Kanhu Kishore Nanda, K. Narayan, Somnath Porey
et al.
A bstract We develop further previous work on de Sitter extremal surfaces and time entanglement structures in quantum mechanics. In the first part, we first discuss explicit quotient geometries. Then we construct smooth bulk geometries with replica boundary conditions at the future boundary and evaluate boundary Renyi entropies in dS / CFT . The bulk calculation pertains to the semiclassical de Sitter Wavefunction and thus evaluates pseudo-Renyi entropies. In 3-dimensions, the geometry in quotient variables is Schwarzschild de Sitter. The 4-dim dS geometry involves hyperbolic foliations and is a complex geometry satisfying a regularity criterion that amounts to requiring a smooth Euclidean continuation. Overall this puts on a firmer footing previous Lewkowycz-Maldacena replica arguments based on analytic continuation for the extremal surface areas via appropriate cosmic branes. In the second part (independent of de Sitter), we study various aspects of time entanglement in quantum mechanics, in particular the reduced time evolution operator, weak values of operators localized to subregions, a transition matrix operator with two copies of the time evolution operator, autocorrelation functions for operators localized to subregions, and finally future-past entangled states and factorization. Based on these, we then give some comments on a cosmological transition matrix using the de Sitter Wavefunction.
Bartłomiej Barczyński, Karolina Frąszczak, Ewelina Grywalska
et al.
According to recent data, changes in the vaginal microbiota could affect the risk of gynaecological cancers. Women suffering from endometrial cancer present significant changes in cervicovaginal microbiota composition. The objective of our study was to characterize the cervicovaginal microbiota of women undergoing hysterectomy due to benign disease, atypical hyperplasia, and endometrial cancer; The study included 96 patients, who undergone surgical treatment due to benign uterine disease, precancerous endometrial lesion, and endometrial cancer. Quantitative and qualitative real-time PCR analysis of DNA isolated from vaginal fornix and endocervical canal samples was performed to detect the 19 most commonly identified microorganisms, including different Lactobacillus spp., Atopobium, Bifidobacterium, Chlamydia, and Gardnerella; At least one of the tested microorganisms was identified in 88.5% of vaginal and 83.3% of cervical samples. Lactobacillus iners was significantly more frequent in patients with benign condition, whereas Dialister pneumosintes and Mobiluncus curtisii was more frequent in cancer patients; Mobiluncus curtisi and Dialister pneumosintes, which were identified as significantly more common in endometrial cancer vaginal samples, may be considered as potential endometrial cancer co-factors which promote/stimulate carcinogenesis. However, the exact mechanism of such activity remains unexplained and requires further investigations.
This is short tutorial on one way to calculate dN/dS ratios between pairs of protein-coding nucleic acid sequences using codeml in the PAML package. Code is intended for use on an Ubuntu 16.04 LTS OS, but it may work on other Unix or Unix-like systems. The programs used in this tutorial are: codeml in the PAML package. On a Ubuntu 16.04 LTS system it should be able to install this tool with "sudo apt install paml". http://abacus.gene.ucl.ac.uk/software/paml.html PAL2NAL. This is essentially a PERL script that you will want to have handy, either by putting it in the folder that you are working in or by putting it somewhere that is in your PATH. http://www.bork.embl.de/pal2nal/ clustal-omaga. You should be able to install this with "sudo apt install clustalo" This is a nice amino acid and nucleic acid alignement program. For purposes here your choice of aligner is not critical, so if you prefer MAFFT or Muscle or something else you can continue using those. http://www.clustal.org/omega/
The etiology of Coronavirus Disease 2019 (COVID-19) can be attributed to severe acute respiratory disease caused by Coronavirus 2, often known as SARS-CoV-2. The impact of renal function on the prognosis of this condition remains uncertain despite its rapid global dissemination and significant morbidity and mortality. There is an association between decreased renal function and increased death rates in the whole population and a prognostic significance in the context of COVID-19. The prevalence of impaired renal function is frequently observed among the aged population, prompting our investigation into the possible implications of this condition on mortality rates. This study aimed to determine the risk factors and variables associated with COVID-19 in hospitals among patients with diabetes and Chronic Kidney Disease (CKD). Study: During the period from February to April 2022, 250 people diagnosed with COVID-19 were admitted to Hilla Hospitals for Internal Medicine, located in Hilla province. The research encompassed a sample size of 250 people diagnosed with COVID-19, consisting of 130 males and 120 females. The age range of the participants ranged from 20 to 80 years. The mild-to-moderate category accounted for 170 cases, 68% of the total, while the severe category accounted for 80 cases, or 32%. The findings of the present investigation indicate significant alterations in blood parameters, including urea, creatinine, D-dimer, and blood glucose, in different stages of COVID-19 infection, namely mild, moderate and severe.