Hasil untuk "Osteopathy"

Harsh Durgia, Rajan Palui, Jayaprakash Sahoo et al.

Diabetes mellitus (DM) is a metabolic disorder that leads to the destruction of various tissues including bones. The pathogenesis of osteoporosis (OP) varies in DM due to many specific factors. DM increases the risk of fracture as well as post-fracture mortality. It is because of this fact that OP treatment should not be neglected in patients with DM. OP therapy comprises anabolic as well as anti-resorptive agents. Primary OP as observed in post-menopausal women is associated with high bone turnover, whereas OP in DM is a disease of low bone turnover. Therefore, anabolic agents seem to be quite promising in cases of OP in DM. Although the anti-fracture efficacy of these drugs is proven beyond any doubt in the general population without DM, evidence in persons with DM is limited. Among the anabolic agents, teriparatide has the most evidence in favor of its efficacy and safety in persons with DM. Studies evaluating other anabolic agents such as abaloparatide and romosozumab in diabetic osteopathy are scarce in the literature. Future studies specifically in both type 1 and type 2 DM populations are needed to evaluate the effects of osteoanabolic agents.

Sarah Stimpfig, Robert Kob, Matthias Kohl et al.

The present study aimed to determine the acute effects of high-intensity dynamic resistance training (HI-DRT) and whole-body electromyostimulation (WB-EMS) on markers of bone formation and resorption in young healthy women. Using a crossover design, 17 students of dentistry (26.5 ± 4.0 years, 21.5 ± 2.5 kg/m²) were randomly assigned to begin either with HI-DRT (five exercises, three sets to repetition maximum) or 20 min of non-superimposed, low-frequency (85 Hz), intermitted (6 s impulse/4 s impulse break) WB-EMS. The study outcome parameters were total Procollagen Type-1 N-Terminal Propeptide (P1NP) and Type-I Collagen Cross-Linked C-Telopeptide (CTX), which were sampled immediately prior to and 15 min post intervention. ANCOVA was applied to determine the main effects, i.e., differences in pre–post changes in CTX and P1NP between the interventions. No participant was lost to follow-up or reported adverse effects related to the exercises. Briefly, we observed significant differences (<i>p</i> = 0.019, d′ = 1.19) for changes in P1NP that were maintained in the HI-DRT (<i>p</i> = 0.446) and decreased in the WB-EMS group (<i>p</i> = 0.002). In contrast, we did not observe differences for HI-DRT- vs. WB-EMS-induced CTX changes (<i>p</i> = 0.509; d′ = 0.134). In summary, while HI-DRT provides significantly more favorable effects on bone formation markers compared to WB-EMS, the clinical significance of this finding in predicting the general effectiveness of an exercise protocol on bone strength remains to be determined. (Clinical trials.gov; registration date: 2025-02-06; ID: NCT06813092.)

Ahmed Nageeb Mahmoud, Alejandro Ordas-Bayon, Desirée Gijón-Cordero et al.

<b>Background/Objectives:</b> Periprosthetic joint infection (PJI) is a challenging problem in orthopedic surgery and is often associated with high morbidity. The treatment becomes even more challenging whenever the microorganism is virulent and/or not widely known as a causative organism on these occasions. This study aims to report on the clinical outcomes of hip hemiarthroplasty prosthetic hip joint infection by an atypical, rare microorganism, <i>Morganella morganii</i> (<i>M. morganii</i>), focusing on morbidity, revisions, and mortality. <b>Methods:</b> This is a retrospective series of four cases of prosthetic joint infections with <i>Morganella morganii</i>, a rare Gram-negative opportunistic facultative anaerobic pathogen, in four patients who received hip hemiarthroplasty for displaced femoral neck fractures at a level 1 trauma center. Clinical notes, laboratory findings, and radiographs were reviewed to extract relevant information regarding the history and outcomes. <b>Results:</b> The patients were four females, with a mean age of 84.27 years at the time of surgery. Two cases (50%) underwent surgical debridement and implant retention, followed by lifelong antibiotic suppression for symptomatic control of persistent wound drainage, and the other two underwent implant removal and resection arthroplasty (one patient) or received an antibiotic spacer (one patient), followed by chronic antibiotic therapy until wound closure. <b>Conclusions:</b> Periprosthetic hemiarthroplasty infection secondary to <i>M. morganii</i> was associated with overall poor outcomes. Antibiotic suppression could be a reasonable option after the surgical debridement or implant removal in <i>M. morganii</i> PJI to control the symptoms.

