials and Methods: The levels of KDM5B, microRNA (miR)-139-3p and high-mobility-group box 2 (SOX2) in LCA tissues and cells, normal tissues and cells were detected. The effect of KDM5B on LCA was evaluated. The upstream miR of KDM5B and the downstream gene and pathway of KDM5B were predicted and their effects on LCA were analyzed. The Wnt/&beta;-catenin pathway-specific activator agonist was delivered into LCA cells expressing miR-139-3p mimic to evaluate the role of the Wnt/&beta;-catenin pathway.Results: KDM5B was highly expressed in LCA, and inhibition of KDM5B suppressed LCA progression. miR-139-3p, downregulated in LCA tissues, was a regulatory miR of KDM5B. Overexpression of miR-139-3p significantly inhibited the malignant biological behaviors of LCA cells. KDM5B promoted SOX2 expression via histone demethylation. SOX2 was highly expressed in LCA, and overexpression of SOX2 promoted LCA progression by inducing the Wnt/&beta;-catenin pathway. Activated Wnt/&beta;-catenin pathway attenuated the inhibitory effect of miR-139-3p mimic on the malignant biological behaviors of LCA cells.Conclusion: miR-139-3p overexpression inhibited LCA development via regulating the KDM5B/SOX2 axis and inhibiting the Wnt/&beta;-catenin pathway.Keywords: laryngeal cancer, microRNA-139-3p, lysine demethylase 5B, high-mobility-group box 2, Wnt/&beta;-catenin pathway

Neoplasms. Tumors. Oncology. Including cancer and carcinogens
DOAJ Open Access 2020
Outcomes of Swallowing Rehabilitation in Patients with Dysphagia: A Retrospective Study

Anindita Arun Banik

Introduction Swallowing, as the first phase of digestion, is one of the most complicated neuromuscular processes of the central nervous system. The presence of dysphagia can itself cause medical, psychosocial, and economic complications. A medical complication of dysphagia includes aspiration pneumonia, malnutrition, significant weight loss, and dehydration. Materials and Methods It was a retrospective study. In information regarding speech and swallowing therapeutics were studied from the routine clinical records by speech pathologist. Results The present retrospective study was focused on highlighting the outcomes of swallowing rehabilitation in patients with dysphagia in various aetiologies. It was observed that swallowing compensatory strategies, postural changes, rehabilitative manoeuvres, thermal stimulation, indirect and direct therapy showed tremendous improvement in patients with dysphagia with various aetiologies.   Conclusion This study provides further information regarding the severity of swallowing physiology in disorders and its improvement subsequent to traditional swallowing therapy which will contribute to literature in Indian context.

Medicine, Otorhinolaryngology
DOAJ Open Access 2020
Does quality of research in otolaryngology correlate with academic impact?

Aasif A. Kazi, Nima A. Vahidi, John Sinkovich et al.

Abstract Objective To determine if the quality of otolaryngology‐related journal articles correlates with traditional measures of article impact. Methods All articles published by Laryngoscope in 2011 were categorized according to level of evidence (LOE) according to the Oxford Center for Evidence Based Medicine rubric. Articles without a level of evidence assigned were alphabetically subcategorized type with letters A‐D corresponding to Contemporary Reports, Case Reports, Basic Science or Animal Studies, and Other respectively. Citations per article were then recorded per article each year from 2012 to 2018. Results A total of 494 articles were included for analysis, 315 had numerical LOE and 179 had alphabetical LOE. There was a strong negative correlation between numerical LOE and median and interquartile number of citations (R = −.9014, P = .037). Overall, numerical LOE had a significantly higher median number of citations per article compared with the non‐number/alphabetical group (14 vs 6, P < .001). Conclusions Higher quality research as determined by level of evidence is in fact being cited more frequently than lower quality articles. Although the scope of this study was relatively limited, these data suggest that better designed studies may exhibit greater impact by traditional measures. Such findings should serve as an impetus for (and validation of) continued pursuit of high LOE research. Level of Evidence NA.

Otorhinolaryngology, Surgery
DOAJ Open Access 2020
Prevalence and Manifestation of Ototoxic Medications Among the Adult Attendees of The Audiovestibular unit at Al-Zahraa University Hospital, Cairo, Egypt

Iman Eladawy, Amal Ahmed, Samia Barghash et al.

