Michael M. Mysinger, Michael Carchia, J. Irwin
et al.
A key metric to assess molecular docking remains ligand enrichment against challenging decoys. Whereas the directory of useful decoys (DUD) has been widely used, clear areas for optimization have emerged. Here we describe an improved benchmarking set that includes more diverse targets such as GPCRs and ion channels, totaling 102 proteins with 22886 clustered ligands drawn from ChEMBL, each with 50 property-matched decoys drawn from ZINC. To ensure chemotype diversity, we cluster each target’s ligands by their Bemis–Murcko atomic frameworks. We add net charge to the matched physicochemical properties and include only the most dissimilar decoys, by topology, from the ligands. An online automated tool (http://decoys.docking.org) generates these improved matched decoys for user-supplied ligands. We test this data set by docking all 102 targets, using the results to improve the balance between ligand desolvation and electrostatics in DOCK 3.6. The complete DUD-E benchmarking set is freely available at http://dude.docking.org.
Karenzha Iftinan, Angga Mardro Raharjo, Dini Agustina
et al.
Introduction: Tinea unguium is a nail infection caused by dermatophytes, characterized by nail discoloration, thickening, and brittleness. Farmers, often exposed to prolonged wet conditions, are at higher risk of this infection. The use of appropriate footwear is recommended to mitigate this risk. However, inadequate personal protective equipment (PPE) usage makes farmers more susceptible to Tinea unguium. Research on Tinea unguium among farmers in Lojejer Village is limited, with differing result on the link between wearing footwear as PPE and the occurance of Tinea unguium. This study aimed to investigate the relationship between the use of footwear as PPE and the incidence of Tinea unguium among farmers in Lojejer Village. Methods: This study uses a cross-sectional observational design. It involved 98 respondents determined using Slovin’s formula. Data were collected through interviews and nail samples, which were subjected to fungal culture on sabouraud dextrose agar (SDA) medium and microscopic examination with lactophenol cotton blue staining. Fisher’s Exact tests were used for analysis. Results: Results revealed that seven farmers (7.14%) were affected by Tinea unguium, predominantly males (85.8%) aged 45–64 years (57.1%). Trichophyton rubrum was identified as the primary dermatophyte, with Aspergillus sp. as a contaminant. Statistical analysis showed no significant relationship between footwear usage, personal hygiene, or footwear hygiene and Tinea unguium (p-values > 0.05). Conclusion: The study found no significant association between footwear use, hpersonal hygiene, and footwear hygiene with Tinea unguium incidence among farmers in Lojejer Village
Elvis Karikari Mensah, Reginald Hammah, Hassan Basahel
et al.
The stability of rock slopes is a critical concern in rock engineering applications due to the potential safety hazards and economic repercussions associated with slope failures. Currently, slope stability analysis relies on various analytical and numerical modeling tools leading to a factor of safety. Parameters such as joint strength are assessed through probabilistic analysis. Despite the established effectiveness of these methods, they often lack the capability to provide a volumetric estimation of the failure zone, primarily because the joint frequency parameter is not considered. By incorporating this parameter, it becomes feasible to construct a three-dimensional discrete fracture network (DFN), which offers a more comprehensive representation of the rock slope structure. This study aims to validate the use of DFN in civil engineering applications using two road-cut case studies from Saudi Arabia. Both case studies are analyzed with the conventional methods and DFN approaches, allowing for a comparative assessment of results. DFN models optimize the utilization of statistical data related to discontinuity persistence and spacing, enabling the construction of both deterministic and stochastic fracture networks. The effects of joint spacing and persistence on the factor of safety and volume of failure are examined. Finally, the advantages and limitations of the DFN on rock slope stability are highlighted and areas for improvement and optimization are discussed.