Ana Santos, Inês Silva, Mariana Monteiro et al.

Introdução: A dismenorreia primária é a patologia ginecológica que afeta mais mulheres em idade fértil estando associada a elevadas taxas de absentismo laboral, pelo impacto negativo que pode ter na qualidade de vida (Ju et al., 2013). Objetivo: Averiguar, através de uma análise crítica da qualidade metodológica, os efeitos da intervenção osteopática na sintomatologia decorrente da dismenorreia primária, bem como o impacto na qualidade de vida em mulheres entre a menarca e a menopausa. Métodos: Através de uma pesquisa, realizada em 25 de abril de 2022, nas bases de dados PubMed, Science Direct, Web of Science Core Collection e EBSCOhost Datasets foram selecionados ensaios clínicos randomizados publicados entre 2012 e 2022, cuja abordagem consistisse numa intervenção osteopática ou intervenção realizada por um osteopata, em participantes com dismenorreia primária. Foram incluídos estudos que avaliassem pelo menos um dos outcomes estipulados de acordo com o método PICO, nomeadamente, a dor e sintomatologia associadas a episódios de dismenorreia e o impacto no bem-estar geral da população em estudo (Wright et al., 2007). Aplicando os critérios de elegibilidade e inclusão, a extração de dados e avaliação da qualidade metodológica foi realizada por dois revisores independentes, intervindo um terceiro em caso de discórdia (Newton, 2014). Resultados: No decurso da pesquisa foram identificados doze artigos, sendo que apenas três cumpriam os critérios de inclusão estipulados. O risco de viés das suas metodologias foi analisado segundo os critérios da ferramenta Cochrane Risk of Bias, identificando-se classificações de baixo risco na maioria dos parâmetros avaliados. Os resultados apresentados defendem a existência de evidência do impacto positivo da osteopatia nesta população, verificando-se uma diminuição da dor lombo pélvica, dor abdominal (intensidade, duração e número de dias), toma de anti-inflamatórios não esteróides (AINEs), absentismo, bem como uma melhoria na qualidade de vida geral. Conclusão: A atual revisão sistemática revela resultados significativos do impacto da abordagem osteopática em mulheres com dismenorreia primária, demonstrando melhorias nos sintomas associados e na qualidade de vida. Contudo, a ausência da cegueira profissional e de protocolos detalhados constituem fontes de viés relevantes. Assim, são recomendados estudos futuros com amostras mais representativas da população, aplicando metodologias mais robustas.

Andrew Bateman, Edward Kirby, Andrew MacMillan et al.

Introduction Attributing musculoskeletal (MSK) pain to normal and commonly occurring imaging findings, such as tendon, cartilage and spinal disc degeneration, has been shown to increase people’s fear of movement, reduce their optimism about recovery and increase healthcare costs. Interventions seeking to reduce the negative effects of MSK imaging reporting have had little effect. To understand the ineffectiveness of these interventions, this study seeks to scope their behavioural targets, intended mechanisms of action and theoretical underpinnings. This information alongside known barriers to helpful reporting can enable researchers to refine or create new more targeted interventions.Methods and analysis The scoping review will be conducted in accordance with the JBI methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. Search terms will be devised by the research team. Searches of MEDLINE, EMBASE, CINAHL, AMED and PsycINFO from inception to current day will be performed. The review will include studies, which have developed or evaluated interventions targeting the reporting of MSK imaging. Studies targeting the diagnosis of serious causes of MSK pain will be excluded. Two independent authors will extract study participant data using predefined extraction templates and intervention details using the Template for Intervention Description and Replication checklist. Interventions will be coded and mapped to the technique, mechanism of action and behavioural target according to the Capability, Opportunity, Motivation-Behaviour (COM-B) model categories. Any explicit models or theories used to inform the selection of interventions will be extracted and coded. The study characteristics, behaviour change techniques identified, behavioural targets according to the COM-B and context specific theories within the studies will be presented in narrative and table form.Ethics and dissemination The information from this review will be used to inform an intervention design process seeking to improve the communication of imaging results. The results will also be disseminated through a peer-reviewed publication, conference presentations and stakeholder events.

Dominik Sieroń, Izabella Jabłońska, Paweł Niemiec et al.