Background: Hearing loss is considered to be one of the most common factors of moderate to severe disability specially in the developing countries. Ototoxicity is inner ear damage due to usage of chemical substances, which can lead to either reversable or permanent hearing loss and/or vestibular loss. Ototoxic hearing impairment can impact the quality of life by many ways; therefore, we should be very careful when it comes to choose drug therapy to minimize the risk.  Aim of the work:To identify the commonly implicated ototoxic medications among the adult Egyptian population and to study its presenting features.Patients and Methods: This is a retrospective study, that involved review for the medical notes of all adult patients, who attended the Audio-Vestibular Unit with otological problems between January 2014 and December 2018. A total of 1110 medical folders were reviewed, and data were manually extracted.Results: The prevalence of ototoxic medication among the adult attendees was 26.6%. The most common manifestation was hearing impairment, as it was reported in 83.2% of the cases. Tinnitus came second by 70% followed by vertigo in 31%. Aspirin was the most common drug used [44.7%] of the patients, followed by aminoglycoside in 15% of our study sample, then the non-steroidal anti-inflammatory drugs (NSAIDS) in 14.3%.Conclusion: Audiometric screening is critical to capture the true prevalence of hearing loss. Baseline audiometric and vestibular function test should be performed before prescribing any ototoxic medication especially in patients with other associated risk factors

Medicine (General)
DOAJ Open Access 2017
Impact of Close and Positive Margins in Transoral Laser Microsurgery for Tis–T2 Glottic Cancer

Ivana Fiz, Ivana Fiz, Francesco Mazzola et al.

IntroductionTransoral laser microsurgery (TLM) represents one of the most effective treatment strategies for Tis–T2 glottic squamous cell carcinomas (SCC). The prognostic influence of close/positive margins is still debated, and the role of narrow band imaging (NBI) in their intraoperative definition is still to be validated on large cohort of patients. This study analyzed the influence of margin status on recurrence-free survival (RFS) and disease-specific survival (DSS).MethodsWe retrospectively studied 507 cases of pTis–T1b (Group A) and 127 cases of pT2 (Group B) glottic SCC. We identified the following margin status: negative (n = 232), close superficial (n = 79), close deep (CD) (n = 35), positive single superficial (n = 146), positive multiple superficial (n = 94), and positive deep (n = 48) and analyzed their impact on RFS and DSS. Close margins were defined by tumor-margin distance &lt;1 mm. Pre-TLM margins were defined by white light in 323 patients, whereas NBI was employed in 311 patients.ResultsIn Group A, DSS and RFS were reduced in positive multiple superficial and positive deep margins (DSS = 96.1 and 97%, both p &lt; 0.05; RFS = 72%, p &lt; 0.001 and 75.8%, p &lt; 0.01). In Group B, DSS was reduced in positive multiple superficial margins (82.4%, p &lt; 0.05). RFS was reduced in positive single superficial, positive multiple superficial, and positive deep margins (62.5, 41.2, and 53.3%, p &lt; 0.01). In the entire population, RFS was reduced in CD margins (77.1%, p &lt; 0.05). Use of NBI led to improvement in RFS and DSS.ConclusionThe study indicates that close and positive single superficial margins do not affect DSS. By contrast, all types of margin positivity predict the occurrence of relapses, albeit with different likelihood, depending on stage/margin type. CD margins should be considered as a single risk factor. Use of NBI granted better intraoperative margins definition.

Neoplasms. Tumors. Oncology. Including cancer and carcinogens
DOAJ Open Access 2015
Partial Recurrent Laryngeal Nerve Paralysis or Paresis? In Search for the Accurate Diagnosis

Alexander Delides, Panagiotis Kokotis, Pavlos Maragoudakis

“Partial paralysis” of the larynx is a term often used to describe a hypomobile vocal fold as is the term “paresis.” We present a case of a dysphonic patient with a mobility disorder of the vocal fold, for whom idiopathic “partial paralysis” was the diagnosis made after laryngeal electromyography, and discuss a proposition for a different implementation of the term.

Otorhinolaryngology
DOAJ Open Access 2014
Long-Term, High-Frequency Tympanometry and Audiometry Results after Cartilage and Fascia Tympanoplasty

Kadir Özdamar, Ümit Taşkın, Salih Aydın et al.