The current paper intends to present the directory lines and paths for the development and implementing construction eco-products, with advanced functionality (materials, elements and structures, models and technologies), considering the efficient and customized valorization of by-products and generated waste of local industries, in the context of National Strategy for Research, Innovation and Smart Specialization 2022-2027 regarding the transition to Circular Economy (EC). This represents one of the two main axes of the research project Nucleu Programme of the National Research Development and Innovation Plan 2022-2027, supported by MCID, "ECODIGICONS" project no. PN 23 35 04 01: “Fundamental-applied research into the sustainable development of construction products (materials, elements, and structures, as well as methods and technologies) that utilizes current national resources to enhance the eco-innovative and durable aspects of Romania's civil and transport infrastructure”, financed by the Romanian Government starting with the beginning of 2023. One of the novelties of the proposed approach of the project is considering the entrepreneurial environment of construction industry or complementary branches as essential stakeholders for the future results of the current scientific research. This dramatically changes the dynamic of the project, in terms of specific objectives, namely their focus on solving the current wastes’ problem by innovatively integrating them into competitive construction products with fast applicability and in accordance with support market requests. By the use of strategic management specific methods (e.g., External Environment (EE) and Internal Environment (IE) evaluation, SWOT analysis and derived specific strategies, etc.), four research directions have been identified for the valorization, at regional or even national level, of mineral additions (inert/hydraulically latent/pozzolanic, etc., derived from waste and industrial by-products (metallurgy, processing industry, construction/demolition, etc.)) by development of eco-smart materials and products for construction. The three directions are related to the considered mineral additions: Power plant ashes (fly ash and/or bottom ash), Steel slag and Garnet type residue Hence, the paper is willing to present the identification and the preliminary analyses of the specified research axes, plotted as necessary steps for achieving an intelligent and sustainable transition of the Romanian construction infrastructure. This approach implicitly ensures in the short and medium term, the increase of the degree of implementation of the principles of the Circular Economy (EC) in Romania, in the existing context which includes relevant factors like: geo-political, industrial and economic, urban and demographic, scientific, socio-cultural and environmental, in accordance with the imperatives of National, European and World Sustainable Development strategies.
Ulfiatul Azizah, Reny Indrayani, Ragil Ismi Hartanti
Introduction: Safety riding is a behavior to minimize the level of danger as well as safety and security in riding that accordance with laws and regulations system in our country. Safety riding is very important, especially for online motorcycle taxi drivers who have a high risk of having a traffic accident at work. Gojek is one of the largest online transportation companies in Indonesia. Method: This research was conducted on Gojek driver partners in three sub-districts of the Jember urban areas Sumbersari, Patrang and Kaliwates. A study that aims to analyze factors related to safety riding on the Gojek Rider community in the urban area of Jember Regency. This study is a quantitative study using an observational analytical research type with a cross-sectional research design with a sample of 75 drivers. Data collection used interview instrument adopted from previous research, observations and documentations. Analysis of the correlation data used the Chi-Square test. Result: This research the majority of Gojek drivers had 2 years of service (72%), good riding knowledge (68%), mobile phone usages usage on the road without pulling over (74,7%), moderate work fatigue (64%), roadworthy vehicles (82.7%) and unsafe riding (61.3%). Conclusion: There is no correlation between length of service and safety riding. There is a correlation between driving knowledge, work fatigue, cell phone use and vehicle factors.
Rosidah Fidiyaningrum, Anita Dewi Prahastuti Sujoso, Reny Indrayani
Introduction: Mild Cognitive Impairment (MCI), according to several studies, has been discovered to be related to exposure to pesticides. Sukorambi Village is the largest vegetable producer village in Jember Regency and pesticides are used in the vegetable cultivation process. This study aimed to analyze the relationship between the age of vegetable farmers and the frequency of pesticide spraying with the incidence of MCI and to analyze differences in the incidence of MCI in farmers and their wives. Methods: This research is an analytical research with a cross-sectional design which was carried out in Sukorambi Village, from June to December 2022. The samples of this research are 142 people, obtained from a proportional stratified random sampling technique and represented groups of farmers in each hamlet. In this case, the research variables include age, frequency of pesticide spraying, as well as the incidence of MCI in vegetable farmers and their wives. Data were further collected through direct interviews, which were then analyzed through bivariate analysis using Spearman and paired t tests. Results: The results showed that the majority of vegetable farmers were above 55 years old and most of them sprayed pesticides for 3-4 and 5-6 times a month. Most farmers and their wives experience MCI. Conclusion: The farmer's age and the frequency of spraying pesticides are related to the incidence of MCI in farmers. There is a significant difference between the incidence of MCI in vegetable farmers and their wives, where MCI is more experienced by vegetable farmer wives.