<i>Background and Objective</i>: Magnetic resonance imaging (MRI) enables the effective evaluation of chondromalacia of the knee joint. Cartilage disease is affected by many factors, including gender, age, and body mass index (BMI). The aim of this study was to check the relationship between the severity of chondromalacia of the femoro-tibial joint and age, gender, and BMI assessed with 1.5T and 3.0T MRI scanners. <i>Materials and Methods</i>: The cross-observational study included 324 patients—159 (49%) females and 165 (51%) males aged 8–87 (45.1 ± 20.9). The BMI of study group was between 14.3 and 47.3 (27.7 ± 5.02). 1.5T and 3.0T MRI scanners were used in the study. The articular cartilage of the knee joint was assessed using the Outerbridge scale. <i>Results</i>: The age of the patients showed a significant correlation with Outerbrige for each compartment of the femorotibial joint (Spearman’s rank correlation rho: 0.69–0.74, <i>p</i> < 0.0001). A higher correlation between BMI and Outerbridge was noted in the femur medial (rho = 0.45, <i>p</i> < 0.001) and the tibia medial (rho = 0.43, <i>p</i> < 0.001) than in the femur lateral (rho = 0.29, <i>p</i> < 0.001) and the tibia lateral compartment (rho = 0.34, <i>p</i> < 0.001). <i>Conclusions</i>: The severity of chondromalacia significantly depends on age and BMI level, regardless of gender.

Moreno-Ballesteros A, García-Gómez FJ, De la Riva-Pérez PA et al.

Kevin K. Haussler, Amie L. Hesbach, Laura Romano et al.

Mobilization and manipulation techniques are often used in small animal and equine practice; however, questions remain concerning indications, dosing and efficacy. A bibliographic search was performed to identify peer-reviewed publications from 1980 to 2020 that evaluated the clinical effects of musculoskeletal mobilization and manipulation techniques in dogs, cats and horses. The search strategy identified 883 papers for review. Inclusion and exclusion criteria were applied. The clinical indications, dosages, outcome parameters, and reported efficacy within each publication were recorded and categorized for comparison with scientific quality assessed according to a standardized grading system. Fourteen articles were included in this systematic review of which 13 were equine and one was a canine study. Seven of these were cohort studies and seven were randomized controlled clinical trials. The canine study involved carpal immobilization-remobilization and all equine studies focused on the effects of passive mobilization (<i>n</i> = 5) or manipulation (<i>n</i> = 8) of the axial skeleton. Study quality was low (<i>n</i> = 4), moderate (<i>n</i> = 7), and high (<i>n</i> = 3) and included a wide array of outcome parameters with varying levels of efficacy and duration of therapeutic effects, which prevented further meta-analysis. Therefore, it was difficult to draw firm conclusions despite all studies reporting positive effects. Optimal technique indications and dosages need to be determined to improve the standardization of these treatment options.

Editorial Board Osteoporosis and Bone Diseases

The Russian Osteoporosis Association, the editors of the journal Osteoporosis and Osteopathies, regretfully report that on May 26, 2019, a famous Russian doctor, professor, doctor of medical sciences, chief freelance traumatologist of the Omsk region Leonid Borisovich Reznik, passed away.

López Gavilanez E, Guerrero Franco K, Segale Bajaña A et al.

Objetivos: Conocer la prevalencia del hiperparatiroidismo primario (HPTP) mediante el cribado con la determinación de PTH y calcio iónico, en una muestra poblacional de Guayaquil (Ecuador). Materiales y métodos: Estudio transversal, prospectivo, realizado entre el 1 enero de 2009 y el 30 noviembre de 2014, en 13.860 personas que acudieron a exámenes de control rutinarios. A todos se les determino en suero la hormona paratiroidea (PTH), el calcio iónico, la creatinina sérica y la 25(OH) vitamina D total (VD total). Se confirmó el diagnóstico de HPTP si el nivel de PTH y/o calcio iónico se mantenía elevado al menos en dos ocasiones diferentes. Se excluyeron los casos con elevación de la creatinina sérica, malabsorción, hepatopatías crónicas, insuficiencia de vitamina D, o los que recibían tratamientos que alteran el metabolismo fosfocálcico. Resultados: Se encontró 61 casos con la PTH elevada al menos en dos ocasiones diferentes. Entre estos, 34 presentaban insuficiencia de vitamina D y fueron excluidos del análisis. En 27 casos (4 hombres y 23 mujeres) se confirmó el diagnóstico de HPTP. La edad media en mujeres fue de 64,5±15,4 años y en hombres de 71,3±12,8 años; los valores de PTH medios fueron 115±24,2 pg/ml; de calcio iónico, 5,15±0,4 mg/dl; de VD total, 47,1±20,2 ng/ml; y de creatinina sérica 0,84±0,2 mg/ml; La prevalencia de HPTP corresponde a 2 casos por mil adultos (IC 95%: 1,71-2,18). El mayor incremento en la prevalencia ocurrió en mujeres ≥60 años. Conclusión: En esta muestra, la prevalencia de HPTP es baja comparada con la reportada en series internacionales, siendo mayor en edades avanzadas y en mujeres. Con el cribado propuesto de PTH y calcio iónico encontramos en la mayoría de los casos la forma normocalcémica de HPTP.