Objective:Fascia or cartilage can be used as grafts in tympanoplasty; however, the disadvantage of cartilage is that it causes stiffness and rigidity in the newly formed tympanic membrane. The aim of this study was to compare the long-term high-frequency tympanometry and audiometry outcomes of tympanoplasty using cartilage and fascia.Methods:Forty patients in whom tragal cartilage was used in type 1 tympanoplasty and 40 patients in whom temporal muscle fascia was used were included in the study. The preoperative and postoperative audiometries of the two groups were compared. Postoperative high-frequency tympanometry (224, 668, 800, and 1000 Hz) and air volume, compliance, and pressure differences of the two groups were also compared.Results:The mean age of the patients was 31.3±4.5 year. The success rates were 96% in the cartilage group and 92% in the fascia group. In the fascia group, the preoperative mean air bone gap was 27.9±97 decibels (dB), and the postoperative mean air bone gap was 19.1±7.6 dB. The postoperative mean air bone gap improvement was 8.8±9.9 dB; the difference was statistically significant. In the cartilage group, the preoperative mean air bone gap was 28.2±9.6 dB, and the postoperative mean air bone gap was 17.2±10.5 dB. The postoperative mean air bone gap improvement was 10.9±10.3 dB; the difference was statistically significant. When postoperative mean air bone gap improvement was compared, there was no statistical difference between the two groups. When high-frequency tympanogram values were compared, there were no significant differences between the two groups at 224, 668, 800, or 1000 Hz frequencies in terms of air volume, compliance, or pressure values.Conclusion:The use of temporal muscle fascia and cartilage in tympanoplasty is statistically similar when compared in terms of tympanic membrane repair, hearing gain, air volume, pressure, and compliance. For this reason, cartilage graft can easily be preferred in tympanoplasty, especially in revision cases and adhesive otitis media, without fear of stiffness or rigidity effects.

Otorhinolaryngology
DOAJ Open Access 2014
Análise do risco ruído em indústria de confecção de roupa

Daniela Dalapicula Barcelos, Soraya Gama de Ataíde

Objetivo : verificar a presença do ruído em indústria de confecção de roupas, visto que este risco é pouco difundido nas pesquisas relacionadas a este ambiente de trabalho.Métodos : a empresa escolhida foi uma fábrica de confecção de roupa localizada em Colatina no Espírito Santo/Brasil. Foram analisados os dois setores com maior risco ruído na empresa, após a exclusão dos funcionários com menos de cinco anos de trabalho neste local, totalizamos uma amostra de seis funcionários. Os trabalhadores selecionados responderam questionário sobre informações e sintomas auditivos e posteriormente, foram analisadas as audiometrias realizadas nos últimos cinco anos.Resultados : por meio de medições realizadas nos setores analisados, constatou-se produção de ruído de 83,5 a 97,8 dB(A). Após observar o histórico das audiometrias, obteve-se 83% dos trabalhadores, destes setores, sem perda auditiva, 16% com perda ocupacional, sendo classificada como estável. Os dados levantados no questionário revelaram que 33% dos trabalhadores sentem-se irritados quando expostos a sons elevados, 50% sentem-se estressados após a jornada de trabalho, e nenhum trabalhador relatou queixa de zumbido, insônia ou dificuldade em entender as pessoas.Conclusão : este ambiente de trabalho apresenta risco ruído, uma vez constatados os níveis de pressão sonora no qual os trabalhadores são expostos durante a jornada de trabalho, bem como a presença de perda auditiva ocupacional, mesmo em menor escala – atribuído ao tempo mínimo de cinco anos de serviços prestados utilizado na pesquisa.

Philology. Linguistics, Otorhinolaryngology
S2 Open Access 2012
Malignant paranasal sinus schwannoma

S. Pádua, Vítor Yamashiro Rocha Soares, André Luís de Queiroz et al.

1 Graduation (Otorhinolaryngologist, Brasilia University). 2 Graduation (Otorhinolaryngology Medical Resident, Brasilia University). 3 Graduation (Assistant Professor, Department of Otorhinolaryngology and Head and Neck Surgery, Brasilia University). 4 PhD in Sciences, ENT Department, University of Sao Paulo (Adjunct Professor, Department of Otorhinolaryngology and Head and Neck Surgery, Brasilia University). 5 PhD in Surgery, ENT Department, Federal University of Sao Paulo (Adjunct Professor, Department of Otorhinolaryngology and Head and Neck Surgery, Brasilia University). Brasilia University Hospital Department of Otorhinolaryngology Head and Neck Surgery. Send correspondence to: Vitor Yamashiro Rocha Soares. SGAN, Via L2 Norte, Quadra 604/605, Asa Norte, HUB, Anexo III. CEP: 70840-050. Tel: 55 (61) 8130-0972. Email: vyrsoares@yahoo.com.br Paper submitted to the BJORL-SGP (Publishing Management System Brazilian Journal of Otorhinolaryngology) on May 30, 2011; and accepted on October 11, 2011. cod. 7974. CASE REPORT Braz J Otorhinolaryngol. 2012;78(4):135. BJORL

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