The popularity of ultralight planes in non-commercial aviation is on the rise; however, non-compliance with regulations and the use of faulty equipment poses significant risks. This study explores the consequences of such lapses in adherence to safety standards by thoroughly examining the conditions leading to an ultralight plane crash, focusing on data related to causative factors. The accident involved an unregistered ultralight aircraft, lacking proper inspection and the required license. The pilot’s error during takeoff led to a stall, resulting in a fatal crash. Upon impact with the ground, the pilot’s shoulder and lap belts were torn off, leading to immediate death. This case underscores the critical importance of compliance with safety regulations in ultralight aviation. The findings illuminate the dire consequences of non-compliance with safety regulations and the utilization of unregistered, uninspected ultralight aircraft in private aviation. The tragic accident analyzed herein underscores the pivotal role of adherence to safety standards in mitigating the risks associated with ultralight planes. The pilot’s fatal error during takeoff, compounded by the absence of proper inspection and licensing, serves as a stark reminder of the potential dangers inherent in neglecting established safety protocols.
Industrial safety. Industrial accident prevention, Medicine (General)
The ceramic industry has been vital to the city’s development and prosperity in Jingdezhen, but the development of the ceramics industry in Jingdezhen has been unclear since China’s economic reforms, which will become a bottleneck limiting the sustainable development of the city. This study explored the spatial agglomeration and spatiotemporal evolution of the ceramics industry in Jingdezhen from 1980 to 2020 using enterprise directory data. The study opted for a microscopic perspective and employed kernel density estimation and exploratory spatial data analysis to obtain the necessary results. It also analyzed the influencing factors using a Geodetector. The results show that the temporal evolution of the ceramics industry in Jingdezhen went through two stages from 1980 to 2020. The number of enterprises experienced exponential growth, with fluctuations. The spatial evolution of the ceramics industry transitioned from a “single-center” to a “double-center” model and further evolved into a “multi-center” model. Moreover, the spatial agglomeration of the ceramics industry underwent the process of “agglomeration-diffusion-polarization”, ultimately developing into four ceramic industrial agglomeration patterns in six hotspots. Agglomeration, historical, technological, policy, and transportation factors had positive effects on the evolution of the ceramics industry in Jingdezhen, with agglomeration being the top contributor. Likewise, there were obvious interactions between the factors. This study can provide a basis for formulating policies to support urban spatial planning for urban revitalization, and provide foundation for the development of the national ceramic culture inheritance and innovation pilot zone in Jingdezhen.
Wahdah Dhiyaul Akrimah, Irlangga Wisnu Wardana, Abdul Rohim Tualeka
Introduction: Non-operational employees of the Terminal Jamrud Surabaya are faced with various work-related issues while performing their duties which can be stressful due to work demands, relationships with many parties, and workloads. This study analyzes the relationship between mental workload and work factors (role ambiguity, role conflict, job insecurity, and interpersonal conflict) with occupational stress for non-operational office employees at Terminal Jamrud Surabaya. Methods: This study was a descriptive observational study with a cross-sectional design. The sampling technique used in this study is total sampling. The sample for this study were all employees of the Terminal Jamrud Surabaya office, up to 30 people. Primary data were collected using a questionnaire to assess stress levels and work factors variables. The mental workload was measured using the NASA - Task Load Index questionnaire. Results: The employees mostly have a mental workload, role ambiguity, role conflict, and interpersonal conflict in the moderate category, while the majority of office employees have job insecurity at a low level. Meanwhile, the stress levels felt by employees were mainly in the moderate category. The strong relationship between mental workload with occupational stress is 0.634, while work factors with stress levels consist of role ambiguity (r=0.523), role conflict (r=0.468), job insecurity (r=0.075), and interpersonal conflict (r=0.445). Conclusion: Variables that have a strong relationship are mental workload variables with stress levels in non-operational office employees at Terminal Jamrud Surabaya, PT Pelabuhan Indonesia III.
Сьогодні, приймально-передавальна апаратура зазнала суттєвого розвитку, здебільшого, завдяки цифровізації. Цифрова техніка стає все популярнішою під час прийому й передачі інформації. Восьмирозрядні мікроконтролери (наприклад, nRF24L01) володіють достатньою швидкістю обробки даних. Забезпечивши аналого-цифрове перетворення та маючи можливості в програмуванні даних мікроконтролерів, відкриваються перспективи для реалізації трансивера. Серія виробів провідної корпорації Nordic Semiconductor містять вбудовані високопродуктивні мультиплексори, що з’єднані з Flash-пам’яттю (ядром) мікроконтролера індустріального стандарту 8052 (наприклад, nRF24L01), та підтримує декілька стандартів конфігурації послідовного порту. Ці вироби є першими інтегрованими схемами, які можна назвати «інтелектуальними прийомо-передавачами» для систем збирання та обробки даних на одному кристалі. На першому етапі обробка фізичних сигналів полягає в необхідності отримання інформації, що міститься в них. Ця інформація наявна в амплітуді сигналу, в частоті або спектральному складі, у фазі чи у відносних часових залежностях декількох сигналів. У деяких випадках бажано змінити формат інформації, яка знаходиться в пакеті сигналу. Наприклад, зміна формату відбувається під час передавання звукового сигналу в телефонній системі з багатоканальним доступом і частотним розділенням. У випадку цифрового зв’язку аналогова звукова інформація спочатку перетворюється на цифрову за допомогою аналого-цифрового перетворювача. Цифрова інформація, що втілює в собі індивідуальні звукові канали, мультиплексується (багатоканальний доступ з часовим розділенням (TDMA)) та передається через послідовну цифрову лінію зв’язку. Метою статті є проведення аналізу особливостей побудови та надання рекомендації щодо застосування радіомодуля nRF24L01 у техніці військового призначення, а також – порівняння основних принципів та стандартів моделювання сигналів і завад в електронних системах, принципів дискретизації, кодування сигналів.