Carrillo López N, Tuñón LePoultel D, Quirós Caso C et al.

Introducción: El calcitriol, fundamental para mantener la homeostasis del calcio y el fósforo en el organismo, puede perjudicar al sistema vascular a dosis elevadas, aumentando el riesgo de calcificación. Objetivo: Evaluar la expresión diferencial de proteínas en células de músculo liso vascular sometidas a una dosis suprafisiológica de calcitriol. Material y métodos: Se cultivaron células de músculo liso vascular de rata (SMAC-R) en presencia de 10-7 M de calcitriol durante 10 días. Se valoró el cambio de fenotipo muscular a óseo mediante actividad fosfatasa alcalina, inmunocitoquímica, reacción en cadena de la polimerasa cuantitativa a tiempo real (qPCR) y Western blot. Mediante electroforesis bidimensional y espectrometría de masas se evaluó el patrón diferencial de proteínas en presencia y ausencia de 10-7 M de calcitriol. Resultados: La exposición a una dosis alta de calcitriol disminuyó significativamente la expresión génica de elastina y la expresión génica y proteica de ?-actina, aumentado la expresión génica de osteocalcina y Runx2 y la proteica de osteoprotegerina. A nivel proteómico se identificaron 10 proteínas diferencialmente expresadas, destacando el aumento en superóxido dismutasa mitocondrial, proteínas del citoesqueleto, de formación de vesículas y del inflamasoma. Por el contrario, hubo 4 proteínas que disminuyeron su expresión, destacando alguna de tipo muscular. Conclusiones: En un modelo de células de músculo liso vascular sometidas a una dosis suprafisiológica de calcitriol se observó un aumento de expresión de proteínas del citoesqueleto, que forman vesículas de matriz y que participan en depurar radicales libres y en la respuesta inflamatoria. La pérdida de fenotipo muscular se vio representada por descensos en la expresión de proteínas típicamente musculares.

Luca Cicchitti, M. Martelli, F. Cerritelli

Background Chronic inflammatory diseases (CID) are globally highly prevalent and characterized by severe pathological medical conditions. Several trials were conducted aiming at measuring the effects of manipulative therapies on patients affected by CID. The purpose of this review was to explore the extent to which osteopathic manipulative treatment (OMT) can be benefi-cial in medical conditions also classified as CID. Methods This review included any type of experimental study which enrolled sub-jects with CID comparing OMT with any type of control procedure. The search was conducted on eight databases in January 2014 using a pragmatic literature search approach. Two independent re-viewers conducted study selection and data extraction for each study. The risk of bias was evaluated according to the Cochrane methods. Heterogeneity was assessed and meta-analysis performed where possible. Results 10 studies met the inclusion criteria for this review enrolling 386 subjects. The search identified six RCTs, one laboratory study, one cross-over pilot studies, one observation-al study and one case control pilot study. Results suggest a potential effect of osteopathic medicine on patients with medical pathologies associated with CID (in particular Chronic Obstructive Pul-monary Disease (COPD), Irritable Bowel Syndrome, Asthma and Peripheral Arterial Disease) com-pared to no treatment or sham therapy although data remain elusive. Moreover one study showed possible effects on arthritis rat model. Meta-analysis was performed for COPD studies only show-ing no effect of any type of OMT applied versus control. No major side effects were reported by those receiving OMT. Conclusion The present systematic review showed inconsistent data on the effect of OMT in the treatment of medical conditions potentially associated with CID, however the OMT appears to be a safe approach. Further more robust trials are needed to determine the direction and magnitude of the effect of OMT and to generalize favorable results.

