Targeted alpha-particle therapy (TAT) employs alpha-emitting radionuclides conjugated to tumor-targeting molecules to deliver localized radiation to cancer cells, showing great promise in treating metastatic cancers. Among these radionuclides, Actinium-225 ($^{225}$Ac, t$_{1/2}$ = 9.9 days) has emerged as a clinically promising candidate. Its decay chain generates four successive alpha emissions, resulting in highly localized and effective cytotoxic damage to cancer cells when delivered to tumor sites. However, the assumption of complete retention of $^{225}$Ac and its radioactive daughters at these target sites is often inaccurate. The nuclear recoil effect can lead to off-target distribution and unintended toxicity. Our results revealed distinct spectral differences between radiolabeled cells and reference samples, demonstrating [$^{225}$Ac]Ac-crown-TATE uptake by AR42J cells. Detection of $^{213}$Po, one of the $^{225}$Ac decay daughters, highlighted partial retention and release of decay products from cells, providing information on intracellular retention and daughter redistribution. Geant4 simulations confirmed the alignment of experimental data with theoretical models, validating the method's accuracy. This study establishes a direct alpha spectroscopy approach for investigating $^{225}$Ac and its daughters' behavior in cells and offers a powerful tool for microdosimetry estimation.
Abstract This review informs about a new textbook for students of the German language with specialist orientation on policing „Němčina (nejen) pro policisty“ („German (not only) for Police Officers“). It comprises topics from different German-speaking countries based on legal studies. As it is intended not only for students of the Police Academy of the Czech Republic in Prague, it can be used by a wider public since it is divided into several parts, including the topics of Security, Law, Criminal Law, Management, and Public Administration, Universities, and Communication. Enclosed, there is a Czech-German Vocabulary as well as German-Czech Vocabulary and Czech-German phrases. A detailed and beneficial Grammar review giving an overview of the necessary grammar needed to acquire the language can be found at the very end. Not only this is a reason why the textbook can be recommended for all levels of language learners.
Abstract A company's competitiveness is influenced by a number of factors, including the suitable training strategy. The effectiveness of a company's training strategy is significantly affected by methods of employee development, among other things. Therefore, this article focuses on which employee development methods are chosen by European companies. Based on a literature review and an analysis of secondary data, the structure of employee development methods in European enterprises is examined. The attitude of firms is analyzed in terms of the use of each method over time from 2005 to 2020 and in terms of firm size. The article provides important insights for further scientific research with regard to the necessity to select appropriate employee development methods. Matching the method with the companies’ requirements can bring an effective training strategy and increase the competitiveness of European companies.
I. Yu. Kargapolov, N. V. Okhotnikov, I. A. Shalimova
et al.
A recently developed three-dimensional version of the quasistatic code LCODE has a novel feature that enables high-accuracy simulations of the long-term evolution of waves in plasma wakefield accelerators. Equations of plasma particle motion are modified to suppress clustering and numerical heating of macroparticles, which otherwise occur because the Debye length is not resolved by the numerical grid. The previously observed effects of premature wake chaotization and wavebreaking disappear with the modified equations.
The spectral and angular properties of diffracted transition radiation (DTR) and parametric radiation (PXR) in the ultrasoft X-ray region generated by the periodic structure upon interaction with a relativistic electron beam with energy of 5.7 MeV are numerically studied using a sample of the periodic structure [Mo/Si]50, known as a multilayer X-ray mirror. Based on calculations, an experimental approach is proposed to separate and identify the contributions of PXR and DTR. The ultrasoft X-ray radiation can be used to eliminate coherent effects occurring in the optical range when diagnosing the submicron electron beam size.
We study an electromagnetic radiation of a small bunch having a variable charge value and crossing a flat interface between two media. Both media are homogeneous, stationary, and isotropic. They may have frequency dispersion but no spatial dispersion. Cherenkov radiation can be generated in the second medium only. It is assumed that the bunch charge value decreases exponentially starting from some time moment after the charge enters the second medium. This means that we take into account the scatter of the particle path lengths, connected with a statistical nature of energy losses of particles. It is taken into account that the filamentous trace consisting of immobile charges is formed in the second medium. We obtain the general solution of the problem. The asymptotic study for the wave zone is carried out. We obtain expressions for the spherical wave as well as for the cylindrical wave generated in the second medium if the charge velocity is sufficiently high. The main properties of radiation are described. If the process of the bunch decay starts from the boundary between media, then the angular distribution of the radiation energy has the single maximum in each from two regions. In the second medium, the radiation, as a rule, is greater than in the vacuum area, and this difference increases with increasing the charge velocity. If the charge velocity is higher than the speed of light in the second medium, then, along with appearance of Cherenkov radiation, the properties of spherical wave change radically. In particular, the main maximum of the angular distribution of the radiation energy increases sharply. If the distance from the charge entry point to the region of the bunch decay is sufficiently large, then the complex interference pattern with many extrema take place.