Barry Turner’s 1978 <i>Man-made Disasters</i> and Charles Perrow’s 1984 <i>Normal Accidents</i> were seminal books but a detailed comparison has yet to be undertaken. Doing so is important to establish content and priority of key ideas underpinning contemporary safety science. Turner’s research found socio-technical and systemic patterns that meant that major organisational disasters could be foreseen and were preventable. Perrow’s macro-structuralist industry focus was on technologically deterministic but unpredictable and unpreventable “system” accidents, particularly rare catastrophes. Andrew Hopkins and Nick Pidgeon respectively suggested that some prominent writers who wrote after Turner may not have been aware of, or did not properly acknowledge, Turner’s work. Using a methodology involving systematic reading and historical, biographical and thematic theory analysis, a detailed review of Turner’s and Perrow’s backgrounds and publications sheds new light on Turner’s priority and accomplishment, highlighting substantial similarities as well as clear differences. <i>Normal Accidents</i> did not cite Turner in 1984 or when republished with major additions in 1999. Turner became better known after a 1997 second edition of <i>Man-made Disasters</i> but under-acknowledgment issues by Perrow and others continued. Ethical citation and potential reasons for under-acknowledgment are discussed together with lessons applicable more broadly. It is concluded that Turner’s foundational importance for safety science should be better recognised.
Industrial safety. Industrial accident prevention, Medicine (General)
Seung Woo Hwangbo, Sherrilene Classen, Justin Mason
et al.
Highly autonomous vehicles (HAV) have the potential of improving road safety and providing alternative transportation options. Given the novelty of HAVs, high-fidelity driving simulators operating in an autonomous mode are a great way to expose transportation users to HAV prior to HAV adoption. In order to avoid the undesirable effects of simulator sickness, it is important to examine whether factors such as age, sex, visual processing speed, and exposure to acclimation scenario predict simulator sickness in driving simulator experiments designed to replicate the HAV experience. This study identified predictors of simulator sickness provocation across the lifespan (N = 210). Multiple stepwise backward regressions identified that slower visual processing speed predicts the Nausea and Dizziness domain with age not predicting any domains. Neither sex, nor exposure to an acclimation scenario predicted any of the four domains of simulator sickness provocation, namely Queasiness, Nausea, Dizziness, and Sweatiness. No attrition occurred in the study due to simulator sickness and thus the study suggests that high-fidelity driving simulator may be a viable way to introduce drivers across the lifespan to HAV, a strategy that may enhance future HAV acceptance and adoption.
Industrial safety. Industrial accident prevention, Medicine (General)
A. K. Majumder, Abdullah Al Nayeem, M. Islam
et al.