B. Vaughan, Annie Carter, Chris Macfarlane et al.

BackgroundMeasurement of the educational environment has become more common in health professional education programs. Information gained from these investigations can be used to implement and measure changes to the curricula, educational delivery and the physical environment. A number of questionnaires exist to measure the educational environment, and the most commonly utilised of these is the Dundee Ready Educational Environment Measure (DREEM).MethodsThe DREEM was administered to students in all year levels of the osteopathy program at Victoria University (VU), Melbourne, Australia. Students also completed a demographic survey. Inferential and correlational statistics were employed to investigate the educational environment based on the scores obtained from the DREEM.ResultsA response rate of 90% was achieved. The mean total DREEM score was 135.37 (+/- 19.33) with the scores ranging from 72 to 179. Some subscales and items demonstrated differences for gender, clinical phase, age and whether the student was in receipt of a government allowance.ConclusionsThere are a number of areas in the program that are performing well, and some aspects that could be improved. Overall students rated the VU osteopathy program as more positive than negative. The information obtained in the present study has identified areas for improvement and will enable the program leaders to facilitate changes. It will also provide other educational institutions with data on which they can make comparisons with their own programs.

O. Thomson, N. Petty, A. Moore

O V YaKUShEVSKAYa, S V YuRENEVA, S Yu KUZNETsOV

Цель: провести анализ влияния золедроновой кислоты на минеральную плотность кости (МПК) и биохимические маркеры костного ремоделирования (БМКР) у постменопаузальных женщин с остеопорозом. Материал и методы. В открытое проспективное исследование в течение 36 месяцев были включены женщины с постменопаузальным остеопорозом, получающие терапию золедроновой кислотой (ЗК) (n=225). Проводились оценка соматического статуса, лабораторные и инструментальные исследования (клинический анализ крови, биохимический анализ крови, общий анализ мочи, биохимические маркеры костного ремоделирования (БМКР) сыворотки крови: B-CrossLaps- маркер резорбции, остеокальцинмаркер костеобразования, остеоденситометрия (двухэнергетическая рентгеновская абсорбциометрия) L1-L4 и Neck. Результаты. Медиана возраста обследованных составила 59 (54-66) лет. Естественная менопауза отмечена у 80,6%, и 19,4% женщин имели индуцированную менопаузу. Медиана возраста наступления менопаузы составила 51 год (от 47 до 53), а медиана продолжительности постменопаузы - 7 (2-13) лет. Согласно полученным данным среди всех переломов преобладали переломы дистального отдела лучевой кости (p<0,05). В работе была проанализирована динамика биохимических маркеров костного ремоделирования (B-Crosslaps, Остеокальцин) исходно и через 1,3,6,9,12 месяцев терапии и сравнена с исходными значениями. Максимальное снижение B-Crosslaps, по сравнению с исходными значениями, было отмечено уже через 1 месяц после каждой последующей инфузии. В дальнейшем отмечено постепенное повышение показателей костной резорбции. Однако, даже через 12 месяцев после внутривенной инфузии ЗК уровень ß-Gosslaps был снижен (р=0,005). Максимальное снижение остеокальцина отмечено через 6 месяцев после каждой повторной инфузии и в течение последующих месяцев данный показатель существенно не менялся (р=0,02). Через 12 месяцев после инфузии получено постепенное повышение маркеров костеобразования, однако значения остеокальцина были также снижены в сравнении с исходом (р=0,016). К концу года терапии степень снижения маркеров резорбции (B-Crosslaps) была в 2 раза большей, чем маркеров костеобразования (остеокальцин). Через 12 месяцев после каждой последующей инфузии проводилась динамическая остеоденситометрия. Терапия ЗК сопровождалась достоверной положительной динамикой МПК в L1-L4 и Neck. Терапия ЗК в течение 36 месяцев сопровождалась увеличением МПК во всех исследуемых областях скелета, что соответствовало стабилизации процессов костного ремоделирования. Суммарная динамика МПК за 3 года терапии ЗК составила в L1-L4 составила +7% (p=0,049), в Neck left +5,9% и в Neck total left +6% (p=0,062) Заключение. Терапия азотсодержащими бисфосфонатами характеризовалась быстрой (уже через 1 месяц) и достоверной супрессией биохимических маркеров костного ремоделирования. Преимущественное подавление процессов резорбции обеспечило положительный баланс костного ремоделирования, увеличение МПК и выраженный антирезорбтивный эффект золедроновой кислоты (p<0,05). Результаты исследования подтвердили возможность использования БМКР для ранней диагностики (через 1 месяц) реакции на антирезорбтивную терапию и определения индивидуального ответа пациентов на проводимую терапию, задолго до изменения МПК.

