Hasil untuk "q-bio.SC"

Muhammad Irfan, Seung Chung

Abstract Tissue injury affects nerve fibers and triggers an immune response, leading to inflammation. The complement system gets activated during inflammatory conditions and has been reported to be involved in the regeneration process. We have demonstrated that the C5a receptor (C5aR) has crucial roles in regeneration and healing processes including nerve sprouting and hard tissue formation. Another C5a-like 2 receptor (C5AR2; C5L2) has been cloned which is still considered controversial due to limited studies. We previously established that C5L2 regulates brain-derived neurotrophic factor (BDNF) secretion in pulp fibroblasts. However, there is no study available on human dental pulp stem cells (DPSCs), especially in the inflammatory context. Stem cell therapy is an emerging technique to treat and prevent several diseases. DPSCs are a great option to be considered due to their great ability to differentiate into a variety of cells and secrete nerve regeneration factors. Here, we demonstrated that C5L2 modulates BDNF secretion in DPSCs. Our results stated that C5L2 silencing through siRNA could increase BDNF production, which could accelerate the nerve regeneration process. Moreover, stimulation with lipopolysaccharide (LPS) enhanced BDNF production in C5L2 silenced DPSCs. Finally, we quantified BDNF secretion in supernatant and cell lysates using ELISA. Our results showed enhanced BDNF production in C5L2 silenced DPSCs and hampered by the p38 MAPK α inhibitor. Taken together, our data reveal that C5L2 modulates BDNF production in DPSCs via the p38 MAPK α pathway.

Armin Goudarzi

This paper presents B-CLEAN-SC, a variation of CLEAN-SC for broadband sources. In contrast to CLEAN-SC, which “deconvolves” the beamforming map for each frequency individually, B-CLEAN-SC processes frequency intervals. Instead of performing a deconvolution iteration at the location of the maximum level, B-CLEAN-SC performs it at the location of the over-frequency-averaged maximum to improve the location estimation. The method is validated and compared to standard CLEAN-SC on synthetic cases and real-world experiments for broad- and narrowband sources. It improves the source reconstruction at low and high frequencies and suppresses noise, while it only increases the need for memory and not computational effort.

A. Murat, G. Slama

USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23), David Cook, DOE Office of Science Atmospheric Radiation Measurement (ARM) Program (United States)

Engº Elvis Jardim Maues, D. Sc. Nelson Marinelli Filho, D. Sc. Gil Eduardo Guimarães et al.

Este projeto aborda a necessidade crescente de garantir a rastreabilidade e qualidade dos carregadores de celular em um mercado globalizado, onde a transparência nos processos é fundamental. O objetivo principal é realizar testes elétricos com rastreabilidade utilizando leitura por QR code e programação através do software LabWindows/CVI da National Instruments. O estudo inicia com a contextualização do problema, destacando a importância da rastreabilidade para garantir a qualidade e confiabilidade dos produtos eletrônicos, como os carregadores de celular. Observou-se a necessidade de implementar métodos que agilizem o processo de teste, visando maximizar a eficiência da produção. Os materiais e métodos empregados envolvem a utilização do software LabWindows/CVI, um ambiente de desenvolvimento ANSI C específico para aplicações de teste e medição. Além disso, foram realizadas observações no setor de teste de carregadores para identificar as lacunas no processo e determinar as melhores estratégias para implementar a rastreabilidade. No processo proposto, a primeira etapa consiste na leitura do QR code da régua e dos carregadores, organizando-os em sequência numérica para registro em um arquivo .txt. Em seguida, a segunda etapa realiza a coleta de dados, executa os testes elétricos necessários e gera um arquivo .csv para armazenamento local, juntamente com um arquivo .xml para registro no banco de dados da empresa. Os resultados incluem a melhoria significativa na eficiência do processo de teste, a garantia da rastreabilidade completa dos carregadores e a otimização do tempo de produção dos equipamentos.

F.I. Popovici, J. Wilkes