Background. Lead (Pb) poses a severe threat to human health and the environment. Worldwide Pb production and consumption have significantly increased along with unplanned industrialization and urbanization, lead smelting, and lead-acid battery processing. The improper management of Pb-containing elements is responsible for Pb pollution. Lead's persistence in nature and bioaccumulation in the food chain can lead to adverse health impacts. Objectives. The present study aims to describe Pb contaminated sites in Bangladesh and Pb concentration in the atmosphere, water, sediments, soil, vegetables, fish, and other foods in Bangladesh. Methods. The present study searched a total of 128 peer-reviewed articles based on a predefined set of criteria (keywords, peer-reviewed journals, and indexing in Scopus, Science Direct, Web of Science, Springer, PubMed, Directory of Open Access Journals (DOAJ), and Bangladesh Journals Online (BanglaJOL) and exclusion criteria (predatory journal and absence of full text in English) and finally selected 63 articles (58 research articles and five (5) reports). The relevant findings on Pb exposure, sources, routes, diet, and impacts in Bangladesh were combined and presented. Results. The reviewed studies identified 175 Pb contaminated sites through soil sample assessment in Bangladesh. The study determined Pb concentrations in air (0.09–376.58 μg/m3, mean 21.31 μg/m3), river water (0.0009–18.7 mg/l, mean 1.07 mg/l), river sediments (4.9–69.75 mg/kg, mean 32.08 mg/kg), fish (0.018–30.8 mg/kg, mean 5.01 mg/kg), soil (7.3–445 mg/kg, mean 90.34 mg/kg), vegetables (0.2–22.09 mg/kg, mean 4.33 mg/kg) and diet items (0.001–413.9 mg/kg, mean 43.22 mg/kg) of which 38.8%, 27.8%, 54.5%, 68.8%, 9.7% and 100% of samples, respectively, exceeded related World Health Organization (WHO), Food and Agriculture Organization (FAO), United States Environmental Protection Agency (USEPA) and Bangladesh Standard Testing Institution (BSTI) guidelines. The present study found that industrial soils are severely polluted with Pb (7.3–445 mg/kg) in Bangladesh. A high Pb concentration has been found in fish muscle and foods, including leafy and non-leafy vegetables collected from different places in Bangladesh. Conclusions. Lead-contaminated foods can enter the human body through dietary intake and consequently lead to long-term adverse health effects. This study may help policymakers to formulate national policies with effective mitigation plans to combat the adverse health impacts of Pb in Bangladesh. Competing Interests. The authors declare no competing financial interests.
Introduction: Every workplace has risks and risks to the safety and health of workers. Personal Protective Equipment (PPE) as the last control or last effort to control risk in workplace. Using personal protective equipment is influenced by a person's behavior which consists of three factors namely predisposing factors, enabling factors and driving factors. The purpose of this study was to analyze factors related to the behavior of using PPE on workers in the filling lithos process PT. Pertamina Lubricants Production Unit Gresik. Metods: This study was an observational analytic study, using a cross sectional research design. The research sample was 41 people, taken randomly using simple random sampling. Data collection includes age, education, years of service, knowledge, motivational attitudes of PPE availability, supervision and regulations regarding PPE. The data analysis used in this study is Spearman's correlation. Results: Showed that there was a relationship between age factors (p = 0.004) and the behavior of PPE use while other factors were knowledge (p = 0.338), motivation (p = 0.137), availability of PPE, regulations on PPE (p = 0.624) with no association behavior of using PPE. Most samples behave disobediently using PPE. Conclusion:Age has a relationship with my personal use of personal protective equipment and most of the workers behave disobedient using personal protective equipment. Keywords: behavior, filling lithos workers, personal protective equipment
Musculoskeletal disorders (MSDs) is a disorder or damage to the joints, ligaments, muscles and other skeletal systems due to unnatural or awkward body position especially if carried on for a long duration. Complaints of MSDs are influenced by internal factors (age, work durration, exercise habits, and body mass index) and external factors (work position and workload). The purpose of this study was to analyze the relationship between internal and external factors on complaints of MSDs to workers in the informal sector. The research design was crossectional approach. Data was analyzed by chi-square. The results of this study to 38 workers show that age (p = 0.102), exercise habits (p = 0.297), BMI (p = 0.332) and work positions (p = 0.864) have no relation to MSDs complaints while work durration (p = 0.019) and energy expenditure (p = 0.000) has a relationship with MSDs complaints. The conclusions of this research was that workload durration and cooking workload have a relationship with the complaints of MSDs in informal workers. Based on the level of MSDs complaint, mostly, workers felt the complaint on the right hand wrist (86%) and right foot (68%). It is recommended to informal workers to stretch the muscles on the sidelines of doing the work so that MSDs complaints can be minimized.
Keywords: cooking work load, informal worker, manufacturing industry of tofu, subjective complaint of MSDs
Oleksandr V. Majstrenko, Roman V. Bubenshсhykov, Ruslan V. Bondar
et al.
The article is devoted for determination of constituents of fire defeat of opponent by the method of construction "tree of aims" recognition, both constituents of process and connections between them, that enabled to carry out dividing of process by the making with the observance of requirement answering the purpose of research and purpose of process, to equivalentness of constituents on relative payment in a having a special purpose effect, and also accordances of principle integrity.