G N ROMANOV, E V RUDENKO, O M LESNYaK

Цель исследования: получить эпидемиологические данные о переломах проксимального отдела бедренной кости (ПОБК) у лиц обоего пола в возрасте 50 лет и старше в Республике Беларусь Материал и методы. Настоящее исследование выполнено в рамках международного многоцентрового исследования ЭВА («Эпидемиология остеопоротических переломов в странах Евразии»), инициированного Российской ассоциацией по остеопорозу при поддержке Международного Фонда остеопороза. Объектом исследования был выбран крупный районный город Мозырь Гомельской области с населением 112 493 (по состоянию на 01.01.2015 г.). Методом сплошного ретроспективного анализа нами изучены источники информации о случаях переломов ПОБК за 2011-2012 гг. В анализ были включены данные вызовов бригад скорой помощи, статистические карты стационарных пациентов, выбывших из отделения травматологии Мозырской городской больницы (коды S72, S72.1 и S72.2 по МКБ-10) и журналы вызовов врача на дом из всех трех поликлиник г. Мозыря. Все выявленные случаи были проанализированы в амбулаторных картах по каждому случаю перелома с целью повышения достоверности частоты случаев и даты наступления переломов, уточнения характера травмы, а также рентгенологического подтверждения и способа лечения. Расчет первичной заболеваемости проведен по стандартной методике с использованием данных по г. Мозырю с численностью населения в возрасте 50 лет и старше (13594 мужчин и 19743 женщин) по полу и возрасту с интервалом 5 лет. Полученные результаты представлены в формате «количество случаев перелома ПОБК на 100000 населения» с распределением по 5-летним возрастным интервалам в зависимости от пола и возраста. Результаты. Углубленный анализ вышеперечисленных источников информации позволил нам выявить 117 случаев переломов ПОБ у лиц в возрасте 50 лет и старше. Из этого количества 83 (70,9%) пациента прошли стационарное лечение и 34 (29,1%) получали лечение на дому под наблюдением травматолога и терапевта в территориальной поликлинике. Наименьшие показатели первичной заболеваемости ПОБК (до 100 на 100000 населения) отмечены в возрастных группах от 50 до 69 лет у женщин и от 50 до 59 лет у мужчин. Начиная с возраста 70 лет, показатели первичной заболеваемости ПОБК у женщин возрастают, достигая своего максимума 1546 на 100000 населения в возрастной группе 85 лет и старше. У мужчин, в отличие от женщин, начиная с возраста от 60 до 84 лет показатели первичной заболеваемости ПОБК остаются стабильными и составляют в среднем от 180 до 249 случаев на 100000 населения. Выводы. 1.Показатели общей первичной заболеваемости низкотравматическими ПОБК среди населения г.Мозыря после 50 лет и старше (Республика Беларусь) составили 190 у женщин и 149 у мужчин на 100 000 населения. 2. Стационарный этап лечения прошли 71% пациентов, а 29% получали лечение амбулаторно.

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Sainz-Aja Guerra JA, Alonso MA, Ferreño Blanco D et al.

La disminución de la densidad mineral ósea (DMO), es decir, del volumen de tejido óseo por unidad de volumen del esqueleto, es característica de la osteoporosis, mientras que se ha sugerido que la artrosis se acompaña de un aumento de la DMO a nivel local y sistémico. Para comprobar esta hipótesis analizamos mediante microTAC el hueso trabecular de la cabeza femoral de 10 pacientes con fractura de cadera y 9 con coxartrosis. El análisis no reveló diferencias significativas entre ambos grupos en el volumen de tejido óseo trabecular, ni en los demás parámetros estructurales analizados. Tampoco se encontró una caída significativa del volumen de hueso trabecular con la edad. Esto indica que el hueso de esta región tiene una evolución peculiar. Los mecanismos responsables de ese comportamiento son desconocidos, pero su esclarecimiento podría, quizás, abrir la puerta a nuevos abordajes en el tratamiento de la pérdida de hueso asociada al envejecimiento.

O. Thomson, N. Petty, A. Moore

B. Bordoni, Emiliano Zanier