In the present paper we introduce a new accelerator concept for ions. The accelerator is nano-structured and can consist of a range of materials. It is capable of generating large ionic currents at moderate ion energies. The nano-structures can be tailored towards the accelerator thus being capable of driving ion beams with very high efficiency. The accelerator is powered by laser arrays consisting of many repetitive and efficient lasers in the $100 \, \text{J}$ range with ultra-short intense laser pulses. Combining nano-structures and the proposed ultra-short pulse lasers can lead to new levels of spatio-temporal control and energy efficiency for fusion applications.
Multicavity Klystron (MCK) is a high power microwave (HPM) vacuum electronic device used to amplify radio-frequency (RF) signals with numerous applications, including radar, radio navigation, space communication, television, radio repeaters, and charged particle accelerators. The microwave-generating interactions in klystrons take place in resonant cavities at discrete locations along the beam. Importantly, there is no electromagnetic coupling between cavities, they are coupled only by the bunched electron beam, which drifts from one cavity to the next. We advance here an analytic theory of MCKs operating in voltage amplification mode associated with the maximal gain. This theory features in particular exact formulas for the MCK instability frequencies, its dispersion relations and optimal values of the MCK parameters providing for maximal gain.
Fei Li, Thamine N. Dalichaouch, Jacob R. Pierce
et al.
We propose a new method for self-injection of high-quality electron bunches in the plasma wakefield structure in the blowout regime utilizing a "flying focus" produced by a drive beam with an energy chirp. In a flying focus the speed of the density centroid of the drive bunch can be superluminal or subluminal by utilizing the chromatic dependence of the focusing optics. We first derive the focal velocity and the characteristic length of the focal spot in terms of the focal length and an energy chirp. We then demonstrate using multidimensional particle-in-cell simulations that a wake driven by a superluminally propagating flying focus of an electron beam can generate GeV-level electron bunches with ultralow normalized slice emittance ($\sim$30 nm rad), high current ($\sim$ 17 kA), low slice energy-spread ($\sim$0.1%) and therefore high normalized brightness ($>10^{19}$ A/rad$^2$/m$^2$) in a plasma of density $\sim10^{19}$ cm$^{-3}$. The injection process is highly controllable and tunable by changing the focal velocity and shaping the drive beam current. Near-term experiments at FACET II where the capabilities to generate tens of kA, <10 fs drivers are planned, could potentially produce beams with brightness near $10^{20}$ A/rad$^2$/m$^2$.
In this work, a comparative study of the susceptibility chart in a partially dielectric-loaded rectangular waveguide and in its equivalent partially dielectric-loaded parallel-plate waveguide with the same height is performed. This study shows how the inhomogeneity of the electric field inside the rectangular waveguide modifies the edges of the multipactor susceptibility chart with respect to that predicted by the parallel-plate waveguide case. Moreover, comparisons of the evolution of the population and the trajectory of the effective electron and the DC field appearing in the waveguide in a point well inside the multipactor region obtained with both models are performed, showing some quantitative differences in the multipactor evolution, but a similar qualitative behaviour is observed.
This paper covers recent progress in the design of optics solutions to minimize collective effects such as beam instabilities, intra-beam scattering or space charge in hadron and lepton rings. The necessary steps are reviewed for designing the optics of high-intensity and high-brightness synchrotrons but also ultra-low emittance lepton storage rings, whose performance is strongly dominated by collective effects. Particular emphasis is given to proposed and existing designs illustrated by simulations and beam measurements.
