Hasil untuk "math.OC"

Menampilkan 20 dari ~1078781 hasil · dari arXiv, DOAJ, CrossRef

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arXiv Open Access 2024
Directional descent

Andrew J. Young

We identity the optimal non-infinitesimal direction of descent for a convex function. An algorithm is developed that can theoretically minimize a subset of (non-convex) functions.

en math.OC
arXiv Open Access 2020
A Fixed Point Framework for Recovering Signals from Nonlinear Transformations

Patrick L. Combettes, Zev. C. Woodstock

We consider the problem of recovering a signal from nonlinear transformations, under convex constraints modeling a priori information. Standard feasibility and optimization methods are ill-suited to tackle this problem due to the nonlinearities. We show that, in many common applications, the transformation model can be associated with fixed point equations involving firmly nonexpansive operators. In turn, the recovery problem is reduced to a tractable common fixed point formulation, which is solved efficiently by a provably convergent, block-iterative algorithm. Applications to signal and image recovery are demonstrated. Inconsistent problems are also addressed.

en math.OC
CrossRef Open Access 2019
Osteoclast (OC) precursor culture v1

Xiang Chen

Osteoclast precursors from human peripheral blood were cultured as previously described. 15 mL of heparin anti-coagulated peripheral blood was obtained by venipuncture from the patient, and a healthy age- and sex-matched control. Peripheral blood mononuclear cells (PBMCs) were isolated using Ficoll-Hypaque Solution. Cells were washed in PBS twice, and plated on 24-well plates at a density of 1×106/well at 37°C in α-MEM, supplemented with 10% FBS, 1% penicillin/streptomycin and 25 ng/ml of macrophage colony stimulating factor (M-CSF) (R&D Systems, Inc., Minneapolis, USA). 6 days later, osteoclast precursor differentiation was induced with the medium supplemented with both 25ng/ml of M-CSF and 30ng/ml RANKL (R&D Systems, Inc., Minneapolis, USA). PBMCs in three wells from each subject were cultured in the absence of M-CSF and RANKL as a negative control.7 days later, TRAP staining was performed using a kit from Sigma-Aldrich (sigma Chemical Co., St. Louis, MO, USA). TRAP-positive cells containing 3 or more nuclei were counted as OCs. 6mm*6mm bovine cortical bone slices were put into cell culture wells at the beginning of OC differentiation. 7 days after co-cultures, the slices were removed and evaluated for OC morphology and pit formation by scanning electron microscope (INCA PENTAFET X3, Oxford Instruments, Abingdon, Oxfordshire, UK).

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