The mean volume reflection angle of a high-energy charged particle passing through a bent crystal is expressed as an integral involving the effective interplanar potential over a single crystal period. Implications for positively and negatively charged particles, and silicon crystal orientations (110) and (111) are discussed. A generic next-to-leading-order expansion in the ratio $E/R$ of the particle energy $E$ to the crystal bending radius $R$ is given. For positively charged particles, the dependence of the mean volume reflection angle on $E/R$ proves to be approximately linear, whereas for negatively charged particles the linear behaviour is modified by an $E/R$-dependent logarithmic factor. Up-to-date experimental data are confronted with predictions based on commonly used atomic potentials.
We report on laser spectroscopic measurements on Li$^+$ ions in the experimental storage ring ESR at the GSI Helmholtz Centre for Heavy Ion Research. Driving the $2s\,^3\!{S}_1\;(F=\frac{3}{2}) \,\leftrightarrow\,2p\,^3\!P_2\;(F=\frac{5}{2}) \leftrightarrow 2s\,^3\!{S}_1\;(F=\frac{5}{2})$ $Λ$-transition in $^7$Li$^+$ with two superimposed laser beams it was found that the use of circularly polarized light leads to a disappearance of the resonance structure in the fluorescence signal. This can be explained by optical pumping into a dark state of polarized ions. We present a detailed theoretical analysis of this process that supports the interpretation of optical pumping and demonstrates that the polarization induced by the laser light must then be at least partially maintained during the round trip of the ions in the storage ring. Such polarized ion beams in storage rings will provide opportunities for new experiments, especially on parity violation.
The goal of this paper is to examine experimental progress in laser wakefield acceleration over the past decade (2004-2014), and to use trends in the data to understand some of the important physical processes. By examining a set of over 50 experiments, various trends concerning the relationship between plasma density, accelerator length, laser power and the final electron beam en- ergy are revealed. The data suggest that current experiments are limited by dephasing and that current experiments typically require some pulse evolution to reach the trapping threshold.
Self-consistent multi-particle simulation plays an important role in studying beam-beam effects and space charge effects in high-intensity beams. The Poisson equation has to be solved at each time-step based on the particle density distribution in the multi-particle simulation. In this paper, we review a number of numerical methods that can be used to solve the Poisson equation efficiently. The computational complexity of those numerical methods will be O(N log(N)) or O(N) instead of O(N2), where N is the total number of grid points used to solve the Poisson equation.
We present few-femtosecond shadowgraphic snapshots taken during the non-linear evolution of the plasma wave in a laser wakefield accelerator with transverse synchronized few-cycle probe pulses. These snapshots can be directly associated with the electron density distribution within the plasma wave and give quantitative information about its size and shape. Our results show that self-injection of electrons into the first plasma wave period is induced by a lengthening of the first plasma period. Three dimensional particle in cell simulations support our observations.
Aakash A. Sahai, T. C. Katsouleas, R. A. Bingham
et al.
We analyze the use of a relativistic laser pulse with a controlled frequency chirp incident on a rising plasma density gradient to drive an acceleration structure for proton and light-ion acceleration. The Chirp Induced Transparency Acceleration (ChITA) scheme is described with an analytical model of the velocity of the snowplow at critical density on a pre-formed rising plasma density gradient that is driven by a positive-chirp in the frequency of a relativistic laser pulse. The velocity of the ChITA-snowplow is shown to depend upon rate of rise of the frequency of the relativistic laser pulse represented by $\frac{ε_0}θ$ where, $ε_0 = \frac{Δω_0}{ω_0}$ and chirping spatial scale-length, $θ$, the normalized magnetic vector potential of the laser pulse $a_0$ and the plasma density gradient scale-length, $α$. We observe using 1-D OSIRIS simulations the formation and forward propagation of ChITA-snowplow, being continuously pushed by the chirping laser at a velocity in accordance with the analytical results. The trace protons reflect off of this propagating snowplow structure and accelerate mono-energetically. The control over ChITA-snowplow velocity allows the tuning of accelerated proton energies.
Synchronized, independently tunable and focused $μ$J-class laser pulses are used to release multiple electron populations via photo-ionization inside an electron-beam driven plasma wave. By varying the laser foci in the laboratory frame and the position of the underdense photocathodes in the co-moving frame, the delays between the produced bunches and their energies are adjusted. The resulting multibunches have ultra-high quality and brightness, allowing for hitherto impossible bunch configurations such as spatially overlapping bunch populations with strictly separated energies, which opens up a new regime for light sources such as free-electron-lasers.